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| 1 | Rhubarb extract partially improves mucosal integrity in chemotherapy-induced intestinal mucositis显示文摘AIM To investigate the effects of orally gavaged aqueous rhubarb extract(RE) on 5-fluorouracil(5-FU)-induced intestinal mucositis in rats. METHODS Female Dark Agouti rats(n = 8/group) were gavaged daily(1 mL) with water, high-dose RE(HDR; 200 mg/kg) or low-dose RE(LDR; 20mg/kg) for eight days. Intestinal mucositis was induced(day 5) with 5-FU(150 mg/kg) via intraperitoneal injection. Intestinal tissue samples were collected for myeloperoxidase(MPO) activity and histological examination. Xenopus oocytes expressing aquaporin 4 water channels were prepared to examine the effect of aqueous RE on cell volume, indicating a potential mechanism responsible for modulating net fluid absorption and secretion in the gastrointestinal tract. Statistical significance was assumed at P < 0.05 by one-way ANOVA. RESULTS B o d y w e i g h t w a s s i g n i f i c a n t l y r e d u c e d i n r a t s administered 5-FU compared to healthy controls(P < 0.01). Rats administered 5-FU significantly increased intestinal MPO levels(≥ 307%; P < 0.001), compared to healthy controls. However, LDR attenuated this effect in 5-FU treated rats, significantly decreasing ileal MPO activity(by 45%; P < 0.05), as compared to 5-FU controls. 5-FU significantly reduced intestinal mucosal thickness(by ≥ 29% P < 0.001) as compared to healthy controls. LDR significantly increased ileal mucosal thickness in 5-FU treated rats(19%; P < 0.05) relative to 5-FU controls. In xenopus oocytes expressing AQP4 water channels, RE selectively blocked water influx into the cell, induced by a decrease in external osmotic pressure. As water efflux was unaltered by the presence of extracellular RE, the directional flow of water across the epithelial barrier, in the presence of extracellular RE, indicated that RE may alleviate water loss across the epithelial barrier and promote intestinal health in chemotherapy-induced intestinal mucositis.CONCLUSION In summary, low dose RE improves selected parameters of mucosal integrity and reduces ileal inflammation, manifesting from 5-FU-induced intestinal mucositis. | Juliana E Bajic Georgina L Eden Lorrinne S Lampton Ker Y Cheah Kerry A Lymn Jinxin V Pei Andrea J Yool Gordon S Howarth | 2016 | World Journal of Gastroenterology2016，22，37： | 3 |
| 2 | Excess potassium induces larval metamorphosis in four marine invertebrate species显示文摘 | YOOL A J GRAU S M HADFIELD M G | 1986 | Biol Bull1986，170，： | 1 |
| 3 | Amplified RNA synthesized from limited quantities of heterogeneous cDNA显示文摘 | Van Gelder R N von Zastrow M E Yool A | 1990 | Proc Natl Acad Sci U S A1990，87，5： | 1 |
| 4 | Amplified RNA synthesized from limited quantities of heterogenenous cDNA显示文摘 | van GELDER R N von ZASREOQ M E YOOL A | 1990 | Proc Natl Acad Sci USA1990，87，5： | 1 |
| 5 | Mechanism of gating and ion conductivity of a possible tetrameric pore in Aquaporin-1 显示文摘 | Yu J Yool A J Schulten K | 2006 | Structure2006，14，9： | 1 |
| 6 | Characterizing the spatial structure of vegetation communities in the Mojave Desert using geostatistical techniques 显示文摘 | Wallace C S A Watts J M Yool S R | 2000 | Computers and Geosciences2000，26，： | 1 |
| 7 | Amplified RNA synthesized from limited quantities of heterogenenous cDNA显示文摘 | Van Gehter RN von Zastrow ME Yool A | 1990 | Proc Natl Acad Sci USA1990，87，5： | 1 |
| 8 | An examination of the 'continental shelf pump' in an open ocean general circulation model显示文摘 | YOOL A FASHAM M J R | 2001 | Global Biogeochemical cycles2001，15，4： | 1 |
| 9 | Improvements to the methylene blue dye test for harmful clay in aggregates for concrete and mor- tar显示文摘 | YOOL A I G LEES T P FRIED A | 1998 | Cement and Concrete Research1998，28，10： | 1 |
| 10 | Functional domains of aquaporin-Ⅰ : keys to physiology, and targets for drug discovery显示文摘 | YOOL A J | 2007 | Curr Pharm Des2007，13，31： | 1 |
| 11 | Structure, function and translational relevance of aquaporin dual water and ion channels显示文摘 | Yool A J Campbell E M | 2012 | Molecular Aspects of Medicine2012，33，56： | 1 |
| 12 | Functional domains of aquaporin-l: keys to physiology, and targets for drug discovery显示文摘 | YOOL A J | 2007 | Curr Pharm Des2007，13，31： | 1 |
| 13 | Near-ubiquity of ice-edge blooms in the Arctic显示文摘 | Perrette M Yool A Quartly G D | 2011 | Biogeosciences2011，8，2： | 1 |
| 14 | Excess potassium induces larval metamorphosis in four marine invertebrate species 显示文摘 | Yool A J Grau S M Hadfield M G | 1986 | Biol Bull1986，，170： | 1 |
| 15 | Improvements to the Methylene Blue Dye Test for Harmful Clay in Aggregate for Concrete and Mortar 显示文摘 | YOOL A I G LEES T P FRIED A | 1998 | Cement and Concrete Research1998，28，10： | 1 |
| 16 | Modelling of autumn plankton bloom dynamics 显示文摘 | Findlay H S Yool A Nodale M | 2006 | Journal of Plankton Research2006，28，2： | 1 |
| 17 | AmplifiedRNA synthesized from limited quantities of heterogenous cDNA 显示文摘 | von Zastrow ME Yool A | 1990 | Proc Natl Acad Sci1990，87，5： | 1 |
| 18 | Structure, function and translational relevance of aquaporin dual water and ion chan- nels 显示文摘 | YOOL A J CAMPBELL E M | 2012 | Mol Aspects Med2012，33，5： | 1 |
| 19 | Control of primary production in the Arctic by nutrients and light: insights from a high resolution ocean general circulation model显示文摘 | Popova E E Yool A Coward A C | 2010 | Biogeoscienees2010，7，： | 1 |
| 20 | What controls primary production in the Arctic Ocean? Results from an intercomparison of five general circulation models with biogeochemistry显示文摘 | Popova E E Yool A Coward A C | 2012 | Journal of Geophysical Research2012，117，： | 1 |
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