| 1 | 对比分析黑斑息肉综合征合并大肠癌组织肿瘤相关基因(英文)显示文摘Objective:The aim of the study was to screen the differentially expressed genes of Peutz-Jeghers syndrome (PJS) and colorectal carcinoma (CRC).Methods:This study used cDNA microarray to comparatively analyze the gene expression profiles of 4 cases of PJS combined with colorectal adenocarcinoma vs.normal mucosae.The cDNA microarray contained 8064 human genes,and then using RT-PCR to test three genes of all.Results:The experimental data showed that fourteen genes were differentially expressed,which were up-regulated in PJS.Fifty-one genes expressions were altered in CRCs,of which 32 were up-regulated,as compared to the normal mucosae.In addition,5 genes were similarly altered in both PJS and CRCs.RT-PCR analyses confirmed the cDNA microarray data for three of those genes:LATS2,APC and MADH4.Conclusion:LCN2,USP4,GRO3,HYAL1 and APC-these differentially expressed genes likely represent biomarkers for early detection of CRC and may be potential therapeutic targets. | Xiaosan Zhu Yichen Dai Qingzhen Nan Zhangxin Chen Junpei Xie Wei Zeng Yuka Fu Yuanyuan Lin Qingna Lian Qiaofang Sang Xiaojuan Zhan | 2011 | The Chinese-German Journal of Clinical Oncology2011，10，8： | 0 |
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