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| 1 | The comprehensive evaluation of China's urbanization and effects on resources and environment显示文摘This paper constructs a comprehensive evaluation index system for the urbanization level in China in terms of four aspects of urbanization connotation:population,economy,society,and land. A comprehensive measurement is carried out for the Chinese urbanization between 1981 and 2006 based on the Entropy method. The results show that the comprehensive level of urbanization in China has a continuous increase with the major features of economic growth and a rapid evolution of the geographical landscape,followed by population urbanization and then social urbanization of health care standard; the distinguished evolutional characteristics can also be found in each of the subsystems. The integrated evolution of urbanization has a profound effect on the resources,energy and the environment,making the land resources and energy security situation under severe pressure. The environment pressure is also increased further. | CHEN Mingxing LU Dadao ZHA Liangsong | 2010 | Journal of Geographical Sciences2010，20，1： | 72 |
| 2 | Cardiomyocyte overexpression of miR-27b induces cardiac hypertrophy and dysfunction in mice显示文摘最近的研究开始在心脏的肥大和机能障碍的致病揭示了 microRNAs (miRNAs ) 的关键角色。在这研究,我们测试了是否转变生长 factor-β(TGF-β) 调整 miRNA 在心脏的肥大和心失败(HF ) 的发展起了一个枢轴的作用。我们观察到 miR-27b 是在 cardiomyocyte 特定的 Smad4 猛烈老鼠的心的 upregulated,它开发了心脏的肥大。在 vitro,实验证明 miR-27b 表示能被 TGF-β 禁止; 1 并且它的 overexpression 支持了 hypertrophic 房间生长,当 miR-27b 抑制导致了 hypertrophic 房间的抑制时,生长由 phenylephrine (PE ) 引起了处理。而且,有 miR-27b 的 cardiomyocyte 特定的 overexpression 的转基因的老鼠的分析表明 miR-27b overexpression 是足够的导致心脏的肥大和机能障碍。我们验证了 peroxisome 激活 proliferator 的 receptor-γ(PPAR-γ) 作为在 cardiomyocyte 的 miR-27b 的一个直接目标。一致地, miR-27b 转基因的老鼠显著地显示了 PPAR-γ 的底层;比控制鼠标。而且,在用在一只 pressure-overload-induced 老鼠的特定的 antagomir 的 miR-27b 的 vivo silencing, HF 的模型增加了心脏的 PPAR-γ表示,稀释心脏的肥大和机能障碍。我们的学习的结果表明那 TGF-β 1-regulated miR-27b 涉及心脏的肥大的规定,并且为心脏病作为一个有效治疗学的目标验证 miR-27b。 | Jian Wang Yao Song Yan Zhang Han Xiao Qiang Sun Ning Hou Shuilong Guo Youliang Wang Kaiji Fan Dawei Zhan Lagabaiyila Zha Yang Cao Zhenhua Li Xuan Cheng Youyi Zhang Xiao Yang | 2012 | Cell Research2012，22，3： | 36 |
| 3 | Basic Soil Productivity of Spring Maize in Black Soil Under Long-Term Fertilization Based on DSSAT Model显示文摘Increasing basic farmland soil productivity has significance in reducing fertilizer application and maintaining high yield of crops. In this study, we defined that the basic soil productivity(BSP) is the production capacity of a farmland soil with its own physical and chemical properties for a specific crop season under local environment and field management. Based on 22-yr(1990-2011) long-term experimental data on black soil(Typic hapludoll) in Gongzhuling, Jilin Province, Northeast China, the decision support system for an agro-technology transfer(DSSAT)-CERES-Maize model was applied to simulate the yield by BSP of spring maize(Zea mays L.) to examine the effects of long-term fertilization on changes of BSP and explore the mechanisms of BSP increasing. Five treatments were examined:(1) no-fertilization control(control);(2) chemical nitrogen, phosphorus, and potassium(NPK);(3) NPK plus farmyard manure(NPKM);(4) 1.5 time of NPKM(1.5NPKM) and(5) NPK plus straw(NPKS). Results showed that after 22-yr fertilization, the yield by BSP of spring maize significantly increased 78.0, 101.2, and 69.4% under the NPKM, 1.5NPKM and NPKS, respectively, compared to the initial value(in 1992), but not significant under NPK(26.9% increase) and the control(8.9% decrease). The contribution percentage of BSP