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| 1 | Long-term outcomes after laparoscopic colectomy显示文摘AIM:To evaluate long-term outcomes in a large series of patients who randomly received laparoscopic or open colorectal resection.METHODS:From February 2000 to December 2004,six hundred sixty-two patients with colorectal disease were randomly assigned to laparoscopic(LPS,n = 330) or open(n = 332) colorectal resection.All patients were analyzed on an intention-to-treat basis.Long-term follow-up was carried out every 6 mo by office visits.In 526 cancer patients five-year overall and disease-free survival were evaluated.Median oncologic follow-up was 96 mo.RESULTS:Eight(4.2%) LPS group patients needed conversion to open surgery.Overall long-term morbidity rate was 7.6%(25/330) in the LPS vs 11.1%(37/332) in the open group(P = 0.17).In cancer patients,fiveyear overall survival was 68.6% in the LPS group and 64.0% in the Open group(P = 0.27).Excluding stage Ⅳ patients,five-year local and distant recurrence rates were 32.5% in the LPS group and 36.8% in the Open group(P = 0.36).Further,no difference in recurrence rate was found when patients were stratified according to cancer stage.CONCLUSION:LPS colorectal resection was associated with a slightly lower incidence of long-term complications than open surgery.No difference between groups was found in overall and disease-free survival rates. | Marco Braga Nicolò Pecorelli Matteo Frasson Andrea Vignali Walter Zuliani Valerio Di Carlo | 2011 | World Journal of Gastrointestinal Oncology2011，3，3： | 8 |
| 2 | Intranasal rapamycin ameliorates Alzheimerlike cognitive decline in a mouse model of Down syndrome显示文摘Background:Down syndrome(DS)individuals,by the age of 40s,are at increased risk to develop Alzheimer-like dementia,with deposition in brain of senile plaques and neurofibrillary tangles.Our laboratory recently demonstrated the disturbance of PI3K/AKT/mTOR axis in DS brain,prior and after the development of Alzheimer Disease(AD).The aberrant modulation of the mTOR signalling in DS and AD age-related cognitive decline affects crucial neuronal pathways,including insulin signaling and autophagy,involved in pathology onset and progression.Within this context,the therapeutic use of mTOR-inhibitors may prevent/attenuate the neurodegenerative phenomena.By our work we aimed to rescue mTOR signalling in DS mice by a novel rapamycin intranasal administration protocol(InRapa)that maximizes brain delivery and reduce systemic side effects.Methods:Ts65Dn mice were administered with InRapa for 12 weeks,starting at 6 months of age demonstrating,at the end of the treatment by radial arms maze and novel object recognition testing,rescued cognition.Results:The analysis of mTOR signalling,after InRapa,demonstrated in Ts65Dn mice hippocampus the inhibition of mTOR(reduced to physiological levels),which led,through the rescue of autophagy and insulin signalling,to reduced APP levels,APP processing and APP metabolites production,as well as,to reduced tau hyperphosphorylation.In addition,a reduction of oxidative stress markers was also observed.Discussion:These findings demonstrate that chronic InRapa administration is able to exert a neuroprotective effect on Ts65Dn hippocampus by reducing AD pathological hallmarks and by restoring protein homeostasis,thus ultimately resulting in improved cognition.Results are discussed in term of a potential novel targeted therapeutic approach to reduce cognitive decline and AD-like neuropathology in DS individuals. | Antonella Tramutola Chiara Lanzillotta Eugenio Barone Andrea Arena Ilaria Zuliani Luciana Mosca Carla Blarzino D.Allan Butterfield Marzia Perluigi Fabio Di Domenico | 2018 | Translational Neurodegeneration2018，7，1： | 3 |
