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| 1 | Clinical asthma phenotyping:A trial for bridging gaps in asthma management显示文摘Asthma is a common disease affecting millions of people worldwide and exerting an enormous strain on health resources in many countries. Evidence is increasing that asthma is unlikely to be a single disease but rather a series of complex, overlapping individual diseases or phenotypes, each defined by its unique interaction between genetic and environmental factors. Asthma phenotypes were initially focused on combinations ofclinical characteristics, but they are now evolving to link pathophysiological mechanism to subtypes of asthma. Better characterization of those phenotypes is expected to be most useful for allocating asthma therapies. This article reviews different published researches in terms of unbiased approaches to phenotype asthma and emphasizes how the phenotyping exercise is an important step towards proper asthma treatment. It is structured into three sections; the heterogeneity of asthma, the impact of asthma heterogeneity on asthma management and different trials for phenotyping asthma. | Magdy Mohamed Zedan Wafaa Nabil Laimon Amal Mohamed Osman Mohamed Magdy Zedan | 2015 | World Journal of Clinical Pediatrics2015，4，2： | 5 |
| 2 | 腹腔镜与开腹全结肠系膜切除术治疗右半结肠癌的比较显示文摘目的:全结肠系膜切除术(complete mesocolic excision,CME)应用于结肠癌治疗中越来越受欢迎。本研究目的是比较腹腔镜CME(laparoscopic complete mesocolic excision,LCME)和开腹CME(open complete mesocolic excision,OC⁃ME)在右半结肠癌治疗中的可行性、安全性、围手术期并发症以及患者的预后方面的差异。方法:这是一项前瞻性研究,纳入了2012年1月至2019年12月在Assiut大学南方埃及肿瘤中心接受根治性CME右半结肠切除术,术后病理证实为Ⅱ期或Ⅲ期的结肠癌患者作为研究对象。根据手术入路方式的不同将患者分为LCME组(n=48)或OCME组(n=48)。结果:LCME组的平均手术时间明显长于OCME组,平均术中出血量更少。LCME组中有4例(8.3%)患者中转开腹。与OCME组相比,LCME组获取淋巴结数目更多【(39.81±16.74)vs.(32.65±12.28),P=0.010】,第一次排气时间更短,术后进流质饮食和恢复正常饮食的时间更早,术后住院时间更短。LCME组术后并发症发生率为14.7%,略低于OC⁃ME组的27.2%(P=0.252)。LCME组的3年总生存率与OCME组相似(78.2%vs.63.2%,P=0.423)。LCME组3年无疾病进展生存率为74.5%,高于OCME组的60.0%,但差异无统计学意义(P=0.266)。结论:对于专科外科医师,LCME在技术上是安全可行的。对于Ⅱ期或Ⅲ期结肠癌患者,LCME的长期肿瘤预后与OCME相当。 | 杜斌斌 姜雷 ZEDAN A ELSHIEKH E OMAR M I | 2021 | 结直肠肛门外科2021，27，3： | 2 |
| 3 | Montelukast as an episodic modifier for acute viral bronchiolitis: A randomized trial显示文摘 | Zedan M GamilN El-AssmyM | 2010 | Allergy Asthma Proc2010，31，2： | 1 |
| 4 | Study of plasmaadrenomedullin level in normal pregnancy and preeciampsia显示文摘 | Senna AA Zedan M Abd El salam GE | 2008 | Medscape J Med?2008 ?10(2)2008，29，： | 1 |
| 5 | Oxaiiplatin - In- duced Neuropathy in Colorectai Cancer: Many Questions With Few An- swers显示文摘 | Zedan A H Hansen T F Fex Svenningsen A | 2014 | Clin Colorectai Cancer2014，13，2： | 1 |
| 6 | Study of plasma adrenomedullin level in normal pregnancy and preclampsia显示文摘 | Senna AA Zedan M el-Salam GE | 2008 | Medscape J Med2008，10，2： | 1 |
| 7 | Combining dynamic and static sli- cing for analysing assembler显示文摘 | WARD M ZEDAN H | 2010 | Science of Computer pro- gramming2010，75，3： | 1 |
| 8 | Genepolymorphismsoftumornecrosisfactoralpha-308andinterleukin-10-1082aGmongasthmaticEgyptianchildren显示文摘 | ZEDAN M SETTINA FARAG M K | 2008 | AllergyAsthmaProc2008，29，： | 1 |
| 9 | Clinical asthma phenotypes:Is there an impact on myocardial performance?显示文摘 | Zedan M Attiaalsawah G El-assmy MM | 2012 | Echocardiography2012，29，5： | 1 |
| 10 | Gene polymorphisms of tumor necrosis factor alpha-308 and interleukin-10-1082 among asthmatic Egyptian children 显示文摘 | Zedan M Settin A Farag M K | 2008 | Allergy Asthma Proc2008，29，3： | 1 |
| 11 | Montelukast as an episodic modifier for acute viral bronchiolitis:a randomized trial 显示文摘 | Zedan M Gamil N E1-Assmy M | 2010 | Allergy Asthma Proc2010，31，2： | 1 |
| 12 | Effect of electricity tariff on the optimum insulation-thickness in building walls as determined by a dynamic heat-transfer model显示文摘 | Al-Sanea S A Zedan M F Al-Ajlan S A | 2005 | Applied Energy2005，82，： | 1 |
| 13 | Study of Plasma Adrenomedullin Level In Normal Pregnancy and Preeclampsia 显示文摘 | Senna AA Zedan M AIM El salam GE | 2008 | Medscape J Med2008，10，2： | 1 |
| 14 | Interleukin-12 and pe- ripheral blood invariant natural killer T cells as an axis in childhood asthma pathogenesis显示文摘 | Zedan M M El-Chennawi F A Fouda A E | 2010 | Iran J Allergy Asthma Immunol2010，9，1： | 1 |
| 15 | Analytical studies of HV insulators in Saudi Arabia显示文摘 | FARAG A S A ZEDAN F M | 1993 | IEEE Trans on Electrical Insulation1993，28，3： | 1 |
| 16 | Ox- aliplatin-lnduced Neuropathy in Colorectal Cancer: Many Questions With Few Answers显示文摘 | Zedan AH Hansen TF Fex Svenningsen A | 2014 | Clin Colorectal Cancer2014，13，2： | 1 |
| 17 | Adjustment factors for the ASHRAE clear-sky model based on solar- radiation measurements in Riyadh 显示文摘 | AI-Sanea S A Zedan M F A1-Ajlan S A | 2004 | Applied Energy2004，9，2： | 1 |
| 18 | The choice of urinary drainage in patients with ureteral calculi of solitary kidneys显示文摘 | Gorelov S Zedan F Startsev V | 2004 | Arch Ital Urol Androl2004，76，2： | 1 |
| 19 | Basal cell nevus syndrome显示文摘 | High A Zedan W | 2005 | Curr Opin Oncol2005，17，2： | 1 |
| 20 | Basal cell nevus syndeome显示文摘 | Zedan W | 2005 | Curt Opin Oncol2005，17，2： | 1 |
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