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| 1 | Picroside Ⅱ down-regulates matrix metalloproteinase-9 expression following cerebral ischemia/reperfusion injury in rats显示文摘Studies have shown that Picroside II attenuates inflammatory reactions following brain ischemia through the inhibition of the TLR-4-NF-κB signal transduction pathway,and ameliorates cerebral edema through the reduction of aquaporin-4 expression.Matrix metalloproteinase-9 (MMP-9),located downstream of the TLR-4-NF-κB signal transduction pathway,can degrade the neurovascular matrix,damage the blood-brain barrier to induce cerebral edema,and directly result in neuronal apoptosis and brain injury.Therefore,the present study further observed MMP-9 expression in the brain tissues of rats with cerebral ischemia/reperfusion injury following Picroside II treatment.Results demonstrated that Picroside II significantly reduced MMP-9 expression in ischemic brain tissues,as well as neuronal apoptosis and brain infarct volume,suggesting Picroside II exhibits neuroprotection by down-regulating MMP-9 expression and inhibiting cell apoptosis. | Xiang Li Xinying Xu Zhen Li Yunliang Guo Qin Li Xiaodan Li Zhen Zhou | 2010 | Neural Regeneration Research2010，5，18： | 13 |
| 2 | Chronic intermittent hypoxia accelerates liver fibrosis in rats with combined hypoxia and nonalcoholic steatohepatitis via angiogenesis rather than endoplasmic reticulum stress显示文摘In the present study,we aimed to investigate the role of endoplasmic reticulum stress(ERS)and its related inflammation and angiogenesis in liver fibrosis in a rat model of combined hypoxia and nonalcoholic steatohepatitis(NASH)and to confirm whether the intervention of hypoxia-inducible factor 1α(HIF1α)can improve fibrosis.Liver histological changes and biochemical indices,HIF1α,inflammatory factors,ERS-related parameters(GRP78,CHOP,caspase-3,and caspase-12),and angiogenesis indices(VEGFA,VEGFR2,and CD34)were evaluated.Compared with the control rats,the liver tissue of rats with hypoxia and NASH had obvious NASH characteristics and hepatic fibrosis was significantly aggravated,including bridging fibrosis in some rats.The mRNA expression levels of HIF1α,VEGFA,and VEGFR2 and total immunohistochemical staining scores of VEGFR2 and CD34 were significantly increased.In addition,HIF1α silencing significantly decreased HIF1α,biochemical indices(ALT,AST,and TG),inflammatory factors(TNFα,IL6,and IL1β),and angiogenesis indices(CD34 and VEGFR2),consequently,improved the hepatic fibrosis score in the rat model of combined hypoxia and NASH.Taken together,chronic intermittent hypoxia accelerates liver fibrosis in rats with combined hypoxia and NASH via angiogenesis rather than ERS and HIF1α intervention can improve liver fibrosis,angiogenesis,inflammatory factors,and biochemical indices.Therefore,HIF1α is a key regulatory factor of liver fibrosis in rats with combined hypoxia and NASH. | Wei Wu Weiping Li Jiaojiao Wei Chunsheng Wang Yunliang Yao Weihua Zhu Weimei He Weimei Zhou Jiang Liu | 2019 | Acta Biochimica et Biophysica Sinica2019，51，2： | 8 |
| 3 | Anti-oxidant effect of picroside II in a rat model of cerebral ischemia/reperfusion injury显示文摘Picroside II,the major active component of picroside,has been shown to induce PC12 cell axonal growth and relieve free radical damage.In vivo experiments have demonstrated that picroside II can improve neurological function in rats with cerebral ischemia/reperfusion injuries.In the present in vivo study,enzyme-linked immunosorbent assay and immunohistochemistry revealed that picroside II increased superoxide dismutase content and reduced inducible nitric oxide synthase content in the ischemic hemisphere.The effects of picroside II were similar to those of salvianic acid A sodium,an active control drug.These results indicate that picroside II exerts a neuroprotective effect,possibly by downregulating inducible nitric oxide synthase expression,increasing superoxide dismutase activity,and inhibiting neuronal apoptosis. | Li Sun Xiaodan Li Ling Wang Lihua Qin Yunliang Guo Zhen Zhou | 2011 | Neural Regeneration Research2011，6，15： | 8 |
