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| 1 | Engineering of drug nanoparticles by HGCP for pharmaceutical applications显示文摘This paper reviews our work on the fundamental principles of high gravity controlled precipitation (HGCP) technology, and its applications in the production of drug nanoparticles, which was carried out in a rotating packed bed (RPB). Several kinds of drug nanoparticles with narrow particle size distributions (PSDs) were successfully prepared via HGCP, including the 300-nm Cefuroxime Axetil (CFA) particles, 200–400-nm cephradine particles, 500-nm salbutamol sulfate (SS) particles (100 nm in width), and 850-nm beclomethasone dipropionate (BDP) particles, etc. Compared to drugs available in the current market, all the drug nanoparticles produced by HGCP exhibited advantages in both formulation and drug delivery, thus improving the bioavailability of drugs. HGCP is essentially a platform technology for the preparation of poorly water-soluble drug nanoparticles for oral and injection delivery, and of inhalable drugs for pulmonary delivery. Consequently, HGCP offers potential applications in the pharmaceutical industry due to its cost-effectiveness, efficient processing and the ease of scaling-up. | Ting-Ting Hua, Jie-Xin Wanga, Zhi-Gang Shena, Jian-Feng Chena,b, a Key Lab for Nanomaterials, Ministry of Education, Beijing University of Chemical Technology, Beijing 100029, China b Research Center of Ministry of Education for High Gravity Engineering and Technology, Beijing University of Chemical Technology, Beijing 100029, China | 2008 | Particuology2008，6，4： | 7 |
| 2 | Response characteristics of an ascending auditory neuron AN3 and its projections in the brain of the bushcricket Gampsocleis grationsa显示文摘The phonotaxis of bushcrickets demonstrates that they have goodcapability of recognizing conspecific songs and locating the sound source,which bases on complicated auditory mechanisms of the central nervoussystem(CNS).This article describes the response characteristics of AN3,an auditory ascending neuron in the prothoracic ganglion,and its projec-tions within the brain.The AN3,with a quasi-tonic discharge pattern,has high sensitivity,directionality and ability to encode sound intensity.Therefore,it plays an important role in auditory information processingof CNS.Its projections in the brain are mainly concentrated in the lateralzone of the deutencephalon,where synaptically connecting local auditoryinterneurons in the brain. | GAO Panpan and SHEN Jun -Xian(Institute of Biophysics, Academia Sinica, Beijing 100080)The phonotaxis of bushcrickets demonstrates that they have good capability of recognizing conspecific songs and locating the sound source, which bases on complicated auditory mechanisms of the central nervous system (CNS). This article describes the response characteristics of AN3, an auditory ascending neuron in the prothoracic ganglion, and its projections within the brain. The AN3 , with a quasi-tonic discharge pattern, has high sensitivity, directionality and ability to encode sound intensity. Therefore, it plays an important role in auditory information processing of CNS. Its projections in the brain are mainly concentrated in the lateral zone of the deutencephalon, where synaptically connecting local auditory interneurons in the brain. | 1992 | Chinese Journal of Acoustics1992，11，1： | 3 |
| 3 | Immune responses to AAV in clinical trials显示文摘 | Mingozzi F High K A | 2011 | Curr Gene Ther2011，11，4： | 1 |
| 4 | Langerhans cell histiocytosis: a review of the current recommendations of the Histiocyte Society显示文摘 | Satter E N High W A | 2008 | Pediatr Dermatol2008，，： | 1 |
| 5 | Gene transfer as an approach to treating hemophilia 显示文摘 | High K A | 2003 | Semin Thromb Hemost2003，29，1： | 1 |
| 6 | Immune responses to AAV vectors: overcoming barriers to successful gene therapy 显示文摘 | Mingozzi F High K A | 2013 | Blood2013，122，1： | 1 |
| 7 | Dairy herd management practices that impact nitrogen utilization efficiency 显示文摘 | JONKER J S KOHN R A HIGH J | 2002 | J Dairy Sci2002，85，： | 1 |
| 8 | 显示文摘 | High K A Laroche R D | 1995 | Computers Chem Engng1995，19，67： | 1 |
| 9 | 显示文摘 | RODGER MA A VRUCH LI H 0 Pelvicm agnetic resonance venog-raphy reveals high rate of pelvic vein thrombosis after cesarean sectionWLEY HE | 2006 | Am J Obstet Gynecol2006，194，43： | 1 |
| 10 | leaching through undisturbed soil columns显示文摘 | PLEYSIER J L JUO A S R Leaching of fertilizer ions in a Ultisolfromthe high rainfall tropics | 1981 | Soil Science Society of America Journal1981，45，： | 1 |
| 11 | In the process of humanization nursing in elderly patients with cardiovascular applications 显示文摘 | High on a boat | 2008 | Journal of modem medicine and health care2008，24，： | 1 |
| 12 | 显示文摘 | Hu X Dong H Y Qiu Z N et aL The effect of high magnetic field characterized by kinetics:Enhancing the biodegradation of acid red 1 with a strain of Bacillus sp | 2007 | International Biodeteriomtion & Biodegradation2007，60，4： | 1 |
| 13 | Dairy herd management practices that impact nitrogen utilization efficiency 显示文摘 | Jonker J S Kohn R A High J | 2002 | Journal of Dairy Sci- ence2002，85，： | 1 |
| 14 | Appfication of a Multi Objective Multi- Leader Particle Swarm Optimization Algorithm on NLP and MIHLP Problems 显示文摘 | Shokrian M High K A | 2014 | Computers & Chemical Engineering2014，60，： | 1 |
| 15 | Free-form optics for illumination 显示文摘 | Design methodology for high Journal of Display Technology Minano JC Benitez P Santamaria A | 2009 | Optical Review2009，16，2： | 1 |
| 16 | Late-stage nodular erythema elevatum diutinum显示文摘 | High W A Hoang M P Stevens K | 2003 | Am Acad Dermatol2003，49，4： | 1 |
| 17 | Age-dependent effects of RPE65 gene therapy for Leb- er' s congenital amaurosis: a phase 1 dose-escalation trial显示文摘 | Maguire AM High KA Auricchio A Wright JF Pierce EA Testa F et ol | 2009 | Lancet2009，374，9701： | 1 |
| 18 | Dependences of ESR line widths and spin-spin relaxation times of single nitrogen defects on the concentration of nitrogen defects in diamond显示文摘 | Wyk J A Van Reynhardt E C High G L | 1997 | J Phys D:Apple Phys1997，30，12： | 1 |
| 19 | Response of Holstein cows to replacing urea with a slowly rumen released urea in a diet high in soluble crude protein显示文摘 | HIGH STREET A ROBINSON PH ROBISONJ | 2010 | Livestock Science2010，129，213： | 1 |
| 20 | Age-dependent effects of RPE65 gene therapy for Leber’s congenital amaurosis: A phase1 dose-escalation trial显示文摘 | MAGUIRE A M HIGH K A AURICCHIO A | 2009 | Lancet2009，374，9701： | 1 |
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