showed a significant rising trend(P<0.05) under 1.5NPKM. The average contribution percentage of BSP among fertilizations ranged from 74.4 to 84.7%, and ranked as 1.5NPKM>NPKM>NPK≈NPKS, indicating that organic manure combined with chemical fertilizers(1.5NPKM and NPKM) could more effectively increase BSP compared with the inorganic fertilizer application alone(NPK) in the black soil. This study showed that soil organic matter(SOM) was the key factor among various fertility factors that could affect BSP in the black soil, and total N, total P and/or available P also played important role in BSP increasing. Compared with the chemical fertilization, a balanced chemical plus manure or straw fertilization(NPKM or NPKS) not only increased the concentrations of soil nutrient, but also improved the soil physical properties, and structure and diversity of soil microbial population, resulting in an iincrease of BSP. We recommend that a balanced chemical plus manure or straw fertilization(NPKM or NPKS) should be the fertilization practices to enhance spring maize yield and improve BSP in the black soil of Northeast China. | ZHA Yan WU Xue-ping HE Xin-hua ZHANG Hui-min GONG Fu-fei CAI Dian-xiong ZHU Ping GAO Hong-jun | 2014 | Journal of Integrative Agriculture2014，13，3： | 25 |
| 4 | Cucurbitacin B induces rapid depletion of the G-actin pool through reactive oxygen species-dependent actin aggregation in melanoma cells显示文摘Cucurbitacin B (崽) ,从 Cucurbitaceae 植物孤立的 triterpenoid 混合物,作为一个有希望的反癌症代理人被报导了,还它的行动机制仍然是争论的。在这研究,我们在鼠科的 B16F10 黑瘤房间探索了崽的潜在的机制。反增长和反侵略效果在有教养的房间被估计,并且在 vivo 反肿瘤,活动在一个鼠科的下的黑瘤模型被评估。流动 cytometry 被采用分析细胞周期分发和反应的氧种(ROS ) 层次。肌动朊层次被西方的污点分析决定,并且微分表示蛋白质的侧面被一条量的 proteomic 途径识别。结果证明那崽在房间增长,殖民地形成,以及移植和黑瘤房间的侵略潜力上施加了禁止的效果。下的黑瘤的生长显著地在当时,与崽对待的老鼠被禁止与控制相比组。而且,崽治疗引起了快速的房间膜 blebbing 和变丑,并且导致了 G2/M-phase 拘捕和 multiploid 房间的形成。尤其是, G 肌动朊水池很快被弄空,肌动朊总数在崽处理以后快速被形成。很多细胞骨架规章的蛋白质是调整的差别。ROS 生产的阻塞显著地减少了 G 肌动朊弄空能力和崽的反肿瘤活动。这些调查结果显示那崽在黑瘤房间通过 ROS 依赖的肌动朊聚集导致 G 肌动朊水池的快速的弄空,它可以部分至少说明它的反肿瘤活动。 | Yanting Zhang Dongyun Ouyang Lihui Xu Yuhua Ji Qingbing Zha Jiye Cai Xianhui He | 2011 | Acta Biochimica et Biophysica Sinica2011，43，7： | 19 |
| 5 | Neutrophil extracellular traps mediate the crosstalk between glioma progression and the tumor microenvironment via the HMGB1/RAGE/IL-8 axis显示文摘Objective:Neutrophil extracellular traps(NETs)produced by tumor-infiltrating neutrophils(TINs)are associated with poor prognosis in patients with several types of cancer.However,the mechanisms underlying the involvement of NETs in glioma progression remain largely unknown.This study aimed to elucidate the roles of NETs in biological processes that drive the crosstalk between glioma progression and the tumor microenvironment.Methods:Neutrophil infiltration and NETs formation were investigated in glioma tissue through immunohistochemistry,and their relationships with clinicopathological features and outcomes were statistically evaluated.The effects of NETs on glioma cell progression were studied in a co-culture system.In vivo and in vitro experiments validated the reactive oxygen species activity and cytokine production of TINs,as well as the ERK signaling pathway activation and the metastasis of gliomas.Results:Neutrophil infiltration and NETs formation were induced in high-grade glioma compared with low-grade glioma.NETs induced by TINs were determined to be an oncogenic marker of high-grade gliomas and to be involved in cell proliferation and invasion.NETs overproduction promoted glioma cell proliferation,migration,and invasion.Furthermore,HMGB1 was found to bind to RAGE and activate the NF-κB signaling pathway in vitro.In addition,NETs stimulated the NF-κB signaling pathway,thus