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| 1 | Major Depressive Disorder: Advances in Neuroscience Research and Translational Applications显示文摘Major depressive disorder(MDD),also referred to as depression,is one of the most common psychiatric disorders with a high economic burden.The etiology of depression is still not clear,but it is generally believed that MDD is a multifactorial disease caused by the interaction of social,psychological,and biological aspects.Therefore,there is no exact pathological theory that can independently explain its pathogenesis,involving genetics,neurobiology,and neuroimaging.At present,there are many treatment measures for patients with depression,including drug therapy,psychotherapy,and neuromodulation technology.In recent years,great progress has been made in the development of new antidepressants,some of which have been applied in the clinic.This article mainly reviews the research progress,pathogenesis,and treatment of MDD. | Zezhi Li Meihua Ruan Jun Chen Yiru Fang | 2021 | Neuroscience Bulletin2021，37，6： | 13 |
| 2 | The Relationship Between Neuroimmunity and Bipolar Disorder:Mechanism and Translational Application显示文摘Neuroimmune system may be involved in the pathological process of bipolar disorder(BD),but the essential association is not fully understood.Accumulating evidence has shown that BD involves the activation of immune cells and the release of inflammatory substances in the central nerve system(CNS).Meanwhile,neuroimmune responses also interact with other hypothesis of the etiology of BD that are widely recognized,such as neurotransmitter systems,neuroendocrine systems,neurotrophic factors,and oxidative stress.Simultaneously,related genes and immune changes in peripheral blood vary with it.Overall,neuroimmunity may play an important role in the pathogenesis of BD,and the inflammatory cytokines,especially interleukin-6 and tumor necrosis factor-alpha,have potential value for the clinical diagnosis and prognosis of BD,as well as predicting the therapeutic effects of drugs.Large-scale studies are needed to extend the evidence on neuroimmunity in BD,and to examine its clinical value for applications such as early prediction and treatment. | Zhiang Niu Lu Yang Xiaohui Wu Yuncheng Zhu Jun Chen Yiru Fang | 2019 | Neuroscience Bulletin2019，35，4： | 8 |
| 3 | The Risk and Prevention of Novel Coronavirus Pneumonia Infections Among Inpatients in Psychiatric Hospitals显示文摘Dear Editor,Since the middle of December 2019,human-to-human transmission of novel coronavirus pneumonia(NCP,also called COVID-19)has occurred among close contacts[1].After the outbreak on January 21,2020,it was swiftly included among the Class B infectious diseases stipulated in the Law of the People’s Republic of China on the Prevention and Control of Infectious Diseases,and measures for prevention and control of Class A infectious diseases were adopted.At 21:27 on February 12,2020,the China News Network updated information to include epidemic data from the National Health Commission and official channels in Hong Kong,Macao,and Taiwan regions:the highest death rate was in Wuhan City(Table 1).Overload of inpatients at hospitals may play a negative role in the overall therapeutic effect and contribute to the death rate. | Yuncheng Zhu Liangliang Chen Haifeng Ji Maomao Xi Yiru Fang Yi Li | 2020 | Neuroscience Bulletin2020，36，3： | 6 |
| 4 | Complement C7 is a novel risk gene for Alzheimer's disease in Han Chinese显示文摘Alzheimer's disease is the most common neurodegenerative disease,and has a high level of genetic heritability and population heterogeneity.In this study,we performed the whole-exome sequencing of Han Chinese patients with familial and/or early-onset Alzheimer's disease,followed by independent validation,imaging analysis and function characterization.We identified an exome-wide significant rare missense variant rs3792646(p.K420Q)in the C7 gene in the discovery stage(P=1.09×10^(-6),odds ratio=7.853)and confirmed the association in different cohorts and a combined sample(1615 cases and 2832 controls,P_(combined)=2.99×10^(-7),odds ratio=1.930).The risk allele was associated with decreased hippocampal