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| 1 | 中国妇女宫颈癌组织中人乳头瘤病毒感染及其地理分布的调查显示文摘应用核酸印迹技术(Southern blot),对我国十四省市自治区的1455例来源宫颈癌、官颈不典型增生、宫颈湿疣和正常宫颈组织,进行人乳头瘤病毒(HPV)感染的型别检测,并分析了其型别地理分布特点。结果发现,815例宫颈癌组织 HPV 总检出率53.5%,其中 HPV16和58型检出率最高,分别是31.9%和7.6%,HPV6/11和18型的检出率为2.3%和1.0%。而在195例宫颈上皮不典型增生中,HPV 总检出率为25.1%,16/58型和6/11型的检出率分别为4.6%、15.9%。206例宫颈湿疣中,HPV 检出率40.8%,6/11型最高,达33.5%。239例正常宫颈组织中,仅检出1例 HPV16型,5例6/11型。提示:我国宫颈癌 HPV 感染以16、58型为主,18型少见。还发现,北方地区的宫颈癌组织中,HPV 感染以16型为主;南方省份长江中下游地区,HPV58 型检出率明显增高,几乎和 HPV16型持平;沿海地区不明的相关型呈上升趋势。提示我国宫颈癌 HPV 感染的型别,可能存在'移行'的地理分布特点。 | 李洁 刘宝印 zur Hausen H 王宏 杨学志 李力 刘文 刘洪隐 陆克昭 刘旭 牛春燕 裴润芳 苏钟浦 王言贵 董继华 张桂宁 刘春杰 许吉林 林毓纯 | 1996 | 中华实验和临床病毒学杂志1996，10，1： | 67 |
| 2 | Pro12Ala polymorphism of the peroxisome proliferator-activated receptor γ2 in patients with fatty liver diseases显示文摘AIM:To test the occurrence of the Pro12Ala mutation of the peroxisome proliferator-activated receptor-γ (PPARγ)2-gene in patients with non-alcoholic fatty liver disease (NAFLD) or alcoholic fatty liver disease (AFLD).METHODS:DNA from a total of 622 specimens including 259 blood samples of healthy blood donors and 363 histologically categorized liver biopsies of patients with NAFLD (n=263) and AFLD (n=100) were analyzed by Real-time polymerase chain reaction using allele-specific probes.RESULTS:In the NAFLD and the AFLD collective,3% of the patients showed homozygous occurrence of the Ala12 PPARγ2-allele,differing from only 1.5% cases in the healthy population.In NAFLD patients,a high incidence of the Ala12 mutant was not associated with the progression of fatty liver disease.However,we observed a significantly higher risk (odds ratio=2.50,CI:1.05-5.90,P=0.028) in AFLD patients carrying the mutated Ala12 allele to develop inflammatory alterations.The linkage of the malfunctioning Ala12-positive PPARγ2 isoform to an increased risk in patients with AFLD to develop severe steatohepatitis and fibrosis indicates a more prominent anti-inflammatory impact of PPARγ2 in progression of AFLD than of NAFLD.CONCLUSION:In AFLD patients,the Pro12Ala single nuclear polymorphism should be studied more extensively in order to serve as a novel candidate in biomarker screening for improved prognosis. | Johannes W Rey Andrea Noetel Aline Hardt Ali Canbay Hakan Alakus Axel zur Hausen Hans Peter Dienes Uta Drebber Margarete Odenthal | 2010 | World Journal of Gastroenterology2010，16，46： | 11 |
| 3 | Papillomaviruses in the causation of human cancers — a brief historical account显示文摘 | Harald zur Hausen | 2008 | Virology2008，，2： | 4 |
| 4 | Nucleoporin 88 expression in hepatitis B and C virus-related liver diseases显示文摘AIM: To investigate the expression of nucleoporin 88 (Nup88) in hepatitis B virus (HBV) and C virus (HCV)-related liver diseases. METHODS: We generated a new monoclonal Nup88 antibody to investigate the Nup88 protein expression by immunohistochemistry (IHC) in 294 paraffin-embedded liver specimens comprising all stages of hepatocellular carcinogenesis. In addition, in cell culture experiments HBV-positive (HepG2.2.15 and HB611) and HBV-negative (HepG2) hepatoma cell lines were tested for the Nup88 expression by Western-immunoblotting to test data obtained by IHC.RESULTS: Specific Nup88 expression was found in chronic HCV hepatitis and unspecific chronic hepatitis, whereas no or very weak Nup88 expression was detected in normal liver. The Nup88 expression was markedly reduced or missing in mild chronic HBV