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| 1 | Artificial intelligence in drug design显示文摘Thanks to the fast improvement of the computing power and the rapid development of the computational chemistry and biology,the computer-aided drug design techniques have been successfully applied in almost every stage of the drug discovery and development pipeline to speed up the process of research and reduce the cost and risk related to preclinical and clinical trials.Owing to the development of machine learning theory and the accumulation of pharmacological data, the artificial intelligence(AI) technology, as a powerful data mining tool, has cut a figure in various fields of the drug design, such as virtual screening,activity scoring, quantitative structure-activity relationship(QSAR) analysis, de novo drug design, and in silico evaluation of absorption, distribution, metabolism, excretion and toxicity(ADME/T) properties. Although it is still challenging to provide a physical explanation of the AI-based models, it indeed has been acting as a great power to help manipulating the drug discovery through the versatile frameworks. Recently, due to the strong generalization ability and powerful feature extraction capability,deep learning methods have been employed in predicting the molecular properties as well as generating the desired molecules,which will further promote the application of AI technologies in the field of drug design. | Feisheng Zhong Jing Xing Xutong Li Xiaohong Liu Zunyun Fu Zhaoping Xiong Dong Lu Xiaolong Wu Jihui Zhao Xiaoqin Tan Fei Li Xiaomin Luo Zhaojun Li Kaixian Chen Mingyue Zheng Hualiang Jiang | 2018 | Science China(Life Sciences)2018，61，10： | 10 |
| 2 | A Novel Pneumatic Soft Gripper with a Jointed Endoskeleton Structure显示文摘In current research on soft grippers,pneumatically actuated soft grippers are generally fabricated using fully soft materials,which have the advantage of flexibility as well as the disadvantages of a small gripping force and slow response speed.To improve these characteristics,a novel pneumatic soft gripper with a jointed endoskeleton structure(E-Gripper)is developed,in which the muscle actuating function has been separated from the force bearing function.The soft action of an E-Gripper finger is performed by some air chambers surrounded by multilayer rubber embedded in the restraining fiber.The gripping force is borne and transferred by the rigid endoskeleton within the E-Gripper finger Thus,the gripping force and action response speed can be increased while the flexibility is maintained.Through experiments,the bending angle of each finger segment,response time,and gripping force of the E-Gripper have been measured,which provides a basis for designing and controlling the soft gripper The test results have shown that the maximum gripping force of the E-Gripper can be 35 N,which is three times greater than that of a fully soft gripper(FS-Gripper)of the same size.At the maximum charging pressure of 150 kPa,the response time is1.123 s faster than that of the FS-Gripper.The research results indicate that the flexibility of a pneumatic soft gripper is not only maintained in the case of the E-Gripper,but its gripping force is also obviously increased,and the response time is reduced.The E-Gripper thus shows great potential for future development and applications. | Zhaoping Wu Xiaoning Li Zhonghua Guo | 2019 | Chinese Journal of Mechanical Engineering2019，32，5： | 9 |
| 3 | Spatiotemporal characteristics of cultural sites and their driving forces in the Ili River Valley during historical periods显示文摘这研究使用 ArcGIS 在西北的中国在 Ili 河山谷分析文化地点的空间与时间的分发。它探索在这些地点之间的关系空间与时间的进化特征,人的历史,和自然环境。结果显示这些地点的数字和比例,和他们的出现的频率,在六个历史的时期期间展出了一个转换塑造 V 的变化趋势。在东方高、在转移到的开始的三个时期的向西空间的分发模式低在西方高、在东方低在后者期间三个时期,在人的活动的空间重心表明一个变化。这些地点主要在等级的斜坡上被散布 15,与他们在春天和秋天时期(770 BC476 BC ) 期间从 75% 增加的比例 Qin 王朝(221 BC207 BC ) 到 93.75% 在 Qing DynastyModern 时期期间。地点举起的集中的分发变了从在春天和秋天 PeriodQin 王朝,和西方的汉(206 BC8 ) 期间分级 48 南部、北的王朝(420589 ) ,到在后者期间分级 14 三个时期。地点的数字从高举起的山和山,并且从高斜坡显示出一个变的趋势到低举起的平原到低斜坡。特别地,这些地点从中间、在上游的区域展出了移植的一个特殊潮湿的进化模式到下游的区域,与位于典型干旱区域的地点的迁居模式对比。学习也认为显著地,影响分发和文化地点的空间与时间的进化的因素是人的因素和自然因素。 | WANG Fang YANG Zhaoping LUAN Fuming XIONG Heigang SHI Hui WANG Zhaoguo ZHAO XingYou QIN Wenmin WU Wenjie LI Dong | 2015 | Journal of Geographical Sciences2015，25，9： | 5 |
