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| 1 | Distribution of HBV genotypes among HBV carriers in Benin:phylogenetic analysis and virological characteristics of HBV genotype E显示文摘AIM: To determine the distribution of Hepatitis B virus (HBV) genotypes in Benin, and to clarify the virological characteristics of the dominant genotype.METHODS: Among 500 blood donors in Benin, 21 HBsAg-positive donors were enrolled in the study. HBV genotypes were determined by enzyme immunoassay and restriction fragment length polymorphism. Complete genome sequences were determined by PCR and direct sequencing.RESULTS: HBV genotype E (HBV/E) was detected in 20/21 (95.2%), and HBV/A in 1/21 (4.8%). From the age-specific prevalence of HBeAg to anti-HBe seroconversion (SC) in 19 HBV/E subjects, SC was estimated to occur frequently in late teens in HBV/E.The comparison of four complete HBV/E genomes from HBeAg-positive subjects in this study and five HBV/E sequences recruited from the database revealed that HBV/E was distributed throughout West Africa with very low genetic divers ity (nucleotide homology 96.7-99.2%).Based on the sequences in the basic core promoter (BCP)to precore region of the nine HBV/E isolates compared to those of the other genotypes, a nucleotide substitution in the BCP, G1757A, was observed in HBV/E.CONCLUSION: HBV/E is predominant in the Republic of Benin, and SC is estimated to occur in late teens in HBV/E. The specific nucleotide substitution G1757A in BCP, which might influence the virological characteristics,is observed in HBV/E. | Kei Fujiwara Yasuhito Tanaka Etsuro Orito Tomoyoshi Ohno Takanobu Kato Kanji Sugihara Izumi Hasegawa Mayumi Sakurai Kiyoaki Ito Atsushi Ozasa Yuko Sakamoto Isao Arita Ahmed El-Gohary Agossou Benoit Sophie I Ogoundele-Akplogan Namiko Yoshihara Ryuzo Ueda Masashi Mizokami | 2005 | World Journal of Gastroenterology2005，11，41： | 3 |
| 2 | Higher serum uric acid is associ- ated with increased arterial stiffness in Japanese individuals 显示文摘 | Nobukazu I Yuko I Ei-Ichi T | 2007 | Atherosclerosis2007，192，： | 1 |
| 3 | Chromatographic analysis of tetracycline antibiotics in foods显示文摘 | Hisao O Yuko I Hiroshi M | 2000 | Journal of Chromatography A2000，882，： | 1 |
| 4 | Inhibition of Plas- minogen Activator Inhibitor-1 Its Mechanism and Effectiveness on Coagulation and Fibrosis 显示文摘 | YUKO I SATORU T MASAOM1 N | 2008 | Arterioscler Thromb Vasc Biol2008，28，： | 1 |
| 5 | Chromatographic analysis of tetracycline antibiotics in foods显示文摘 | Hisao O Yuko I Hiroshi M | 2000 | Journal of Chromatography A2000，882，12： | 1 |
| 6 | Bioconversion of waste office paper to gluconic acid in a turbine blade reactor by the filamentous fungus Aspergillus nige 显示文摘 | Yuko I Enoek Y P Naoyuki O | 2006 | Bioresource Technology2006，97，： | 1 |
| 7 | Cyclophosphamide decrea- ses the number,percentage and the function of CD25+ CD4+regulatory T cells ,which suppress induction of contact hypersensitivity显示文摘 | YUKO I MASATOSHI N CHIZURU T | 2005 | J Dermatol Sci2005，39，2： | 1 |
| 8 | Microwave-assisted one step high-throughput synthesis of benzimidazoles显示文摘 | Shou Y L Yuko I Ethan Stewart | 2006 | Tetrahedron Letters2006，47，： | 1 |
| 9 | Extrauterine growth restriction in preterm infants of gestational age ≤32 weeks显示文摘 | MOTOICHIRO S KAZUO I YUKO S | 2008 | Pediatr Int2008，50，1： | 1 |
| 10 | IFN-γ Protects Cerulein-Induced Acute Pancreatitis by Repressing NF-κB Activation显示文摘 | Takahito H Yuko I Akihiko K | | 0，，11： | 1 |
| 11 | Generation of phosphorylated histone H2AX by benzene metabolites 显示文摘 | Mio I Tatsushl T Yuko I | 2008 | Toxicol Vitro2008，22，8： | 1 |
| 12 | Thioredoxin-2 is an essential gene regulating mitochondria-dependent apoptosis 显示文摘 | TANAKA T FUMIHITO H YUKO Y I | 2002 | EMBO2002，21，7： | 1 |
| 13 | Pleural to serum CEA ratio in lung adenocarcinoma显示文摘 | Hiroaki S Hiroichi I Yuko TY | 2002 | Clin Oncol2002，14，2： | 1 |
| 14 | Association between serum uric acid,metabolic syndrome,and carotid atheroscle- rosis in Japanee individuals 显示文摘 | Nobukazu I Yuko I Ei-Ichi T | 2005 | Arterioscler Thromb Vasc Biol2005，25，5： | 1 |
| 15 | Exlra ulerine growth restricv tion in pretem infants of gestational age ≤32 weeks 显示文摘 | Motoichiro S Kazuo I Yuko S | 2008 | Pedi- atr Int2008，50，1： | 1 |
| 16 | High-throughput anal-ysis of tetracycline and penicillin antibiotics in animal tissuesusing electrospray tandem mass spectrometry with selectedreaction monitoring transition显示文摘 | Tomomi G Yuko I Sadaji Y | 2005 | Journal of ChromatographyA2005，1100，2： | 1 |
| 17 | Tea catechins with a gaUoylmoiety suppress postprandial hypertriacylglycerolemia by delaying lymphatic transport of dietary fat in rats显示文摘 | Ikuo I Koichi T Yuko S | 2005 | J Nutr2005，135，2： | 1 |
| 18 | In situ formed silica particle in rubber vulcanizate by the sol-gel method显示文摘 | Yuko I Shinzo K | 1997 | Polymer1997，38，17： | 1 |
| 19 | Three new bicou matins from Citrus hassaku显示文摘 | Yuko T Toshimi N Motoharu J I | 1994 | Chemical &Pharmaceutical Bulletin1994，，42： | 1 |
| 20 | Inhibition of plasminogen activator inhibitor-1: its mechanism and effectiveness on coagulation and fibrosis显示文摘 | Yuko I Satoru T Masaomi N | 2008 | Arterioscler Thromb Vasc Biol2008，28，4： | 1 |
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