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| 1 | Smart biomaterials: Surfaces functionalized with proteolytically stable osteoblast-adhesive peptides显示文摘Engineered scaffolds for bone tissue regeneration are designed to promote cell adhesion,growth,proliferation and differentiation.Recently,covalent and selective functionalization of glass and titanium surfaces with an adhesive peptide(HVP)mapped on[351e359]sequence of human Vitronectin allowed to selectively increase osteoblast attachment and adhesion strength in in vitro assays,and to promote osseointegration in in vivo studies.For the first time to our knowledge,in this study we investigated the resistance of adhesion sequences to proteolytic digestion:HVP was completely cleaved after 5 h.In order to overcome the enzymatic degradation of the native peptide under physiological conditions we synthetized three analogues of HVP sequence.A retro-inverted peptide D-2HVP,composed of D amino acids,was completely stable in serum-containing medium.In addition,glass surfaces functionalized with D-2HVP increased human osteoblast adhesion as compared to the native peptide and maintained deposition of calcium.Interestingly,D-2HVP increased expression of IBSP,VTN and SPP1 genes as compared to HVP functionalized surfaces.Total internal reflection fluorescence microscope analysis showed cells with numerous filopodia spread on D-2HVP-functionalized surfaces.Therefore,the D-2HVP sequence is proposed as new osteoblast adhesive peptide with increased bioactivity and high proteolytic resistance. | Annj Zamuner Paola Brun Michele Scorzeto Giuseppe Sica Ignazio Castagliuolo Monica Dettin | 2017 | Bioactive Materials2017，2，3： | 3 |
| 2 | Inflammationinduced by Bothrops asper venom : release of proinflammatory cy-tokines and eicosanoids,and role of adhesion molecules in leuko-cyte infiltration shock显示文摘 | Zamuner S R Zuliani J P Fernandes CM | 2005 | Toxicon2005，46，7： | 1 |
| 3 | Radiative Transfer in Real Gases Using Reciprocal and Forward Monte Carlo Methods and a Correlated-k Approach 显示文摘 | Tesse L Dupoirieux F Zamuner B | 2002 | Int J Heat and Mass Transfer2002，45，： | 1 |
| 4 | Aspirin, but not NO- releasing aspirin ( NCX-4016), interacts with selective COX-2 inhibitots to aggravate gastric damage and inflammation显示文摘 | Wallace JL Zamuner SR McNight W | 2004 | Am J Physiol Gastrointest Liver Physiol2004，286，： | 1 |
| 5 | Effect of single and repeat doses of casopitant on the pharmacoki- netics of CYP450 3A4 substrates midazolam and nifedipine 显示文摘 | Zamuner S Johnson BM Pagliarusco S | 2010 | Br J Clin Pharmacol2010，70，4： | 1 |
| 6 | Inflammatory events induced by Lys-49 and Asp-49 phospholipases A2 isolated from Bothrops asper snake venom:role of catalytic activity显示文摘 | Zuliani JP Fernandes CM Zamuner SR | 2005 | Toxicon2005，45，3： | 1 |
| 7 | Inflammatoryeffects of BaP1 a metalloproteinase isolated from Bothrops asper snake venom:Leukocyte recruitment and release of cytokines显示文摘 | Fernandes CM Zamuner SR Zuliani JP | 2006 | Toxicon2006，47，5： | 1 |
| 8 | Effect of single and repeat doses of casopitant on the pharmacokinetics of CYP450 3A4substrates midazolam and nifedipine显示文摘 | Zamuner S Johnson BM Pagliarusco S | 2010 | Br J Clin Pharmacol2010，70，4： | 1 |
| 9 | Inflammatoryeffects of BaPl a metalloproteinase isolated from Bothrops aspersnake venom: leukocyte recruitment and release of cytokines显示文摘 | Fernandes CM Zamuner SR Zuliani JP | 2006 | Toxicon2006，47，5： | 1 |
| 10 | Aspirin, but not NO-releasing aspirin (NCX-4016), interacts with selective COX-2 inhibitors to aggravate gastric damage and inflammation显示文摘 | Wallace JL Zamuner SR McNight W | 2004 | Am J Physiol Gastrointest Liver Physiol2004，286，： | 1 |
| 11 | Nanoelectrode ensembles as recognition platform for electrochemical immunosensors显示文摘 | Pozzi M S Zamuner M Tormen M | | 0，，12： | 1 |
| 12 | Inflammatory events induced by Lys-49 and Asp-49 phospholipases A2 isolated from Bothrops asper snake venom:role of catalytic activity显示文摘 | Zuliani JP Fernandes CM Zamuner SR | 2005 | Toxicon2005，45，3： | 1 |
| 13 | Facile and selective covalent grafting of an RGD-peptide to electrospun scaf- folds improves HUVEC adhesion显示文摘 | Dettin M Zamuner A Roso M | 2015 | J Pept Sci2015，21，10： | 1 |
| 14 | Infla-mmation induced by Bothrops asper venom :release of proinflammatory cytokines and eicosanoids, and role of adhesion molecules in leukocyte infiltration显示文摘 | Zamuner S R Zuliani J P Fernandes C M | 2005 | Toxicon2005，46，7： | 1 |
| 15 | Inflammatory events induced by Lys-49 and Asp-49 phospholipases A2 isolated from Bothrops asper snake venom: role of catalytic activity 显示文摘 | Zuliani JP Fernandes CM Zamuner SR | 2005 | Toxicon2005，45，3： | 1 |
| 16 | Relationship between sympathetic activity and pain intensity in fibromyalgia显示文摘 | Zamuner A R Barbic F Dipaola F | 2015 | Clin Exp Rheumatol2015，33，188： | 1 |
| 17 | Comparison of phosphorus fertilization diagnostic methods for wheat under no-tillage显示文摘 | Zamuner E C Picone L I Echeverria H E | 2006 | Soil & Tillage Research2006，89，1： | 1 |
| 18 | Analgesic effect of Light-Emitting Diode ( LED)therapy at wavelengths of 635 and 945 nm on bothrops-moojeni venom-induced hyperalgesia显示文摘 | Nikele Nadur-Andrade Stella K Zamuner Elaine F Tonio-lo | 2014 | Photochemistryand Photobiology2014，90，： | 1 |
| 19 | Inflammatory effects of BaP1 a metalloproteinase isolated from Bothrops asper snake venom, Leukocyte recruitment and release of cytokines 显示文摘 | Cristina Maria Fernandes Stella Regina Zamuner Juliana Pavan Zuliani | 2006 | Toxicon2006，47，15： | 1 |
| 20 | Aspirin,but not NO-releasing aspirin(NCX-4016),interacts with selective COX-2 inhibitors to aggravate gastric damage and inflammation显示文摘 | Zamuner SR McNight W | 2004 | Am J Physiol Gastrointest Liver Physiol2004，286，： | 1 |
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