volume and poorer working memory performance in early adulthood,thus resulting in an earlier age of disease onset.Overexpression of the mutant p.K420Q disturbed cell viability,immune activation and β-amyloid processing.Electrophysiological analyses showed that the mutant p.K420Q impairs the inhibitory effect of wild type C7 on the excitatory synaptic transmission in pyramidal neurons.These findings suggested that C7 is a novel risk gene for Alzheimer’s disease in Han Chinese. | Deng-Feng Zhang Yu Fan Min Xu Guihong Wang Dong Wang Jin Li Li-Li Kong Hejiang Zhou Rongcan Luo Rui Bi Yong Wu Guo-Dong Li Ming Li Xiong-Jian Luo Hong-Yan Jiang Liwen Tan Chunjiu Zhong Yiru Fang Chen Zhang Nengyin Sheng Tianzi Jiang Yong-Gang Yao | 2019 | National Science Review2019，6，2： | 6 |
| 5 | Impacts of exercise interventions on different diseases and organ functions in mice显示文摘Background'. In recent years, much evidence has emerged to indicate that exercise can benefit people when performed properly. This reviewsummarizes the exercise interventions used in studies involving mice as they are related to special diseases or physiological status. To furtherunderstand the effects of exercise interventions in treating or preventing diseases, it is important to establish a template for exercise interventionsthat can be used in future exercise-related studies.Methods'. PubMed was used as the data resource for articles. To identify studies related to the effectiveness of exercise interventions for treatingvarious diseases and organ functions in mice, we used the following search language: (exercise [Title] OR training [Title] OR physical activity[Title]) AND (mice [title/abstract] OR mouse [title/abstract] OR mus [title/abstract]). To limit the range of search results, we included 2 filters:one that limited publication dates to 'in 10 years,^ and one that sorted the results as 'best match^^. Then we grouped the commonly used exercisemethods according to their similarities and differences. We then evaluated the effectiveness of the exercise interventions for their impact on diseasesand organ functions in 8 different systems.Results'. A total of 331 articles were included in the analysis procedure. The articles were then segmented into 8 systems for which the exerciseinterventions were used in targeting and treating disorders: motor system (60 studies), metabolic system (45 studies), cardio-cerebral vascularsystem (58 studies), nervous system (74 studies), immune system (32 studies), respiratory system (7 studies), digestive system (1 study), and thesystem related to the development of cancer (54 studies). The methods of exercise interventions mainly involved the use of treadmills, voluntarywheel-running, forced wheel-running, swimming, and resistance training. It was found that regardless of the specific exercise method used, mostof them demonstrated positive effects on various systemic diseases and organ functions. Most diseases were remitted with exercise regardless ofthe exercise method used, although some diseases showed the best remission effects when a specific method was used.Conclusion-. Our review strongly suggests that exercise intervention is a cornerstone in disease prevention and treatment in mice. Because exerciseinterventions in humans typically focus on chronic diseases, national fitness, and body weight loss, and typically have low intervention com・pliance rates, it is important to use mice models to investigate the molecular mechanisms underlying the health benefits from exerciseinterventions in humans. | Shanshan Guo Yiru Huang Yan Zhang He Huang Shangyu Hong Tiemin Liu | 2020 | Journal of Sport and Health Science2020，9，1： | 5 |