infection and inversely correlated with HBcAg expression. Irrespective of the HBV- or HCV-status, increasing Nup88 expression was observed in cirrhosis and dysplastic nodules, and Nup88 was highly expressed in hepatocellular carcinomas. The intensity of Nup88 expression significantly increased during carcinogenesis (P < 0.0001) and correlated with dedifferentiation (P < 0.0001). Interestingly, Nup88 protein expression was significantly downregulated in HBV-positive HepG2.2.15 (P < 0.002) and HB611 (P < 0.001) cell lines as compared to HBV-negative HepG2 cells. CONCLUSION: Based on our immunohistochemical data, HBV and HCV are unlikely to influence the expression of Nup88 in cirrhotic and neoplastic liver tissue, but point to an interaction of HBV with the nuclear pore in chronic hepatitis. The expression of Nup88 in nonneoplastic liver tissue might reflect enhanced metabolic activity of the liver tissue. Our data strongly indicate a dichotomous role for Nup88 in non-neoplastic and neoplastic conditions of the liver. | Martina Knoess Anna Kordelia Kurz Olga Goreva Nuran Bektas Kai Breuhahn Magarethe Odenthal Peter Schirmacher Hans Peter Dienes C Thomas Bock Hanswalter Zentgraf Axel zur Hausen | 2006 | World Journal of Gastroenterology2006，12，36： | 4 |
| 5 | Alternative Transcription Initiation and the AUG Context Configuration Control Dual-Organellar Targeting and Functional Competence of Arabidopsis Lon 1 Protease显示文摘细胞的动态平衡包括女伴和朊酶依靠蛋白质质量控制的部件。在细菌和 eukaryoticorganelles, Lon 朊酶在移开不能挽回地损坏的蛋白质并且从而阻止 accumulationof 起一个关键作用有害降级抵抗的总数。基因表示,实时房间的成像, immunobiochemical,和功能的 complementationapproaches 为对叶绿体和线粒体双指向的 Lon1 提供最后的证据。Dual-organellar depositionof Lon1 isoforms 经由漏的核糖体 scanningfrom 取决于 transcriptional 规定和其他的翻译开始从最佳 Kozak 一致广泛地背离的第一 8 月顺序上下文。在 Arabidopsis lon1-1 异种的部分互补的细胞器特定的 Lon1 targetingresults,而完整的互补被指向的 dual-organellar 完全完成。两最佳并且 non-optimalAUG 顺序上下文在酵母是功能的并且便于漏的核糖体扫描当 mitochondrial presequence 被使用时,补充 pim1 显型。生物信息的搜索与 Lon1 类型双指向的顺序组织识别了一小部分 Arabidopsis 基因。Lon4, Lon1 的 paralog,模糊 presequence 多半从祖先的象 Lon1 一样基因的成双的 presequences 演变,产生单个双目标的蛋白质 isoform。我们要求那 Lon1 和它的 subfunctional paralog Lon4 发展了 transcriptional 和 posttranscriptional 的互补子集对为 dual-organellar targeting.Key 词的 environmentalcues 应答的规章的部件: | Gerasimos Daras Stamatis Rigas Dikran Tsitsekian Hadas Zur Tamir Tuller Polydefkis Hatzopoulos | 2014 | Molecular Plant2014，7，6： | 4 |
| 6 | Specifc inflammatory osteoclast precursors induced during chronic inflammation give rise to highly active osteoclasts associated with inflammatory bone loss显示文摘Elevated osteoclast(OC)activity is a major contributor to inflammatory bone loss(IBL)during chronic inflammatory diseases.However,the specific OC precursors(OCPs)responding to inflammatory cues and the underlying mechanisms leading to IBL are poorly understood.We identified two distinct OCP subsets:Ly6C^(hi)CD11b^(hi) inflammatory OCPs(iOCPs)induced during chronic inflammation,and homeostatic Ly6C^(hi)CD11b^(lo)OCPs(hOCPs)which remained unchanged.Functional and proteomic characterization revealed that while iOCPs were rare and displayed low osteoclastogenic potential under normal conditions,they expanded during chronic inflammation and generated OCs with enhanced activity.In contrast,hOCPs were abundant and manifested high osteoclastogenic potential under normal conditions but generated OCs with low activity and were unresponsive to the inflammatory environment.Osteoclasts derived from iOCPs expressed