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| 1 | Species and genetic diversity affect leaf litter decomposition in subtropical broadleaved forest in southern China显示文摘Aims Litter decomposition is a fundamental process within ecosystem functioning,and it is largely dependent on the biodiversity of ecosystems.We explored the effects of species diversity and genetic diversity of litter on the litter decomposition rate.Methods We used laboratory microcosms to determine whether species diversity and genetic diversity and their interaction affect leaf litter decomposition.We set up 8 treatments containing 1,2,4 diversity levels of four broad-leaf species(Alniphyllum fortunei,Idesia polycarpa,Cinnamomum camphora and Daphniphyllum oldhamii)both in species and genetic sense.Totally 246 microcosms containing same amount of soil and litter of prescribed diversity treatment were stored in the dark at 25℃for 12 weeks.Important Findings The effect of litter species diversity on litter decomposition was largely dependent on species composition of the litter mixture in terms of species identity.Overall,the decomposition rate increased linearly with the richness of seed family when the species identity was disregarded.However,no interactive effect of species diversity and genetic diversity on mass loss was detected.The litter decomposition rate was found to be unrelated to the initial carbon(C),whereas it was negatively correlated with the initial total nitrogen(N)and N:P ratio.However,the regression curves of the litter decomposition rate against the total P and C:N ratio displayed quadratic parabolas opening upward and downward,respectively.This study demonstrated how species and/or genetic diversity and the stoichiometry of litter per se affect litter decomposition.Further studies should be performed in the long term to ascertain how such effects operate and how they change during the decomposition process,particularly in response to varying composition and diversity of standing plants in the environments. | Shanshan Li Yuewei Tong Zhengwen Wang | 2017 | Journal of Plant Ecology2017，10，1： | 13 |
| 2 | On fast estimation of direction of arrival for underwater acoustic target based on sparse Bayesian learning显示文摘The Direction of Arrival(DOA) estimation methods for underwater acoustic target using Temporally Multiple Sparse Bayesian Learning(TMSBL) as the reconstructing algorithm have the disadvantage of slow computing speed.To solve this problem,a fast underwater acoustic target direction of arrival estimation was proposed.Analyzing the model characteristics of block-sparse Bayesian learning framework for DOA estimation,an algorithm was proposed to obtain the value of core hyper-parameter through MacKay's fixed-point method to estimate the DOA.By this process,it will spend less time for computation and provide more superior recovery performance than TMSBL algorithm.Simulation results verified the feasibiUty and effectiveness of the proposed algorithm. | WANG Biao ZHU Zhihui DAI Yuewei | 2017 | Chinese Journal of Acoustics2017，36，1： | 9 |
| 3 | Simulating Mechanism of Interaction Between Ports and Cities Based on System Dynamics: A Case of Dalian, China显示文摘Port-city system is a complex and integral system, and it can be simulated by system dynamic method, which is used to be employed to solve nonlinear problems. Based on the causality of the every element in the port-city system, the authors analyzed the feedback relation and logical relation among the system variables and system structure. A system-dynamic flow chart and correlation equations were put forward with VENSIM software, the quantitative relation was described, and the model was debugged. The development trend of the main influence factors in port-city system was simulated. By changing the parameters values of variables in the model, we studied the influence degree of each related factor. It is found that: 1) Foreign trade throughput of port play an important role in the development of export-oriented economy. 