| 4 | Silicon lithium-ion battery anode with enhanced performance: Multiple effects of silver nanoparticles显示文摘Silicon has been regarded as one of the most promising next generation lithium-ion battery anode. However, the poor cyclic stability of the Si based anode has severely limited its practical applications, which is even worse with high mass loading density(>1 mg cm^(-2)). A new concept has been developed to enhance the electrochemical performance of the Si nanoparticle anode. Silver nanoparticles are composited with the silicon nanoparticles in a facile way for the first time. It is found that the mechanical properties of the Si electrode have been significantly improved by the incorporation of the silver nanoparticles, leading to enhanced cyclic performance. With the Si/Ag mass ratio of 4:1, the reversible specific discharge capacity is retained as 1156 m A h g^(-1) after 100 cycles at 200 mA g^(-1), which is more than three times higher than that of the bare silicon(318 mA h g^(-1)). The rate performance has been effectively improved as well due to excellent electron conductivity of the silver nanoparticles. | Shanshan Yin Qing Jia Xiuxia Zuo Shuang Xie Kai Fang Yonggao Xia Jinlong Li Bao Qiu Meimei Wang Jianzhen Ban Xiaoyan Wang Yi Zhang Ying Xiao Luyao Zheng Suzhe Liang Zhaoping Liu Cundong Wang Ya-Jun Cheng | 2018 | Journal of Materials Science & Technology2018，34，10： | 4 |
| 5 | Increased production of recombinant prourokinase with porous microcarrier cell culture by periodic pressure oscillation in a stirred tank reactor显示文摘 | 胡显文 Gao Lihua Li Zuohu Xiao Chengzu Xu Zhaoping | 2006 | High Technology Letters2006，12，3： | 3 |
| 6 | Controlling COVID-19 Transmission due to Contaminated Imported Frozen Food and Food Packaging显示文摘BACKGROUND The emergence of the coronavirus disease 2019(COVID-19)has been sharply increasing with more than eighty million confirmed cases worldwide(1).It has been contained in China through stringent nonpharmaceutical interventions(2).A combination of strict border control and quarantine measures have effectively prevented the spread of the virus from infected travelers,but the risk of resurgence caused by other routes of transmission(fomite transmission)has been identified in a number of localized outbreaks(3-7). | Li Bai Yeru Wang Yibaina Wang Yongning Wu Ning Li Zhaoping Liu | 2021 | China CDC weekly2021，3，2： | 2 |
| 7 | Interpretable machine-learning strategy for soft-magnetic property and thermal stability in Fe-based metallic glasses显示文摘Fe-based metallic glasses(MGs)have been extensively investigated due to their unique properties,especially the outstanding soft-magnetic properties.However,conventional design of soft-magnetic Fe-based MGs is heavily relied on“trial and error”experiments,and thus difficult to balance the saturation flux density(Bs)and thermal stability due to the strong interplay between the glass formation and magnetic interaction.Herein,we report an eXtreme Gradient Boosting(XGBoost)machine-learning(ML)model for developing advanced Fe-based MGs with a decent combination of Bs and thermal stability. | Zhichao Lu Xin Chen Xiongjun Liu Deye Lin Yuan Wu Yibo Zhang Hui Wang Suihe Jiang Hongxiang Li Xianzhen Wang Zhaoping Lu | 2020 | npj Computational Materials2020，，1： | 2 |
| 8 | COVID-19 Outbreaks Linked to Imported Frozen Food in China:Status and Challege显示文摘Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)RNA contamination was reported on China’s imported frozen foods and packaging materials.However,there was no evidence of this disease initiated by environment-to-human transmission until the outbreak of coronavirus disease 2019(COVID-19)in Beijing in June 2020.This article aimed to analyze and summarize COVID-19 outbreaks related to cold-chain foods to provide a scientific basis for tracing the epidemiological trajectory of the pandemic,providing risk assessments,and mitigation policies.Overall,37 COVID-19 outbreaks and 5,741 infected cases were reported within the study period.It was found that 7 outbreaks and 689 cases were linked to imported frozen foods.The first index case among the 7 outbreaks was exposed to SARS-CoV-2-contaminated outer packaging of frozen food,triggering the subsequent community transmission.This study supported the speculation that cold-chain foods act as a pathway for SARS-CoV-2 and might present a risk for virus transmission between countries and regions.Handlers and processors exposed to the imported frozen foods should be effectively self-protected,daily monitored for clinical manifestations of COVID-19,and tested for SARS-CoV-2 nucleic acid at regular intervals. | Jiahui Wang Fengqin Li Zhaoping Liu Ning Li | 2022 | China CDC weekly2022，4，22： | 2 |