promoting IL-8 secretion in glioblastoma.Subsequently,IL-8 recruited neutrophils which in turn mediated NETs formation via the PI3 K/AKT/ROS axis in TINs.Conclusions:Our results suggest that NETs produced by TINs mediate the crosstalk between glioma progression and the tumor microenvironment by regulating the HMGB1/RAGE/IL-8 axis.Targeting NETs formation or IL-8 secretion may be an effective approach to inhibit glioma progression. | Caijun Zha Xiangqi Meng Lulu Li Shan Mi Da Qian Ziwei Li Pengfei Wu Shaoshan Hu Shihong Zhao Jinquan Cai Yanhong Liu | 2020 | Cancer Biology & Medicine2020，17，1： | 19 |
| 6 | Metabonomic phenotype and identification of “heart blood stasis obstruction pattern” and “qi and yin deficiency pattern” of myocardial ischemia rat models显示文摘The traditional Chinese medicine concepts of 'Xinxueyuzuzheng (heart blood stasis obstruction pattern)' and 'Qiyinliangxuzheng (qi and yin deficiency pattern)' for myocardial ischemia rat models were constructed in the present study. Endogenous metabolites in rat plasma were analyzed using the GC/TOF-MS-based metabonomic method. Significant metabolic differences were observed between the control and two model groups, and the three groups were distinguished clearly by pattern recognition. Compared with those of the control, the levels of hydroxyproline, threonic acid, glutamine and citric acid were strikingly up or down-regulated in model rats. The metabolites contributing most to the classification between the two 'pattern' rats were identified, such as valine, serine, threonine, ornithine, hydroxyproline, lysine, 2-hydroxybutanoic acid, 3-hydroxybutanoic acid, galactofuranose and inositol. These compounds were indicated as the potential biomarkers. The results suggested that the two 'patterns' are involved in dysfunction in oxidative stress, energy metabolism and amino acid metabolism. These findings also provided the substantial foundation for exploring the scientific connotation of these two 'Zhengxing (pattern types)' of myocardial ischemia, and 'Bianzheng (pattern identification)'. | YAN Bei1, A JiYe1, HAO HaiPing1, WANG GuangJi1, ZHU XuanXuan2, 3, ZHA WeiBin1, LIU LinSheng1, GUAN EnZe3, ZHANG Ying1, GU ShengHua1, HUANG Qing1 & ZHENG YuanTing1 1Key Laboratory of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing 210009, China 2Pharmacological Laboratory of Clinical Research Institute, Jiangsu Provincial Hospital of Traditional Chinese Medicine, Nanjing 210029, China 3College of Pharmacy, Nanjing University of Traditional Chinese Medicine, Nanjing 210029, China | 2009 | Science China(Life Sciences)2009，52，11： | 19 |
| 7 | CPG Control for Biped Hopping Robot in Unpredictable Environment显示文摘 | Tingting Wang Wei Guo Mantian Li Fusheng Zha Lining Sun | 2012 | Journal of Bionic Engineering2012，9，1： | 17 |
| 8 | Activation of the PI3K/AKT pathway mediates FSH-stimulated VEGF expression in ovarian serous cystadenocarclnoma显示文摘有证据建议那刺激滤泡的荷尔蒙(FSH ) 能由在癌症细胞增加脉管的 endothelial 生长因素(VEGF ) 表示便于卵巢的癌症的 neovascularization,尽管这个过程的内在的分子的机制不是众所周知的。因此,我们在卵巢的癌症房间线 SKOV-3 和 ES-2 在 VEGF 表示上调查了 FSH 的效果。有 FSH 的治疗显著地在一个剂量依赖者和时间依赖者举止增加了 VEGF 表示。另外, FSH 治疗提高了 survivin 和组织缺氧可诱导的 factor-1 (HIF-1 ) 的表示。survivin 或 HIF-1 击倒压制的 VEGF 表示,但是 survivin 仅仅击倒禁止的刺激 FSH 的 VEGF 表示。有 LY294002 的预告的处理,一个 phosphoinositide 3-kinase (PI3K )/AKT 禁止者,抵销 FSH,而是治疗与 U0126 导致的 survivin 的提高的表示,激活 mitogen 的蛋白质 kinase/extracellular 调整信号的 kinase 禁止者,没有如此的效果。我们进一步证明卵巢的浆液的 cystadenocarcinoma 样品有积极 AKT 和比的染色的 phosphorylated AKT (pAKT ) 蛋白质的许多更高的发生良性的卵巢的 cystadenoma 取样了(p < 0.01 ) 。5 年的幸存率仅仅在有卵巢的浆液的 cystadenocarcinoma 的病人是大约 15% 有 AKT 和 pAKT 表示,而它在没有 AKT 或 pAKT 表示的那些是大约 80% 。一起拿,这些结果显示 FSH 由 upregulating 增加 VEGF 的表示 survivin 的表示,它被发信号的 PI3K/AKT 激活小径。在 survivin 和 VEGF 的刺激 FSH 的表示理解 PI3K/AKT 小径的角色将为与卵巢的浆液的 cystadenocarcinoma 为病人评估预后并且为对这疾病追求有效治疗是有益的。 | Yan Huang Keqin Hua Xianrong Zhou Hongyan Jin Xiaojun Chen Xin Lu Yinhua Yu Xiliang Zha Youji Feng | 2008 | Cell Research2008，18，7： | 17 |
