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| 1 | miR-182参与调节胶质母细胞瘤的凋亡、生长和分化(英文)显示文摘Glioblastoma multiforme(GBM)is a lethal,therapy-resistant brain cancer consisting of numerous tumor cell subpopulations,including stem-like glioma-initiating cells(GICs),which contribute to tumor recurrence following initial response to therapy.Here,we identified miR-182 as a regulator of apoptosis,growth,and differentiation programs whose expression level is correlated with GBM patient survival.Repression of Bcl2-like12(Bcl2L12),c-Met,and hypoxia-inducible factor 2α(HIF2A)is of central importance to miR-182 anti-tumor activity,as it results in enhanced therapy susceptibility,decreased GIC sphere size,expansion,and stemness in vitro.To evaluate the tumor-suppressive function of miR-182 in vivo,we synthesized miR-182-based spherical nucleic acids(182-SNAs);i.e.,gold nanoparticles covalently functionalized with mature miR-182 duplexes.Intravenously administered 182-SNAs penetrated the bloodbrain/blood-tumor barriers(BBB/BTB)in orthotopic GBM xenografts and selectively disseminated throughout extravascular glioma parenchyma,causing reduced tumor burden and increased animal survival.Our results indicate that harnessing the anti-tumor activities of miR-182 via safe and robust delivery of 182-SNAs represents a novel strategy for therapeutic intervention in GBM. | Kouri FM Hurley LA Daniel WL Day ES Hua Y Hao L Peng CY Merkel TJ Queisser MA Ritner C Zhang H James CD Sznajder JI Chin L Giljohann DA Kessler JA Peter ME Mirkin CA Stegh AH | 2015 | 中华神经外科疾病研究杂志2015，14，2： | 14 |
| 2 | SELECTIVE DISSOLUTION OF GOLD IN AN ALKALINETHIOUREA SOLUTION BY ELECTROLYSIS显示文摘Anodic polarization behavior of gold, silver, copper, nickel and iron in potentiostatic condition has been examined in an alkaline aqueous thiourea solution, where gold is hardly dissoluble normally. The addition of Na2SO3 into the solution can accelerate anodic dissolution of gold. The factors affecting selective dissolution of gold in the alkaline thiourea solution by electrolysis have been studied, and the optimum condition was obtained. In 0.1 mol/L thiourea solution of pH 12. 5 containing 0. 5 mol/L Na2SO3 and 2. 5% acetone, at the potential of 0. 34 V vs NHE, at the temperature of 323 K, the dissolved mass of gold anode with the exposed area of 1. 0 cm2 reached more than 300 mg·dm-3 within 30 min, and other metals such as silver, copper, nickel and iron could hardly dissolve. | Zhang Chuanfu Chai Liyuan Zhong Haiyun (Department of Nonferrous Metallurgy, Central South University of Technology, Changsha 410083, China)Masazumi Okido RyouichiIchino(center erforIntegratedResearchinScienceandEngineering NagoyaUniversity,Nagoya464,Ja | 1997 | Journal of Central South University1997，9，2： | 8 |
| 3 | Combined transplantation of GDAs^(BMP) and hr-decorin in spinal cord contusion repair显示文摘Following spinal cord injury, astrocyte proliferation and scar formation are the main factors inhibiting the regeneration and growth of spinal cord axons. Recombinant decorin suppresses inflammatory reactions, inhibits glial scar formation, and promotes axonal growth. Rat models of T8 spinal cord contusion were created with the NYU impactor and these models were subjected to combined transplantation of bone morphogenetic protein-4-induced glial-restricted precursor-derived astrocytes and human recombinant decorin transplantation. At 28 days after spinal cord contusion, double-immunofluorescent histochemistry revealed that combined transplantation inhibited the early inflammatory response in injured rats. Furthermore, brain-derived neurotrophic factor, which was secreted by transplanted cells, protected injured axons. The combined transplantation promoted axonal regeneration and growth of injured motor and sensory neurons by inhibiting astrocyte proliferation and glial scar formation, with astrocytes forming a linear arrangement in the contused spinal cord, thus providing axonal regeneration channels. | Liang Wu Jianjun Li Liang Chen Hong Zhang Li Yuan Stephen JA Davies | 2013 | Neural Regeneration Research2013，8，24： | 6 |