| 9 | Comparative study on pyrolysis of bamboo in microwave pyrolysis-reforming reaction by binary compound impregnation and chemical liquid deposition modified HZSM-5显示文摘The deactivation of catalyst is a significant reason for its limited application during the catalytic fast pyrolysis(CFP)process.To reduce the coke formation,binary compound impregnation(BCI)and chemical liquid deposition(CLD)were used to modify HZSM-5 catalysts.At the same time,the self-designed microwave reactor separated the pyrolysis of bamboo and catalytic upgrading of primary vapor,which made the catalytic effect more thorough.Experimental results indicated that CLD used TiO 2 deposition to cover external acid sites,while BCI by phosphorus-nickel could cover and partly destroy superficial acid sites through two different ways.Within the scope of the loaded amount studied,the yield of aromatic hydrocarbons in the oil phase increased at first and then decreased,while the coke formation reduced continuously.BTX(benzene,toluene and xylene),the most valuable product in bio-oil,drastically increased by 39.1%and 22.6%respectively over the CLD and BCI modified catalysts.Considering the catalytic performance as well as cost,CLD over HZSM-5 has more advantages in the CFP process to upgrade bio-oil. | Haoran Du Zhaoping Zhong Bo Zhang Kun Shi Zhaoying Li | 2020 | Journal of Environmental Sciences2020，32，8： | 2 |
| 10 | Self-supporting nanoporous Ni/metallic glass composites with hierarchically porous structure for efficient hydrogen evolution reaction显示文摘Searching for free-standing and cost-efficient hydrogen evolution reaction(HER)electrocatalysts with high efficiency and excellent durability remains a great challenge for the hydrogen-based energy industry.Here,we report fabrication of a unique hierarchically porous structure,i.e.,nanoporous Ni(NPN)/metallic glass(MG)composite,through surface dealloying of the specially designed Ni_(40)Zr_(40)Ti_(20)MG wire.This porous composite is composed of micrometer slits staggered with nanometer pores,which not only enlarges effective surface areas for the catalytic reaction,but also facilitates the release of H2 gas.As a result,the NPN/MG hybrid electrode exhibited the prominent HER performance with a low overpotential of 78 m V at 10 m A cm^(-2)and Tafel slope of 42.4 m V dec^(-1),along with outstanding stability in alkaline solutions.Outstanding catalytic properties,combining with their free-standing capability and cost efficiency,make the current composite electrode viable for HER applications. | Jing Wang Li You Zhibin Li Xiongjun Liu Rui Li Qing Du Xianzhen Wang Hui Wang Yuan Wu Suihe Jiang Zhaoping Lu | 2021 | Journal of Materials Science & Technology2021，，14： | 2 |
| 11 | Interspecific Hybridization Between Crassostrea angulata and C. ariakensis显示文摘Interspecific hybridization can generate heterosis, which is proven to be a useful tool in selective breeding programs for oyster culture. Crassostrea angulata and C. ariakensis are two important economic shellfish species in China. We conducted 2 × 2 reciprocal crosses to determine whether these two species can cross-fertilize and their hybrids can hatch, survive and perform heterosis. Fertilization was found symmetrical without delay. The rate of fertilization success of C. angulata ♀× C. ariakensis ♂ was lower than that of C. ariakensis ♀× C. angulata ♂, and the success rate of both hybridizations was lower than that of two intraspecific crosses each. During the planktonic period, survival rate of the progeny was lower in the hybrid crosses than in the intraspecific crosses. On day 360, mean shell height of the progeny of C. angulata ♀× C. angulata ♂ was highest, which was followed by that of C. angulata ♀× C. ariakensis ♂, C. ariakensis ♀× C. ariakensis ♂ and C. ariakensis ♀× C. angulata ♂ in a descending order. Morphology of adults produced by the hybrid crosses was similar to that of C. angulata. Both hybrids underwent normal gonad development and produced mature gametes in the mating season. This study provided new insights into the quantitative traits in interspecific crosses of Crassostrea species, thus being of guidance value for selective breeding of oyster. | YAO Tuo ZHANG Yuehuan YAN Xiwu WANG Zhaoping LI Dongchun SU Jiaqi YU Ruihai | 2015 | Journal of Ocean University of China2015，14，4： | 2 |
| 12 | Mathematical Analysis and Simulation of the Neural Circuit for Locomotion in Lamnprey显示文摘 | Alex Lewis Silvia Scarpetta | 2004 | Phys Rev lett2004，198，： | 1 |