| 9 | An Outlook on Promoting Healthy Development of Renewable Energy显示文摘Importance of developing alternative energy● We shall take alternative energy as a foreseeable,strategic and long-range issue, and pay great attention to it from the angle of national strategy. | Zhao Xizheng: President, China Electricity Council Shi Dinghuan: Counselor, State Council, and Chairman, Chinese Renewable Energy Association Wang Zhongying: Director, Center for Renewable Energy Development, Energy Research Institute, National Development and Reform Commission Zha Aijun: Consultant, Economic Construction Department, Ministry of Finance Xu Haoxun: Global Director Partner, McKinsey & Company Zhang Wenkai | 2008 | Electricity2008，19，4： | 15 |
| 10 | SEUSS and PIF4 Coordinately Regulate Light and Temperature Signaling Pathways to Control Plant Growth显示文摘 | Junling Huai Xinyu Zhang dialong Li Tingting Ma Ping Zha Yanjun Jing Rongcheng Lin | 2018 | Molecular Plant2018，11，7： | 15 |
| 11 | Role of cell adhesion signal molecules in hepatocellular carcinoma cell apoptosis显示文摘AIM: Cell adhesion molecules and their signal molecules play a very important role in carcinogenesis. The aim of this study is to elucidate the role of these molecules and the signal molecules of integrins and E-cadherins, such as (focal adhesion kinase) FAK, (integrin linked kinase)ILK, and β-catenin in hepatocellular carcinoma cell apoptosis.METHODS: We first synthesized the small molecular compound, S-(1,2-dichlorovinyl)-L-cysteine (DCVC), and identified it, by element analysis and 1H NMR. To establish the apoptosis model of the SMMC-7721 hepatocellular carcinoma cell, we treated cells with DCVC in EBSS for different concentrations or for various length times in the presence of 20 μmol/L N,N-diphenyl-p-phenylenediamine,which blocks necrotic cell death and identified this model by flow cytometry and DNA ladder. Then we studied the changes of FAK, ILK, β-catenin, and PKB in this apoptotic model by Western blot.RESULTS: We found that the loss or decrease of cell adhesion signal molecules is an important reason in apoptosis of SMMC-7721 hepatocellular carcinoma cell and the apoptosis of SMMC-7721 cell was preceded by the loss or decrease of FAK, ILK, PKB, and β-catenin or the damage of cell-matrix and cell-cell adhesion.CONCLUSION: Our results suggested that the decrease of adhesion signal molecules, FAK, ILK, PKB, and β-catenin,could induce hepatocellular carcinoma cell apoptosis. | Jian-Min Su Li-Ying Wang Yu-Long Liang Xi-Liang Zha | 2005 | World Journal of Gastroenterology2005，11，30： | 15 |
| 12 | Developmental Genetics Analysis for Plant Height in indica Hybrid Rice Across Environments显示文摘The developmental genetics of plant height was analyzed from two groups of three-line indica hybrid rice at two environmental conditions based on the NCII design,using the additive-dominant developmental genetics models and the statistic methods.The results showed that the rice genotypes and environmental conditions could both affect plant height,and the effects of environment on plant height decreased gradually with plant development.Additive and dominant effects both governed the performance of plant height at all developmental stages.However,the degrees of effect varied among the rice genotypes.Moreover,the interaction between environments and genotypes also affected plant height.The genetic effects differed at