| 4 | Morphology of polar ionospheric O^+ ion upflow: FAST observations during quiet time显示文摘With energetic ion measurements on FAST satellite, the morphologic features of quiet-time ionospheric O+ ion upflowing at altitudes of 2000 to 4000 km are drawn out for the first time. The pre-noon cusp/cleft is the predominant region of upflowing occurrence for O+ with lower energy. Meanwhile the pre-dawn sector near the equatorward edge of the plasma convection dominates the occurrence for the higher energy O+ ions. No matter whether the energy is lower or higher, the upflows occur often over a wide MLT range of lower latitudes outside the auroral oval. The upflowing within the pre-midnight (21:00― 22:00 MLT) auroral oval carrys larger energy fluxes, with extremely large fluxes for higher energy O+ appearing near the polar cap boundary. For altitudes of 2000―4200 km under observation, the ion conics occur much more frequently than ion beams. Ion beams are rarely found below 3000 km, while the conics occur uniformly over the observed altitudes. | DANG Ge MA ShuYing ZHOU YunLiang | 2007 | Chinese Science Bulletin2007，52，24： | 3 |
| 5 | Reflections on the Catastrophic 2020 Yangtze River Basin Flooding in Southern China显示文摘During the summer of 2020,southern China suffered from catastrophic flooding,the massive basin flood mainly occurred in the Yangtze River's middle and lower reaches.As of July 20,2020,the cumulative precipitation since the rain season started exceeded 500 mm over most of the Yangtze River Basin,reaching>1,200 mm in some areas of the lower reaches,exceeding the same period in 1998,the severest flood year in the past 60 years.Several water gauge stations at Poyang Lake and Chaohu Lake exceeded their historical record values.The water levels in the Wuhan section of the Yangtze River were among the highest ever recorded.As of July 22,2020,45.5 million people had been affected by the floods,with 142 people having died or were missing,and the direct economic losses expected to be around 116 billion RMB(~16.5 billion US dollars).However,the losses from this flood are much lower than those of previous major floods.For example,the catastrophic 1998 flooding led to 1,526 deaths and economic losses of 255 billion RMB(~36.4 billion US dollars).The reasons behind this are worthy of further study and discussion,and may be used for reference in the future and for other countries. | Ke Wei Chaojun Ouyang Hongtao Duan Yunliang Li Mingxing Chen Jiao Ma Huicong An Shu Zhou | 2020 | The Innovation2020，1，2： | 2 |
| 6 | Prediction of SYM-H index by NARX neural network from IMF and solar wind data显示文摘SYM-H is one of the important indices for space weather. It indicates the intensity of magnetic storm, similarly to Dst index but with much higher time-resolution. In this paper an artificial neural network (ANN) of Nonlinear Auto Regressive with eXogenous inputs (NARX) has been developed to predict SYM-H index from solar wind and IMF data. In comparison with usual BP and Elman network, the new NRAX model shows much better prediction capability. For 15 testing great storms including 5 super-storms of Min. SYM-H < -200 nT, the cross-correlation of SYM-H indices between NARX network predicted and really observed is 0.91 as a whole. For the 5 individual super-storms, the lowest coefficients is 0.91 relating to the super-storm of March 2001 with Min.SYM-H of -434 nT; while for the two super-storms with Min. SYM-H ranging from -300 nT to -400 nT, the correlations reach as high as 0.93 and 0.96 respectively. The remarkable improvement of the model performance can be attributed to such a key feedback from the network output of SYM-H with a suitable length (about 120 min) to the input, which implies that some information on the quasi real-time ring currents with a proper length of history does its work in the prediction. It tells us that, in addition to the direct driving by solar wind and IMF, the own status of the ring current plays an important role in its evolution especially for recovery phase and must properly be considered in storm-time SYM-H prediction by ANN. The neural network model of NARX developed in this paper provides an effective way to achieve it. | CAI Lei MA ShuYing CAI HongTao ZHOU YunLiang LIU RuoSi | 2009 | Science China(Technological Sciences)2009，52，10： | 2 |