| 13 | Preparation of hydrophobic transparent paper via using polydimethylsiloxane as transparent agent显示文摘Transparent paper with good hydrophobicity and flexibility was expected to act as an alternative substrate in fabrication of flexible electronics.However,conventional paper made of cellulose fibers was opaque and hydrophilic without undergoing special processing.Herein,cellulose fiber paper was treated by impregnating with hydrolyzed tetraethyl orthosilicate(TEOS)followed by coating with hydrophobic polydimethylsiloxane(PDMS)to prepare hydrophobic transparent pa-per.The results showed that silica nanoparticles produced by the TEOS hydrolysis improved the paper transparency to some extent,increased the paper thermal stability,but still remained the hydrophilicity of paper.After the paper was further coated with the PDMS and the PDMS was consolidated,the paper became clearly transparent and hydrophobic.The processed paper had a transmittance of more than 90%at 550 nm.The water contact angle of the paper reached about 110°.This work provided a new approach for the fabrication of hydrophobic transparent paper with conventional cellulose fiber paper. | Feixiang Guan Zhaoping Song Furong Xin Huili Wang Dehai Yu Guodong Li Wenxia Liu | 2020 | Journal of Bioresources and Bioproducts2020，5，1： | 1 |
| 14 | Intake of Soy Food and Soy Isoflavones by Rural Adult Women in China显示文摘 | Zhaoping Liu M D Wenxian Li BSc Jing Sun BSc | 2004 | Asia Pacific J Clin Nutr2004，13，2： | 1 |
| 15 | Seasonal Variation of the Glycogen Enzyme Activity in Diploid and Triploid Pacific Oyster Gonad During Sexual Maturation显示文摘The glycogen content and the activities of two key enzymes in glycogen metabolism, glycogen phosphorylase and gly- cogen synthetase, in the gonad of diploid and triploid Pacific oysters (Crassostrea gigas) were compared during maturation. The glycogen content in the gonad of diploids decreased with gametogenesis (by 85.7%), but the glycogen content in the gonad of trip- loids did not vary significantly. Activity of glycogen phosphorylase (GP) in the gonad of diploids decreased with gametogenesis (by 55.5%), while GP activity of triploids did not vary significantly during maturation. Activity of glycogen synthetase (GS) in the gonad of diploids increased slightly with gametogenesis, reaching a peak in June. Activity of GS declined sharply from June to July, which might be due to gonad spawning. GS activity of triploid oysters in spawning time (July and August) was significantly higher than that in other months, which might be explained with a ‘compensating’ mechanism for the higher glycogen content in triploids. | KONG Lingfeng WANG Zhaoping YU Ruihai LI Qi WANG Rucai | 2007 | Journal of Ocean University of China2007，6，4： | 1 |
| 16 | Absorbents based on maleic anhydride-modified cellulose fibers/diatomite for dye removal显示文摘 | Yuan Li Huining Xiao Mindong Chen Zhaoping Song Yi Zhao | 2014 | Journal of Materials Science2014，，19： | 1 |
| 17 | A geological assessment method of floor water inrush risk and its application显示文摘 | Zhaoping Meng Guoqing Li Xiaotong Xie | 2012 | Engineering Geology2012，，： | 1 |
| 18 | Experimental research on the permeability of high-rank coal under a varying stress and its influencing factors显示文摘 | Zhaoping Meng Guoqing Li | 2013 | Engineering Geology2013，，： | 1 |
| 19 | Preparation and performance analysis of inorganic polymer floeeulant PZFSiC 显示文摘 | Can Li Meng Zhaoping Pan Jienan | 2004 | Journal of China University of Mining and Technology : English Edtion2004，14，2： | 1 |
| 20 | Nanoparticle-stabilized Alkenyl Succinic Anhydride(ASA)Emulsions:A Review显示文摘Alkenyl succinic anhydride(ASA) is a popular paper-sizing agent that is generally added to papermaking systems as an aqueous emulsion. Herein, we reviewed the recent work focusing on ASA emulsions stabilized by solid particles. Solid particle-stabilized ASA emulsions generally possess high ASA content and exhibit good sizing performance. The particles that have been used to stabilize ASA emulsions typically include montmorillonite, laponite, alumina, TiO_2, Fe_3O_4, polyaluminum sulfate(PAS), and cellulose nanocrystals(CNCs). Montmorillonite is the first extensively studied particle stabilizer for ASA emulsions. Laponite is undoubtedly the most competent particle stabilizer for preparing ASA emulsions with high sizing efficiency. Montmorillonite and laponite can be used individually as stabilizers after modification or as co-stabilizers with other particles or polymers. TiO_2, alumina, PAS, and CNCs are commonly used as stabilizers either individually or with other particles. | WenXia Liu HuiLi Wang GuoDong Li DeHai Yu ZhaoPing Song | 2017 | Paper And Biomaterials2017，2，1： | 1 |
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