2) The development of primary industry and secondary industry affects most of the water transportation demand. With the constant increase of tertiary industry proportion in the industrial structure, the demand of national economy for water transportation decreases gradually. 3) Water transportation presents a kind of oversupply development situation, so port construction should properly slow down. 4) With the development of ports, its direct and indirect contribution to urban economy has been continuously increasing, but contribution rate will be continuously decreasing. | LUAN Weixin CHEN Hang WANG Yuewei | 2010 | Chinese Geographical Science2010，20，5： | 8 |
| 4 | A Remote Sensing-based Analysis on the Impact of Wenchuan Earthquake on the Core Value of World Nature Heritage Sichuan Giant Panda Sanctuary显示文摘In this study,we used remotely sensed data,GIS modeling,and statistical methods to evaluate the damage caused by the Wenchuan Earthquake (May 12,2008) to the giant panda (Ailuropoda melanoleuca) habitat in the World Nature Heritage Sichuan Giant Panda Sanctuary (WHSGPS) in China.A landscape ecological analysis found increases of landscape heterogeneity,complexity,and fragmentation in the giant panda habitat after the earthquake.A terrain analysis found that slope and elevation are directly associated with the distribution of the damaged areas.As slope and elevation increase,the size of the damaged area keeps increase until to a peak,and then starts to drop.The total area of the damaged vegetation in our study area is 114.26 km 2,accounting for 3.78% of the study area;30.46% of that 114.26 km 2 is located in the Core Zone of WHSGPS.There are 18.57km 2 of the damaged vegetation located in the identified suitable giant panda habitat,accounting for 1.75% of the total area of suitable giant panda habitats in the study area.Based on these findings,we conclude that the Wenchuan Earthquake does not have significant impact on the WHSGPS as a whole. | YU Hu ZHAO Yongtao MA Yuewei SUN Yulian ZHANG Hu YANG Shihong LUO Yong | 2011 | Journal of Mountain Science2011，8，3： | 8 |
| 5 | 四川三台钙蒙脱石的矿物学与有机化处理研究显示文摘对四川三台钙蒙脱石进行了矿物学和有机化处理研究。化学成分分析、晶体化学式与层间可交换阳离子数计算、X射线衍射分析和热分析都表明三台膨润土属钙基膨润土,属型为切托 Otay型。用十八烷基三甲基氯化铵、十八烷基二甲基苄基氯化铵、十二烷基二甲基苄基氯化铵三种季铵盐阳离子表面活性剂对四川三台钙蒙脱石进行了有机化处理。结果表明,用十八烷基三甲基氯化铵处理的效果最好。 | 彭同江 Nelson Belzile 孙红娟 Yuewei Chen John Huang 刘福生 | 2004 | 矿物学报2004，24，1： | 8 |
| 6 | Improved quantum bacterial foraging algorithm for tuning parameters of fractional-order PID controller显示文摘The quantum bacterial foraging optimization(QBFO)algorithm has the characteristics of strong robustness and global searching ability. In the classical QBFO algorithm, the rotation angle updated by the rotation gate is discrete and constant,which cannot affect the situation of the solution space and limit the diversity of bacterial population. In this paper, an improved QBFO(IQBFO) algorithm is proposed, which can adaptively make the quantum rotation angle continuously updated and enhance the global search ability. In the initialization process, the modified probability of the optimal rotation angle is introduced to avoid the existence of invariant solutions. The modified operator of probability amplitude is adopted to further increase the population diversity.The tests based on benchmark functions verify the effectiveness of the proposed algorithm. Moreover, compared with the integerorder PID controller, the fractional-order proportion integration differentiation(PID) controller increases the complexity of the system with better flexibility and robustness. Thus the fractional-order PID controller is applied to the servo system. The tuning results of PID parameters of the fractional-order servo system show that the proposed algorithm has a good performance in tuning the PID parameters of the fractional-order servo system. | LIU Lu SHAN Liang DAI Yuewei LIU Chenglin QI Zhidong | 2018 | Journal of Systems Engineering and Electronics2018，29，1： | 6 |
