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| 1 | Far-field super-resolution imaging by nonlinearly excited evanescent waves显示文摘Abbe’s resolution limit,one of the best-known physical limitations,poses a great challenge for any wave system in imaging,wave transport,and dynamics.Originally formulated in linear optics,the Abbe limit can be broken using nonlinear optical interactions.We extend the Abbe theory into a nonlinear regime and experimentally demonstrate a far-field,label-free,and scan-free super-resolution imaging technique based on nonlinear four-wave mixing to retrieve near-field scattered evanescent waves,achieving a sub-wavelength resolution ofλ∕5.6.This method paves the way for numerous new applications in biomedical imaging,semiconductor metrology,and photolithography. | Zhihao Zhou Wei Liu Jiajing He Lei Chen Xin Luo Dongyi Shen Jianjun Cao Yaping Dan Xianfeng Chen Wenjie Wan | 2021 | Advanced Photonics2021，3，2： | 6 |
| 2 | Progesterone Enhances Immunoregulatory Activity of Human Mesenchymal Stem Cells Via PGE 2 and IL ‐6显示文摘 | Xiaoyin Zhao Liu Liu Dan Liu Hongye Fan Yaping Wang Yali Hu Yayi Hou | 2012 | Am J Reprod Immunol2012，，： | 1 |
| 3 | Progesterone Enhances Immunoregulatory Activity of Human Mesenchymal Stem Cells Via PGE 2 and IL ‐6显示文摘 | Xiaoyin Zhao Liu Liu Dan Liu Hongye Fan Yaping Wang Yali Hu Yayi Hou | 2012 | Am J Reprod Immunol2012，，4： | 1 |
| 4 | The composition study of silicon oxynitride prepared by PECVD 显示文摘 | Dan Yaping Yue Ruifeng Wang Yan | 2001 | ICSICT2001，，6： | 1 |
| 5 | Activating transcription factor 4 increases chemotherapeutics resistance of human hepatocellular carcinoma显示文摘 | Zhuhong Zhang Jing Yin Chunyan Zhang Ning Liang Nan Bai Antao Chang Yanhua Liu Zongjin Li Xiaoyue Tan Na Li Dan Lv Rong Xiang Yaping Tian Chenghu Liu | 2012 | Cancer Biology & Therapy2012，，6： | 1 |
| 6 | Identification of liver metastasis-associated genes in human colon carcinoma by mRNA profiling显示文摘Objective: Liver metastasis,which contributes substantially to high mortality,is the most common recurrent mode of colon carcinoma.Thus,it is necessary to identify genes implicated in metastatic colonization of the liver in colon carcinoma.Methods: We compared mRNA profiling in 18 normal colon mucosa(N),20 primary tumors(T) and 19 liver metastases(M) samples from the dataset GSE49355 and GSE62321 of Gene Expression Omnibus(GEO) database.Gene ontology(GO) and pathways of the identified genes were analyzed.Co-expression network and proteinprotein interaction(PPI) network were employed to identify the interaction relationship.Survival analyses based on The Cancer Genome Atlas(TCGA) database were used to further screening.Then,the candidate genes were validated by our data.Results: We identified 22 specific genes related to liver metastasis and they were strongly associated with cell migration,adhesion,proliferation and immune response.Simultaneously,the results showed that C-X-C motif chemokine ligand 14(CXCL14) might be a favorable prediction factor for survival of patients with colon carcinoma.Importantly,our validated data further suggested that lower CXCL14 represented poorer outcome and contributed to metastasis.Gene set enrichment analysis(GSEA) showed that CXCL14 was negatively related to the regulation of stem cell proliferation and epithelial to mesenchymal transition(EMT).Conclusions: CXCL14 was identified as a crucial anti-metastasis regulator of colon carcinoma for the first time,and might provide novel therapeutic strategies for colon carcinoma patients to improve prognosis and prevent metastasis. | Jianling Liu Dan Wang Chaoqi Zhang Zhen Zhang Xinfeng Chen Jingyao Lian Jinbo Liu Guixian Wang Weitang Yuan Zhenqiang Sun Weijia Wang Mengjia Song Yaping Wang Qian Wu Ling Cao Dong Wang Yi Zhang | 2018 | Chinese Journal of Cancer Research2018，30，6： | 1 |
| 7 | Smart drug delivery systems to overcome drug resistance in cancer immunotherapy显示文摘Cancer immunotherapy,a therapeutic approach that inhibits tumors by activating or strengthening anti-tumor immunity,is currently an important clinical strategy for cancer treatment;however,tumors can develop drug resistance to immune surveillance,resulting in poor response rates and low therapeutic efficacy.In addition,changes in genes and signaling pathways in tumor cells prevent susceptibility to immunotherapeutic agents.Furthermore,tumors create an immunosuppressive microenvironment via immunosuppressive cells and secrete molecules that hinder immune cell and immune modulator infiltration or induce immune cell malfunction.To address these challenges,smart drug delivery systems(SDDSs)have been developed to overcome tumor cell resistance to