|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Impact of dendritic cell vaccines pulsed with Wilms’ tumour-1 peptide antigen on the survival of patients with advanced non-small cell lung cancers显示文摘 | Hidenori Takahashi Masato Okamoto Shigetaka Shimodaira Shun-ichi Tsujitani Masaki Nagaya Takefumi Ishidao Junji Kishimoto Yoshikazu Yonemitsu | 2012 | European Journal of Cancer2012，，： | 3 |
| 2 | Dendritic cell-based vaccine for pancreatic cancer in Japan显示文摘'Vaccell' is a dendritic cell(DC)-based cancer vaccine which has been established in Japan. The DCs play central roles in deciding the direction of host immune reactions as well as antigen presentation. We have demonstrated that DCs treated with a streptococcal immune adjuvant OK-432, produce interleukin-12, induce Th1-dominant state, and elicit anti-tumor effects, more powerful than those treated with the known DCmaturating factors. We therefore decided to mature DCs by the OK-432 for making an effective DC vaccine, Vaccell. The 255 patients with inoperable pancreatic cancer who received standard chemotherapy combined with DC vaccines, were analyzed retrospectively. Survival time of the patients with positive delayed type hypersensitivity(DTH) skin reaction was significantly prolonged as compared with that of the patients with negative DTH. The findings strongly suggest that there may be 'Responders' for the DC vaccine in advanced pancreatic cancer patients. We next conducted a smallscale prospective clinical study. In this trial, we pulsed HLA class Ⅱ-restricted WT1 peptide(WT1-Ⅱ) in addition to HLA class Ⅰ-restricted peptide(WT1-Ⅰ) into the DCs. Survival of the patients received WT1-Ⅰ and-Ⅱ pulsed DC vaccine was significantly extended as compared to that of the patients received DCs pulsed with WT1-Ⅰ or WT1-Ⅱ alone. Furthermore, WT1-specific DTH positive patients showed significantly improved the overall survival as well as progressionfree survival as compared to the DTH negative patients. The activation of antigen-specific immune responses by DC vaccine in combination with standard chemotherapy may be associated with a good clinical outcome in advanced pancreatic cancer. We are now planning a pivotal study of the Vaccell in appropriate protocols in Japan. | Masato Okamoto Masanori Kobayashi Yoshikazu Yonemitsu Shigeo Koido Sadamu Homma | 2016 | World Journal of Gastrointestinal Pharmacology and Therapeutics2016，7，1： | 2 |
| 3 | Prognostic factors related to add-on dendritic cell vaccines on patients with inoperable pancreatic cancer receiving chemotherapy: a multicenter analysis显示文摘 | Masanori Kobayashi Shigetaka Shimodaira Kazuhiro Nagai Masahiro Ogasawara Hidenori Takahashi Hirofumi Abe Mitsugu Tanii Masato Okamoto Sun-ichi Tsujitani Seiichi Yusa Takefumi Ishidao Junji Kishimoto Yuta Shibamoto Masaki Nagaya Yoshikazu Yonemitsu | 2014 | Cancer Immunology, Immunotherapy2014，，： | 2 |
| 4 | Inhibitory activity of epigallocatechin gallate (EGCG)in paraquat-induced microsomal lipid peroxidation-a mechanism of protective effects of EGCG against paraquat toxicity显示文摘 | HIGUCHI A YONEMITSU K KOREEDA A | 2003 | Toxicology2003，183，13： | 1 |
| 5 | Preclinical and therapeutic utility of HVJ liposomes as a gene transfer vector for hepatocellular carcinoma using herpes simplex virus thymidine kinase显示文摘 | Hasegawa H Shimada M Yonemitsu Y | 2001 | Cancer Gene Ther2001，8，： | 1 |
| 6 | Troglitazone induces GIUT4 translocation in L6 myotubes 显示文摘 | Yonemitsu S Nishimura H Shintani M | 2001 | Diabetes2001，50，： | 1 |
| 7 | Evaluation of tran- scatheter arterial embolization with gelatin sponge parti- cles, microcoils, and n-butyl cyanoacrylate for acute arteri- al bleeding in a coagulopathic condition显示文摘 | Yonemitsu T Kawai N Sato M | 2009 | J Vasc Interv Radiol2009，20，9： | 1 |
| 8 | Efficacy of high-dose corti- costeroid in the early stage of viral acute liver failure 显示文摘 | Fujiwara K Yasui S Yonemitsu Y | 2013 | Hepatol Res2013，，： | 1 |
| 9 | Photoinduced polarization inversion in a polymeric molecule显示文摘 | Sun X Fu R L Yonemitsu K | 2000 | Phys Rev Lett2000，84，13： | 1 |
| 10 | Fibroblast growth factor-2 determines severity of joint disease in adjuvant-induced arthritis in rats显示文摘 | Yamashita A Yonemitsu Y Okano S | 2002 | J Immunol2002，168，1： | 1 |
| 11 | Giant cell reparative granuloma of the cranial vault显示文摘 | UCHINO A KATO A YONEMITSU N | 1996 | AJNR Am J Neuroradiol1996，17，： | 1 |
| 12 | Hemagglutinating virus of Japan-liposome-mediated gene transfer of endothelial nitric oxide synthase inhibits intimal hyperplasia of canine vein grafts under conditions of poor runoff显示文摘 | Matsumoto T Komori K Yonemitsu Y | 1998 | J Vasc Surg1998，27，： | 1 |
| 13 | Immunostimulatory vir- otherapy using recombinant Sendai virus as a new cancer thera- peutic regimen显示文摘 | Yonemitsu Y Ueda Y Kinoh H | 2008 | Front Biosci2008，13，： | 1 |
| 14 | Lobetyolin and lobetyol from hairy root culture of Lobelia inflate 显示文摘 | Ishimaru K Yonemitsu H Shimomura K | 1991 | Phytochemistry1991，30，7： | 1 |
| 15 | Platelet-derived growth factor-AA is an essential and autocrine regulator of vascular endothelial growth factor expression in non-small cell lung car- cinomas显示文摘 | Shikada Y Yonemitsu Y Koga T | 2005 | Cancer Res2005，65，16： | 1 |
| 16 | Nursing Professionalism:A national survey of professionalism among Japanese nurses显示文摘 | Tanaka M Yonemitsu Y Kawamoto R | 2014 | Int J Nurse Pract2014，20，6： | 1 |
| 17 | Cancer immunotherapy using dendritic cells: current status and perspective显示文摘 | Okano S Yonemitsu Y Suetishi K | 2007 | Fukuoka Igaku Zasshi2007，98，7： | 1 |
| 18 | Transfer of wil d-type p 53 gene effectively inhibits vascular smooth muscle cell proliferation in vitro and in vivo显示文摘 | Kaneda Y Tanaka S | 1998 | Circ Res1998，82，2： | 1 |
| 19 | Gene therapy for experimental critical limb ischemia:cceleration of limb loss by overexpression of VEGF165 but not of FGF-2显示文摘 | Masaki I Yonemitsu Y Yamashita A | 2002 | Circ Res2002，90，： | 1 |
| 20 | FGF-2 gene transfercan stimulate HGF expression,irrespective of hypoxia-mediated down regulation in ischemic limbs显示文摘 | Onimaru M Yonemitsu Y Tanii M | 2002 | Circ Res2002，91，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员