|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Human umbilical cord mesenchymal stem cell transfusion in immune non-responders with AIDS:a multicenter randomized controlled trial显示文摘We examined the safety and efficacy of human umbilical cord mesenchymal stem cell(hUC-MSC)infusion for immune nonresponder(INR)patients with chronic HIV-1 infection,who represent an unmet medical need even in the era of efficient antiretroviral therapy(ART).Seventy-two INR patients with HIV were enrolled in this phase II randomized,double-blinded,multicenter,placebo-controlled,dose-determination trial(NCT01213186)from May 2013 to March 2016.They were assigned to receive high-dose(1.5 x 106/kg body weight)or low-dose(0.5 x 106/kg body weight)hUC-MSC,or placebo.Their clinical and immunological parameters were monitored during the 96-week follow-up study.We found that hUC-MSC treatment was safe and well-tolerated.Compared with baseline,there was a statistical increase in CD4+T counts in the high-dose(P<0.001)and low-dose(P<0.001)groups after 48-week treatment,but no change was observed in the control group.Kaplan-Meier analysis revealed a higher cumulative probability of achieving an immunological response in the low-dose group compared with the control group(95.8%vs.70.8%,P=0.00A).However,no significant changes in CD4/CD84-T counts and CD4/CD8 ratios were observed among the three groups.In summary,hUC-MSC treatment is safe.However,the therapeutic efficacy of hUC-MSC treatment to improve the immune reconstitution in INR patients still needs to be further investigated in a large cohort study. | Lifeng Wang Zheng Zhang Ruonan Xu Xicheng Wang Zhanjun Shu Xiejie Chen Siyu Wang Jiaye Liu Yuanyuan Li Li Wang Mi Zhang Wei Yang Ying Wang Huihuang Huang Bo Tu Zhiwei Liang Linghua Li Jingxin Li Yuying Hou Ming Shi Fu-Sheng Wang | 2021 | Signal Transduction and Targeted Therapy2021，6，7： | 0 |
| 2 | Distinct chemokines selectively induce HIV-1 gp120-integrinα4β7 binding via triggering conformer-specific activation ofα4β7显示文摘Dear Editor,Gut associated lymphoid tissue(GALT)is the principal site where human immunodeficiency virus 1(HIV-1)replicates.CD4^(+) T cells residing in GALT are predominant targets of HIV-1 during the acute phase of infection.CD4^(+) T cells expressing a high level of gut-homing receptor integrin α4β7 are more susceptible to productive infection by HIV-1. | Shu Wang ChangDong Lin Yue Li ZhaoYuan Liu JunLei Wang YouHua Zhang ZhanJun Yan YueBin Zhang GuoHui Li JianFeng Chen | 2021 | Signal Transduction and Targeted Therapy2021，6，8： | 0 |
| 3 | Effectiveness and Controversy of Convalescent Plasma Therapy for Coronavirus Disease 2019 Patients显示文摘Since the coronavirus disease 2019(COVID-19)began to spread,it remains pandemic worldwide.The European Medicines Agency’s human medicines committee and Food and Drug Administration have only granted a conditional marketing authorization for remdesivir to treat COVID-19.It is essential to apply other valuable treatments.Convalescent plasma(CP),donated by persons who have recovered from COVID-19,is the cellular component of blood that contains specific antibodies.Therefore,to determine the feasibility of CP for COVID-19,the effectiveness and controversy are discussed in depth here.It is suggested that CP plays a certain role in the treatment of COVID-19.As a treatment,it may have its own indications and contraindications,which need to be further discussed.Meanwhile,it is critical to establish a standard procedure for treatment from CP collection,preservation,transport,to transfusion,and conduct some large sample randomized controlled trials to confirm the transfusion dosage,appropriate time,frequency,and actively prevent adverse outcomes that may occur. | Zhanjun Shu Peipei Wu Qianqian Qian Li Zhou Dandan Du Mengxuan Ding Tao Peng Ke Fang | 2022 | Infectious Diseases & Immunity2022，2，1： | 0 |
| 4 | A Case Report of a Pregnant Woman with CoVID-19 and Tuberculosis显示文摘We presented a case of a 32-week pregnant woman with coronavirus disease 2019 and tuberculosis delivering a healthy baby.She was treated with antituberculosis and other symptomatic treatments,and the nucleic acid test;the sputum tuberculosis bacterial smear turned negative;and the symptoms were significantly relieved. | Weiwei Song Jingru Li Nadila Abulizi Tao Peng Ke Fang Na Xie Zhanjun Shu | 2023 | Infectious Diseases & Immunity2023，3，1： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员