immunomodulators,restore or boost immune cell activity,and magnify immune responses.To combat resistance to small molecules and monoclonal antibodies,SDDSs are used to co-deliver numerous therapeutic agents to tumor cells or immunosuppressive cells,thus increasing the drug concentration at the target site and improving efficacy.Herein,we discuss how SDDSs overcome drug resistance during cancer immunotherapy,with a focus on recent SDDS advances in thwarting drug resistance in immunotherapy by combining immunogenic cell death with immunotherapy and reversing the tumor immunosuppressive microenvironment.SDDSs that modulate the interferon signaling pathway and improve the efficacy of cell therapies are also presented.Finally,we discuss potential future SDDS perspectives in overcoming drug resistance in cancer immunotherapy.We believe that this review will contribute to the rational design of SDDSs and development of novel techniques to overcome immunotherapy resistance. | Wenzhe Yi Dan Yan Dangge Wang Yaping Li | 2023 | Cancer Biology & Medicine2023，20，4： | 1 |
| 8 | Size-selec- tive nanoparticle growth on few-layer graphene films显示文摘 | Luo Zhengtang Somers Luke A Dan Yaping | 2010 | Nano Lett2010，10，3： | 1 |
| 9 | The red deer antler:Bioinspired design of an Al-Si composite with a fenestrated network-particle structure显示文摘Conventional Al-Si materials always have a coarse and discontinuous Si structure,which limits their application as thermal management materials.Fortunately,nature has evolved efficient strategies to form complex microstructures that exhibit excellent wear resistance and thermal properties;one such example is found in the red deer antler.Here,inspired by the antler structure,AleSi composites with a novel fenestrated network-particle structure(F-N)and with a common isolated island structure(I-I)are designed and prepared.Subsequently,the dynamic formation of F-N is tracked and studied using computational fluid dynamics(CFD)simulation.To investigate the reinforcement mechanisms of F-N,the wear resistances and thermal properties of F-N and I-I are compared and analyzed.Simulation and experimental results show that the reconstruction of a semi-continuous structure promotes the formation of a striated structure,whereas flowing Si particles provide some sites for the formation of the fenestrated structure.The dynamic formation of F-N is strongly influenced by the convectionediffusion process and the flow path.Moreover,this biomimetic F-N structure exhibits better wear resistance and thermal properties than I-I,owing to its strong structural support and high expansion resistance.This work is expected to provide new perspectives on the microstructural design of thermal management materials with good wear resistance. | Zhe Wang Yanjun Zhang Song Jiang Jun Wang Dan Du Xueliang Wang Yaping Wang | 2020 | Journal of Materiomics2020，6，3： | 1 |
| 10 | Stimulated emission at 1.54 μm from erbium/oxygen-doped silicon-based light-emitting diodes显示文摘Silicon-based light sources, including light-emitting diodes(LEDs) and laser diodes(LDs) for information transmission, are urgently needed for developing monolithic integrated silicon photonics. Silicon with erbium ions(Er^(3+)) doped by ion implantation is considered a promising approach, but it suffers from an extremely low quantum efficiency. Here we report an electrically pumped superlinear emission at 1.54 μm from Er/O-doped silicon planar LEDs, which are produced by applying a new deep cooling process. Stimulated emission at room temperature is realized with a low threshold current of ~6 mA(~0.8 A∕cm^(2)). Time-resolved photoluminescence and photocurrent results have revealed the complex carrier transfer dynamics by relaxing electrons from the Si conduction band to the Er^(3+) ion. This picture differs from the frequently assumed energy transfer via electron–hole pair recombination of the silicon host. Moreover, the amplified emission from the LEDs is likely due to a quasi-continuous Er/O-related donor band created by the deep cooling technique. This work paves the way for fabricating superluminescent diodes or efficient LEDs at communication wavelengths based on rare-earth-doped silicon. | JIN HONG HUIMIN WEN JIAJING HE JINGQUAN LIU YAPING DAN JENS W.TOMM FANGYU YUE JUNHAO CHU CHUNGANG DUAN | 2021 | Photonics Research2021，9，5： | 0 |
