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您的检索式：作者名="Yaxiao Gong"
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| 1 | Acute high-altitude hypoxic brain injury Identification of ten differential proteins显示文摘Hypobaric hypoxia can cause severe brain damage and mitochondrial dysfunction,and is involved in hypoxic brain injury.However,little is currently known about the mechanisms responsible for mitochondrial dysfunction in hypobaric hypoxic brain damage.In this study,a rat model of hypobaric hypoxic brain injury was established to investigate the molecular mechanisms associated with mitochondrial dysfunction.As revealed by two-dimensional electrophoresis analysis,16,21,and36 differential protein spots in cerebral mitochondria were observed at 6,12,and 24 hours post-hypobaric hypoxia,respectively.Furthermore,ten protein spots selected from each hypobaric hypoxia subgroup were similarly regulated and were identified by mass spectrometry.These detected proteins included dihydropyrimidinase-related protein 2,creatine kinase B-type,isovaleryl-CoA dehydrogenase,elongation factor Ts,ATP synthase beta-subunit,3-mercaptopyruvate sulfurtransferase,electron transfer flavoprotein alpha-subunit,Chain A of 2-enoyl-CoA hydratase,NADH dehydrogenase iron-sulfur protein 8 and tropomyosin beta chain.These ten proteins are all involved in the electron transport chain and the function of ATP synthase.Our findings indicate that hypobaric hypoxia can induce the differential expression of several cerebral mitochondrial proteins,which are involved in the regulation of mitochondrial energy production. | Jianyu Li Yuting Qi Hui Liu Ying Cui Li Zhang Haiying Gong Yaxiao Li Lingzhi Li Yongliang Zhang | 2013 | Neural Regeneration Research2013，8，31： | 6 |
| 2 | Parvifoline AA靶向Peroxiredoxins Ⅰ/Ⅱ激活NK细胞介导的肝脏肿瘤免疫显示文摘文章简介诸多临床研究已证实肿瘤免疫治疗可改善肿瘤患者的预后,显著延长患者的生存期。自然杀伤细胞(NK)是重要的免疫细胞类群,其表面的活化型受体NKG2D与肿瘤细胞表面对应配体的相互作用对于NK细胞执行早期肿瘤免疫监视非常重要。 | 朱惠芳 王彬 Lingmei Kong Tao An Gentao Li Hongyu Zhou Liang Gong Zhangxun Zhao Yaxiao Gong Handong Sun 普诺·白玛丹增 李艳 | 2020 | 科学新闻2020，，2： | 0 |
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