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您的检索式：作者名="Yesim Altay"
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| 1 | Endoscopic submucosal dissection for premalignant lesions and noninvasive early gastrointestinal cancers显示文摘AIM: To investigate the indication, feasibility, safety, and clinical utility of endoscopic submucosal dissection (ESD) in the management of various gastrointestinal pathologies. METHODS: The medical records of 60 consecutive patients (34 female, 26 male) who underwent ESD at the gastroenterology department of Kocaeli University from 2006-2010 were examined. Patients selected for ESDhad premalignant lesions or non-invasive early cancers of the gastrointestinal tract and had endoscopic and histological diagnoses. Early cancers were considered to be confined to the submucosa, with no lymph node involvement by means of computed tomography and endosonography. RESULTS: Sixty ESD procedures were performed. The indications were epithelial lesions (n = 39) (33/39 adenoma with high grade dysplasia, 6/39 adenoma with low grade dysplasia), neuroendocrine tumor (n = 7), cancer (n = 7) (5/7 early colorectal cancer, 2/7 early gastric cancer), granular cell tumor (n = 3), gastrointestinal stromal tumor (n = 2), and leiomyoma (n = 2). En bloc and piecemeal resection rates were 91.6% (55/60) and 8.3% (5/60), respectively. Complete and incomplete resection rates were 96.6% (58/60) and 3.3% (2/60), respectively. Complications were major bleeding [n = 3 (5%)] and perforations [n = 5 (8.3%)] (4 colon, 1 stomach). Two patients with colonic perforations and two patients with submucosal lymphatic and microvasculature invasion (1 gastric carcinoid tumor, 1 colonic adenocarcinoma) were referred to surgery. During a mean follow-up of 12 mo, 1 patient with adenoma with high grade dysplasia underwent a second ESD procedure to resect a local recurrence. CONCLUSION: ESD is a feasible and safe method for treatment of premalignant lesions and early malignant gastrointestinal epithelial and subepithelial lesions. Successful en bloc and complete resection of lesions yield high cure rates with low recurrence. | Sadettin Hulagu Omer Senturk Cem Aygun Orhan Kocaman Altay Celebi Tolga Konduk Deniz Koc Goktug Sirin Ugur Korkmaz Ali Erkan Duman Neslihan Bozkurt Gokhan Dindar Tan Attila Yesim Gurbuz Orhan TarcinDivision of Gastroenterology Derince State Hospital Kocaeli 41900 Turkey Cem Kalayci | 2011 | World Journal of Gastroenterology2011，17，13： | 23 |
| 2 | 糖尿病患者成功控制高血糖后中央角膜厚度的变化(英文)显示文摘目的:研究糖尿病患者中央角膜厚度与血糖浓度(糖化血红蛋白,HbA1c)的关系。方法:对52例HbA1c>7%的2型糖尿病患者行单中心、前瞻性临床试验。结果显示,平均随访6mo后,血糖浓度控制效果不佳。记录性别、病程,采用超声波测厚仪测量中央角膜厚度,取三次测量的平均值。患者在内分泌科门诊进行治疗。当HbA1c≤7%时,再次记录中央角膜厚度,并比较治疗前后的HbA1c水平和中央角膜厚度。结果:治疗前后平均中央角膜厚度分别为552.30±29.26μm和542.36±27.20μm,平均HbA1c水平分别为(9.36±1.79)%和(6.45±0.70)%,差异显著(P=0.0001,配对t检验)。结论:中央角膜厚度随HbA1c水平的降低(血糖控制良好)而显著下降,但高血糖和正常血糖患者中央角膜厚度平均值均在正常范围内。因此,在对糖尿病患者进行眼部检查时应注意HbA1c。 | Yesim Altay Ayse Burcu Firdevs Ornek | 2014 | 国际眼科杂志2014，14，4： | 1 |
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