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| 1 | Atomically Dispersed Ruthenium Catalysts with Open Hollow Structure for Lithium-Oxygen Batteries显示文摘Lithium–oxygen battery with ultrahigh theoretical energy density is considered a highly competitive next-generation energy storage device,but its practical application is severely hindered by issues such as difficult decomposition of discharge products at present.Here,we have developed N-doped carbon anchored atomically dispersed Ru sites cathode catalyst with open hollow structure(h-RuNC)for Lithium–oxygen battery.On one hand,the abundance of atomically dispersed Ru sites can effectively catalyze the formation and decomposition of discharge products,thereby greatly enhancing the redox kinetics.On the other hand,the open hollow structure not only enhances the mass activity of atomically dispersed Ru sites but also improves the diffusion efficiency of catalytic molecules.Therefore,the excellent activity from atomically dispersed Ru sites and the enhanced diffusion from open hollow structure respectively improve the redox kinetics and cycling stability,ultimately achieving a high-performance lithium–oxygen battery. | Xin Chen Yu Zhang Chang Chen Huinan Li Yuran Lin Ke Yu Caiyun Nan Chen Chen | 2024 | Nano-Micro Letters2024，16，2： | 0 |
| 2 | Targeting a cryptic allosteric site of SIRT6 with small-molecule inhibitors that inhibit the migration of pancreatic cancer cells显示文摘SIRT6 belongs to the conserved NAD^(+)-dependent deacetylase superfamily and mediates multiple biological and pathological processes.Targeting SIRT6 by allosteric modulators represents a novel direction for therapeutics,which can overcome the selectivity problem caused by the structural similarity of orthosteric sites among deacetylases.Here,developing a reversed allosteric strategy Allo Reverse,we identified a cryptic allosteric site,Pocket Z,which was only induced by the bi-directional allosteric signal triggered upon orthosteric binding of NAD^(+).Based on Pocket Z,we discovered an SIRT6 allosteric inhibitor named JYQ-42.JYQ-42 selectively targets SIRT6 among other histone deacetylases and effectively inhibits SIRT6 deacetylation,with an IC50 of 2.33μmol/L.JYQ-42 significantly suppresses SIRT6-mediated cancer cell migration and pro-inflammatory cytokine production.JYQ-42,to our knowledge,is the most potent and selective allosteric SIRT6 inhibitor.This study provides a novel strategy for allosteric drug design and will help in the challenging development of therapeutic agents that can selectively bind SIRT6. | Qiufen Zhang Yingyi Chen Duan Ni Zhimin Huang Jiacheng Wei Li Feng Jun-Cheng Su Yingqing Wei Shaobo Ning Xiuyan Yang Mingzhu Zhao Yuran Qiu Kun Song Zhengtian Yu Jianrong Xu Xinyi Li Houwen Lin Shaoyong Lu Jian Zhang | 2022 | Acta Pharmaceutica Sinica B2022，12，2： | 0 |
| 3 | Hollow catalysts through different etching treatments to improve active sites and oxygen vacancies for high-performance Li-O_(2)battery显示文摘Li-O_(2)batteries are regarded as one of the most promising next-generation battery systems due to their high theoretical energy density,finding effective cathode catalysts with fine-tuned structure is a key way to improve the performance.Herein,based on the structure of cubic zeolitic imidazolate framework-67(ZIF-67),a series of hollow catalysts were synthesized by different chemical etching treatments.Firstly,from the perspective of metal,nickel nitrate is used for etching,hollow Ni ZIF is obtained through Kirkendall effect.Secondly,hollow TA-ZIF is obtained by adding tannic acid to replace the methylimidazole ligand.Hollow structures have larger surface areas,materials can expose more active sites,which can lead to better performance of Li-O_(2)batteries.On this basis,having more oxygen vacancies can also improve the battery performance.At the same time,further loading noble metal ruthenium on the synthesized cobalt-based catalyst can effectively reduce the overpotential of Li-O_(2)battery and improve the battery performance.For TA-ZIF with more stable hollow structure and more oxygen vacancies,the cycle performance reaches 330 cycles after loading Ru.Compared with the 64 cycles of solid Co_(3)O_(4),it has a great improvement. | Jiachen Qiu Yuran Lin Shuting Zhang Jie Ma Yu Zhang Mengwei Yuan Genban Sun Caiyun Nan | 2023 | Nano Research2023，16，5： | 0 |
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