| 7 | Implementation method of Oil and Gas Geologic Information System with ArcGIS Engine显示文摘ComGIS is the mainstream of developing GIS currently.Developing Geographic Information System with the technology of components can reduce the difficulties of developing,improving the developing efficiency and enhancing the flexibility and opening of system.ArcObjects(AO) is based on the technology of COM,and ArcGIS Engine(AE) is a set of embedded AO which can extend to various platforms.Compared with AO,ArcGIS Engine can shorten the period of developing and improve the efficiency greatly.Having introduced the techniques of ArcObjects and ArcGIS Engine,we offer the method of developing GIS with Visual Basic and ArcGIS Engine with Oil and Gas Geologic Information System. | Chunyan DENG Yunliang YU Shixiang LIU Ruiqing QIE Zhiguo ZHOU | 2007 | Global Geology2007，10，1： | 2 |
| 8 | BiVO_(4)/TiO_(2) heterojunction with rich oxygen vacancies for enhanced electrocatalytic nitrogen reduction reaction显示文摘The large-scale production of ammonia mainly depends on the Haber-Bosch process,which will lead to the problems of high energy consumption and carbon dioxide emission.Electrochemical nitrogen fixation is considered to be an environmental friendly and sustainable process,but its efficiency largely depends on the activity and stability of the catalyst.Therefore,it is imperative to develop high-efficient electrocatalysts in the field of nitrogen reduction reaction(NRR).In this paper,we developed a BiVO_(4)/TiO_(2) nanotube(BiVO_(4)/TNT)heterojunction composite with rich oxygen vacancies as an electrocatalytic NRR catalyst.The heterojunction interface and oxygen vacancy of BiVO_(4)/TNT can be the active site of N2 dynamic activation and proton transition.The synergistic effect of TiO_(2) and BiVO_(4) shortens the proton transport path and reduces the over potential of chemical reaction.BiVO_(4)/TNT has high ammonia yield of 8.54µg·h^(−1)·cm^(−2) and high Faraday efficiency of 7.70%in−0.8 V vs.RHE in 0.1 M Na_(2)SO_(4) solution. | Yunliang Liu Peiji Deng Ruqiang Wu Ramadan A.Geioushy Yaxi Li Yixian Liu Fengling Zhou Haitao Li Chenghua Sun | 2021 | Frontiers of physics2021，16，5： | 1 |
| 9 | Field-aligned current distribution and response to interplanetary conditions during a superstorm——CHAMP observation显示文摘With geomagnetic measurements on board of CHAMP satellite, the characteristics of global large-scale field-aligned currents (FACs) in the topside ionosphere are investigated along with their responses to interplanetary conditions for the superstorm of November, 2003. It is found that (1) The storm-time FAC densities enhanced greatly in comparison with quiet period and the enhancements show hemispheric asymmetry of both summer-winter and sunlit-dark. (2) For the first time, it is revealed that the lati-tude-integrated FAC density is controlled mainly by solar wind dynamic pressure rather than IMF. (3) FACs expanded equatorward dramatically, with the lowest latitude being 45° MLat or more; on the day-side this expansion was controlled directly by IMF Bz, showing an interaction time scale of about 25 min in the solar wind-magnetosphere-ionosphere coupling system, and a nonlinear saturation of the equatorward expansion when IMF Bz < -30 nT; while on the nightside, the expansion and recovery lagged about 3 h behind the IMF changes but nearly in phase with changes of SYM-H index. (4) During the storm main phase, the nightside FAC latitude coverage extended to 25° or wider, appearing multi-sheet current structure with more than 10 sheets. | WANG Hui MA ShuYing Hermann LUEHR ZHOU YunLiang DANG Ge | 2007 | Chinese Science Bulletin2007，52，2： | 1 |
