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| 1 | Tunable 3D Nanofiber Architecture of Polycaprolactone by Divergence Electrospinning for Potential Tissue Engineering Applications显示文摘The creation of biomimetic cell environments with micro and nanoscale topographical features resembling native tissues is critical for tissue engineering. To address this challenge, this study focuses on an innovative electrospinning strategy that adopts a symmetrically divergent electric field to induce rapid self-assembly of aligned polycaprolactone(PCL) nanofibers into a centimeter-scale architecture between separately grounded bevels. The 3D microstructures of the nanofiber scaffolds were characterized through a series of sectioning in both vertical and horizontal directions. PCL/collagen(type I)nanofiber scaffolds with different density gradients were incorporated in sodium alginate hydrogels and subjected to elemental analysis. Human fibroblasts were seeded onto the scaffolds and cultured for 7 days. Our studies showed that the inclination angle of the collector had significant effects on nanofiber attributes, including the mean diameter, density gradient, and alignment gradient. The fiber density and alignment at the peripheral area of the 45°-collector decreased by 21% and 55%, respectively, along the z-axis,while those of the 60°-collector decreased by 71% and 60%, respectively. By altering the geometry of the conductive areas on the collecting bevels, polyhedral and cylindrical scaffolds composed of aligned fibers were directly fabricated. By using a four-bevel collector, the nanofibers formed a matrix of microgrids with a density of 11%. The gradient of nitrogen-to-carbon ratio in the scaffold-incorporated hydrogel was consistent with the nanofiber density gradient. The scaffolds provided biophysical stimuli to facilitate cell adhesion, proliferation, and morphogenesis in 3D. | George Z.Tan Yingge Zhou | 2018 | Nano-Micro Letters2018，10，4： | 5 |
| 2 | Modeling the density gradient of 3D nanofiber scaffolds fabricated by divergence electrospinning显示文摘Following recent insights on structure-cell-function interactions and the critical role of the extracellular matrix(ECM),the latest biofabrication approaches have increasingly focused on designing materials with biomimetic microarchitecture.Divergence electrospinning is a novel fabrication method for three-dimensional(3D)nanofiber scaffolds.It is introduced to produce 3D nanofiber mats that have numerous applications in regenerative medicine and tissue engineering.One of the most important characteristics of 3D nanofiber mats is the density gradient.This study provides a statistical analysis and response surface modeling framework based on experimental data to evaluate the manner by which the geometric designs of double-bevel collectors influence the fiber density gradient.Specifically,variance of analysis and sensitivity analysis were performed to identify parameters that had significant effects,and a response surface model embedded with seven location indicators was developed to predict the spatial distribution of fiber density for different collector designs.It was concluded that the collector height,bevel angle,and their interactions were significant factors influencing the density gradient.This study revealed the sensitivity of system configuration and provided an optimization tool for process controllability of microstructure gradients. | Muhammad Adib Uz Zaman Dilshan Sooriyaarachchi Ying-Ge Zhou George Z.Tan Dong-Ping Du | 2021 | Advances in Manufacturing2021，9，3： | 1 |
| 3 | HVOF热喷涂制备Fe基非晶合金涂层的微观结构和摩擦磨损性能研究显示文摘通过高速氧燃料火焰喷涂制备一种Fe59Cr12Nb5B20Si4非晶金属涂层,与商用316L不锈钢相比,以实现更低的热导率和更好的耐磨防护效果。所制备的涂层具有致密层状结构(孔隙率小于1%),有轻微的氧化发生。Fe基涂层的微观结构中具有非晶骨架并有纳米晶析出,其热导率(2.66 W/m K)显著低于不锈钢涂层(5.87 W/m K)。得益于这种微观结构,涂层硬度可达到1258±92 HV。因为涂层磨损机理的改变,涂层的摩擦系数和磨损量在200℃时上升,并在400℃时下降。涂层在室温时的磨损机理主要为疲劳磨损并伴有氧化磨损。在200℃时,由于第三粒的磨损,磨损过程加速。400℃下涂层耐磨性能的下降可能导致大面积的氧化膜的生成。 | H.H.Yao Z.Zhou K.Z.Tang Z.Tan G.H.Wang D.Y.He 王玉 | 2017 | 热喷涂技术2017，9，4： | 0 |
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