| 3 | Actual concept of 'probiotics':Is it more functional to science or business?显示文摘It is our contention that the concept of a probiotic as a living bacterium providing unspecified health benefits is inhibiting the development and establishment of an evidence base for the growing field of pharmacobiotics.We believe this is due in part to the current regulatory framework,lack of a clear definition of a probiotic,the ease with which currently defined probiotics can be positioned in the market place,and the enormous profits earned for minimum investment in research.To avoid this,we believe the following two actions are mandatory:international guidelines by a forum of stakeholders made available to scientists and clinicians,patient organizations,and governments;public research funds made available to the scientific community for performing independent rigorous studies both at the preclinical and clinical levels. | Michele Caselli Francesca Cassol Girolamo Calò John Holton Giovanni Zuliani Antonio Gasbarrini | 2013 | World Journal of Gastroenterology2013，19，10： | 3 |
| 4 | Laparoscopic Versus Open Colorectal Surgery: A Randomized Trial on Short-Term Outcome显示文摘 | Marco Braga Andrea Vignali Luca Gianotti Walter Zuliani Giovanni Radaelli Paola Gruarin Paolo Dellabona Valerio Di Carlo | 2002 | Annals of Surgery2002，，6： | 2 |
| 5 | BACE1 role in Alzheimer’s disease and other dementias:from the theory to the practice显示文摘Beta-site amyloid precursor protein(APP)cleaving enzyme-1(BACE1):brief overview on the biology and its role in Alzheimer’s disease(AD)pathogenesis:AD is a multifactorial and multifaceted disease,with a complex and still not completely understood pathogenesis(Cervellati et al.,2016;Iturria-Medina et al.,2016).Multiple hypotheses have been proposed to explain the pathobiology of the disease. | Carlo Cervellati Giuseppe Valacchi Giovanni Zuliani | 2021 | Neural Regeneration Research2021，16，12： | 2 |
| 6 | High interleukin -6 plasma levels are associated with functional impairment in older patients with vascular dementia显示文摘 | Zuliani G Guerra G Ranzini M | 2007 | Int J Geriatr Psychiatry2007，22，4： | 1 |
| 7 | Randomized clinical trial of lap- aroscopic versus open left colonic resection 显示文摘 | Braga M Frasson M Zuliani W | 2010 | BritishJoumalof Sur- gery2010，97，8： | 1 |
| 8 | Plasma cytokines profile in older subjects with late onset Alzheimer's dis ease or vascular dementia显示文摘 | Zuliani G Ranzini M Guerra G | 2007 | J Psychiatr Res2007，41，8： | 1 |
| 9 | Metabolic and functional results after laparoscopic colorectal surgery: a randomized, controlled trial 显示文摘 | Braga M Vignali A Zuliani W | 2002 | Dis Colon Rectum2002，45，8： | 1 |
| 10 | Bayesian statistical model chec- king with application to Stateflow/Simulink verification 显示文摘 | Zuliani P Platzer A Clarke E M | 2013 | Formal Methods in System Design2013，43，2： | 1 |
| 11 | Changes in CO2 emissions after crop conversion from continuous maize to alfalfa 显示文摘 | Alberti G Vedove GD Zuliani M Peressotti A Castaldi S Zerbi G | 2010 | Agric Ecosyst Environ2010，136，： | 1 |
| 12 | Metabolic and functional results after laparoscopic colorectal surgery显示文摘 | Braga M Vignali A Zuliani W | 2002 | Dis Colon Rectum2002，45，8： | 1 |
| 13 | A condition number for point matching with application to registration and post-registration error estimation显示文摘 | Kenney C Manjunath B S and Zuliani M | 2003 | IEEE Transactions on Pattern Analysis and Machine Intelligence2003，25，11： | 1 |
| 14 | Central nervous system neuronal surface antibody associated syndromes:review and guidelines for recognition显示文摘 | Zuliani L Graus F Giometto B | 2012 | J Neurol Neurosurg Psychiatry2012，83，： | 1 |
| 15 | The history of autosomal recessive hypercholesterolemia ( ARH ): from clinical observations to gene identification显示文摘 | Fellin R Arca M Zuliani G | 2015 | Gene2015，555，1： | 1 |
| 16 | Randomized clinical trial of laparoscopic versus open left colonic resection显示文摘 | Braga M Frasson M Zuliani W | | 0，，08： | 1 |
| 17 | Metabolic and func-tional results after laparoscopic colorectal surgery 显示文摘 | Braga M Vignali A Zuliani W et a/ | 2002 | DisColon Rectum2002，45，8： | 1 |
| 18 | NO aspirins:antithrombotic activity of derivatives of acetylsalicylic acid releasing nitric oxide显示文摘 | Minuz P Lechi C Zuliani V | 1998 | Cardiovasc Drug Rev1998，16，： | 1 |
| 19 | Inflammationinduced by Bothrops asper venom : release of proinflammatory cy-tokines and eicosanoids,and role of adhesion molecules in leuko-cyte infiltration shock显示文摘 | Zamuner S R Zuliani J P Fernandes CM | 2005 | Toxicon2005，46，7： | 1 |
| 20 | Laparoscopic versus open colorectal surgery:cost-benefit analysis in a single-center randomized trial显示文摘 | Braga M Vignali A Zuliani W | | 0，，06： | 1 |
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