| 10 | Distribution of Triatomines,the Vector of Chagas Disease--Southern China,2016−2018显示文摘What is already known on this topic?Triatomines,also known as kissing bugs,are widespread vectors for Chagas disease which affects 6-8 million people worldwide.Two species of triatomines have been previously reported in China.What is added by this report?This study showed data from the first investigation of triatomine distribution in China.Triatoma rubrofasciata and a novel species of triatomine in 170 habitats in 30 cities in southern China were recorded in this investigation.What are the implications for public health practice?Considering the worldwide spread of Chagas disease and new species of trypanosomiasis,strengthening the monitoring of triatomines and their associated diseases in southern China is vital to prevent and control these diseases. | Qin Liu Fangwei Wu Yunliang Shi Wencheng Lu Hanguo Xie Yunhai Guo Dan Zhu Yuanyuan Li Yi Zhang Xiao-nong Zhou | 2020 | China CDC weekly2020，2，33： | 1 |
| 11 | Large-scale separation of alkaloids from Gelsemium elegans by pH-zone-refining counter-current chromatography with a new solvent system screening method显示文摘 | Lei Fang Jie Zhou YunLiang Lin Xiao Wang Qinglei Sun Jia-Lian Li Luqi Huang | 2013 | Journal of Chromatography A2013，，： | 1 |
| 12 | Energy and carbon performance of urban buildings using metamodeling variable importance techniques显示文摘Global urbanization causes more environmental stresses in cities and energy efficiency is one of major concerns for urban sustainability.The variable importance techniques have been widely used in building energy analysis to determine key factors influencing building energy use.Most of these applications,however,use only one type of variable importance approaches.Therefore,this paper proposes a procedure of conducting two types of variable importance analysis(predictive and variance-based)to determine robust and effective energy saving measures in urban buildings.These two variable importance methods belong to metamodeling techniques,which can significantly reduce computational cost of building energy simulation models for urban buildings.The predictive importance analysis is based on the prediction errors of metamodels to obtain importance rankings of inputs,while the variance-based variable importance can explore non-linear effects and interactions among input variables based on variance decomposition.The campus buildings are used to demonstrate the application of the method proposed to explore characteristic of heating energy,cooling energy,electricity,and carbon emissions of buildings.The results indicate that the combination of two types of metamodeling variable importance analysis can provide fast and robust analysis to improve energy efficiency of urban buildings.The carbon emissions can be reduced approximately 30%after using a few of effective energy efficiency measures and more aggressive measures can lead to the 60%of reduction of carbon emissions.Moreover,this research demonstrates the application of parallel computing to expedite building energy analysis in urban environment since more multi-core computers become increasingly available. | Yunliang Liu Wei Tian Xiang Zhou | 2021 | Building Simulation2021，14，3： | 1 |
| 13 | 6-45 Brief Introduction of IMP Electron Linear Accelerator Development and Its Applications显示文摘An electron linear accelerator (e-LINAC) is under designing and constructing in IMP for various imaging diagnostics application. The primary layout design is shown in Fig. 1. The e-LINAC is based on two kinds of electron guns, thermionic radio frequency (RF) gun for high average current and photocathode RF gun for ultra-short bunch length, which are able to provide various beam parameters and can satisfy requirement of the beam parameters from many applications. | Zhang Zimin Zhao Quantang Cao Shuchun Shen Xiaokan Zong Yang Zhu Yunliang Zhou Youwei Gai Wei | 2015 | IMP & HIRFL Annual Report2015，，1： | 0 |
