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| 1 | Impact of a clinical pathway on treatment outcome in patients with acute pancreatitis显示文摘AIM:To determine the impact of a clinical pathway(CP) on acute pancreatitis(AP) treatment outcome.METHODS:A retrospective analysis of medical records was performed. We compared the results of AP treatment outcome over two time periods in our centre,before(2006-2007) and after(2010-2012) the implementation of a CP. The CP comprised the following indicators of quality:performance of all laboratory tests on admission(including lipids and carbohydrate deficient transferrin),determination of AP aetiology,abdomen ultrasound(US) within the first 24 h after admission,contrast-enhanced computed tomography of the abdomen in all cases of suspected pancreatic necrosis,appropriately selected and sufficiently used antibiotic therapy(if necessary),pain control,adequate hydration,control of haemodynamic parameters and transfer to the Intensive Care Unit(ICU)(if necessary),endoscopic retrograde cholangiopancreatography(ERCP) in biliary AP,surgical treatment(if necessary),and advice on outpatient follow-up after discharge. A comparison of the length of stay with that in other Slovenian hospitals was also performed.RESULTS:There were 139 patients treated in the three-year period after the introduction of a CP,of which 81(58.3%) were male and 58(41.7%) female. The patients' mean age was 59.6 ± 17.3 years. The most common aetiologies were alcoholism and gallstones(38.8% each),followed by unexplained(11.5%),drug-induced,hypertriglyceridemia,post ERCP(2.9% each) and tumours(2.2%). Antibiotic therapy was prescribed in 72(51.8%) patients. Abdominal US was performed in all patients within the first 24 h after admission. Thirty-two(23.0%) patients were treated in the ICU. Four patients died(2.9%). In comparison to 2006-2007,we found an increased number of alcoholic and biliary AP and an associateddecrease in the number of unexplained aetiology cases. The use of antibiotics also significantly decreased after the implementation of a CP(from 70.3% to 51.8%; P = 0.003). There was no statistically significant difference in mortality(1.8% vs 2.9%). The length of stay was significantly shorter when compared to the Slovenian average(P = 0.018).CONCLUSION:The introduction of a CP has improved the treatment of patients with AP,as assessed by all of the observed parameters. | Miroslav Vujasinovic Jana Makuc Bojan Tepes Apolon Marolt Zdenko Kikec Nace Robac | 2015 | World Journal of Gastroenterology2015，21，30： | 13 |
| 2 | Important parameters in plasma jets for the production of RONS in liquids for plasma medicine: A brief review显示文摘Reactive oxygen and nitrogen species (RONS) are among the key factors in plasma medicine. They are generated by atmospheric plasmas in biological fluids, living tissues and in a variety of liquids. This ability of plasmas to create a delicate mix of RONS in liquids has been used to design remote or indirect treatments for oncological therapy by treating biological fluids by plasmas and putting them in contact with the tumour;Documented effects include selective cancer cell toxicity, even though the exact mechanisms involved are still under investigation. However, the 'right' dose for suitable therapeutical activity is crucial and still under debate. The wide variety of plasma sources hampers comparisons. This review focuses on atmospheric pressure plasma jets as the most studied plasma devices in plasma medicine and compiles the conditions employed to generate RONS in relevant liquids and the concentration ranges obtained. The concentrations of H2O2, NO2^-, NO3^- and short-lived oxygen species are compared critically to provide a useful overview for the reader. | Anna Khlyustova Cédric Labay Zdenko Machala Maria-Pau Ginebra Cristina Canal | 2019 | Frontiers of Chemical Science and Engineering2019，13，2： | 4 |
| 3 | Association of Psb28 and Psb27 Proteins with PSII-PSI Supercomplexes upon Exposure of Synechocystis sp. PCC 6803 to High Light显示文摘 | Martina Beckova Zdenko Gardian Jianfeng Yu Peter Konik Peter J. Nixon Josef Komenda | 2017 | Molecular Plant2017，10，1： | 3 |
