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| 1 | The Flowering Repressor SVP Confers Drought Resistance in Arabidopsis by Regulating Abscisic Acid Catabolism显示文摘陆上的植物必须应付干旱应力幸存。在干旱应力下面,植物由增加它的生合成并且减少积累植物激素 abscisic 酸(骆驼毛的织物) 它的分解代谢。然而,响应干旱控制骆驼毛的织物分解代谢的规章的小径仍然保持大部分不清楚。这里,我们报导 flowering 抑压者短植物的阶段(SVP ) 被干旱应力和伙伴与 ABA 分解代谢小径基因 CYP707A1, CYP707A3 和 AtBG1 的倡导者区域导致,引起 CYP707A1 和 CYP707A3 的减少的表示但是在 Arabidopsis 的 AtBG1 的提高的表示离开。在 AtBG1 的 CYP707A1 和 CYP707A3 或 overexpression 的 Loss-of-function 变化能由增加细胞的骆驼毛的织物层次救 svp 异种植物的干旱过分敏感的显型。一起,我们的结果建议 SVP 是骆驼毛的织物分解代谢的一个中央管理者 ? 并且包含 SVP, CYP707A1/3,和 AtBG1 的一条规章的小径在植物反应起一个关键作用浇赤字和植物干旱抵抗。 | Zhen Wang Fuxing Wang Yechun Hong Juanjuan Yao Zhizhong Ren Huazhong Shi Jian-Kang Zhu | 2018 | Molecular Plant2018，11，9： | 12 |
| 2 | SIZ1-Mediated SUMOylation of ROS1 Enhances Its Stability and Positively Regulates Active DNA Demethylation in Arabidopsis显示文摘The 5-methylcytosine DNA glycosylase/lyase REPRESSOR OF SILENCING 1(ROS1)-mediated active DNA demethylation is critical for shaping the genomic DNA methylation landscape in Arabidopsis.Whether and how the stability of ROS1 may be regulated by post-translational modifications is unknown.Using a methylation-sensitive PCR(CHOP-PCR)-based forward genetic screen forArabidopsis DNA hyper-methyl-ation mutants,we identified the SUMO E3 ligase SIZ1 as a critical regulator of active DNA demethylation.Dysfunction of SIZ1 leads to hyper-methylation at approximately 1000 genomic regions.SIZ1 physically in-teracts with ROS1 and mediates the SUMOylation of ROS1.The SUMOylation of ROS1 is reduced in siz1 mutant plants.Compared with that in wild-type plants,the protein level of ROS1 is significantly decreased,whereas there is an increased level of ROS1 transcripts in siz1 mutant plants.Our results suggest that SIZ1-mediated SUMOylation of ROS1 promotes its stability and positively regulates active DNA demethylation. | Xiangfeng Kong Yechun Hong Yi-Feng Hsu Huan Huang Xue Liu Zhe Song Jian-Kang Zhu | 2020 | Molecular Plant2020，13，12： | 3 |
| 3 | The Arabidopsis spliceosomal protein SmEb modulates ABA responses by maintaining proper alternative splicing of HAB1显示文摘Abscisic acid(ABA)signaling is critical for seed germination and abiotic stress responses in terrestrial plants.PremRNA splicing is known to regulate ABA signaling.However,the involvement of canonical spliceosomal components in regulating ABA signaling is poorly understood.Here,we show that the spliceosome component Sm core protein SmEb plays an important role in ABA signaling.SmEb expression is up-regulated by ABA treatment,and analysis of Arabidopsis smeb mutant plants suggest that SmEb modulates the alternative splicing of the ABA signaling component HAB1 by enhancing the HAB1.1 splicing variant while repressing HAB1.2.Overexpression of HAB1.1 but not HAB1.2 rescues the ABA-hypersensitive phenotype of smeb mutants.Mutations in the transcription factor ABI3,4,or 5 also reduce the ABA hypersensitivity of smeb mutants during seed germination.Our results show that the spliceosomal component SmEb plays an important role in ABA regulation of seed germination and early seedling development. | Yechun Hong Juanjuan Yao Huazhong Shi Yunjuan Chen Jian-Kang Zhu Zhen Wang | 2021 | Stress Biology2021，1，1： | 1 |
| 4 | Natural variation in SlSOS2 promoter hinders salt resistance during tomato domestication显示文摘Increasing soil salinization seriously impairs plant growth and development,resulting in crop loss.The Salt-Overly-Sensitive(SOS)pathway is indispensable to the mitigation of Na+toxicity in plants under high salinity.However,whether natural variations of SOS2 contribute to salt tolerance has not been reported.Here a natural variation in the SlSOS2 promoter region was identified to be associated with root Na+/K+ratio and the loss of salt resistance during tomato domestication.This natural variation contains an ABI4-binding cis-element and plays an important role in the repression of SlSOS2 expression.Genetic evidence revealed that SlSOS2 mutations increase root Na+/K+ratio under salt stress conditions and thus attenuate salt resistance in tomato.Together,our findings uncovered a critical but previously unknown natural variation of SOS2 in salt resistance,which provides valuable natural resources for genetic breeding for salt resistance in cultivated tomatoes and other crops. | Yechun Hong Xijin Guan Xu Wang Dali Kong Shuojun Yu Zhiqiang Wang Yongdong Yu Zhen-Fei Chao Xue Liu Sanwen Huang Jian-Kang Zhu Guangtao Zhu Zhen Wang | 2023 | Horticulture Research2023，10，1： | 0 |