most developmental stages.Furthermore,the expression of additive effect was more active than that of dominant effect.Conditional interaction effects with environment also influenced plant height during genetic development,especially at the early stage.Mid-parent heterosis(HMP) increased gradually with the developmental stage of plant height,and maximized at the latest stage,whereas the heterosis over the better parent(HBP) showed small differences among the genotypes,and kept stable at the later stage,with positive numeric value.At most developmental stages,conditional HMP was positively significant,while conditional HBP was negatively significant.All above results suggest that HMP and HBP have some new expressions in all developmental periods and the levels and directions are quite different. | PENG Tao ZHONG Bing-qiang LING Ying-hua YANG Zheng-lin ZHA Ren-ming XIE Rong LIU Cheng-yuan HE Guang-hua | 2009 | Rice science2009，16，2： | 14 |
| 13 | Differential regulations of blood pressure and perturbed metabolism by total ginsenosides and conventional antihypertensive agents in spontaneously hypertensive rats显示文摘 | Ji-ye AA Guang-ji WANG Hai-ping HAO Qing HUANG Yi-hong LU Bei YAN Wei-bin ZHA Lin-sheng LIU An KANG | 2010 | Acta Pharmacologica Sinica2010，31，8： | 14 |
| 14 | Ranking approach of cross-efficiency based on improved TOPSIS technique显示文摘The cross-efficiency evaluation method is reviewed which is developed as a data envelopment analysis (DEA) extensive tool.The cross-efficiency evaluation method is utilized to identify the decision making unit (DMU) with the best practice and to rank the DMUs by their respective cross-efficiency scores.The main drawbacks of the cross-efficiency evaluation method when the ultimate average cross-efficiency scores are used to evaluate and rank the DMUs are also pointed out.With the research gap,an improved technique for order preference by similarity to ideal solution (TOPSIS) is introduced to rank the cross-efficiency by eliminating the average assumption.Finally,an empirical example is illustrated to examine the validity of the proposed method. | Jie Wu Jiasen Sun Yong Zha Liang Liang | 2011 | Journal of Systems Engineering and Electronics2011，22，4： | 14 |
| 15 | Relationship between electrochemical characteristics and SCC of X70 pipeline steel in an acidic soil simulated solution显示文摘Stress corrosion cracking (SCC) of X70 pipeline steel in simulated solution of the acidic soil in Yingtan in China was investigated using slow strain rate test (SSRT), SEM and potentiodynamic polarization technique. Experiment results indicate that X70 steel is highly susceptible to SCC as applied potential reduces, which is manifested in loss of toughness and brittle fracture. Constant polarization current can detect the occurrence of SCC. The lower the polarization current is the sooner stress corrosion cracking occurs. The SCC mechanisms are different at varying potentials. When potential is higher than open circuit potential, anodic process controls SCC, whereas when potential is far lower than open circuit potential, cathodic process controls SCC, and between these two potential regions, a combined electrochemical process controls the SCC. Stress or strain has a synergistic effect with electrochemical reactions to accelerate the cathodic hydrogen evolution process, which makes the X70 pipeline steel to be more susceptible to SCC. | Zhiyong LIU Xiaogang LI Yingrui ZHANG Cuiwei DU Guoli ZHA | 2009 | Acta Metallurgica Sinica(English Letters)2009，22，1： | 13 |
