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| 1 | Colorectal cancer and dysplasia in inflammatory bowel disease显示文摘Both ulcerative colitis and Crohn’s disease carry an increased risk of developing colorectal cancer. Established risk factors for cancer among patients with inflammatory bowel disease (IBD) include the younger age at diagnosis, greater extent and duration of disease, increased severity of inflammation, family history of colorectal cancer and coexisting primary sclerosing cholangitis. Recent evidence suggests that current medical therapies and surgical techniques for inflammatory bowel disease may be reducing the incidence of this complication. Nonetheless heightened vigilance and a careful, comprehensive approach to prevent or minimize the complications of invasive cancer are warranted in this unique cohort of patients. Current guidelines for the prevention and early detection of cancer in this high risk population are grounded in the concept of an inflammation-dysplasia- carcinoma sequence. A thorough understanding of the definition and natural history of dysplasia in IBD, as well as the challenges associated with detection and interpretation of dysplasia are fundamental to developing an effective strategy for surveillance and prevention, and understanding the limitations of the current approach to prevention. This article reviews the current consensus guidelines for screening and surveillance of cancer in IBD, as well as presenting the evidence and rationale for chemoprevention of cancer and a discussion of emerging technologies for the detection of dysplasia. | Timothy L Zisman David T Rubin | 2008 | World Journal of Gastroenterology2008，14，17： | 13 |
| 2 | Interaction of obesity and inflammatory bowel disease显示文摘Inflammatory bowel disease(IBD) is a chronic inflammatory condition of unknown etiology that is thought to result from a combination of genetic, immunologic and environmental factors. The incidence of IBD has been increasing in recent decades, especially in developing and developed nations, and this is hypothesized to be in part related to the change in dietary and lifestyle factors associated with modernization. The prevalence of obesity has risen in parallel with the rise in IBD, suggesting a possible shared environmental link between these two conditions. Studies have shown that obesity impacts disease development and response to therapy in patients with IBD and other autoimmune conditions. The observation that adipose tissue produces pro-inflammatory adipokines provides a potential mechanism for the observed epidemiologic links between obesity and IBD, and this has developed into an active area of investigative inquiry. Additionally, emerging evidence highlights a role for the intestinal microbiota in the development of both obesity and IBD, representing another potential mechanistic connection between the two conditions. In this review we discuss the epidemiology of obesity and IBD, possible pathophysiologic links, and the clinical impact of obesity on IBD disease course and implications for management. | Jason W Harper Timothy L Zisman | 2016 | World Journal of Gastroenterology2016，22，35： | 6 |
| 3 | Synergy is achieved by complementation with Apo2L/TRAIL and actinomycin D in Apo2L/TRAIL-mediated apoptosis of prostate cancer cells: role of XIAP in resistance显示文摘 | Ng CP Zisman A Bonavida B | 2002 | Prostate2002，53，4： | 1 |
| 4 | The changing natural history of renal cell carcinoma显示文摘 | Pantuck AJ Zisman A Belldegrun AS | 2001 | J Urol2001，166，5： | 1 |
| 5 | Improved prognostication of renal cell carcinoma using an integrated staging system 显示文摘 | Zisman A Pantuck AJ Dorey F | 2001 | J Clin Oncol2001，19，6： | 1 |
| 6 | Induction of G250-targeted and T-cell-mediated antitumor activity against renal cell carcinoma using a chimeric fusion protein consisting of G250 and granulocyte/monocyte-colony stimulating factor显示文摘 | Tso CL Zisman A Pantuck A | 2001 | Cancer Res2001，61，21： | 1 |
| 7 | Relation of the equilibrium contact angle to liquid and solid constitution显示文摘 | Zisman W A | 1964 | Advanced Chemistry1964，43，： | 1 |
| 8 | Collecting duct renal cell carci- noma:clinical study of a rare tumor 显示文摘 | Chao D Zisman A Pantuck A J | 2002 | J Urol2002，167，1： | 1 |
| 9 | Relation of the equilibrium contact angle to liquid and solid constitution 显示文摘 | ZISMAN W A | 1964 | Advances in Chemistry Series1964，43，： | 1 |
| 10 | Collecting duct renal cell carcinoma: clinical study of a rare tumor 显示文摘 | Chao D Zisman A Pantuck AJ | 2002 | J Urol2002，167，1： | 1 |
| 11 | Angiotensin - (1 -7) foliation in the intact human heart:in vivo dependence on angiotensin Ⅱ as substrate 显示文摘 | Zisman LS Meixell GE Bristow MR | 2003 | Circulation2003，108，14： | 1 |
| 12 | 显示文摘 | Mehrad B Burdiek MD Zisman DA | 2007 | Bioehem Biophys Res2007，353，1： | 1 |
| 13 | Kidney stones: an update on current pharmacological management and future directions 显示文摘 | Xu H Zisman A L Coe F L | 2013 | Expert Opin Pharmacother2013，14，4： | 1 |
| 14 | Changing concepts in the management of renal oncocytoma显示文摘 | Zisman A Pantunk A J | 2002 | Urology2002，59，5： | 1 |
| 15 | Increased angiotensin-(1-7)-forming activity in failing human heart ventricles:evidence for upregulation of the angiotensin-converting enzyme homologue ACE2显示文摘 | ZISMAN LS KELLER RS WEAVER B | 2003 | Circulation2003，108，14： | 1 |
| 16 | Renal cell carcinoma with retroperitoneal lymph nodes:role of lymph node dissection显示文摘 | Pantuck AJ Zisman A Dorey F | 2003 | J Urol2003，169，6： | 1 |
| 17 | The effects of intrathecal morphine on patients undergoing minimally invasive direct coronary artery bypass surgery显示文摘 | Zisman E Shenderey A Ammar R | 2005 | J Cardiothorac Vasc Anesth2005，19，1： | 1 |
| 18 | Paclitaxel,estramustine and carboplatin combination chemotherapy after initial docetaxel-based chemotherapy in castration-resistant prostate cancer显示文摘 | Sella A Yarom N Zisman A | 2009 | Oncology2009，76，6： | 1 |
| 19 | Induction of G250-targetedand T-cell-mediated antitumor activity against renal cell carcinomausing a chimeric fusion protein consisting of G250 and granulocyte/monocyte-conlony stimulating factor显示文摘 | Tso CL Zisman A Pantuck A | 2001 | Cancer Res2001，61，21： | 1 |
| 20 | Glucose toxicity and the development of diabetes in mice with muscle-specific inactivation of GLUT4显示文摘 | Kim JK Zisman A Fillmore JJ | 2001 | J Clin Invest2001，108，： | 1 |
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