| 6 | Atypical features and treatment choices in bipolar disorders:a result of the National Bipolar Mania Pathway Survey in China显示文摘In this study,we examined the point prevalence rate of atypical features in bipolar disorder,and estimated the potential impact of these features on treatment practices in China. Using the atypical features criteria of the Diagnostic and Statistical Manual of the American Psychiatric Association(DSM-IV),we documented the atypical symptoms in 3 906 consecutive participants with bipolar disorder enrolled at 26 psychiatric services across China. We further assessed the association between atypical features and the treatment approaches,including the prescription of antidepressants. The overall point prevalence rate of atypical features was 9.1% among patients with various bipolar disorder subtypes. When the definition was broadened to include atypical features B,the overall rate increased to 11.8%. Interestingly,among patients with the mixed state and remission subtypes,there was a significant difference in the rates of antidepressant medication usage between patients who met and those who did not meet the criteria for atypical features B. These fi ndings indicate a trend of using antidepressants for these two types of patients with atypical features. Further,for both mixed state and remission patients,treatment approaches were related to atypicalfeatures B. Our findings provide evidence to assist clinicians to readily recognize atypical features in bipolar subtypes and can propose treatments based on these diagnoses. | Daihui Peng Ting Shen Linda Byrne Chen Zhang Yueqi Huang Xin Yu Jingping Zhao Marita McCabe David Mellor Yiru Fang | 2015 | Neuroscience Bulletin2015，31，1： | 4 |
| 7 | Embedding lead halide perovskite quantum dots in carboxybenzene microcrystals improves stability显示文摘铅卤化物 perovskite 量点(PQD ) 的稳定性被在 carboxybenzene microcrystals 嵌入他们改进。结果塑造针的混合 microcrystals 保存了 PQD 的强壮的光致发光。与以前报导的包含聚苯乙烯的 PQD 相比, carboxybenzene 晶体是柔韧的并且保护了点免受潮湿和 photodegradation 的伤害。提高的稳定性被归因于 carboxybenzene microcrystals 的紧密的矩阵,它保护了 PQD 免受潮湿的伤害。这万用的策略保护了各种各样的 QD,包括所有无机的 PQD 和 chalcogenide QD (例如, CdSe/ZnS QD 和 CuInS/ZnS QD ) 。它提供保护 PQD 的一个灵巧、万用的方法并且可以启用应用在固态有象显示,激光,和轻射出二极管那样的高颜色质量要求的系统。 | Wei Xu Zhixiong Cai Feiming Li Jing Dong Yiru Wang Yaqi Jiang Xi Chen | 2017 | Nano Research2017，10，8： | 4 |
| 8 | Are subsyndromal symptomatic depression and major depressive disorder distinct disorders?显示文摘 | Zhenghui YI Yiru FANG | 2012 | 上海精神医学2012，24，5： | 4 |
| 9 | Scalable and facile synthesis of V_(2)O_(5) nanoparticles via ball milling for improved aerobic oxidative desulfurization显示文摘In recent years, transition-metal oxides(TMOs) have been long employed for aerobic oxidative desulfurization. However, the inherent bottlenecks, such as the low explosion of active sites, limit the application of bulk TMOs catalyst. In this study, V_(2)O_(5) nanoparticles with oxygen vacancies were prepared in large-scale via facile ball milling strategy with adding oxalic acid as a reducing agent. The as-prepared catalysts exhibit remarkable sulfur removal for oils with different initial S-concentrations and different substrates. Sulfur removal could reach up to 99.7%(< 2 ppm) under the optimized reaction conditions. This work provides a feasible desulfurization strategy for fuel oils. | Yiru Zou Chao Wang Hanxiang Chen Haiyan Ji Qian Zhu Wenshu Yang Linlin Chen Zhigang Chen Wenshuai Zhu | 2021 | Green Energy & Environment2021，6，2： | 4 |
| 10 | MICROSTRUCTURE OF INTERFACE BETWEEN HVOF SPRAYED WC-Co COATING AND SPRING STEEL SUBSTRATE显示文摘MICROSTRUCTUREOFINTERFACEBETWEENHVOFSPRAYEDWC-CoCOATINGANDSPRINGSTEELSUBSTRATE￥ShaoBeiling;LiuAnsheng;WangXiaohua;LiYonghong;... | Shao Beiling Liu Ansheng Wang Xiaohua Li Yonghong Zou Linying Wang Jing Zhang Jianguo Shi Changyong Zhou Yiru(General Research institute For Nonferrous Metals,Beijing 100088) | 1996 | 中国有色金属学会会刊:英文版1996，6，4： | 3 |
| 11 | Confined Ni-In intermetallic alloy nanocatalyst with excellent coking resistance for methane dry reforming显示文摘Carbon dioxide and methane are two main greenhouse gases which are contributed to serious global warming.Fortunately,dry reforming of methane(DRM),a very important reaction developed decades ago,can convert these two major greenhouse gases into value-added syngas or hydrogen.The main problem retarding its industrialization is the seriously coking formation upon the nickel-based catalysts.Herein,a series of confined indium-nickel(In-Ni)intermetallic alloy nanocatalysts(In_(x)Ni@SiO_(2))have been prepared and displayed superior coking resistance for DRM reaction.The sample containing 0.5 wt.