| 7 | Essential role of the CUL4B ubiquitin ligase in extra-embryonic tissue development during mouse embryogenesis显示文摘CUL4B ubiquitin ligase 基因的变化有原因地被连接到 syndromic X 连接智力迟钝(XLMR ) 。然而,在 neuronal 和发展缺点的 CUL4B 变化的病原的角色没被理解。我们与 Cul4b 的指向的混乱产生了老鼠,并且与显著生长抑制观察了胚胎的致命性并且在胚胎外的纸巾增加了 apoptosis。Cul4b,然而并非它的 paralog Cul4a,在胚胎外的纸巾驿站培植在高水平被表示。在一根胚胎外的房间线的 CUL4B 表示的 Silencing 导致了 CUL4 底层 p21 Cip1/WAF 和 G2/M 房间周期逮捕 Cip1/WAF 。Cul4b 的 Epiblast 特定的删除阻止了胚胎的致命性并且产生了可行 Cul4b 空老鼠。因此,当时在胚胎非必需合适, Cul4b 在胚胎外的纸巾执行一个必要发展角色。我们的学习提供策略产生可行 Cul4b 缺乏的老鼠为潜在的 neuronal 和人的 CUL4B XLMR 病人的行为的缺乏建模。 | Liren Liu Yan Yin Yuewei Li Lisa Prevedel Elizabeth H Lacy Liang Ma Pengbo Zhou | 2012 | Cell Research2012，22，8： | 6 |
| 8 | Chromopeptide A, a highly cytotoxic depsipeptide from the marine sediment-derived bacterium Chromobacterium sp. HS-13-94显示文摘A bicyclic depsipeptide, chromopeptide A(1), was isolated from a deep-sea-derived bacterium Chromobacterium sp. HS-13-94. Its structure was determined by extensive spectroscopic analysis and by comparison with a related known compound. The absolute configuration of chromopeptide A was established by X-ray diffraction analysis employing graphite monochromated Mo K_α radiation(λ ? 0.71073 ?) with small Flack parameter 0.03. Chromopeptide A suppressed the proliferation of HL-60, K-562, and Ramos cells with average IC_(50) values of 7.7, 7.0, and 16.5 nmol/L, respectively. | Zhenfang Zhou Xin Wang Hui Zhang Jingya Sun Linghui Zheng Hongchun Liu Jidong Wang Aijun Shen Meiyu Geng Yuewei Guo | 2015 | Acta Pharmaceutica Sinica B2015，5，1： | 6 |
| 9 | Survey of reefs based on Landsat 8 operational land imager(OLI)images in the Nansha Islands, South China Sea显示文摘A detailed survey of the reefs in the Nansha Islands' sea that are of strategic importance is conducive to their future development. In this study, a total of 50 Landsat 8 operational land imager(OLI) images were used to analyze the geological features and spectral characteristics of the Nansha reefs. The exposed islands/sandbanks,reef flats and sub-tidal reefs were identified with the near-infrared band, the red and green bands, and the blue band, respectively. Based on the relationships among various characteristics and bands illustrated in the OLI images, the maximum between-cluster variance threshold algorithm(OTSU method) and the mathematical morphology were employed to extract characteristic parameters of the spatial geometry of the reefs from top to bottom, which were subsequently operated by a series of post-processing methods such as vectorization,simplification and topological analysis. Among the 132 standalone reefs and 16 atolls that are identified in the study, four reefs have yet to be named in the Standard Names of Various Islands in the South China Sea and the website Nansha Islands Online(http://gffzzd4db47f6efa542b8hb0wv9ofqckxv6uou.ffgz.tsg.suse.edu.cn/). Another 24 ones are exposed to the atmosphere even during high tides. Taiping Island with an area of 0.57 km^2 represents the largest exposed geological feature. This study demonstrated the applicability of medium-resolution satellite images to derive the coral reef information effectively and thus provided information for the related departments that are responsible to manage the coast.An improved resolution of multispectral bands with the panchromatic band in higher spatial resolution(15 m for OLI image) is expected to provide an optimum satellite based approach to map marine habitats. | DUAN Yuewei LIU Yongxue LI Manchun ZHOU Minxi YANG Yuhao | 2016 | Acta Oceanologica Sinica2016，35，10： | 5 |
| 10 | Mapping epistasis and environment × QTX interaction based on four-omics genotypes for the detected QTX loci controlling complex traits in tobacco显示文摘Using newly developed methods and software, association mapping was conducted for chromium content and total sugar in tobacco leaf, based on four-omics datasets. Our objective was to collect data on genotype and phenotype for 60 leaf samples at four developmental stages, from three plant architectural positions and for three cultivars that were grown in two locations. Association mapping was conducted to detect genetic variants at quantitative trait SNP(QTS) loci, quantitative