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| 1 | Proteomic analysis reveals distinctive protein profiles involved in CD8^(+) T cell-mediated murine autoimmune cholangitis显示文摘Autoimmune cholangitis arises from abnormal innate and adaptive immune responses in the liver,and T cells are critical drivers in this process.However,little is known about the regulation of their functional behavior during disease development.We previously reported that mice with T cell-restricted expression of a dominant negative form of transforming growth factor beta receptor type Ⅱ(dnTGFβ RII)spontaneously develop an autoimmune cholangitis that resembles human primary biliary cholangitis(PBC).Adoptive transfer of CD8^(+) but not CD4^(+) T cells into Rag1^(−/−)mice reproduced the disease,demonstrating a critical role for CD8^(+) T cells in PBC pathogenesis.Herein,we used SOMAscan technology to perform proteomic analysis of serum samples from dnTGFβRII and B6 control mice at different ages.In addition,we analyzed CD8 protein profiles after adoptive transfer of splenic CD8^(+) cells into Rag1^(−/−)recipients.The use of the unique SOMAscan aptamer technology revealed critical and distinct profiles of CD8 cells,which are key to biliary mediation.In total,254 proteins were significantly increased while 216 proteins were significantly decreased in recipient hepatic CD8^(+) cells compared to donor splenic CD8^(+) cells.In contrast to donor splenic CD8^(+) cells,recipient hepatic CD8^(+) cells expressed distinct profiles for proteins involved in chemokine signaling,focal adhesion,T cell receptor and natural killer cell-mediated cytotoxicity pathways. | Weici Zhang Ren Zhang Jun Zhang Ying Sun Patrick SC Leung Guo-Xiang Yang Zongwen Shuai William M Ridgway M Eric Gershwin | 2018 | Cellular & Molecular Immunology2018，15，8： | 3 |
| 2 | Analysis of Transformation Models with Censored Data显示文摘 | Wei LJ Ying Z | 1995 | Biometrika1995，83，： | 1 |
| 3 | Alpha2β1 integrin regulated lineage commitment in multipotent human colorectal cancer cells显示文摘 | Kirkland SC Ying H | 2008 | J Biol Chem2008，283，27： | 1 |
| 4 | Elucidation of a protease-sensitive site involved in the binding of calcium to C-reactive protein显示文摘 | Kinoshita CM Ying SC Hugli TE | | 0，，： | 1 |
| 5 | Prevention of HIV-1infection with early antiretroviral therapy显示文摘 | Myron SC Ying QC Marybeth M | 2011 | N Engl J Med2011，365，： | 1 |
| 6 | Regulating effects of novel CpG chitosan nanoparticles on immune responses of mice to porcine paratyphoid vaccines 显示文摘 | Fu ML Ying SC Wu M | 2012 | Biomed Environ Sci2012，19，： | 1 |
| 7 | Growth inhibition of human en- dothelial cells by the phyto-oestrogen biochanin A, a metabolite of genistein显示文摘 | YING C HSU JT SHIEH SC | 2001 | Br J Nutr2001，85，5： | 1 |
| 8 | A review of the current scientific and regulatory status of nanomedicines and the challenges ahead显示文摘 | Hock SC Ying YM Wah CL | 2011 | J Pharm Sci Technol2011，65，2： | 1 |
| 9 | Particle swarm optimi- zation for parameter determination and feature selection of support vector machines 显示文摘 | Lin SW Ying KC Chen SC | 2008 | Expert Systems with Appli- cations2008，35，4： | 1 |
| 10 | SAMHDI: a novel antiviral factor in intrinsic immunity显示文摘 | CHEN ZM ZHANG LJ YING SC | 2012 | Future Microbiol2012，7，9： | 1 |
| 11 | WNTSA exhibits tumor-suppressive activity through antagonizing the Wnt/ beta-catenin signaling, and is frequently methylated in eolorectal cancer 显示文摘 | Ying J Li H Yu J Ng KM Poon FF Wong SC | 2008 | Clin Cancer Res2008，14，1： | 1 |
| 12 | Particle swarm optirniza tion for parameter determination and feature selection of sup port vector machines显示文摘 | Lin SW Ying K C Chen SC | 2008 | Expert Systems with Applications2008，35，4： | 1 |
| 13 | Phenotypie heterogeneity and associations of two aldose reductase gene polymorphisms with ne- phropathy and retinopathy in type 2 diabetes 显示文摘 | Ying W Maggie CY Lee SC | 2003 | Diabetes Care2003，26，8： | 1 |
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