%of In loading(In_(0.5)Ni@SiO_(2))shows the best balance of carbon deposition resistance and DRM reactivity even after 430 h long term stability test.The boosted carbon resistance can be ascribed to the confinement of core–shell structure and to the transfer of electrons from Indium to Nickel in In-Ni intermetallic alloys due to the smaller electronegativity of In.Both the silica shell and the increase of electron cloud density on metallic Ni can weaken the ability of Ni to activate C–H bond and decrease the deep cracking process of methane.The reaction over the confined InNi intermetallic alloy nanocatalyst was conformed to the Langmuir-Hinshelwood(L-H)mechanism revealed by in situ diffuse reflectance infrared Fourier transform spectroscopy(in-situ DRIFTS).This work provides a guidance to design high performance coking resistance catalysts for methane dry reforming to efficiently utilize these two main greenhouse gases. | Wenming Liu Le Li Sixue Lin Yiwei Luo Zhenghong Bao Yiru Mao Kongzhai Li Daishe Wu Honggen Peng | 2022 | Journal of Energy Chemistry2022，31，2： | 3 |
| 12 | Hypothalamic-Pituitary-End-Organ Axes:Hormone Function in Female Patients with Major Depressive Disorder显示文摘Classic hypothalamic-pituitary-end-organ feedback loops–the hypothalamic-pituitary-adrenal axis(HPAA),hypothalamic-pituitary-thyroidal axis(HPTA),and hypothalamic-pituitary-gonadal axis(HPGA)–are associated with the neuroendocrine and immune systems in major depressive disorder(MDD).Female patients with MDD present with evident neuroendocrine and immunological changes.Glucocorticoid,thyroid hormone,and reproductive steroid levels fluctuate with menstrual cycles,which might lead to glucocorticoid receptor resistance,impairment of triiodothyronine conversion,and sex hormone secretion disorders.In this review,we summarize the independent and interactive functions of these three axes in female MDD patients.The similar molecular structure of steroids implies an interrelationship between the hypothalamic-pituitary-end-organ axes and the competitive inhibitory effects at the receptor level,especially when considering the HPAA and HPGA. | Yuncheng Zhu Xiaohui Wu Rubai Zhou Oliver Sie Zhiang Niu Fang Wang Yiru Fang | 2021 | Neuroscience Bulletin2021，37，8： | 3 |
| 13 | Crashworthiness uncertainty analysis of typical civil aircraft based on Box–Behnken method显示文摘The crashworthiness is an important design factor of civil aircraft related with the safety of occupant during impact accident. It is a highly nonlinear transient dynamic problem and may be greatly influenced by the uncertainty factors. Crashworthiness uncertainty analysis is conducted to investigate the effects of initial conditions, structural dimensions and material properties. Simplified finite element model is built based on the geometrical model and basic physics phenomenon. Box–Behnken sampling and response surface methods are adopted to obtain gradient information.Results show that the proposed methods are effective for crashworthiness uncertainty analysis.Yield stress, frame thickness, impact velocity and angle have great influence on the failure behavior,and yield stress and frame thickness dominate the uncertainty of internal energy. Failure strain and tangent modulus have the smallest influence on the initial peak acceleration, and gradients of mean acceleration increase because the appearance of material plastic deformation and element failure. | Ren Yiru Xiang Jinwu | 2014 | Chinese Journal of Aeronautics2014，27，3： | 3 |
| 14 | Highly uniform ultrasound-sensitive nanospheres produced by a pH-induced micelle-to-vesicle transition for tumor-targeted drug delivery显示文摘尽管有高 echogenicity 的充满气体的 microbubbles 是广泛地应用的 inclinical ultrasonography,微米规模粒子尺寸在稳固的肿瘤的处理阻碍他们的使用,它对目标可存取不到几百纳米。我们此处建议包含导致 apH 的核心壳 micelle-to-vesicle 转变准备拥有多重特征的超声敏感的聚合 nanospheres (在结构的 polymersomes ) 的一条不平常的途径,包括进水的腔的一个阶段过渡的成像代理人的 nanosize, monodispersity,和加入。这些特征不经由为 polymersome 准备的常规双乳剂方法是可完成的。nanospheres 与双 pH 敏感基于新奇 triblock 共聚物被构造。外部低频率的超声导致的成像代理人的 liquid-to-gas 阶段转变可以为一个快速的药版本破坏 nanospheres,与在一个肿瘤内的同时的渗透织物的药交货。这些效果可以为有效癌症治疗的发展向新机会提供很少不利效果。 | Yiru Wang Tinghui Yin Zhenwei Su Chen Qiu Yong Wang Rongqin Zheng Meiwan Chen Xintao Shuai | 2018 | Nano Research2018，11，7： | 3 |
