|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Clinical and histopathological correlations of fecal calprotectin release in colorectal carcinoma显示文摘AIM:To determine calprotectin release before and after colorectal cancer operation and compare it to tumor and histopathological parameters.METHODS:The study was performed on patients with diagnosed colorectal cancer admitted for operation.Calprotectin was measured in a single stool sample before and three months after the operation using an enzymelinked immunosorbent assay(ELISA).Calprotectin levels greater than or equal to 50μg/g were considered positive.The compliance for collecting stool samples was assessed and the value of calprotectin was correlated to tumor and histopathological parameters of intra-and peri-tumoral inflammation.Surgical specimens were fixed in neutral buffered formalin and stained with hematoxylin and eosin.Staging was performed according to the Dukes classification system and the 7th edition tumor node metastasis classification system.Intra-and peri-tumoral inflammation was graded according to the Klintrup criteria.Immunohistochemical quantification was performed for MPO,CD45R0,TIA-1,CD3,CD4,CD8,CD57,and granzyme B.Statistical significance was measured using Wilcoxon signed rank test,Kruskal Wallis test and Spearman’s rank correlation coefficient as appropriate.RESULTS:Between March 2009 and May 2011,80 patients with colorectal cancer(46 men and 34 women,with mean age of 71±11.7 years old)were enrolled in the study.Twenty-six patients had rectal carcinoma,29 had left-side tumors,23 had right-side tumors,and2 had bilateral carcinoma.In total,71.2%of the patients had increased levels of calprotectin before the operation(median 205μg/g,range 50-2405μg/g)and experienced a significant decrease three months after the operation(46μg/g,range 10-384μg/g,P<0001).The compliance for collecting stool samples was 89.5%.Patients with T3 and T4 tumors had significantly higher values than those with T1 and T2 cancers(P=0.022).For all other tumor parameters(N,M,G,L,V,Pn)and location,no significant difference in calprotectin concentration was found.Furthermore,the calprotectin levels and histological grading of both peri-and intra-tumoral inflammation was not correlated.Additional testing with specific markers for lymphocytes and neutrophils also revealed no statistically significant correlation.CONCLUSION:Fecal calprotectin decreases significantly after colorectal cancer operation.Its value depends exclusively on the individual T-stage,but not on other tumor or histopathological parameters. | Frank Serge Lehmann Francesca Trapani Ida Fueglistaler Luigi Maria Terracciano Markus von Flüe Gieri Cathomas Andreas Zettl Pascal Benkert Daniel Oertli Christoph Beglinger | 2014 | World Journal of Gastroenterology2014，20，17： | 6 |
| 2 | APPROACHES FOR SUSTAINABLE MANUFACTURING显示文摘Sustainable development is a holistic approach harmonizing ecological, economical and socio-political needs with respect to the superior objective of enhancing human living standards. Thereby the availability of natural resources and the conservation of the ecosystems have to be considered that future generations have the possibility to meet their own needs. A long-term economical development demands the transition from a source-sink economy to a cycle economy as a result of limited resources, limited environmental capacities to absorb waste and emissions as well as increasing needs of a growing population. A reference model for sustainability in manufacturing is presented and used to illustrate sustainable approaches with respect to management, technology, process and product. Adaptation of products and components is a vital element for supporting efficient reuse of products and components. Consequently adaptation contributes to the ambitious goals of sustainability. Technological enablers for adaptation as modularity, information and communication technology are exemplarily introduced. Moreover, approaches for disseminating knowledge in sustainability are given. | GüNTHER Seliger SEBASTIAN Kernbaum MARCO Zettl | 2007 | Chinese Journal of Mechanical Engineering2007，20，1： | 3 |
| 3 | Simple method for the continuous production of carbon nanotubes显示文摘 | Ishigami M Cumings J Zettl A | 2000 | Chemical Physics Letters2000，319，： | 1 |
| 4 | Eigenvalues of regular Sturm-Liouville problems 显示文摘 | Kong Qingkai Zettl A | 1996 | J Differential Equations1996，131，： | 1 |
| 5 | R E Nanotube Nanodevice显示文摘 | PHILIP G COLLINS A ZETTL HIROSHI BANDO ANDREAS THESS SMALLEY | 1997 | Science1997，278，： | 1 |
| 6 | Coating single-walled carbon nanotubes with tin oxide显示文摘 | Hart WQ Zettl A | 2003 | Nano Lett2003，3，5： | 1 |
| 7 | La- ryngeal inflammatory myofibroblastic tumors: differ- ent clinical appearance and histomorphologic presenta- tion of one entity显示文摘 | VOLKER H U SCHEICH M ZETTL A | 2010 | Head Neck2010，32，： | 1 |
| 8 | Longitudinal extensive transverse myelitis-it\'s not all neuromyelitis optica显示文摘 | TREBST C RAAB P VOSS E V ROMMER P ABU-MUGHEISIB M ZETTL U K | 2011 | Nat Rev Neurol2011，7，： | 1 |
| 9 | Nanomechanics of carbon nanotubes显示文摘 | Kis A Zettl A | 2008 | Philos Trans Royal Soc A2008，366，： | 1 |
| 10 | Low friction nanoscale linear bearing realized from multiwall carbon nanotubes显示文摘 | CUMINGS J ZETTL A | 2000 | Science2000，289，： | 1 |
| 11 | Measurement of the elastic modulus of a multi-wall boron nitride nanotube显示文摘 | Chopra N G Zettl A | 1998 | Solid State Communications1998，105，： | 1 |
| 12 | Two-interval Sturm-Liouville operators in direct sum spaces withinner product multiples显示文摘 | SUN Jiong WANG Aiping Zettl A | 2007 | Results in Mathematics2007，50，12： | 1 |
| 13 | A clear look at the neuroimmunol ogy ofmuhiple sclerosis and beyond显示文摘 | Selmi C Mix E Zettl UK | 2012 | Autoimmun Rev2012，11，： | 1 |
| 14 | C,a new carbon solid显示文摘 | Piskoti C Yarger J Zettl A | 1998 | Nature1998，393，： | 1 |
| 15 | Coating single-walled carbon nanotubes with tin oxide显示文摘 | Han W Q Zettl A | 2003 | Nano Lett2003，3，5： | 1 |
| 16 | The Friedrichs extension of singular differential operators 显示文摘 | Marietta M Zettle A | 2000 | Journal of Differential Equation2000，160，： | 1 |
| 17 | Autoimmune disorders affecting both the central and peripheral nervous system显示文摘 | Kamm C Zettl UK | 2012 | Autoimmun Rev2012，11，： | 1 |
| 18 | Dependence of the nth Sturm-Liouville eigenvalue on the problem显示文摘 | Kong Q K Wu H Y Zettle A | | 0，，： | 1 |
| 19 | Generalized symmetric ordinary differential expressions I: The general theory显示文摘 | Everitt W N and Zettl A | 1979 | Nieuw Archief voor Wiskunde1979，，3： | 1 |
| 20 | Nanotube nanodevice显示文摘 | Collins Philip G Zettl A | 1997 | Science1997，278，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员