trait transcript(QTT) differences,quantitative trait protein(QTP) variability, and quantitative trait metabolite(QTM) changes,which can be summarized as QTX locus variation. The total heritabilities of the four-omics loci for both traits tested were 23.60% for epistasis and 15.26% for treatment interaction.Epistasis and environment × treatment interaction had important impacts on complex traits at all-omics levels. For decreasing chromium content and increasing total sugar in tobacco leaf, six methylated loci can be directly used for marker-assisted selection, and expression of ten QTTs, seven QTPs and six QTMs can be modified by selection or cultivation. | Liyuan Zhou Ruiyuan Li Longjiang Fan Yuewei Shi Zhihong Wang Shengdong Xie Yijie Gui Xueliang Ren Jun Zhu | 2013 | The Crop Journal2013，1，2： | 4 |
| 11 | Damping Collaborative Optimization of Five-suspensions for Driver-seat-cab Coupled System显示文摘Both the seat and cab system of truck play a vital role in ride comfort.The damping matching methods of the two systems are studied separately at present.However,the driver,seat,and cab system are one inseparable whole.In order to further improve ride comfort,the seat suspension is regarded as the fifth suspension of the cab,a new idea of 'Five-suspensions' is proposed.Based on this idea,a 4 degree-of-freedom driver-seat-cab coupled system model is presented.Using the tested cab suspensions excitations as inputs and seat acceleration response as compared output,the simulation model is built.Taking optimal ride comfort as target,a new method of damping collaborative optimization for Five-suspensions is proposed.With a practical example of seat and cab system,the damping parameters are optimized and validated by simulation and bench test.The results show the seat vertical frequency-weighted RMS acceleration values tested for the un-optimized and optimized Five-suspensions are 0.50 m/s^2 and 0.39 m/s^2,respectively,with a decrease by 22.0%,which proves the model and method proposed are correct and reliable.The idea of 'Five-suspensions' and the method proposed provide a reference for achieving global optimal damping matching of seat suspension and cab suspensions. | ZHAO Leilei ZHOU Changcheng YU Yuewei | 2016 | Chinese Journal of Mechanical Engineering2016，29，4： | 4 |
| 12 | Onshore-offshore wind energy resource evaluation based on synergetic use of multiple satellite data and meteorological stations in Jiangsu Province,China显示文摘The demand for efficient and cost-effective renewable energy is increasing as traditional sources of energy such as oil,coal,and natural gas,can no longer satisfy growing global energy demands.Among renewable energies,wind energy is the most prominent due to its low, manageable impacts on the local environment.Based on meteorological data from 2006 to 2014 and multi-source satellite data (i.e.,Advanced Scatterometer,Quick Scatterometer,and Windsat)from 1999 to 2015,an assessment of the onshore and offshore wind energy potential in Jiangsu Province was performed by calculating the average wind speed,average wind direction,wind power density, and annual energy production (AEP).Results show that Jiangsu has abundant wind energy resources,which increase from inland to coastal areas.In-onshore areas, wind power density is predominantly less than 200 W/m^2, while in offshore areas,wind power density is concentrates in the range of 328-500 W/m^2.Onshore areas comprise more than 13,573.24 km^2,mainly located in eastern coastal regions with good wind farm potential The total wind power capacity in onshore areas could be as much as 2.06×10^5 GWh.Meanwhile,offshore wind power generation in Jiangsu Province is calculated to reach 2×10^6 GWh, which is approximately four times the electricity demand of the entire Jiangsu Province.This study validates the effective application of Advanced Scatterometer,Quick Scatterometer,and Windsat data to coastal wind energy monitoring in Jiangsu.Moreover,the methodology used in this study can be effectively applied to other similar coastal zones. | Xianglin WEI Yuewei DUAN Yongxue LIU Song JIN Chao SUN | 2019 | Frontiers of Earth Science2019，13，1： | 4 |