| 15 | Fabrication of Non-woven Fabric-Based SERS Substrate for Direct Detection of Pesticide Residues in Fruits显示文摘In surface-enhanced Raman scattering(SERS),flexible substrate plays an important role in target molecular collection from various shape surfaces and increases the analytical sensitivity.In this study,silver nanoparticles(Ag NPs)were deposited on a non-woven fabric used as an SERS substrate by self-assembly,in situ growing or the self-assembly/in situ growing combination method.4-Aminothiophenol was selected as a model molecular for the evaluation of the SERS performance using the substrates.The Ag NPs substrate prepared by self-assembly/in situ growing method presented the best Raman enhancement effect and its enhancement factor was estimated as high as 3.59106.The substrate was applied to the determination of four pesticide residues on the surfaces of fruit samples through wipe sampling,and the results revealed the good reproducibility of SERS responses and high detection sensitivity.The prepared flexible substrate was simple to fabricate and environmentally friendly.It could be expected to be a useful tool in rapid on-site test of pesticide residues on fruit surfaces because of its high sensitivity,convenience and non-destructive characteristics. | Lemei Cai Zhuo Deng Jing Dong Shidong Song Yiru Wang Xi Chen | 2017 | Journal of Analysis and Testing2017，1，4： | 3 |
| 16 | Exploring detailed urban-rural development under intersecting population growth and food production scenarios: Trajectories for China’s most populous agricultural province to 2030显示文摘Henan,China,is likely the most populous agricultural province worldwide.It is China’s major grain-producing area,with a continuously increasing population(96 million),which is greater than 93%of countries worldwide.However,this province has been experiencing unprecedented urbanization recently due to national policies and measures,such as a plan to build the capital city of Henan into a national center,resulting in severe conflicts in land use that endanger food security regionally and globally.To facilitate decision-making on this problem,we explored the detailed urban-rural development of Henan by modeling these land-use conflicts.Conventional modeling of a region’s urban-rural development is to navigate trade-offs(a)solely between different land-use types(b)by assuming that each type provides a single service(e.g.,croplands produce all the food),and(c)under a polynomial regression-based projection of population.In contrast,we considered both land-use type and intensity,resulting in a detailed land system for Henan.By introducing the concept of land system services(e.g.,food production),we established a many-to-many relationship between land system classes and services.These allowed us to carry out the most comprehensive modeling of Henan’s urban-rural development under eighteen combined scenarios of population growth and land-use policies on food production.The modeling results of these scenarios provide a solid basis for making decisions regarding Henan’s urban-rural development.We also revealed the influence mechanism of population growth,land-use policies,and their combinations,highlighting the benefits of securing food production by agricultural intensification rather than merely expanding the area of cropland. | GAO Peichao XIE Yiru SONG Changqing CHENG Changxiu YE Sijing | 2023 | Journal of Geographical Sciences2023，33，2： | 2 |
| 17 | GhKT2: a novel K^+ transporter gene in cotton(Gossypium hirsutum)显示文摘Potassium is an essential nutrient for plant growth and productivity of crops. K+transporters are important for K+uptake and transport in plants. However,information on the function of K+transporters and K+channels in cotton is limited. The KT/KUP/HAK protein family is essential for a variety of physiological processes in plants, including nutrient acquisition and regulation of development. This study, identified a K+transporter gene,Gh KT2, expressed in the roots of cotton(Gossypium hirsutum) cv. Liaomian17. The deduced transcript of Gh KT2 is highly homologous to Cluster II of KUP/HAK/KT K+transporters and is