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| 1 | Micronutrient deficiencies in patients with chronic atrophic autoimmune gastritis: A review显示文摘Chronic atrophic autoimmune gastritis(CAAG) is an organ-specific autoimmune disease characterized by an immune response, which is directed towards the parietal cells and intrinsic factor of the gastric body and fundus and leads to hypochlorhydria, hypergastrinemia and inadequate production of the intrinsic factor. As a result, the stomach's secretion of essential substances, such as hydrochloric acid and intrinsic factor, is reduced, leading to digestive impairments. The most common is vitamin B12 deficiency, which results in a megaloblastic anemia and iron malabsorption, leading to iron deficiency anemia. However, in the last years the deficiency of several other vitamins and micronutrients, such as vitamin C, vitamin D, folic acid and calcium, has been increasingly described in patients with CAAG. In addition the occurrence of multiple vitamin deficiencies may lead to severe hematological, neurological and skeletal manifestations in CAAG patients and highlights the importance of an integrated evaluation of these patients. Nevertheless, the nutritional deficiencies in CAAG are largely understudied. We have investigated the frequency and associated features of nutritional deficiencies in CAAG in order to focus on any deficit that may be clinically significant, but relatively easy to correct. This descriptive review updates and summarizes the literature on different nutrient deficiencies in CAAG in order to optimize the treatment and the follow-up of patients affected with CAAG. | Federica Cavalcoli Alessandra Zilli Dario Conte Sara Massironi | 2017 | World Journal of Gastroenterology2017，23，4： | 16 |
| 2 | Clinical outcome in patients with hilar malignant strictures type Ⅱ Bismuth-Corlette treated by minimally invasive unilateral versus bilateral endoscopic biliary drainage显示文摘BACKGROUND:Stenting of malignant hilar strictures remains a standard endoscopic treatment in patients with unresectable tumors.The aim of this two-center prospective study was to compare unilateral versus bilateral drainage in hilar malignant stenosis Bismuth-Corlette type II.METHODS:During a 3-year period,a total of 49 patients with hilar tumors(Bismuth-Corlette type II) were referred for endoscopic treatment,following the criteria of unresectability.Ultrasound,computed tomography scan and magnetic resonance cholangiopancreatography(MRCP) were previously performed in all patients in order to facilitate endoscopic retrograde cholangiopancreatography(ERCP).The stricture was first passed by the hydrophilic guide-wire and then contrast medium was injected.Mechanical bile duct dilation was performed,followed by plastic stent placement only in the liver lobe which was previously opacified.The procedures were performed under conscious sedation.The patients were followed up for the next 12 months with a stent exchange every 3 months.Primary outcome was assessed by patient survival in the first 12 months after the procedure.RESULTS:All 49 patients were treated with ERCP while 39(79.59%) had successful stent placement.Among these,32 had hilar cholangiocarcinoma(82%) and 7(18%) had gallbladder cancer.Two groups of patients had Bismuth II strictures:A,21 patients(54%) with unilateral contrast injection and drainage,and B,18(46%) with bilateral contrast injection and drainage.A total of 57 plastic stents were used(10 Fr,89%;11.5 Fr,11%).Group B showed a lower bilirubin level 7 days after the procedure(P=0.008).Early complications were cholangitis(3 patients,2 in group A and 1 in group B) and acute pancreatitis(2 patients,1 each in A and B) with no statistical difference between the groups.Late complications were stent migration(5 patients,1 in A and 4 in B) and stent clogging(6 patients,2 in A and 4 in B) showing a significant difference between the groups(P<0.01).The first stent replacement after 3 months was successful in 87% of patients(four died due to disease progression and one due to cardiopulmonary insufficiency) showing no statistical difference between the groups.At 6 months follow-up,72% patients survived,with no statistical difference between the groups.A final follow-up(12 months) showed the survival rate of 18%(4 patients from group A and 3 from group B)(P>0.05).CONCLUSIONS:A minimally invasive approach,based on the criterion that every bile duct being opacified needs to be drained,is associated with a lower incidence of early complications.Considering that the clinical outcome measured by bilirubin level was lower in patients with bilateral drainage 7 days after the procedure,we assumed that drainage of 50% or more of the liver volume leads to sufficient drainage effectiveness. | Milutin Bulajic Nikola Panic Miodrag Radunovic Radisav Scepanovic Radoslav Perunovic Predrag Stevanovic Tatjana Ille Maurizio Zilli Mirko Bulajic | 2012 | Hepatobiliary & Pancreatic Diseases International2012，11，2： | 8 |