| 4 | 环境铅暴露与血压的关系:2003-2010美国健康和营养调查显示文摘在铅暴露逐渐降低的环境下,该文通过分析2003-2010美国健康和营养调查资料,旨在研究血铅与血压、高血压的关系。纳入研究对象12 725人,其中非洲裔21.1%,西语裔20.5%,白人58.4%,女性48.7%。与非非洲裔比较,非洲裔的血压[126.5/71.9比123.9/69.6mm Hg(1mm Hg=0. | Hara A Thijs L Asayama K Gu YM Jacobs L Zhang ZY Liu YP Nawrot TS Staessen JA 刘莉 叶鹏 | 2014 | 中华高血压杂志2014，22，10： | 3 |
| 5 | nhibitory Role of Pentraxin-3 in Esophageal Squamous Cell Carcinoma显示文摘 | Dan Ja | 2016 | Chinese Medical Journal2016，，18： | 3 |
| 6 | 强化降压对高血压患者左心室肥厚的影响显示文摘目前尚不清楚超出推荐值的强化降压是否更能降低高血压患者的左心室肥厚(left ventricular hypertrophy,LVH)发生风险,以及LVH风险降低能否解释强化降压的益处。Soliman等纳入收缩压干预试验(systolic blood pressure intervention,SPRINT)中患有高血压但无糖尿病的8164例受试者(平均年龄67.9岁,女性35.3%,31.2%为非洲裔), | 刘莉 叶鹏 Soliman EZ Ambrosius WT Cushman WC Zhang ZM Bates JT Neyra JA Carson TY Tamariz L Ghazi L Cho ME Shapiro BP He J Fine LJ Lewis CE SPRINT Research Study Group | 2017 | 中华高血压杂志2017，25，6： | 2 |
| 7 | Blood pressure lowering for primary and secondary prevention of stroke 显示文摘 | Zhang H Thijs L Staessen JA | 2006 | Hypertension2006，48，2： | 1 |
| 8 | Insertion of an extra amino acid is the main cause of the low affinity of penicillin-binding protein 2 in penicillin-resistant strains of Neisseria gonorrhoeae 显示文摘 | Brannigan JA Tirodimos IA Zhang QY | 1990 | Mol Microbiol1990，4，： | 1 |
| 9 | Calpain and caspase processing of caspase-12 contribute to the ER stress induced cell death pathway in differentiated PC12 cells 显示文摘 | Martinez JA Zhang Z Svetlov SI | 2010 | Apoptosis2010，15，12： | 1 |
| 10 | Inventory management with asset - based financing显示文摘 | Buzacott JA Zhang RQ | 2004 | Management Science2004，，9： | 1 |
| 11 | Identification of differentially expressed genes in human prostate cancer using subtraxtion and microarray显示文摘 | Xu JC Stolk JA Zhang XQ | 2000 | Cancer Res2000，60，6： | 1 |
| 12 | Anti-HIV activity of medicinal herbs:usage and potential development显示文摘 | Wu JA Attele AS Zhang L | 2001 | Am J Chin Meal2001，29，1： | 1 |
| 13 | Blood pressure lowering for primary andsecondary prevention of stroke显示文摘 | Zhang H Thijs L Staessen JA | 2006 | Hypertension2006，48，： | 1 |
| 14 | Induction of Monocyte Chemoattractant Protein-1 (MCP-1) and Its Receptor CCR2 in Primary Sensory Neurons Contributes to Paclitaxel-Induced Peripheral Neuropathy显示文摘 | Zhang H Boyette-Davis JA Kosturakis AK | 2013 | J Pain2013，14，10： | 1 |
| 15 | Calpain and caspase processing of caspase-12 contribute to the ER stress-induced cell death pathway in differentiated PC12 cells显示文摘 | Martinez JA Zhang ZQ Svetlov SI | 2010 | Apoptosis2010，15，12： | 1 |
| 16 | Sponta- neous hypercholesterolemia and arterial lesions in mice lacking apolipoprotein E 显示文摘 | Zhang SH Reddick RL Piedrahita JA | 1992 | Science1992，258，5081： | 1 |
| 17 | Heme oxygenase-1, oxidation, inflamma- tion, and atherosclerosis 显示文摘 | Araujo JA Zhang M Yin F | 2012 | Front Pharmaco12012，7，3： | 1 |
| 18 | Sponta-neous hyper- cholesterolemia and arterial lesions in mice lacking aopolipoprotein E 显示文摘 | Zhang SH Reddick RL Piedrahita JA | 1992 | Science1992，258，5081： | 1 |
| 19 | Caveolin-2 deficient mice show evidence of severe pulmonary dysfunction without disruption of caveolae显示文摘 | Razani B Wang XB Engelman JA Battista M Lagaud G Zhang XL | 2002 | Mol Cell Biol2002，22，： | 1 |
| 20 | Anti - HIV activity of medicinal herbs :usage and potential development 显示文摘 | Wu JA Attele AS Zhang L | 2001 | An J Chin Med2001，29，1： | 1 |
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