3篇
您的检索式：作者名="ZHENG Guisen"
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| 1 | Clay with high fluorine and endemic fluorosis caused by indoor combustion of coal in southwestern China显示文摘 | Baoshan ZHENG Daishe WU Binbin WANG Mingshi WANG Xiaojing LIU Aimin WANG Guisen XIAO Pugao LIU Robert B. Finkelman | 2006 | Chinese Journal Of Geochemistry2006，25，B08： | 2 |
| 2 | 北京西山地区岩溶洞穴氡浓度研究显示文摘对北京西山某岩溶洞穴1至4层进行了氡浓度测量,研究洞穴中氡浓度的变化特征,从时间和空间两个方面探讨其变化规律及其对人身体的危害。研究结果表明,天然溶洞在不同深度位置,氡浓度存在明显差异,随着深度的增加,氡浓度呈现线性的增长特征;溶洞内氡浓度在7、8、9月相对较高,平均浓度6123Bq/m^3,10、11、12月氡浓度较低,平均浓度2784Bq/m^3,呈现出季节性的变化特征,即夏季高而冬季低;溶洞内由氡及其子体所产生的年平均内照射剂量约为566 m Sv·a^(-1),超出国家规定公众年有效剂量的安全范围。建议对已经对公众开放的天然溶洞,进行氡浓度检测,采取有效的防氡降氡措施,减少氡及其子体的辐射,对人身体所产生的危害。 | 张晓亮 吕金波 张磊 张悦泽 白凌燕 刘振华 XU Jixiang ZHENG Guisen YU Chunlin | 2017 | 城市地质2017，12，3： | 1 |
| 3 | Carbazole and tetrahydro-carboline derivatives as dopamine D_(3) receptor antagonists with the multiple antipsychotic-like properties显示文摘Dopamine D_(3) receptor(D_(3)R)is implicated in multiple psychotic symptoms.Increasing the D_(3)R selectivity over dopamine D_2 receptor(D_2R)would facilitate the antipsychotic treatments.Herein,novel carbazole and tetrahydro-carboline derivatives were reported as D_(3)R selective ligands.Through a structure-based virtual screen,ZLG-25(D_(3)R K_i=685 nmol/L;D_2R K_i>10,000 nmol/L)was identified as a novel D_(3)R selective bitopic ligand with a carbazole scaffold.Scaffolds hopping led to the discovery of novel D_(3)R-selective analogs with tetrahydro-β-carboline or tetrahydro-γ-carboline core.Further functional studies showed that most derivatives acted as h D_(3)R-selective antagonists.Several lead compounds could dose-dependently inhibit the MK-801-induced hyperactivity.Additional investigation revealed that 23j and 36b could decrease the apomorphine-induced climbing without cataleptic reaction.Furthermore,36b demonstrated unusual antidepressant-like activity in the forced swimming tests and the tail suspension tests,and alleviated the MK-801-induced disruption of novel object recognition in mice.Additionally,preliminary studies confirmed the favorable PK/PD profiles,no weight gain and limited serum prolactin levels in mice.These results revealed that 36b provided potential opportunities to new antipsychotic drugs with the multiple antipsychotic-like properties. | Zhongtang Li Fan Fang Yiyan Li Xuehui Lv Ruqiu Zheng Peili Jiao Yuxi Wang Guiwang Zhu Zefang Jin Xiangqing Xu Yinli Qiu Guisen Zhang Zhongjun Li Zhenming Liu Liangren Zhang | 2023 | Acta Pharmaceutica Sinica B2023，13，11： | 0 |
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