| 13 | Prognostic value of pre-and post-transplantation 18F-fluorodeoxyglucose positron emission tomography results in non-Hodgkin lymphoma patients receiving autologous stem cell transplantation显示文摘Objective: High-dose chemotherapy(HDC) followed by autologous stem cell transplantation(ASCT) is the standard of care in the upfront or relapsed/refractory setting in some patients with non-Hodgkin lymphoma(NHL).However,a proportion of patients do not respond to ASCT.^(18)F-fluorodeoxyglucose(FDG) positron emission tomography(PET)/computed tomography(CT) has been widely used for staging,response evaluation,and prognosis prediction.Here,we investigated the prognostic role of PET/CT in NHL patients before and after ASCT.Methods: A retrospective study was conducted at Peking University Cancer Hospital.All NHL patients who underwent ASCT between March 2010 and July 2016 were identified.Patients who had PET/CT scan before and after ASCT were included.Deauville criteria(5-point scale) were used to interpret PET scans.Univariate and multivariate survival analyses were performed using Cox regression.The predictive value of PET scanning was estimated by comparing the area under the receiver operating characteristic(ROC) curve.Results: In total,79 patients were enrolled in this study.In univariate analysis,pre-and post-ASCT PET result was identified as prognostic factors for 3-year progression-free survival(PFS) and overall survival(OS).Patients with negative pre-ASCT PET result demonstrated significantly better PFS(84.2% vs.54.2%) and OS(89.2% vs.63.6%) than patients with positive pre-ASCT PET result.PFS(91.6% vs.25.3%) and OS(96.5% vs.36.8%) were also significantly different between patients with negative and positive post-ASCT PET result.Multivariate analysis also showed a significant association between survival and post-ASCT PET result.ROC analysis revealed that the predictive value of post-ASCT PET result was superior to that of pre-ASCT PET result alone.Combined pre-and post-ASCT PET result is better for predicting outcomes in patients with NHL receiving transplantation.Deauville criteria score >3 was identified as the best cutoff value for post-ASCT PET.Conclusions: Post-ASCT PET result was more important than pre-ASCT PET result in predicting outcomes for NHL patients who underwent ASCT.The prognostic significance can be improved when combining preASCT PET result with post-ASCT PET result.Deauville criteria can be used for interpreting PET scans in this scenario. | Zhitao Ying Lan Mi Xuejuan Wang Yuewei Zhang Zhi Yang Yuqin Song Xiaopei Wang WenZheng Ningjing Lin Meifeng Tu Yan Xie Lingyan Ping Chen Zhang Weiping Liu LijuanDeng Jun Zhu | 2017 | Chinese Journal of Cancer Research2017，29，6： | 3 |
| 14 | Neutron halo state of ^(13)C显示文摘Angular distributions for the 12C(d, p)13C transfer reactions have been measured at Ed = 11.8 MeV, and compared with those of the DWBA calculations. By means of this comparison, density distributions of the last neutron in the ground state and the first 1/2+ state of 13C are extracted. The properties of these states in 13C have also been studied in the framework of the nonlinear relativistic mean-field theory with NL-SH parameters. It is found that the first l/2+ state in 13C is a neutron halo state shown by both the experimental and theoretical density distributions of the last neutron. | LIU Zuhua, LIN Chengjian, LI Zhichang, ZHANG Huanqiao, CHEN Baoqiu, MA Zhongyu, WU Yuewei, LIU Jiancheng & LI ShuyuanChina Institute of Atomic Energy, Beijing 102413, China | 2001 | Chinese Science Bulletin2001，46，1： | 3 |