predicted to contain 11 transmembrane domains. Gh KT2 has been localized to the plasma membrane, and its transcripts were detected in roots, stems, leaves and shoot apices of cotton seedlings.Consistently, b-glucuronidase(GUS) expression driven by the Gh KT2 promoter could be detected in roots, mesophyll cells, and leaf veins in transgenic Arabidopsis. In addition,the expression of Gh KT2 was induced by low K+stress in cotton roots and p Gh KT2::GUS-transgenic Arabidopsis seedlings. The Gh KT2-overexpression Arabidopsis lines plants were larger and showed greater K+accumulation than the wild type(WT) regardless of K+concentration supplied. The net K+influx rate, measured by the noninvasive micro-test technique, in root meristem zone of Gh KT2-transgenic Arabidopsis lines was significantly greater than that of WT. Taken together, this evidence indicates that Gh KT2 may participate in K+acquisition from low or high external K+, as well as K+transport and distribution in plants. | Yiru WANG Juan XU Mingcai ZHANG Xiaoli TIAN Zhaohu LI | 2018 | Frontiers of Agricultural Science and Engineering2018，5，2： | 2 |
| 18 | Role of biological rhythm dysfunction in the development and management of bipolar disorders: a review显示文摘Disturbance of biological rhythms contributes to the onset of bipolar disorders and is an important clinical feature of the condition.To further explore the role of biological rhythms in bipolar disorders,95 English articles published between 1968 and 2019 were retrieved from the PubMed database and analysed.We herein review the outcomes of studies on biological rhythm disturbance in bipolar disorders,including the epidemiology,aetiology,clinical features(eg,sleep,feeding and eating disorders)and treatment of the condition evaluated by patients*selfreport and biological indicators such as melatonin.Our report supports the characterisation of biological rhythm disturbance as a significant clinical feature affecting the onset and development of bipolar disorders and reviews classical and novel treatments,such as chronotherapy,that can be applied in the clinical practice.Our analysis indicates that a more comprehensive study of the pathophysiology,clinical phenomenology and treatment of biological rhythm disturbance is required. | Yiming Chen Wu Hong Yiru Fang | 2020 | General Psychiatry2020，33，1： | 2 |
| 19 | Correction to: Major Depressive Disorder: Advances in Neuroscience Research and Translational Applications显示文摘Correction to:Neurosci.Bull.2021 http://gffzzd3cc09b8251d45dfs9bbqb9nwwuun6u9b.ffgz.tsg.suse.edu.cn/10.1007/sl2264-021-00638-3 The original version of this article unfortunately contained two mistakes.1.In the“Acknowledgements”,the“the National Basic Research”should be changed into“the National Key Research”. | Zezhi Li Meihua Ruan Jun Chen Yiru Fang | 2021 | Neuroscience Bulletin2021，37，6： | 2 |
| 20 | A novel trajectory planning strategy for aircraft emergency landing using Gauss pseudospectral method显示文摘To improve the survivability during an emergency situation, an algorithm for aircraft forced landing trajectory planning is proposed. The method integrates damaged aircraft modelling and trajectory planning into an optimal control framework. In order to deal with the complex aircraft flight dynamics, a solving strategy based on Gauss pseudospetral method(GPM) is presented.A 3-DOF nonlinear mass-point model taking into account the wind is developed to approximate the aircraft flight dynamics after loss of thrust. The solution minimizes the forced landing duration, with respect to the constraints that translate the changed dynamics, flight envelope limitation and operational safety requirements. The GPM is used to convert the trajectory planning problem to a nonlinear programming problem(NLP), which is solved by sequential quadratic programming algorithm. Simulation results show that the proposed algorithm can generate the minimum-time forced landing trajectory in event of engine-out with high efficiency and precision. | Shaohua MENG Jinwu XIANG Zhangping LUO Yiru REN Nanjian ZHUANG | 2014 | Control Theory and Technology2014，12，4： | 2 |
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