| 14 | 6-46 Research Progress of a 100 MeV Electron Linac for High Energy Electron Radiography显示文摘High Energy Electron Radiography (HEER) is a new method suitable for High Energy Density Physics (HEDP) research that uses a high energy electron beam as a probe for time resolved imaging measurements of high energy density processes in materials[1]. A high energy electron imaging research platform based on a 100 MeV Electron Linac (e-Linac) which was designed for experimental research of HEER has been proposed by Electron Accelerator Group in IMP. This e-Linac has two injection beam lines. One is a thermionic RF gun with Alpha magnet and quadrupole magnets, and the other is a photo-cathode RF gun with emittance compensation solenoid(Fig. 1), and parameters details is shown in Table 1. The experimental terminals of this e-linac have been designed for HEER and the Thick Target X-ray imaging. | Cao Shuchun Zhang Zimin Shen Xiaokang Liu Ming Zong Yang Zhu Yunliang Zhou Youwei Wang Yanru Zhang Xiaoming Li Zhongping Zhao Quantang Xiao Rongqing Jing Yi Gai Wei | 2015 | IMP & HIRFL Annual Report2015，，1： | 0 |
| 15 | 6-49 Primary Design and Simulation of LEBT for High Energy Electron Radiography显示文摘At the beginning of 2013, the Institute of Modern Physics proposed to develop electron radiography technique based on high-energy and short-pulsed electron accelerator, which is applied to high energy density state/thick target diagnostics[1]. A low energy beam transport system (LEBT) was designed to matching the transmission between the gun and the LINAC. | Zhu Yunliang Zhang Zimin Cao Shuchun Liu Ming Shen Xiaokang Zong Yang Zhang Xiaoming Wang Yanru Zhou Youwei Li Zhongping Zhao Quantang Xiao Rongqing Jing Yi | 2015 | IMP & HIRFL Annual Report2015，，1： | 0 |
| 16 | Abdominoplasty for Patients Who Underwent Surgical Weight Loss:Differences between the Asian and Western Populations and the Associated Controversies显示文摘Abdominal contour deformities pose an aesthetic challenge to patients with massive weight loss.This article reviews the similarities and differences in obesity between the Asian and Western populations.A comprehensive classification system combining the objective description of structural deformities with patients’discomfort or physical function is required to classify the abdominal contour deformities.The authors also proposed several controversial issues,including the classification of abdominal deformities,surgical techniques,and complications,providing an evidence-based review for selecting the appropriate surgical method for Asian patients to achieve satisfying clinical outcomes and avoid complications. | Renpeng ZHOU Xiujun FU Yimin LIANG Chen WANG Yunliang QIAN Danru WANG | 2020 | Chinese Journal Of Plastic and Reconstructive Surgery2020，2，3： | 0 |
| 17 | 5-8 Recent Progress of High Energy Electron Radiography Research Platform in Lanzhou显示文摘High Energy Electron Radiography(HEER)is a new method suitable for High Energy Density Physics(HEDP)research that uses a high energy electron beam as a probe for time resolved imaging measurements of high energy density processes in materials[1].A High Energy Electron Radiography Research Platform(HEERRP)based on a 50 MeV Electron Linac(e-Lianc)which was designed for experimental research of HEER has been proposed by Electron Accelerator Group in IMP.This e-Linac has two injection beam lines,one is a thermionic RF gun with Alpha Magnet and Quadrupole magnets,and the other is a photo-cathode RF gun with emittance compensation Solenoid,see the Fig.1,and parameters details see the Table 1. | Cao Shuchun Zhang Ziming Xu Junkui Liu Ming Shen Xiaokang Zong Yang Zhu Yunliang Zhou Youwei Wang Yanru Li Zhongping Zhao Quantang Xiao Rongqing Jing Yi Wei Gai | 2016 | IMP & HIRFL Annual Report2016，，1： | 0 |
| 18 | 5-9 Progress of High Energy Electron Radiography Experiment Designed by IMP&THU&ANL显示文摘In 2013,Institute of Modern Physics(IMP)proposed a new diagnostic method for high energy density state/thick target diagnostics[1].The first verification experiment was done by IMP,Tsinghua University(THU)and Argonne National Laboratory(ANL),the spatial resolution reached 10μm[2].In 2016,a new beam line was designed by IMP&THU&ANL and some new results was obtained from the experiments.Fig.1 shows the layout of the newly designed[3]beam line.This beam line was based on photo-injector linear accelerator systems(LINAC)in THU. | Zhu Yunliang Zhang Zimin Yuan Ping Cao Shuchun Liu Ming Xiao Jiahao Zong Yang Zhou Youwei Zhao Quantang Shen Xiaokang Wang Yanru | 2016 | IMP & HIRFL Annual Report2016，，1： | 0 |
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