| 3 | Somatostatin analogs for gastric carcinoids:for many, but not all显示文摘Gastric carcinoids(GCs) are classified as: type Ⅰ,related to hypergastrinemia due to chronic atrophic gastritis(CAG), type Ⅱ, associated with Zollinger-Ellison syndrome in multiple endocrine neoplasia type 1, and type Ⅲ, which is normogastrinemic. The management of type-Ⅰ gastric carcinoids(GC1s) is still debated,because of their relatively benign course. According to the European Neuroendocrine Tumor Society guidelines endoscopic resection is indicated whenever possible;however, it is not often feasible because of the presence of a multifocal disease, large lesions, submucosal invasion or, rarely, lymph node involvement. Therefore,somatostatin analogs(SSAs) have been proposed as treatment for GC1 s in view of their antisecretive,antiproliferative and antiangiogenic effects. However,in view of the high cost of this therapy, its possible side effects and the relatively benign course of the disease,SSAs should be reserved to specific subsets of 'high risk patients', i.e., those patients with multifocal or recurrent GCs. Indeed, it is reasonable that, after the development of a gastric neuroendocrine neoplasm in patients with a chronic predisposing condition(such as CAG), other enterochromaffin-like cells can undergo neoplastic proliferation, being chronically stimulated by hypergastrinemia. Therefore, definite indications to SSAs treatment should be established in order to avoid the undertreatment or overtreatment of GCs. | Sara Massironi Alessandra Zilli Dario Conte | 2015 | World Journal of Gastroenterology2015，21，22： | 5 |
| 4 | Production Rules for Stereo Acquisition显示文摘 | Zilly F Kluger J Kauff P | | 0，，04： | 1 |
| 5 | A light-weight compression method for Java card technology显示文摘 | Massimiliano Zilli Wolfgang Raschke Reinhold Weiss Christian Steger Johannes Loinig | 2014 | ACM SIGBED Review - Special Issue on the 4th Embedded Operating Systems Workshop (EWiLi 2014)2014，11，4： | 1 |
| 6 | Toluene and styrene removal from air in biofilters 显示文摘 | Zilli M Palazzi E Sene L | 2001 | Process Biochem2001，37，： | 1 |
| 7 | Macro kinetic and quantitative microbial investigation on a bench scale biofiher treating styrene polluted gaseous streams 显示文摘 | I Zilli M Converti A Difeliee R | 2003 | Bioteehnol Bioeng2003，83，： | 1 |
| 8 | Long term results after lymphatic venous anastomoses for the treatment of obstructive lymphe dema显示文摘 | Boccardo F Zilli A | 2001 | Microsurgery2001，21，4： | 1 |
| 9 | Phenol removal from waste gases with a biological filter by Pseudomonas putida 显示文摘 | Zilli M Converti A Lodi A | 1993 | Biotechnol Bioeng1993，41，： | 1 |
| 10 | d-Glucose transport in deeapod crustacean hepatopancreas 显示文摘 | Verri T Mandal A Zilli L | 2001 | Comparative Biochemistry & Physiology: Part A2001，130，3： | 1 |
| 11 | The use of vein graft s in the treatment of peripheral lymphedemas: long-term results显示文摘 | Campisi C Boccardo F Zilli A | 2001 | Microsurge ry2001，21，4： | 1 |
| 12 | Antimitochondrial antibody profiles in primary billiary cirrhosis distinguish at early stages between a benign and a progressive course:a prospective study on 200 patients followed for 10 year显示文摘 | Klein R Pointner H Zilly W | 1997 | Liver1997，17，3： | 1 |
| 13 | Laboratory-scale experiments with a powdered compost biofilter treating benzenepolluted air 显示文摘 | Zilli M Guafino C Daffonchio D | 2005 | Process Biochemistry2005，40，6： | 1 |
| 14 | The use of vein grafts in the treatment of peripheral lymphedemas: long-term results 显示文摘 | Campisi C Boccardo F Zilli A | 2001 | Microsurgery2001，21，4： | 1 |
| 15 | Regio- and stereoselectivity of P450-catalysed hydroxylation of steroids controlled by laboratory evolution 显示文摘 | KILLE S ZILLY F E ACEVEDO J P | 2011 | Nat Chem2011，3，9： | 1 |
| 16 | Production rules for stereo acquisition显示文摘 | Zilly F Kluger J Kauff P | 2011 | Proceedings of the IEEE2011，99，4： | 1 |
| 17 | The Austral basin in Geologia y recursos naturales de Santa Cruz geology and natural resources of Santa Cruz, Haller显示文摘 | Norberto Zilli Miguel Pedrazzini Gustavo Peroni | 2002 | Relatorio-Congreso Geologico Argentino2002，15，： | 1 |
| 18 | Evalution of DNA damage in dicentrarchus labrax sperm following cryopreservation显示文摘 | ZILLI L SEHIAVONE R ZONNO V | 2003 | Cryobiology2003，47，： | 1 |
| 19 | Triple antiviral therapy for chronic hepatitis C with interferon-alpha,ribavirin and amantadine in nonresponders to interferon-alpha and ribavirin显示文摘 | Zilly M Lingenauber C Desch S | 2002 | Eur J Med Res2002，7，4： | 1 |
| 20 | Impact of ^18F-FDG PET/ CT on target volume delineation in recurrent or residual gynaecologic carcinoma 显示文摘 | Vees H Casanova N Zilli T | 2012 | Radiat Oncol2012，7，： | 1 |
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