|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Rational Design and Application of an Indolium-Derived Heptamethine Cyanine with Record-Long Second Near-Infrared Emission显示文摘Heptamethine cyanine dyes,typified by indocyanine green,have been extensively employed as bioimaging indicators and theranostic agents.Significant efforts have been made to develop functional heptamethine cyanine dyes with outstanding bioimaging and theranostic utilities.In this work,we rationally designed and successfully developed a novel indolium-like heptamethine cyanine dye by installing indolium-derived polycyclic aromatic hydrocarbons on the terminal ends of a conjugated polyene backbone.This dye showed excellent photostability and showed bright fluorescent emission in the second near-infrared(NIR-Ⅱ)window with a peak at approximately 1120 nm.Such long wavelength emission prompted a superior bioimaging resolution in vivo.In particular,this NIR-Ⅱ dye had the remarkable capability of marking the blood vessels of the hindlimbs,abdomens,and brains of mice.More significantly,this dye involved a typical indolium-like heptamethine skeleton and exhibited two strong absorption bands in the 700–1300 nm NIR range,which endowed it with an intrinsic tumor-targeting capability and a high photothermal conversion efficiency(up to 68.2%),serving for the photothermal therapy of tumors under the guidance of NIR-Ⅱ fluorescence imaging.This work provides an efficient design strategy for achieving indolium-like heptamethine cyanine dyes with further NIR-Ⅱ emission. | Xiaoxie Ma Yurou Huang Syed Ali Abbas Abedi Heejeong Kim Tan Teck Boon Davin Xiaogang Liu Wen-Chao Yang Yao Sun Sheng Hua Liu Jun Yin Juyoung Yoon Guang-Fu Yang | 2022 | CCS Chemistry2022，4，6： | 2 |
| 2 | Target identification of natural medicine with chemical proteomics approach:probe synthesis,target fishing and protein identification显示文摘Natural products are an important source of new drugs for the treatment of various diseases.However,developing natural productbased new medicines through random moiety modification is a lengthy and costly process,due in part to the difficulties associated with comprehensively understanding the mechanism of action and the side effects.Identifying the protein targets of natural products is an effective strategy,but most medicines interact with multiple protein targets,which complicate this process.In recent years,an increasing number of researchers have begun to screen the target proteins of natural products with chemical proteomics approaches,which can provide a more comprehensive array of the protein targets of active small molecules in an unbiased manner.Typically,chemical proteomics experiments for target identification consist of two key steps:(1)chemical probe design and synthesis and(2)target fishing and identification.In recent decades,five different types of chemical proteomic probes and their respective target fishing methods have been developed to screen targets of molecules with different structures,and a variety of protein identification approaches have been invented.Presently,we will classify these chemical proteomics approaches,the application scopes and characteristics of the different types of chemical probes,the different protein identification methods,and the advantages and disadvantages of these strategies. | Xiao Chen Yutong Wang Nan Ma Jing Tian Yurou Shao Bo Zhu Yin Kwan Wong Zhen Liang Chang Zou Jigang Wang | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 2 |
| 3 | Lanthanide-Doped Nanoparticles with Near-Infrared-to- Near-Infrared Luminescence for Bioimaging显示文摘Lanthanide (行,或稀土元素) 做的 nanoparticles 为他们的突出的光性质是著名的并且广泛地为生物应用被使用了,特别在生物试金和医药成像。最近,广泛的注意近红外线(NIR ) 波长范围戏剧性地为它的快反馈,高空间的分辨率和深织物穿入增加了。纸巾在这个区域有最小的吸收度。当很多优秀评论基于 lanthanide 盖住生物医学的成像的各种各样的方面时做的 nanoparticles,没有评论,系统地与 lanthanide 总结 NIR-to-NIR 成像做的 nanoparticles。在这评论,我们在成像基于 lanthanide 做了的 NIR-to-NIR 的最近的发展集中 nanoparticles,并且在它讨论挑战和机会。 | Yurong Wei Xiangdong Yang Yurou Ma Shengfu Wang Quan Yuan | 2016 | Chinese Journal of Chemistry2016，34，6： | 1 |
| 4 | Applications of DNA Nanotechnology in Synthesis and Assembly of Inorganic Nanomaterials显示文摘除了它的继承基因功能, DNA 是有可编程、可预言的特征的最聪明、很灵活的自我装配的 nanomaterials 之一,综合并且集合它,越来越多的科学家把 DNA 与 nanomaterials 相结合并且把他们放进设计。在这评论, DNA 分子的行动的四个模式以一个比喻、直觉的方法被介绍,基于它在 nanomaterials 的合成和汇编起的四个不同作用:与设计得好的有约束力的地点,直接便于 Au/Pd/Ag/Cu nanowires 的(c) 成核地点, nanoparticles,用作盖住代理人阻止水晶生长,并且控制的 nano- 数组和(d) 指导 nanoparticle 汇编,(b) 2D 或 3D 支架的聪明的连接器缩放的(a) 和形态学。到肯定,功能的 DNA 分子的这最先进的联合和无机的 nanomaterials 极大地被鼓励向分析科学,生命科学,环境科学,和他们能探讨的另外的有希望的地的发展的步。指导 DNA 的 nanofabrication 在不久的将来将最后在我们的范围以外远超过期望。 | Yurou Ma Xiangdong Yang Yurong Wei Quan Yuan | 2016 | Chinese Journal of Chemistry2016，34，3： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员