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| 1 | SOX11可表达于Cyclin D1阴性母细胞样套细胞淋巴瘤显示文摘近期的研究表明SOX11表达有助于套细胞淋巴瘤(MCL)的诊断,包括具有典型形态学改变的cyclin D1阴性MCL。本文作者探讨了SOX11在B细胞非霍奇金淋巴瘤(B-NHL)某些亚型中的表达模式及其特异性,并将其作为免疫表型特征分析cyclin D1阴性的母细胞样MCL(该组病例系首次报道)的识别价值。 | Zeng W Fu K Quintanilla-Fend L 孙琦(摘译) 樊祥山(审校) | 2012 | 临床与实验病理学杂志2012，28，2： | 14 |
| 2 | Cell cycle-related kinase reprograms the liver immune microenvironment to promote cancer metastasis显示文摘The liver is an immunologically tolerant organ and a common metastatic site of multiple cancer types.Although a role for cancer cell invasion programs has been well characterized,whether and how liver-intrinsic factors drive metastatic spread is incompletely understood.Here,we show that aberrantly activated hepatocyte-intrinsic cell cycle-related kinase(CCRK)signaling in chronic liver diseases is critical for cancer metastasis by reprogramming an immunosuppressive microenvironment.Using an inducible liverspecific transgenic model,we found that CCRK overexpression dramatically increased both B16F10 melanoma and MC38 colorectal cancer(CRC)metastasis to the liver,which was highly infiltrated by polymorphonuclear-myeloid-derived suppressor cells(PMNMDSCs)and lacking natural killer T(NKT)cells.Depletion of PMN-MDSCs in CCRK transgenic mice restored NKT cell levels and their interferon gamma production and reduced liver metastasis to 2.7% and 0.7%(metastatic tumor weights)in the melanoma and CRC models,respectively.Mechanistically,CCRK activated nuclear factor-kappa B(NF-κB)signaling to increase the PMN-MDSC trafficking chemokine C-X-C motif ligand 1(CXCL1),which was positively correlated with liver-infiltrating PMN-MDSC levels in CCRK transgenic mice.Accordingly,CRC liver metastasis patients exhibited hyperaaivation of hepatic CCRK/NF-κB/CXCL1 signaling,which was associated with accumulation of PMN-MDSCs and paucity of NKT cells compared to healthy liver transplantation donors.In summary,this study demonstrates that immunosuppressive reprogramming by hepatic CCRK signaling undermines antimetastatic immunosurveillance.Our findings offer new mechanistic insights and therapeutic targets for liver metastasis intervention. | Xuezhen Zeng Jingying Zhou Zhewen Xiong Hanyong Sun Weiqin Yang Myth T.S.Mok Jing Wang Jingqing Li Man Liu Wenshu Tang Yu Feng Hector Kwong-Sang W ang Shun-Wa Tsang King-Lau Chow Philip Chun Yeung John Wong Paul Bo-San Lai Anthony Wing-Hung Chan Ka Fai To Stephen Lam Chan Qiang Xia Jing Xue Xiao Chen Jun Yu Sui Peng Joseph Jao-Yiu Sung Ming Kuang Alfred Sze-Lok Cheng | 2021 | Cellular & Molecular Immunology2021，18，4： | 5 |
| 3 | 2003—2015年中国恶性肿瘤生存率变化:基于17个以人群为基础的肿瘤登记处数据的汇总分析显示文摘中国2003—2015年恶性肿瘤生存率远低于发达国家,且存在很大的地域差异性,以人群为基础的肿瘤生存率数据对了解我国肿瘤防治效果至关重要,因此本研究着重分析2003-2015年间中国恶性肿瘤患者的生存情况及变化趋势。本研究从中国国家癌症中心肿瘤登记中心抽取17个肿瘤登记点的肿瘤登记资料,包括2003—2013年间所有诊断为原发性浸润性恶性肿瘤患者(年龄为0~99岁),及其截至2015年12月31日的生存状态随访数据,分析了2003—2015年间所有恶性肿瘤及26个不同癌种的5年相对生存率,并按不同性别、年龄和地域分布进行描述和分析。 | Zeng H Chen W Zheng R 谢双华(编译) | 2019 | 中华预防医学杂志2019，53，12： | 3 |