| 4 | Stable gastric pentadecapeptide BPC 157 in the treatment of colitis and ischemia and reperfusion in rats: New insights显示文摘AIM To provide new insights in treatment of colitis and ischemia and reperfusion in rats using stable gastric pentadecapeptide BPC 157. METHODS Medication [BPC 157,L-NAME,L-arginine(alone/combined),saline] was bath at the blood deprived colon segment. During reperfusion,medication was BPC 157 or saline. We recorded(USB microscope camera) vessel presentation through next 15 min of ischemic colitis(ICrats) or reperfusion(removed ligations)(IC + RL-rats);oxidative stress as MDA(increased(IC-and IC + RLrats)) and NO levels(decreased(IC-rats);increased(IC + RL-rats)) in colon tissue. IC + OB-rats [IC-rats had additional colon obstruction(OB)] for 3 d(IC + OBrats),then received BPC 157 bath. RESULTS Commonly,in colon segment(25 mm,2 ligations on left colic artery and vein,3 arcade vessels within ligated segment),in IC-,IC + RL-,IC + OB-rats,BPC 157(10 μg/kg) bath(1 m L/rat) increased vessel presentation,inside/outside arcade interconnections quickly reappeared,mucosal folds were preserved and the pale areas were small and markedly reduced. BPC 157 counteracted worsening effects induced by L-NAME(5 mg) and L-arginine(100 mg). MDA-and NO-levels were normal in BPC 157 treated IC-rats and IC + RLrats. In addition,on day 10,BPC 157-treated IC + OBrats presented almost completely spared mucosa with very small pale areas and no gross mucosal defects;the treated colon segment was of normal diameter,and only small adhesions were present.CONCLUSION BPC 157 is a fundamental treatment that quickly restores blood supply to the ischemically injured area and rapidly activates collaterals. This effect involves the NO system. | Antonija Duzel Josipa Vlainic Marko Antunovic Dominik Malekinusic Borna Vrdoljak Mariam Samara Slaven Gojkovic Ivan Krezic Tinka Vidovic Zdenko Bilic Mario Knezevic Marko Sever Nermin Lojo Antonio Kokot Marijan Kolovrat Domagoj Drmic Jaksa Vukojevic Tamara Kralj Katarina Kasnik Marko Siroglavic Sven Seiwerth Predrag Sikiric | 2017 | World Journal of Gastroenterology2017，23，48： | 2 |
| 5 | Wheat/maize or wheat/soybean strip intercropping显示文摘 | Long Li Jianhao Sun Fusuo Zhang Xiaolin Li Zdenko Rengel Sicun Yang | 2001 | Field Crops Research2001，，3： | 2 |
| 6 | Circulating Cytokine Levels in Acute Pancreatitis—Model of SIRS/CARS Can Help in the Clinical Assessment of Disease Severity显示文摘 | Ivan Gunjaca Josip Zunic Mihaela Gunjaca Zdenko Kovac | 2012 | Inflammation2012，，2： | 2 |
| 7 | Numerical analysis and experi- mental investigation of welding residual stresses and distortions in a T-joint fillet weld 显示文摘 | Mato Peric Zdenko Tonkovic | 2014 | Materials and Design2014，53，： | 1 |
| 8 | Importance of seed Zn content for wheat growth on Zn-deficient soil显示文摘 | Zdenko Rengel Robin D Graham | 1995 | Plant and Soil1995，173，： | 1 |
| 9 | Age- and Region-Dependent Changes in Human Lumbar Vertebral Bone: A Histomorphometric Study显示文摘 | Olga Cvijanovic Dragica Bobinac Sanja Zoricic Zdenko Ostojic Ivana Maric Zeljka Crncevic-Orlic Ines Kristofic Ljerka Ostojic | 2004 | Spine2004，，21： | 1 |
| 10 | Historic Overview and Recent Advances in the ynthesis of Super-statins显示文摘 | Zdenko C | 2010 | Curr Org Chem2010，14，： | 1 |
| 11 | Carbon nanotube-polymer composites : Chemistry, pro- cessing, mechanical and electrical properties 显示文摘 | Spitalsky Zdenko Tasis Dimitrios Papagelis Konstanti- nos | 2010 | Progress in Polymer Science2010，35，： | 1 |
| 12 | The Role of classic risk factors and prothrombotic factor gene mutations in ischemic stroke risk development in young and middle-- aged individuals显示文摘 | Visnja Supanc Zdenko Sonicki Ines Vukasovic | 2014 | Journal of Stroke and Cerebro- vascular Diseases2014，23，3： | 1 |
| 13 | An efficient synthesis of ( S ) -3-aminomethyl-5-methylhexanoic acid (Pregabalin) via quinine-mediated desymmetrization of cyclic anhydride 显示文摘 | Hamelsak zdenko Stipetic lrena Avdagic Amir | 2007 | Tetrahedron : Asymmetry2007，18，12： | 1 |
| 14 | Standard Uncertainty in Each Measurement Result Explicit or Implicit 显示文摘 | | 1997 | Measurement1997，20，2： | 1 |
| 15 | Carbon nanotube polymer composites: Chemistry, processing, mechanicaland electrical properties 显示文摘 | Zdenko S S Dimitrios T Konstantinos P P | 2010 | Progress in Polymer Science2010，35，： | 1 |
| 16 | Standard Uncertainty in Each Measurement Result Explicit or Implicit显示文摘 | Zdenko Godec | 1997 | Measurement1997，20，2： | 1 |
| 17 | Novel Laser Therapy in Treatment of Onychomycosis 显示文摘 | Jasmina Kozarev Zdenko Vizintin | 2010 | Journal of the Laser and Health Academy2010，1，2： | 1 |
| 18 | Canola cultivars differ in nitrogen utiliza- tion efficiency at vegetative stage 显示文摘 | Zlatko S Zdenko R | 2006 | Field Crops Res2006，97，： | 1 |
| 19 | Nitrogen utilization efficiency in canola eultivars at grain harvest 显示文摘 | Zlatko S Zdenko R | 2006 | Plant Soil2006，283，29： | 1 |
| 20 | Circulating Cytokine Levels in Acute Pancreatitis—Model of SIRS/CARS Can Help in the Clinical Assessment of Disease Severity显示文摘 | Ivan Gunjaca Josip Zunic Mihaela Gunjaca Zdenko Kovac | 2012 | Inflammation2012，，2： | 1 |
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