| 5 | The Sm core protein SmEb regulates salt stress responses through maintaining proper splicing of RCD1 pre-mRNA in Arabidopsis显示文摘Salt stress adversely impacts crop production.Several spliceosome components have been implicated in regulating salt stress responses in plants,however,the underlying molecular basis is still unclear.Here we report that the spliceosomal core protein SmEb is essential to salt tolerance in Arabidopsis.Transcriptome analysis showed that SmEb modulates alternative splicing of hundreds of pre-mRNAs in plant response to salt stress.Further study revealed that SmEb is crucial in maintaining proper ratio of two RCD1 splicing variants(RCD1.1/RCD1.2)important for salt stress response.In addition,RCD1.1 but not RCD1.2 is able to interact with the stress regulators and attenuates saltsensitivity by decreasing salt-induced cell death in smeb-1 mutant.Together,our findings uncovered the essential role of SmEb in the regulation of alternative pre-mRNA splicing in salt stress response. | Yechun Hong Yang Gao Jia Pang Huazhong Shi Tingting Li Huiying Meng Dali Kong Yunjuan Chen Jian-Kang Zhu Zhen Wang | 2023 | Journal of Integrative Plant Biology2023，65，6： | 0 |
| 6 | Lunasin peptide promotes lysosome-mitochondrial mediated apoptosis and mitotic termination in MDA-MB-231 cells显示文摘Lunasin,a novel bioactive peptide,is well-known for its anti-proliferation activity.However,the mechanism of this effect is still poorly reported.Here,synthesized lunasin was used and its anti-proliferative function was observed at the concentration of 0.25 mg/m L in human breast cancer cell MDA-MB-231.Conjoint analysis of transcriptome and proteome of MDA-MB-231 cells was further performed.The results demonstrated that cysteinyl aspartate specific proteinase(CASP)3,CASP 7,and CASP 14 were significantly up-regulated after lunasin exposure,together with an increased Bax/Bcl-2 ratio from 22.9 to 210.6,which indicated that caspase-mediated mitochondria intrinsic apoptosis was highly activated.Moreover,lysosomal pathway was signifi cantly suppressed under lunasin exposure,suggesting that lysosome may cooperate with mitochondria to participate in apoptosis.In addition,lunasin also down-regulated genes involved in DNA replication in MDA-MB-231 cells.Overall,our study reveals that the anti-proliferation effect of lunasin peptide might be triggered via the inhibition of DNA replication and cell mitosis,as well as the promotion of lysosome-mitochondrial mediated cell apoptosis. | Yuqiong Hao Huimin Guo Yechun Hong Xin Fan Yumei Su Xiushi Yang Guixing Ren | 2022 | Food Science and Human Wellness2022，11，6： | 0 |
| 7 | SUMO E3 ligase SIZ1 negatively regulates arsenite resistance via depressing GSH biosynthesis in Arabidopsis显示文摘Arsenic is a metalloid toxic to plants,animals and human beings.Small ubiquitin-like modifier(SUMO)conjugation is involved in many biological processes in plants.However,the role of SUMOylation in regulating plant arsenic response is still unclear.In this study,we found that dysfunction of SUMO E3 ligase SIZ1 improves arsenite resistance in Arabidopsis.Overexpression of the dominant-negative SUMO E2 variant resembled the arsenite-resistant phenotype of siz1 mutant,indicating that SUMOylation plays a negative role in plant arsenite detoxification.The siz1 mutant accumulated more glutathione(GSH)than the wild type under arsenite stress,and the arsenite-resistant phenotype of siz1 was depressed by inhibiting GSH biosynthesis.The transcript levels of the genes in the GSH biosynthetic pathway were increased in the siz1 mutant comparing with the wild type in response to arsenite treatment.Taken together,our findings revealed a novel function of SIZ1 in modulating plant arsenite response through regulating the GSH-dependent detoxification. | Yechun Hong Yunjuan Chen Huazhong Shi Xiangfeng Kong Juanjuan Yao Mingguang Lei Jian-Kang Zhu Zhen Wang | 2022 | Stress Biology2022，2，1： | 0 |
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