| 15 | PHOTOREALISTIC COMPUTER GRAPHICS FORENSICS BASED ON LEADING DIGIT LAW显示文摘As the advent and growing popularity of image rendering software,photorealistic computer graphics are becoming more and more perceptually indistinguishable from photographic images.If the faked images are abused,it may lead to potential social,legal or private consequences.To this end,it is very necessary and also challenging to find effective methods to differentiate between them.In this paper,a novel leading digit law,also called Benford's law,based method to identify computer graphics is proposed.More specifically,statistics of the most significant digits are extracted from image's Discrete Cosine Transform(DCT) coefficients and magnitudes of image's gradient,and then the Support Vector Machine(SVM) based classifiers are built.Results of experiments on the image datasets indicate that the proposed method is comparable to prior works.Besides,it possesses low dimensional features and low computational complexity. | Xu Bo Wang Junwen Liu Guangjie Dai Yuewei | 2011 | Journal of Electronics(China)2011，28，1： | 3 |
| 16 | Deep-blue organic light-emitting diodes based on a doublet d-f transition cerium(Ⅲ) complex with 100% exciton utilization efficiency显示文摘Compared to red and green organic light-emitting diodes(OLEDs),blue OLEDs are still the bottleneck due to the lack of efficient emitters with simultaneous high exciton utilization efficiency(EUE)and short excited-state lifetime.Different from the fluorescence,phosphorescence,thermally activated delayed fluorescence(TADF),and organic radical materials traditionally used in OLEDs,we demonstrate herein a new type of emitter,cerium(Ⅲ)complex Ce-1 with spin-allowed and parity-allowed d-f transition of the centre Ce^(3+) ion.The compound exhibits a high EUE up to 100% in OLEDs and a short excited-state lifetime of 42 ns,which is considerably faster than that achieved in efficient phosphorescence and TADF emitters.The optimized OLEDs show an average maximum external quantum efficiency(EQE)of 12.4% and Commission Internationale de L’Eclairage(CIE)coordinates of(0.146,0.078). | Liding Wang Zifeng Zhao Ge Zhan Huayi Fang Hannan Yang Tianyu Huang Yuewei Zhang Nan Jiang Lian Duan Zhiwei Liu Zuqiang Bian Zhenghong Lu Chunhui Huang | 2020 | Light(Science & Applications)2020，9，1： | 3 |
| 17 | Cembrane-type diterpenoids from the South China Sea soft coral Sarcophyton mililatensis显示文摘Eight cembrane-type diterpenoids, namely,(t)-(6 R)-6-hydroxyisosarcophytoxide(1),(t)-(6 R)-6-acetoxyisosarcophytoxide(2),(t)-17-hydroxyisosarcophytoxide(3), sarcomililatins A–D(4–7), and sarcomililatol(8), were isolated from the soft coral Sarcophyton mililatensis collected from Weizhou Island, Guangxi Autonomous Region, together with 2 known related analogues,(t)-isosarcophytoxide(9) and(t)-isosarcophine(10). The structures of these compounds were elucidated by a combination of detailed spectroscopic analyses, chemical methods, and comparison with reported data.The absolute configuration of compound 1 was established by the modified Mosher's method, while the absolute configurations of compounds 4 and 5 were assigned by electronic circular dichroism(ECD)spectroscopy and that of compound 8 was established by time-dependent density functional theory electronic circular dichroism(TD-DFT ECD) calculation. In in vitro bioassays, compound 9 displayed significant cytotoxicity against the human cancer cell lines human promyelocytic leukemia cells(HL-60)and human lung adenocarcinoma cells(A-549) with IC_(50) values of 0.7870.21 and 1.2670.80 μmol/L,respectively. Compounds 4 and 9 also showed moderate inhibitory effects on the TNFα-induced Nuclear factor kappa B(NF-κB, a therapeutical target in cancer) activation, showing IC_(50) values of 35.23712.42 and 22.5274.44 μmol/L, respectively. | Songwei Li Fei Ye Zhengdan Zhu Hui Huang Shuichun Mao Yuewei Guo | 2018 | Acta Pharmaceutica Sinica B2018，8，6： | 3 |