| 4 | Image-adaptive watermarking using visual models显示文摘 | Podilchuk C I Zeng W | | 0，，： | 2 |
| 5 | Electroless Ni-P coating of cenospheres using silver nitrate activator 显示文摘 | Zeng A X Xiong W H Xu J | 2005 | Surface&Coatings Technology2005，197，23： | 1 |
| 6 | YAG laser percussion drilling of a functional multi-layer thin plate 显示文摘 | WANG A H WANG W Y BAI Z K XIE C S ZENG D W SONG W L | 2007 | Optics & Laser Technology2007，39，： | 1 |
| 7 | A probabilistic reasoning-based decision support system for selecting remediation technologies for petroleum-contaminated sites 显示文摘 | HE L CHAN C W HUANG G H ZENG G M | 2006 | Expert Systems with Applications2006，30，4： | 1 |
| 8 | ZnO light-emitting diode grown by plasma-assisted metal organic chemical vapor deposition显示文摘 | Xu W Z Ye Z Z Zeng Y J | 2006 | Appl Phys Lett2006，88，17： | 1 |
| 9 | On-site safety evaluation for earth faults 显示文摘 | ZENG Xiangjun LI K K cHAN W L | 2003 | IEEE Trans on Industry Applications2003，39，15： | 1 |
| 10 | Complete relative stereochemistry of maitotoxin 显示文摘 | Zeng W Demattei J A Wu J P | 1996 | J Am Chem Soc1996，，： | 1 |
| 11 | High concentration and productivity of 1,3-propanediol from continuous fermentation of glycerol by Klebsiella pneumoniae显示文摘 | Menzel K Zeng A P Deckwer W D | 1997 | Enzyme Microbiol Techol1997，，20： | 1 |
| 12 | Image-adaptive watermarking using visual models显示文摘 | Podilchuk C J Zeng W J | 1998 | Selected Areas Communications1998，16，4： | 1 |
| 13 | An investigation of a new near-beta forging process for titanium alloys and its application in aviation components显示文摘 | Zhou Y G Zeng W D Yu H Q | 2005 | Mater Sci Eng A2005，393，1： | 1 |
| 14 | Application of the kurtosis statistic to the evaluation of the risk of hearing loss in workers exposed to high-level complex noise 显示文摘 | ZHAO Y M QIU W ZENG L | 2010 | Ear Hear2010，31，4： | 1 |
| 15 | The influence of Chinese minimally invasive percutaneous nephrolithotomy on intrarenal pelvic pressure clin-ically显示文摘 | Zeng G Xia S Zhong W | 2006 | Inter J Urol2006，13，1： | 1 |
| 16 | Impact of interval between neoadjuvant chemoradiotherapy and surgery for rectal cancer on surgical and oncologic outeome显示文摘 | Zeng W G Zhou Z X Liang J W | 2014 | J Surg Oncol2014，110，4： | 1 |
| 17 | Protection of boar spermatozoa from cold shock damage by 2-hydroxypropyl-beta-cyclodextrin 显示文摘 | Zeng W Terada T | 2001 | Theriogenolo- gy2001，55，： | 1 |
| 18 | Concentration and mode of occurrence of trace elements in marine oil shale from the Bilong Co area,northern Tibet,China显示文摘 | FU X G WANG J ZENG Y H TAN F W FENG X L | | 0，，01： | 1 |
| 19 | Enhancement of the light output power of InGaN/GaN lightemitting diodes grown on pyramidal patterned sapphire substrates in the micro-and nanoscale显示文摘 | Gao H Y Yan F W Zhang Y Li J M Zeng Y P Wang G H | | 0，，01： | 1 |
| 20 | Microstructure Control of Zn/ZnO Core/Shell Nanoparticles and Their Temperature-Dependent Blue Emissions显示文摘 | Zeng H Li Z Cai W | | 0，，51： | 1 |
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