| 16 | Unconformity structures controlling stratigraphic reservoirs in the north-west margin of Junggar basin, North-west China显示文摘构造运动在 Junggar 盆的西北边缘形成了几不顺从。基于露头,核心,和样品的数据,不顺从是其形成与捱过联系的结构的身体,沥滤,并且 onlap。同时,结构的身体可以被划分成三层,包括上面的层,中间的层,和更低的层。有好主要的孔的上面的层用作烃移植系统,并且也积累烃。有紧密和韧性的中间的层能作为帽子岩石,其力量与深度增加起一个作用。有好第二等的孔的更低的层能由于捱过并且沥滤形成 stratigraphic 截断陷井。躺在在侏罗记之间的不顺从的一座典型 stratigraphic 水库并且在 Junggar 盆的西北边缘三叠纪细致地被分析以便揭示控制因素的钥匙。结果证明在 stratigraphic onlap 水库的烃分发被 onlap 线控制,在 stratigraphic 截断水库的烃分发被截断线限制,并且中间的层充当了封上岩石的钥匙。一个结论因此被画那“二根线(onlap 线和截断线) 和身体(不顺从结构的身体) ”控制 stratigraphic 水库的形成和分发[出版摘要] | Kongyou WU Douglas PATON Ming ZHA | 2013 | Frontiers of Earth Science2013，7，1： | 13 |
| 17 | Berbamine exhibits potent antitumor effects on imatinib-resistant CML cells in vitro and in vivo显示文摘 | Yan-lin WEI Lei XU Yun LIANG Xiao-hua XU, Xiao-ying ZHA | 2009 | Acta Pharmacologica Sinica2009，30，4： | 13 |
| 18 | A review on China's constructed wetlands in recent three decades:Application and practice显示文摘Constructed wetlands(CWs)have been introduced to and developed in China for environmental engineering over the most prosperous three decades(1990–2020).To study the origin,development process,and future trend of CWs,this review summarized a wide range of literatures between 1990 and 2020 by Chinese authors.Firstly,the publication number over years,research highlights,and the author contributions with the most published papers in this field were conducted through bibliometric analysis.Secondly,the most principal components of CWs,substrates and macrophytes were summarized and analyzed.Thirdly,the typical application cases from traditional CWs,pond systems to combined pond-wetland systems were presented.In China,CWs were predominately distributed in the east of the so-called'Hu Huanyong Line'.Therefore CWs were limited by the socio-economic level and climatic conditions.It is unquestionable that the overall level of China's CWs has improved significantly,and one of the most prominent features has started towards the plural pattern development.There has been a trend of large-scale or low-cost CW application in the recent years.However,lifecycle research and management are required for better strategies in the future. | Hong Zhang Wenzhong Tang Weidong Wang Wei Yin Honglei Liu Xiaomin Ma Yiqi Zhou Pei Lei Dongyang Wei Litian Zhang Cao Liu Jinmiao Zha | 2021 | Journal of Environmental Sciences2021，33，6： | 13 |
| 19 | Management of granulomatous lobular mastitis: an international multidisciplinary consensus(2021 edition)显示文摘Granulomatous lobular mastitis(GLM) is a rare and chronic benign inflammatory disease of the breast. Difficulties exist in the management of GLM for many front-line surgeons and medical specialists who care for patients with inflammatory disorders of the breast. This consensus is summarized to establish evidence-based recommendations for the management of GLM. Literature was reviewed using PubMed from January 1, 1971 to July 31, 2020. Sixty-six international experienced multidisciplinary experts from 11 countries or regions were invited to review the evidence.Levels of evidence were determined using the American College of Physicians grading system, and recommendations were discussed until consensus. Experts discussed and concluded 30 recommendations on historical definitions,etiology and predisposing factors, diagnosis criteria, treatment, clinical stages, relapse and recurrence of GLM. GLM was recommended as a widely accepted definition. In addition, this consensus introduced a new clinical stages and management algorithm for GLM to provide individual treatment strategies. In conclusion, diagnosis of GLM depends on a combination of history, clinical manifestations, imaging examinations, laboratory examinations and pathology.The approach to treatment of GLM should be applied