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| 1 | Analysis and Experiments on Two Linear Discriminant Analysis Methods显示文摘Foley-Sammon linear discriminant analysis (FSLDA) and uncorrelated linear discriminant analysis (ULDA) are two well-known kinds of linear discriminant analysis. Both ULDA and FSLDA search the kth discriminant vector in an n-k+1 dimensional subspace, while they are subject to their respective constraints. Evidenced by strict demonstration, it is clear that in essence ULDA vectors are the covariance-orthogonal vectors of the corresponding eigen-equation. So, the algorithms for the covariance-orthogonal vectors are equivalent to the original algorithm of ULDA, which is time-consuming. Also, it is first revealed that the Fisher criterion value of each FSLDA vector must be not less than that of the corresponding ULDA vector by theory analysis. For a discriminant vector, the larger its Fisher criterion value is, the more powerful in discriminability it is. So, for FSLDA vectors, corresponding to larger Fisher criterion values is an advantage. On the other hand, in general any two feature components extracted by FSLDA vectors are statistically correlated with each other, which may make the discriminant vectors set at a disadvantageous position. In contrast to FSLDA vectors, any two feature components extracted by ULDA vectors are statistically uncorrelated with each other. Two experiments on CENPARMI handwritten numeral database and ORL database are performed. The experimental results are consistent with the theory analysis on Fisher criterion values of ULDA vectors and FSLDA vectors. The experiments also show that the equivalent algorithm of ULDA, presented in this paper, is much more efficient than the original algorithm of ULDA, as the theory analysis expects. Moreover, it appears that if there is high statistical correlation between feature components extracted by FSLDA vectors, FSLDA will not perform well, in spite of larger Fisher criterion value owned by every FSLDA vector. However, when the average correlation coefficient of feature components extracted by FSLDA vectors is at a low level, the performance of FSLDA are comparable with ULDA. | Xu Yong Jin Zhong Yang Jingyu Tang Zhengmin Zhao Yingnan | 2006 | 工程科学(英文版)2006，4，3： | 0 |
| 2 | Temporal and spatial stability of the EM/PM molecular subtypes in adult diffuse glioma显示文摘Detailed characterizations of genomic alterations have not identified subtype-specific vulnerabilities in adult gliomas. Mapping gliomas into developmental programs may uncover new vulnerabilities that are not strictly related to genomic alterations. After identifying conserved gene modules co-expressed with EGFR or PDGFRA (EM or PM), we recently proposed an EM/PM classification scheme for adult gliomas in a histological subtype- and grade-independent manner. By using cohorts of bulk samples, paired primary and recurrent samples, multi-region samples from the same glioma, single-cell RNA-seq samples, and clinical samples, we here demonstrate the temporal and spatial stability of the EM and PM subtypes. The EM and PM subtypes, which progress in a subtype-specific mode, are robustly maintained in paired longitudinal samples. Elevated activities of cell proliferation, genomic instability and microenvironment, rather than subtype switching, mark recurrent gliomas. Within individual gliomas, the EM/PM subtype was preserved across regions and single cells. Malignant cells in the EM and PM gliomas were correlated to neural stem cell and oligodendrocyte progenitor cell compartment, respectively. Thus, while genetic makeup may change during progression and/or within different tumor areas, adult gliomas evolve within a neurodevelopmental framework of the EM and PM molecular subtypes. The dysregulated developmental pathways embedded in these molecular subtypes may contain subtype-specific vulnerabilities. | Jing Feng Zheng Zhao Yanfei Wei Zhaoshi Bao Wei Zhang Fan Wu Guanzhang Li Zhiyan Sun Yanli Tan Jiuyi Li Yunqiu Zhang Zejun Duan Xueling Qi Kai Yu Zhengmin Cong Junjie Yang Yaxin Wang Yingyu Sun Fuchou Tang Xiaodong Su Chuan Fang Tao Jiang Xiaolong Fan | 2023 | Frontiers of Medicine2023，17，2： | 0 |
| 3 | The plasmodesmata-associated β-1,3-glucanase gene GhPdBG regulates fiber development in cotton显示文摘Trichomes are specialized structures that originate from epidermal cells of organs in higher plants.The cotton fiber is a unique single-celled trichome that elongates from the seed coat epidermis.Cotton(Gossypium hirsutum)fibers and trichomes are models for cell differentiation.In an attempt to elucidate the intercellular factors that regulate fiber and trichome cell development,we identified a plasmodesmal β-1,3-glucanase gene(designated GhPdBG)controlling the opening and closing of plasmodesmata in cotton fibers.Structural and evolutionary analysis showed haplotypic variation in the promoter region of the GhPdBG gene among 352 cotton accessions,but high conservation in the coding region.GhPdBG was expressed predominantly in cotton fibers and localized to plasmodesmata(PD).Expression patterns of PdBG that corresponded to PD permeability were apparent during fiber development in G.hirsutum and G.barbadense.The PdBG-mediated opening-closure of PD appears to be involved in fiber development and may account for the contrasting fiber traits of these two species.Ectopic expression of GhPdBG revealed that it functions in regulating fiber and trichome length and/or density by modulating plasmodesmatal permeability.This finding suggests that plasmodesmal targeting of GhPdBG,as a switch of intercellular channels,regulates single-celled fiber and trichome development in cotton. | Yijie Fan Shuangshuang Lin Yanhui Lyu Haihong Shang Youlu Yuan Zhengmin Tang Chengzhi Jiao Aiyun Chen Piyi Xing Li Zhang Yuxiao Sun Haixia Guo Tongtong Li Zhonghai Ren Fanchang Zeng | 2023 | The Crop Journal2023，11，6： | 0 |
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