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| 1 | STING signaling activation inhibits HBV replication and attenuates the severity of liver injury and HBV-induced fibrosis显示文摘The covalently closed circular DNA(cccDNA)of HBV plays a crucial role in viral persistence and is also a risk factor for developing HBV-induced diseases,including liver fibrosis.Stimulator of interferon genes(STING),a master regulator of DNA-mediated innate immune activation,is a potential therapeutic target for viral infection and virus-related diseases.In this study,agonist-induced STING signaling activation in macrophages was revealed to inhibit cccDNA-mediated transcription and HBV replication via epigenetic modification in hepatocytes.Notably,STING activation could efficiently attenuate the severity of liver injury and fibrosis in a chronic recombinant cccDNA(rcccDNA)mouse model,which is a proven suitable research platform for HBV-induced fibrosis.Mechanistically,STING-activated autophagic flux could suppress macrophage inflammasome activation,leading to the amelioration of liver injury and HBV-induced fibrosis.Overall,the activation of STING signaling could inhibit HBV replication through epigenetic suppression of cccDNA and alleviate HBV-induced liver fibrosis through the suppression of macrophage inflammasome activation by activating autophagic flux in a chronic HBV mouse model.This study suggests that targeting the STING signaling pathway may be an important therapeutic strategy to protect against persistent HBV replication and HBV-induced fibrosis. | Yuqi Li Minjing He Ziyu Wang Zhiyun Duan Zhiwei Guo Ziteng Wang Ruijie Gong Tianhao Chu Jiabin Cai Bo Gao | 2022 | Cellular & Molecular Immunology2022，19，1： | 7 |
| 2 | The antigenicity of SARS-CoV-2 Delta variants aggregated 10 high-frequency mutations in RBD has not changed sufficiently to replace the current vaccine strain显示文摘Emerging SARS-CoV-2 variants are the most serious problem for COVID-19 prophylaxis and treatment.To determine whether the SARS-CoV-2 vaccine strain should be updated following variant emergence like seasonal flu vaccine,the changed degree on antigenicity of SARS-CoV-2 variants and H3N2 flu vaccine strains was compared.The neutralization activities of Alpha,Beta and Gamma variants’spike protein-immunized sera were analysed against the eight current epidemic variants and 20 possible variants combining the top 10 prevalent RBD mutations based on the Delta variant,which were constructed using pseudotyped viruses.Meanwhile,the neutralization activities of convalescent sera and current inactivated and recombinant protein vaccine-elicited sera were also examined against all possible Delta variants.Eight HA protein-expressing DNAs elicited-animal sera were also tested against eight pseudotyped viruses of H3N2 flu vaccine strains from 2011–2019.Our results indicate that the antigenicity changes of possible Delta variants were mostly within four folds,whereas the antigenicity changes among different H3N2 vaccine strains were approximately 10–100-fold.Structural analysis of the antigenic characterization of the SARS-CoV-2 and H3N2 mutations supports the neutralization results.This study indicates that the antigenicity changes of the current SARS-CoV-2 may not be sufficient to require replacement of the current vaccine strain. | Jiajing Wu Jianhui Nie Li Zhang Hao Song Yimeng An Ziteng Liang Jing Yang Ruxia Ding Shuo Liu Qianqian Li Tao Li Zhimin Cui Mengyi Zhang Peng He Youchun Wang Xiaowang Qu Zhongyu Hu Qihui Wang Weijin Huang | 2022 | Signal Transduction and Targeted Therapy2022，7，2： | 1 |
| 3 | Crystallinity-defect matching relationship of g-C_(3)N_(4): Experimental and theoretical perspectives显示文摘Good crystallinity can reduce the charge recombination centers caused by defects,whilst structures with strong polycondensation have high charge mobility,leading to more charge transfer to the material surface for reaction.Much effort has been put into the preparation of a highly efficient g-C_(3)N_(4) with defects to improve its application potential under the premise in high crystallinity.Hence,this review paper emphasizes the importance to balance the defect and crystallinity of g-C_(3)N_(4).In addition,detailed discussion on the relationship between defects and activity of g-C_(3)N_(4) was carried out based on its applications in environmental purification(e.g.,VOCs oxidation,NOx oxidation,H_(2)O_(2) evolution,sterili-zation,pesticide oxidation)and energy conversion(H_(2) evolution,N2fixation and CO_(2) reduction).Lastly,the challenge in developing more efficient defective g-C_(3)N_(4) photocatalytic materials is summarized. | Yuhan Li Ziteng Ren Zhengjiang He Ping Ouyang Youyu Duan Wendong Zhang Kangle Lv Fan Dong | 2024 | Green Energy & Environment2024，9，4： | 0 |
| 4 | Effect of Seedling Quality on Growth,Yield and Quality of Angelica sinensis显示文摘[Objectives]Aiming at the problems of high bolting rate,low yield and poor quality traits in the production of Angelica sinensis in Qinghai Province,this study investigated the effect of seeding quality on the growth,yield and quality of A.sinensis.[Methods]Field experiments were carried out in five aspects,including different seedling shapes,different seedling sizes,different seedling ages,different seedling raising methods,and different seedling sources.The effect of seedling quality on the survival rate,bolting rate,main quality traits(root length,root fresh weight,root head thickness,root head length)and yield of A.sinensis was investigated.[Results]The seedlings,0.2-0.5 cm in diameter,100-110-d old,raised from three-year-old provenance in cultivated land by conventional method,were more preferable,and their survival rate was high,bolting rate was low,yield is high,and quality traits performed well.[Conclusions]The seedlings,0.2-0.5 cm in diameter,100-110-d old,raised from three-year-old provenance in cultivated land by conventional method,were more preferable,and their survival rate was high,bolting rate was low,yield is high,and quality traits performed well. | Ziteng HE Youhua CAI Lianzhen HE Zongren LI Shengping HE Qide DONG Shenglong HU Changman LI | 2021 | Medicinal Plant2021，12，1： | 0 |
| 5 | Effects of rainfall intensities and slope gradients on nitrogen loss at the seedling stage of maize(Zea mays L.)in the purple soil regions of China显示文摘Loss of soil nitrogen has been reported to reduce soil productivity and result in eutrophication.The objective of this work was to understand the mechanisms of nitrogen loss at the maize seedling stage from purple soil in the sloping farmlands of southwest China.The characteristics of nitrogen loss were explored in experiments simulating rainfall conditions during the maize seedling stage at different rainfall intensities(60 mm/h,90 mm/h,and 120 mm/h)and slope gradients(10°,15°,and 20°).The results showed that the runoff and sediment yield increased with time.The surface runoff and sediment yield increased with the rainfall intensity and slope gradient.Nitrogen losses increased in the surface runoff and sediment but decreased in the interflow as the rainfall intensity and slope gradient increased.Dissolved total nitrogen(DTN)was the main form of nitrogen in the surface runoff and interflow,and nitrate nitrogen(NO3-N)was the main form of DTN.The surface runoff and sediment accounted for less than half of the TN losses.Thus,interflow was the main pathwayfor nitrogen loss.The regression lines between the surface runoff and forms of nitrogen losses in the runoff and interflow were linear.The results indicated that an increasing rainfall intensity and slope gradient generally increased the surface runoff,sediment,andnitrogen losses.However,the opposite trend was observed for the interflow and its nitrogen losses. | Shuqin He Yuanbo Gong Ziheng Zheng Ziteng Luo Bo Tan Yunqi Zhang | 2022 | International Journal of Agricultural and Biological Engineering2022，15，2： | 0 |
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