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| 1 | SHP2 regulates skeletal cell fate by modifying SOX9 expression and transcriptional activity显示文摘Chondrocytes and osteoblasts differentiate from a common mesenchymal precursor, the osteochondroprogenitor(OCP), and help build the vertebrate skeleton. The signaling pathways that control lineage commitment for OCPs are incompletely understood. We asked whether the ubiquitously expressed protein-tyrosine phosphatase SHP2(encoded by Ptpn11) affects skeletal lineage commitment by conditionally deleting Ptpn11 in mouse limb and head mesenchyme using 'Cre-lox P'-mediated gene excision.SHP2-deficient mice have increased cartilage mass and deficient ossification, suggesting that SHP2-deficient OCPs become chondrocytes and not osteoblasts. Consistent with these observations, the expression of the master chondrogenic transcription factor SOX9 and its target genes Acan, Col2a1, and Col10a1 were increased in SHP2-deficient chondrocytes, as revealed by gene expression arrays, q RT-PCR, in situ hybridization, and immunostaining. Mechanistic studies demonstrate that SHP2 regulates OCP fate determination via the phosphorylation and SUMOylation of SOX9, mediated at least in part via the PKA signaling pathway. Our data indicate that SHP2 is critical for skeletal cell lineage differentiation and could thus be a pharmacologic target for bone and cartilage regeneration. | Chunlin Zuo Lijun Wang Raghavendra M.Kamalesh Margot E.Bowen Douglas C.Moore Mark S.Dooner Anthony M.Reginato Qian Wu Christoph Schorl Yueming Song Matthew L.Warman Benjamin G.Neel Michael G.Ehrlich Wentian Yang | 2018 | Bone Research2018，6，2： | 3 |
| 2 | Rapid quantitative detection of brucella melitensis by a label-free impedance immunosensor based on a gold nanoparticle-modified screen-printed carbon electrode 显示文摘 | Wu Haiyun Zuo Yueming Cui Chuanjin | 2013 | Sensors2013，13，7： | 1 |
| 3 | Spatio-temporal processing for muhichannel biosensors using support vector machines显示文摘 | Yueming Zuo Shantanu Chakrabartty | 2006 | IEEE Sensors Journal2006，6，6： | 1 |
| 4 | Rapid quantitative detection of brucella melitensis by a label-free impedance immunosensor based on a gold nanoparticle-modified screen-printed carbon electrode显示文摘 | Wu Haiyun Zuo Yueming Cui Chuanjin | 2013 | Sensor2013，13，： | 1 |
| 5 | Security-Critical Components Recognition Algorithm for Complex Heterogeneous Information Systems显示文摘With the skyrocketing development of technologies,there are many issues in information security quantitative evaluation(ISQE)of complex heterogeneous information systems(CHISs).The development of CHIS calls for an ISQE model based on security-critical components to improve the efficiency of system security evaluation urgently.In this paper,we summarize the implication of critical components in different filed and propose a recognition algorithm of security-critical components based on threat attack tree to support the ISQE process.The evaluation model establishes a framework for ISQE of CHISs that are updated iteratively.Firstly,with the support of asset identification and topology data,we sort the security importance of each asset based on the threat attack tree and obtain the security-critical components(set)of the CHIS.Then,we build the evaluation indicator tree of the evaluation target and propose an ISQE algorithm based on the coefficient of variation to calculate the security quality value of the CHIS.Moreover,we present a novel indicator measurement uncertainty aiming to better supervise the performance of the proposed model.Simulation results show the advantages of the proposed algorithm in the evaluation of CHISs. | Jinxin Zuo Yueming Lu Hui Gao Tong Peng Ziyv Guo Tong An Enjie Liu | 2021 | Computers, Materials & Continua2021，，8： | 0 |
| 6 | Comprehensive Information Security Evaluation Model Based on Multi-Level Decomposition Feedback for IoT显示文摘The development of the Internet of Things(IoT)calls for a comprehensive in-formation security evaluation framework to quantitatively measure the safety score and risk(S&R)value of the network urgently.In this paper,we summarize the architecture and vulnerability in IoT and propose a comprehensive information security evaluation model based on multi-level decomposition feedback.The evaluation model provides an idea for information security evaluation of IoT and guides the security decision maker for dynamic protection.Firstly,we establish an overall evaluation indicator system that includes four primary indicators of threat information,asset,vulnerability,and management,respectively.It also includes eleven secondary indicators of system protection rate,attack detection rate,confidentiality,availability,controllability,identifiability,number of vulnerabilities,vulnerability hazard level,staff organization,enterprise grading and service continuity,respectively.Then,we build the core algorithm to enable the evaluation model,wherein a novel weighting technique is developed and a quantitative method is proposed to measure the S&R value.Moreover,in order to better supervise the performance of the proposed evaluation model,we present four novel indicators includes residual risk,continuous conformity of residual risk,head-to-tail consistency and decrease ratio,respectively.Simulation results show the advantages of the proposed model in the evaluation of information security for IoT. | Jinxin Zuo Yueming Lu Hui Gao Ruohan Cao Ziyv Guo Jim Feng | 2020 | Computers, Materials & Continua2020，，10： | 0 |
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