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| 1 | Comparative effectiveness of i-SCAN^(TM) and high-definition white light characterizing small colonic polyps显示文摘AIM:To evaluate accuracy of in vivo diagnosis of adenomatous vs non-adenomatous polyps using i-SCAN digital chromoendoscopy compared with high-definition white light.METHODS:This is a single-center comparative effectiveness pilot study.Polyps(n = 103) from 75 averagerisk adult outpatients undergoing screening or surveillance colonoscopy between December 1,2010 and April 1,2011 were evaluated by two participating endoscopists in an academic outpatient endoscopy center.Polyps were evaluated both with high-definition white light and with i-SCAN to make an in vivo prediction of adenomatous vs non-adenomatous pathology.We determined diagnostic characteristics of i-SCAN and highdefinition white light,including sensitivity,specificity,and accuracy,with regards to identifying adenomatous vs non-adenomatous polyps.Histopathologic diagnosis was the gold standard comparison.RESULTS:One hundred and three small polyps,detected from forty-three patients,were included in the analysis.The average size of the polyps evaluated in the analysis was 3.7 mm(SD 1.3 mm,range 2 mm to 8 mm).Formal histopathology revealed that 54/103(52.4%) were adenomas,26/103(25.2%) were hyperplastic,and 23/103(22.3%) were other diagnoses include 'lymphoid aggregates','non-specific colitis,' and 'no pathologic diagnosis.' Overall,the combined accuracy of endoscopists for predicting adenomas was identical between i-SCAN(71.8%,95%CI:62.1%-80.3%) and high-definition white light(71.8%,95%CI:62.1%-80.3%).However,the accuracy of each endoscopist differed substantially,where endoscopist A demonstrated 63.0% overall accuracy(95%CI:50.9%-74.0%) as compared with endoscopist B demonstrating 93.3% overall accuracy(95%CI:77.9%-99.2%),irrespective of imaging modality.Neither endoscopist demonstrated a significant learning effect with i-SCAN during the study.Though endoscopist A increased accuracy using i-SCAN from 59%(95%CI:42.1%-74.4%) in the first half to 67.6%(95%CI:49.5%-82.6%) in the second half,and endoscopist B decreased accuracy using i-SCAN from 100%(95%CI:80.5%-100.0%) in the first half to 84.6%(95%CI:54.6%-98.1%) in the second half,neither of these differences were statistically significant.CONCLUSION:i-SCAN and high-definition white light had similar efficacy predicting polyp histology.Endoscopist training likely plays a critical role in diagnostic test characteristics and deserves further study. | Johanna L Chan Li Lin Michael Feiler Andrew I Wolf Diana M Cardona Ziad F Gellad | 2012 | World Journal of Gastroenterology2012，18，41： | 3 |
| 2 | Hypertension:a novel regulator of adaptive immunity in atherosclerosis显示文摘 | Ziad M | 2004 | Hypertension2004，44，： | 1 |
| 3 | Ventilator-associated pneumonia in adults in developing countries:A systematic review显示文摘 | Yaseen A Nehad AS Ziad M | 2008 | lnt J Infect Dis2008，12，： | 1 |
| 4 | Recent Advances on the Role ofCytokines in Atherosclerosis显示文摘 | Hafid AO Soraya T Ziad M | 2011 | Arterioscler Thromb Vasc Biol2011，31，5： | 1 |
| 5 | 显示文摘 | Ziad M Andrea G Carmen MF | 2001 | Circ Res2001，89，： | 1 |
| 6 | Studies on the stability of chicken IgY in different sugars, complex carbohydrates and food materials 显示文摘 | ZIAD W J RONALD R M | 2000 | Food Agr lmmunol2000，12，4： | 1 |
| 7 | Functional characterization of a salt and thermotolerant glutaminase from Lactobacillus rhamnosus显示文摘 | Weingand Ziade A Gerber Decombaz C Affolter M | 2003 | Enzyme and Microbial Technolo- gy2003，32，7： | 1 |
| 8 | Noise resistant pulse oximetry using a synthetic reference signal显示文摘 | Frans M Ziad Elghazzawi | 2000 | IEEE Transaction on Biomedical Engineering2000，47，8： | 1 |
| 9 | NF-KB activation in atheroselerosis: a friend or a foe 显示文摘 | Ziad M Main T Hajra L Evans AI Chen M Hyduk SJ | 2004 | Blood2004，13，3： | 1 |
| 10 | Ventilator associated pneu- monia in adults in developing eountries:A systematic review显示文摘 | Yaseen A0 Nehad AS Ziad M | 2008 | Int J Infect Dis2008，12，： | 1 |
| 11 | Knowledge, practice, and attitude among iranian nurses, midwives and students regarding standard isolation precautions 显示文摘 | MEHRDUD A ZIAD A M | 2007 | Infect Control Hosp Epidemiol2007，28，24： | 1 |
| 12 | Use of botulinum toxin type A to improve treatment of facial wounds: a prospective random- ized study 显示文摘 | ZIADE M DOMERGUE S BATIFOL D | 2013 | J Plast Reconstr Aesthet Surg2013，66，2： | 1 |
| 13 | Varying anatomical injection points within the thoracic paravertebral space:effect on spread of solution and nerve blockade显示文摘 | Naja MZ Ziade MF El Rajab M | 2004 | Anaesthesia2004，59，4： | 1 |
| 14 | Face Recognition Using the Discrete Cosine Transform显示文摘 | Ziad M Martin D | 2001 | International Journal of Computer Vision2001，43，3： | 1 |
| 15 | Use ofbotulinum toxin type A to improve treatment of facial wounds:a prospective randomized study显示文摘 | Ziade M Domergue S Batifol D | 2013 | J Plast Reconstr Aesthet Surg2013，66，2： | 1 |
| 16 | Environmental management of the stone cutting industry显示文摘 | KHALED N ZIAD M BLAIR B | 2009 | Journal of Environmental Management2009，90，1： | 1 |
| 17 | Ventilator-associated pneu- monia in adults in developing countries:A systematic review 显示文摘 | Yaseen A Nehad AS Ziad M | 2008 | Int J Infect Dis2008，12，： | 1 |
| 18 | Duality in finite element method显示文摘 | M Elias Ziad | 1968 | J Engng Mech Div Am Soc Civ Engrs1968，94，4： | 1 |
| 19 | Intrinsic vulnerability,hazard and risk mapping for karst aquifers:A case study显示文摘 | Ziad A M Amjad A | | 0，，3： | 1 |
| 20 | Ventilator-associated pneumonia in adults in developing countries:A systematic review显示文摘 | Yaseen A Nehad AS Ziad M | 2008 | Int J Infect Dis2008，12，： | 1 |
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