| 1 | MicroRNA-140 regulates cell growth and invasion in pancreatic duct adenocarcinoma by targeting iASPP显示文摘MicroRNAs 是从在经由绑定调整蛋白质表示水平到 mRNA 起重要作用的 RNA 发卡结构处理的 22 核苷酸 RNA,也压制它的翻译或加快它的降级。在人,他们调整很编码蛋白质的基因,包括在癌症和另外的疾病重要的基因。在这研究, microRNA-140 (miR-140 ) 的表示被表明显著地在胰腺的管腺癌标本和房间线被压制,与他们的邻近的正常纸巾相比。在生物信息学分析的帮助下, p53 (iASPP ) 的刺激 apoptosis 蛋白质的禁止者被识别是 miR-140 的一个直接目标,并且酶记者实验证实了这发现。miR-140 的 Overexpression 减少 iASPP, Np63, MMP2,和 MMP9 的蛋白质表情。PANC-1 房间的生长和侵略被 miR-140 的 overexpression 在 vitro 稀释。PANC-1 房间线上的 miR-140 的镇压效果能被 iASPP 的用手的 overexpression 部分外面平衡。首先,这些调查结果提供了卓见进 miR-140 的功能的机制,建议 miR-140/iASPP 轴可以防碍 proliferative 和胰腺的管腺癌房间的侵略性质,并且显示 miR-140 能是为胰腺的管腺癌的一个潜在的治疗学的目标。 | Shuai Liang Xuejun Gong Gewen Zhang Gengwen Huang Yebin Lu Yixiong Li | 2016 | Acta Biochimica et Biophysica Sinica2016，48，2： | 4 |
| 2 | An Investigation Report on Production Conditions of Sugarcane in Guangxi in 2016显示文摘To predict and assess production conditions of sugarcane in Guangxi in 2016,by using methods of field survey and data collection,the seedling situation,breed structure,planting area,planting period,plant diseases and insect pests of sugarcane in six major sugarcane producing cities of Guangxi were surveyed. The results show that the overall situation of sugarcane seedlings in Guangxi in 2016 became slightly worse than that in 2015,but there were enough good sugarcane seedlings in 2016. The dead heart rate of sugarcane decreased in most sugarcane regions from 2015 to 2016,that is,the comprehensive control of borers gave initial results; the smut infection rate of sugarcane rose from 2015 to 2016 and tended to increase. The situation of decrease in the planting area of sugarcane in three consecutive years was controlled,and the planting area of sugarcane increased slightly from 2015 to 2016. Due to the construction of ' double high' bases,the breed variety of sugarcane in Guangxi was improved further in 2016. It is necessary to strengthen field management and conduct chemical weeding,prevention and control of borers and aphids in the later period in time. | Yuchi DENG Weizan WANG RonghuaZHANG Shiyun TANG Shanhai LIN Qiang LIANG Weixing DUAN Xiang LI Guoying LU Shijian HAN Youzong HUANG Yebin YANG Yanni HUANG Lunwang WANG | 2017 | Asian Agricultural Research2017，9，6： | 0 |
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