| 18 | Nutritional properties of Europen eel(Anguilla anguilla)bone peptide-calcium and its apoptosis effect on Caco-2 cells显示文摘The present study aimed at making a rational usage for European eel bone by-products by preparing Europen eel bone peptide chelated calcium(EBPC-Ca).Nutritional properties and bioactivity of EBPC-Ca were evaluated.Results showed that nutritional properties of calcium ions will cause intra-and inter-molecular folding and aggregation of peptide to uniformly form EBPC-Ca chelate.The chelated compound of EBPC and calcium ion triggered a strong apoptosis in heterogeneous human epithelial colorectal adenocarcinoma(Caco-2)in concentration-and time-dependent manners.Western blot analysis revealed that the EBPC-Ca induced apoptosis may be the result of a blocked autophagy flux through mitochondrial-dependent pathway.Additionally,the increase in FGF-23 protein expression inhibited the absorption of calcium ions and alleviated cell apoptosis.It was also found that the cell apoptosis occurs with significant increases in the levels of reactive oxygen species(ROS)and Ca^(2+)in the cells,indicating the anti-tumor potential of EBPC-Ca may involve multiple channels. | Hui Teng Yuewei Qian Xiaoyun Fan Hui Cao Yuting Tian Lei Chen | 2022 | Food Science and Human Wellness2022，11，6： | 3 |
| 19 | Changes in the frequency of myeloid-derived suppressor cells after transarterial chemoembolization with gelatin sponge microparticles for hepatocellular carcinoma显示文摘Purpose: A series of clinical studies have established the safety and efficacy of transcatheter arterial chemoembolization(TACE) with gelatin sponge microparticles(GSMs) in treating hepatocellular carcinoma(HCC). HCC can lead to obvious necrosis inside tumors, especially larger ones, although it is unclear whether such necrotic tumor tissue can induce favorable immune reactions against the tumor. Myeloid-derived suppressor cells(MDSCs)have immunosuppressive functions and are currently considered a very important cell type affecting tumor immunity. This study observed changes in MDSC frequency in peripheral blood before and after GSM–TACE to evaluate the effect on the immune function of HCC patients.Methods: Eight patients diagnosed with HCC underwent GSM–TACE treatment in the Hepatobiliary Interventional Department of Beijing Tsinghua Chang Gung Hospital, Beijing, China;we followed up with the patients over a period of 30 days post-surgery. We used flow cytometry(FCM) to quantify the frequency of MDSCs in peripheral blood before TACE, 10 days after surgery and 30 days after surgery.Results: MDSC frequency after GSM–TACE had a significant downward trend. Pre-TACE, it was 30.73% ? 11.93%,decreasing to 18.60% ? 11.37% at 10 days after operation. This decrease was not statistically significant(P > 0.05). MDSC frequency was even lower 30 days after TACE(7.63% ? 7.32%) than at 10 days after TACE(P < 0.05), and there was a significant difference compared with pre-TACE(P < 0.001). We evaluated tumor response at 30 days after GSM–TACE according to the Modified Response Evaluation Criteria in Solid Tumors(mRECIST), and all eight patients showed partial response(PR).Conclusion: Our results confirmed that GSM–TACE was beneficial for improving anti-tumor immunity in the treatment of HCC. | Yuanxun Yue Zhizhong Ren Ying Liu Yuewei Zhang | 2019 | Journal of Interventional Medicine2019，2，1： | 2 |
| 20 | Decoration of Terpyridine with Electron-Rich Unit TH DTAP: an Efficient Way to Explore Fluorescence Sensors for Recognizing Metal Ions显示文摘The electron-donating unit 2,3,4,6-tetrahydro-1,6-dithia-3a-azaphenalene (THDTAP) was introduced onto terpyridine (TPy) to give a donor-acceptor (D-A) type TPy-ligand (compound 2).Upon selective oxidation of two sulfur atoms on the THDTAP moiety of 2,the ligands 3-6 were created.The electronic structures of 2-6 were evaluated by theoretical,electrochemical,and spectroscopic investigations.The oxidation on the sulfur atoms brings significant influence on the electron-donating ability of THDTAP moiety,subsequently,leads to fine modulations on intramolecular charge-transfer (ICT) of 2-6 and the electronically excited states of the complexes of 2-6 with metal ions.Based on the optical response of 2-6 toward metal ions,the step-by-step recognition of Zn2+,Cd2+,and Ag+ ions is set up by employing 2 and 3 as combined fluorescence sensors. | Taoshan Xu Dongxu Li Chaoxian Yan Yuewei Wu Cheng-Shan Yuan Xiangfeng Shao | 2019 | Chinese Journal of Chemistry2019，37，9： | 2 |
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