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| 1 | Mechanobiology:A new frontier for human pluripotent stem cells显示文摘Our understanding of the molecular and cellular mechanisms that control self-renewal,pluripotency and differentiation of human pluripotent stem cells(hPSCs)and our progress toward harnessing the regenerative potential of these cells to treat human diseases are advancing at a rapid rate.Human pluripotent stem cells(hPSCs)include human embryonic stem cells(hESCs)and human induced pluripotent stem cells(hiPSCs).Their unique capacity for indefinite self-renewal(unlimited proliferation)in vitro coupled with their ability to differentiate into almost any cell type present in the adult body(pluripotency)provide a potentially | Jianping Fu Yubing Sun Koh Meng Aw Yong | 2013 | 医用生物力学2013，28，S1： | 1 |
| 2 | Glycogen synthase kinase 3 controls T-cell exhaustion by regulating NFAT activation显示文摘Cellular immunity mediated by CD8+T cells plays an indispensable role in bacterial and viral clearance and cancers.However,persistent antigen stimulation of CD8+T cells leads to an exhausted or dysfunctional cellular state characterized by the loss of effector function and high expression of inhibitory receptors during chronic viral infection and in tumors.Numerous studies have shown that glycogen synthase kinase 3(GSK3)controls the function and development of immune cells,but whether GSK3 affects CD8+T cells is not clearly elucidated.Here,we demonstrate that mice with deletion of Gsk3αand Gsk3βin activated CD8+T cells(DKO)exhibited decreased CTL differentiation and effector function during acute and chronic viral infection.In addition,DKO mice failed to control tumor growth due to the upregulated expression of inhibitory receptors and augmented T-cell exhaustion in tumor-infiltrating CD8+T cells.Strikingly,anti-PD-1 immunotherapy substantially restored tumor rejection in DKO mice.Mechanistically,GSK3 regulates T-cell exhaustion by suppressing TCR-induced nuclear import of NFAT,thereby in turn dampening NFAT-mediated exhaustion-related gene expression,including TOX/TOX2 and PD-1.Thus,we uncovered the molecular mechanisms underlying GSK3 regulation of CTL differentiation and T-cell exhaustion in anti-tumor immune responses. | Yubing Fu Jinjia Wang Chenfeng Liu Kunyu Liao Xianjun Gao Ronghan Tang Binbin Fan Yazhen Hong Nengming Xiao Changchun Xiao Wen-Hsien Liu | 2023 | Cellular & Molecular Immunology2023，20，10： | 0 |
| 3 | Regulating dissolution chemistry of nitrates in carbonate electrolyte for high-stable lithium metal batteries显示文摘Lithium metal batteries(LMBs)have received increasing attention due to the high energy density.However,the practical application of LMBs is limited due to the incompatibility of ester electrolytes.Transition metal(TM)nitrates have been reported as effective additives in ester electrolyte to improve the stability of lithium anode.Unfortunately,the nitrates are restricted to use due to their poor solubility.We find that the nitrates containing crystal water have high solubility in ester electrolytes.Considering that most TM nitrates contain crystal water and the crystal water can be used as a perfect solubilizer of nitrates,thus,the method is of universality and facile without introducing any solubilizing agent.Herein,In(NO_(3))_(3.6)H_(2)O is chosen as one typical case with increased solubility up to 0.2 M compared with In(NO_(3))_(3)which hardly dissolves in ester electrolyte.The additive promotes the rapid and stable formation of the solid electrolyte interface(SEI),which effectively inhibits the lithium dendrites formation.Moreover,the induced cathode electrolyte interface(CEI)maintains the structural stability of Li Ni_(0.8)Co_(0.1)Mn_(0.1)O_(2)(NCM811).As a result,the electrochemical performance of Li|NCM811 cell is obviously improved.Our study provides a new idea for dissolving nitrates in ester electrolytes and discloses the synergistic function of TM-ions. | Yazhen Zhu Xiang Li Yubing Si Xiuqing Zhang Pengfei Sang Yongzhu Fu | 2022 | Journal of Energy Chemistry2022，31，10： | 0 |
| 4 | Grapevine-like high entropy oxide composites boost high-performance lithium sulfur batteries as bifunctional interlayers显示文摘Lithium-sulfur batteries(LSBs)with high energy densities have been demonstrated the potential for energy-intensive demand applications.However,their commercial applicability is hampered by hysteretic electrode reaction kinetics and the shuttle effect of lithium polysulfides(LiPSs).In this work,an interlayer consisting of high-entropy metal oxide(Cu_(0.7)Fe_(0.6)Mn_(0.4)Ni_(0.6)Sn_(0.5))O_(4) grown on carbon nanofibers(HEO/CNFs)is designed for LSBs.The CNFs with highly porous networks provide transport pathways for Li^(+) and e^(-),as well as a physical sieve effect to limit LiPSs crossover.In particular,the grapevine-like HEO nanoparticles generate metal-sulfur bonds with LiPSs,efficiently anchoring active materials.The unique structure and function of the interlayer enable the LSBs with superior electrochemical performance,i.e.,the high specific capacity of 1381 mAh g^(-1) at 0.1 C and 561 mAh g^(-1) at 6 C.This work presents a facile strategy for exploiting high-performance LSBs. | Huarong Fan Yubing Si Yiming Zhang Fulong Zhu Xin Wang Yongzhu Fu | 2024 | Green Energy & Environment2024，9，3： | 0 |
| 5 | Recycling of Old Industrial Buildings in Xichang显示文摘With the advent of the post-industrial era, a large number of idle old industrial buildings have been produced in the city. How to deal with idle old industrial buildings has become a reality. Taking the transformation of the factory building of Chang'an Machinery Plant in Xichang for example, the paper analyzed the recycling strategy of old industrial buildings from the basic conditions and transformation contents of the project, re-constructed the new connotation of the building, so as to exert the use value of the old industrial buildings, with a view to providing a reference for the organic renewal and sustainable development of the city. | WANG Changhong FU Yubing | 2019 | Journal of Landscape Research2019，11，2： | 0 |
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