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| 1 | Tumor necrosis factor-α-G308A polymorphism is associated with liver pathological changes in hepatitis C virus patients显示文摘AIM To investigate the association of tumor necrosis factor alpha(TNFα)-G308 A polymorphism with different liver pathological changes in treatment-na?ve Egyptian patients infected with hepatitis C virus(HCV) genotype 4.METHODS This study included 180 subjects,composed of 120 treatment-na?ve chronic HCV patients with different fibrosis grades(F0-F4) and 60 healthy controls. The TNFα-G308 A region was amplified by PCR and the different genotypes were detected by restriction fragment length polymorphism analysis. The TNFα protein was detected by enzyme-linked immunosorbent assay. The influence of different TNFα-G308 A genotypes on TNFα expression and liver disease progression were statistically analyzed. The OR and 95%CI were calculated to assess the relative risk confidence.RESULTS Current data showed that the TNFα-G308 A SNP frequency was significantly different between controls and HCV infected patients(P = 0.001). Both the AA genotype and A allele were significantly higher in late fibrosis patients(F2-F4,n = 60) than in early fibrosis patients(F0-F1,n = 60)(P = 0.05,0.04 respectively). Moreover,the GA or AA genotypes increased the TNFα serum level greater than the GG genotype(P = 0.002). The results showed a clear association between severe liver pathological conditions(inflammation,steatosis and fibrosis) and(GA + AA) genotypes(P = 0.035,0.03,0.04 respectively). The stepwise logistic regression analysis showed that the TNFα genotypes(GA + AA) were significantly associated with liver inflammation(OR = 3.776,95%CI: 1.399-10.194,P = 0.009),severe steatosis(OR = 4.49,95%CI: 1.441-14.0,P = 0.010) and fibrosis progression(OR = 2.84,95%CI: 1.080-7.472,P = 0.034). Also,the A allele was an independent risk factor for liver inflammation(P = 0.003),steatosis(P = 0.003) and fibrosis(P = 0.014). CONCLUSION TNFα SNP at nucleotide-308 represents an important genetic marker that can be used for the prognosis of different liver pathological changes in HCV infected | Noha G Bader El Din Sally Farouk Reem El-Shenawy Marwa K Ibrahim Reham M Dawood Mostafa M Elhady Ahmed M Salem Naglaa Zayed Ahmed Khairy Mostafa K El Awady | 2016 | World Journal of Gastroenterology2016，22，34： | 3 |
| 2 | 源自天然席夫碱的过渡金属配合物在分光光度法测天然水中的Fe(Ⅲ)的应用(英文)显示文摘描述了一种新颖、简便的合成含五齿配位基的大环席夫碱配体的方法,制备和表征了该席夫碱的1∶1包合物。用化学和光谱学方法测定了标题配合物的组成,认为在所有配合物中配位金属原子取八面体结构。数据表明:配体起O2N4六齿结构而每个环绕金属原子在八面体环境中。配合物的红外和1H NMR光谱符合中心金属原子的配位结果。用分光光度法测定了配合物的稳定常数。用共轭余量法(CR method)计算了在热分解的不同阶段配合物活化的动力学和热力学参数。此外,用抑菌圈直径法筛选了配体及其金属配合物抑制细菌和真菌的能力。用回收率试验研究了天然螯合配体在不同天然水体中对Fe(Ⅲ)离子配合作用的影响。 | Khalil M M H Mohamed G G Ismail E H Zayed M E Kamel B A | 2012 | 无机化学学报2012，28，7： | 1 |
| 3 | Investigation of the effectiveness of some adsorbent materials in oil spill clean up 显示文摘 | SAYED S A ZAYED A M | 2006 | Desalination2006，194，： | 1 |
| 4 | Selerdum in higher plants显示文摘 | TERRY N ZAYED A M de SOUZA M P | 2000 | Ann Rev Plant Physiol Plant Mol Biol2000，51，： | 1 |
| 5 | Consolidation analysis of a cross-anisotropic homogeneous elastic soil using a finite layer numerical method显示文摘 | Mei G X Yin J H Zai J M | 2004 | International Journal for Numerical and Analytical Methods in Geomechanics2004，28，2： | 1 |
| 6 | Effects of arbuscular mycorrhizal fungi on the rooting and growth of beach plum (Prunus maritima) cuttings 显示文摘 | Zai X M Qin P Wan S W Zhao F G Wang G Yan D L | 2007 | J Hort Sci Biotech2007，82，6： | 1 |
| 7 | Parathyroid hormone increases cytosolic calcium concentration in adult rat cardiac myocytes 显示文摘 | Smogorzewski M Zayed M Zhang YB | 1993 | Am J Physiol1993，269，： | 1 |
| 8 | Obstacles detection from disparity properties in a particular Stereo vision system configuration 显示文摘 | ZAYED M BOONAERT J | 2003 | IEEE Transaction on Intelligent Transportation Systems2003，1，： | 1 |
| 9 | Chromium accumulation, translocation and chemical speciation in vegetable crops 显示文摘 | Zayed A Lytle C M Qian J H | 1998 | Planta1998，206，： | 1 |
| 10 | Decomposition of 14C-fenitrothion under the influence of UV and sunlight under tropical and subtropical conditions显示文摘 | Zayed S M Mahdy F | 2008 | Cheraosphere2008，70，： | 1 |
| 11 | Increased aquaporin-4 expression in ammonia-treated cultured astrocytes 显示文摘 | Zai KV Rama Rao M Chen J | 2003 | Neuroreport2003，18，14： | 1 |
| 12 | Investigation of a heat transfer augmenter as a fouling cleaner and its optimum geometry in tube-side of a condenser 显示文摘 | Yang S R Wang J M Zai G D | 1992 | Experimental Thermal and Fluid Science1992，5，6： | 1 |
| 13 | Phytoaccumulation of trace elements by wetland plants, Water Hyacinth 显示文摘 | Zhu Y L Zayed A M Qian J H | 1999 | Journal of Environmental Quality1999，28，1： | 1 |
| 14 | Rapid gastric emptying,rather than delayed gastric emptying,might provoke functional dyspepsia显示文摘 | Kusano M Zai H Shimoyama Y | 2011 | J Gastroenterol Hepatol2011，26，3： | 1 |
| 15 | Phase I study of eptifibatide in patients with sickle cell anaemia显示文摘 | Lee SP Ataga KI Zayed M | 2007 | Br J Haematol2007，139，4： | 1 |
| 16 | Accumulation and volatilization of different chemical species of selenium by plants显示文摘 | Zayed A Lyde C M Terry N | 1998 | Planta1998，206，2： | 1 |
| 17 | Solvent-assisted molten salt process A new route to syn- thesis a Fe2 O3/C nanocomposite and its electrochemical performance in lithium-ion batteries显示文摘 | Mohd Faiz Hassana Rahmana M M Zai Ping Guo | 2010 | Electrochimica Acta2010，55，： | 1 |
| 18 | Selenium in higher plants显示文摘 | Terry N Zayed A De Souza M | 2000 | Annual review of plant biology2000，51，1： | 1 |
| 19 | Accumulation and volatilization of different chemical species of selenium by plants显示文摘 | ZAYED A M LYTLE C M TERRY N | 1998 | Planta1998，206，： | 1 |
| 20 | Efficacy of essential oils in the control of cumin root rot disease caused by Fusarium spp 显示文摘 | Hashem M Moharama A M Zaied A A | 2010 | Crop Protection2010，29，： | 1 |
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