higher levels of resorptive and metabolic proteins than those generated from hOCPs,highlighting that different osteoclast populations are formed by distinct precursors.We further identified the TNF-αand S100A8/A9 proteins as key regulators that control the iOCP response during chronic inflammation.Furthermore,we demonstrated that the response of iOCPs but not that of hOCPs was abrogated in tnf-α^(-/-)mice,in correlation with attenuated IBL.Our findings suggest a central role for iOCPs in IBL induction.iOCPs can serve as potential biomarkers for IBL detection and possibly as new therapeutic targets to combat IBL in a wide range of inflammatory conditions. | Yaron Meirow Milena Jovanovic Yuval Zur Juliana Habib Daniele Filippo Colombo Nira Twaik Hadas Ashkenazi-Preiser Kerem Ben-Meir Ivan Mikula Jr. Or Reuven Guy Kariv Leonor Daniel Saja Baraghithy Yehuda Klein Jeroen Krijgsveld Noam Levaot Michal Baniyash | 2022 | Bone Research2022，10，3： | 2 |
| 7 | Oral delivery of DNA vaccines using attenuated Salmonella typhimurium as carrier显示文摘 | Darji A zur Lage S Garbe A J | 2000 | FEMS Immunol Med Microbiol2000，27，4： | 1 |
| 8 | Presence of papillomavirus sequences in condylomatous lesions of the mamillae and in invasive carcinoma of the breast显示文摘 | De Villiers EM Sandstrom RE zur Hausen H | 2005 | Breast Cancer Res2005，7，1： | 1 |
| 9 | Papillomaviruses Causing Cancer evasion from hostcell control in early events in carcinogenesis显示文摘 | | 2000 | J Natl Cancer Inst2000，92，： | 1 |
| 10 | Comparison of two methods of adding jitter to artificial neural network training显示文摘 | JIANG Y METZ C E | 2004 | International Congress Series2004，1268，： | 1 |
| 11 | Cervical carcinoma and human papillomavirus : on the road to preventing amaj or human cancer 显示文摘 | zur Hausen H | 2001 | J Nat Cancer Inst2001，93，4： | 1 |
| 12 | Photoselective Netting: an Emerging Approach in Protected Agriculture显示文摘 | Shahak Y Rather K Zur N | 2009 | Aeta Hort2009，807，： | 1 |
| 13 | Evaluation of Mat-thiola incana as a source of omega-3-linolenic acid 显示文摘 | Yaniv Z Schaffemann D Zur M | 1997 | Ind Crop /Vop1997，6，34： | 1 |
| 14 | Microstructtwe effects on microcmcking and brittle failure of dolomites显示文摘 | HATZOR Y H ZUR A MIMRAN Y | 1997 | Tectonophysics1997，281，34： | 1 |
| 15 | Mesodermal fate decision of a stem cell : the Wnt switch 显示文摘 | Davis L A Zur Nieden N I | 2008 | Cell Mol Life Sci2008，65，17： | 1 |
| 16 | Papillomavirus infections--a major cause of human cancers显示文摘 | zur Hausen H | 1996 | Biochim Biophys Acta1996，1288，2： | 1 |
| 17 | Papillomaviruses causing cancer: evasion from host-cell control in early events in carcinogenesis显示文摘 | Zur Hausen H | 2000 | J Natl Cancer Inst2000，92，9： | 1 |
| 18 | Tests for adaptive RAPD variation in population genetic structure of wildbarley,Hordeum spontaneum Koch显示文摘 | Volis S Yakubov B Shulgina I Ward D Zur V Mendlinger S | 2001 | Biological Journal of the Linnean Society2001，，74： | 1 |
| 19 | Expression of transketolase TKTL1 predicts colon and urothelial cancer patient survival:Warburg effect reinterpreted显示文摘 | Langbein S Zerilli M Zur Hausen A | 2006 | Br J Cancer2006，94，4： | 1 |
| 20 | A synthetic E7 gene of human papillomavirus type 16 that yields enhanced expression of the protein in mammalian cells and is useful for DNA immunization studies显示文摘 | Cid-Arregui A Juarez V zur Hausen H | 2003 | J Virol2003，77，88： | 1 |
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