according to the different clinical stage of GLM. This evidencebased consensus would be valuable to assist front-line surgeons and medical specialists in the optimal management of GLM. | Qian-Qian Yuan Shu-Yuan Xiao Omar Farouk Yu-Tang Du Fereshte Sheybani Qing Ting Tan Sami Akbulut Kenan Cetin Afsaneh Alikhassi Rami Jalal Yaghan Irmak Durur-Subasi Fatih Altintoprak Tae Ik Eom Fatih Alper Mustafa Hasbahceci David Martínez-Ramos Pelin Seher Oztekin Ava Kwong Cedric W.Pluguez-Turul Kirstyn EBrownson Shirish Chandanwale Mehran Habib Liu-Yi Lan Rui Zhou Xian-Tao Zeng Jiao Bai Jun-Wen Bai Qiong-Rong Chen Xing Chen Xiao-Ming Zha Wen-Jie Dai Zhi-Jun Dai Qin-Yu Feng Qing-Jun Gao Run-Fang Gao Bao-San Han Jin-Xuan Hou Wei Hou Hai-Ying Liao Hong Luo Zheng-Ren Liu Jing-Hua Lu Bin Luo Xiao-Peng Ma Jun Qian Jian-Yong Qin Wei Wei Gang Wei Li-Ying Xu Hui-Chao Xue Hua-Wei Yang Wei-Ge Yang Chao-Jie Zhang Fan Zhang Guan-Xin Zhang Shao-Kun Zhang Shu-Qun Zhang Ye-Qiang Zhang Yue-Peng Zhang Sheng-Chu Zhang Dai-Wei Zhao Xiang-Min Zheng Le-Wei Zheng Gao-Ran Xu Wen-Bo Zhou Gao-Song Wu | 2022 | Military Medical Research2022，9，4： | 13 |
| 20 | Clinicopathological and prognostic significance of galectin-1 and vascular endothelial growth factor expression in gastric cancer显示文摘AIM: To evaluate the expression of galectin-1 and vascular endothelial growth factor (VEGF) in gastric cancer and investigate their relationships with clinicopathologic factors and prognostic significance. METHODS: Galectin-1 and VEGF were immunohistochemically investigated in tumor samples obtained from 214 gastric cancer patients with all tumor stages. Immunohistochemical analyses for galectin-1 and VEGF expression were performed on formalin-fixed, paraffin-embedded sections of surgical specimens. The relationship between the expression and staining intensity of galectin-1 and VEGF, clinicopathologic variables, and patient survival were analyzed. All patients underwent follow-up until cancer-related death or more than five years after tumor resection. P values < 0.05 were considered statistically significant.RESULTS: Immunohistochemical staining demonstrated that 138 of 214 gastric cancer samples (64.5%) were positive for galectin-1, and 116 out of 214 gastric cancer samples (54.2%) were positive for VEGF. There was a significant association between galectin-1 and VEGF expression; VEGF was detected in 60.1% of galectin-1-positive samples and 43.4% of galectin-1-negative samples (P < 0.05). Galectin-1 expression was associated with tumor size, tumor location, stage, lymph node metastases, and VEGF expression (all P < 0.05). VEGF expression was related to tumor size, stage, and lymph node metastases (all P < 0.05). The 5-year survival rate was 56.6% for galectin-1-positive patients and 69.2% for galectin-1-negative patients, and the prognosis for galectin-1-positive patients was significantly poorer compared with galectin-1-negative patients (χ 2 = 13.880, P = 0.000). The 5-year survival rates for VEGF-positive and VEGF-negative patients were 53.4% and 70.5%, respectively (χ2 = 4.619, P = 0.032). The overall survival rate of patients with both galectin-1 and VEGF overexpression in gastric cancer tissue samples was significantly poorer than other groups (both P < 0.05).CONCLUSION: Galectin-1 expression was positively associated with VEGF expression. Both galectin-1 and VEGF can serve as independent prognostic indicators of poor survival for gastric cancer after gastrectomy. | Jie Chen Su-Jun Zhou Yun Zhang Guo-Qiang Zhang Tian-Zhou Zha Yi-Zhong Feng Kai Zhang | 2013 | World Journal of Gastroenterology2013，19，13： | 12 |
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