| 11 | Neuroprotection of a cocktail therapy involving anti-intercellular adhesion molecule 1 antibody and insulin-like growth factor 1 in treatment of cerebral ischemia/reperfusion injury in cats Nuclear magnetic resonance examination and pathological validatio显示文摘BACKGROUND: The pathophysiological mechanisms of ischemia are extremely complicated. It is difficult to confirm and maintain the therapeutic effects if only one neuroprotective agent is used. It is hypothesized that a cocktail therapy involving a combined application of neuroprotective agents is feasible and offers excellent therapeutic potential. OBJECTIVE: To evaluate the neuroprotective effects of a cocktail therapy of insulin-like growth factor 1 (IGF1) combined with anti-intercellular adhesion molecule 1 (ICAM1) antibody in the treatment of cerebral ischemia/reperfusion injury using medical imaging, pathology, and functional neurological deficit scoring techniques. DESIGN, TIME AND SETTING: This randomized, controlled, neuroimaging analysis of function and pathological observation was performed at the Laboratory of Molecular Imaging, Second Hospital, Hebei Medical University between September 2006 and December 2007. MATERIALS: Transient middle cerebral artery occlusion (MCAO) was induced in 24 healthy adult cats. Anti-ICAM1 antibody and IGF1 were sourced from the Shanghai Kangcheng Biological Product Co., Ltd., China. Stereotaxic apparatus was purchased from the Center for Medical Apparatus and Instruments, Shandong Liaocheng People’s Hospital, China. The in situ apoptosis kit was provided by the Beijing Zhongshan Biotechnique Co., Ltd., China. METHODS: Twenty-four cat models of MCAO were randomly divided into four groups (n = 6): control, IGF1, anti-ICAM1 antibody and cocktail therapy. Following a 2-hour ischemia and subsequent lateral cerebral ventricular puncture, 100 μg IGF1(cerebral ventricular), 100 μg anti-ICAM1 antibody (i.v.), 50 μg IGF1(lateral cerebral ventricular) + 50 μg anti-ICAM1 antibody (i.v.), and 100 μg physiological saline (i.v.) were administered to the IGF1, anti-ICAM1 antibody, cocktail therapy and control groups, respectively. On the following day, the same administration was performed again. MAIN OUTCOME MEASURES: Pathological observation of the cerebral dura mater tissue surrounding the MCAO target site was performed by electron microscopy. At days 3 and 7 following MCAO induction, the volume of the cerebral infarction was measured by Philips functional neurological deficit scoring and nuclear magnetic resonance imaging. RESULTS: Pathological observation revealed that the control group exhibited a great number of swollen neurons, glial cells and vascular endothelial cells, and showed severely injured mitochondria with an absence of the double membrane structure. The same phenomena were partially alleviated in the IGF1 and anti-ICAM1 antibody groups, and the most obvious alleviation of injuries was in the cocktail therapy group. At day 6 following MCAO establishment, the cocktail therapy group exhibited the smallest cerebral infarction volumes among the four groups (F = 71.322, P < 0.01). At days 3 and 7 following MCAO induction, the F value of Philips functional neurological deficit scoring was 10.398 and 14.430, respectively (P < 0.01); however, the best neurological functional recovery was in the cocktail therapy group. CONCLUSION: A cocktail therapy of IGF1 combined with anti-ICAM1 antibody produces better neuroprotective effects than IGF1 or anti-ICAM1 alone, as judged by injury to mitochondria and swelling in and around neurons and glial cells. | Huaijun Liu Liqun Yan Yaping Hou Shuochun Wu Dan He Linfang Li Yankai Wu BoyuanHuang Fei Yang | 2008 | Neural Regeneration Research2008，3，12： | 0 |
| 12 | 代谢成像揭示白血病起始细胞归巢于骨内膜微环境并有效对称分裂的独特偏好显示文摘文章简介白血病起始细胞(leukemia-initiatingcells,LICs)在不同骨髓微环境中的代谢特征及其与细胞命运决定的关系尚不清楚。研究团队利用遗传编码的高度灵敏的NADH/NAD+代谢感受器(So Nar)标记和指示小鼠和患者白血病细胞代谢状态,构建了实时在体代谢成像体系,并阐明了白血病细胞中存在明显的代谢异质性。 | Xiaoxin Hao Hao Gu Chiqi Chen Dan Huang Yuzheng Zhao Li Xie Yejun Zou Hui Sophie Shu Yaping Zhang Xiaoxiao He Xiaoyun Lai Xiaocui Zhang Bo OZhou Cheng Cheng Zhang Guo-Qiang Chen 于卓 杨弋 郑俊克 | 2020 | 科学新闻2020，，2： | 0 |
| 13 | Ambient Temperature is A Strong Selective Factor Influencing Human Development and Immunity显示文摘Solar energy,which is essential for the origin and evolution of all life forms on Earth,can be objectively recorded through attributes such as climatic ambient temperature(CAT),ultraviolet radiation(UVR),and sunlight duration(SD).These attributes have specific geographical variations and may cause different adaptation traits.However,the adaptation profile of each attribute and the selective role of solar energy as a whole during human evolution remain elusive.Here,we performed a genome-wide adaptation study with respect to CAT,UVR,and SD using the Human Genome Diversity Project-Centre Etude Polymorphism Humain(HGDP-CEPH)panel data.We singled out CAT as the most important driving force with the highest number of adaptive loci(6 SNPs at the genome-wide 1×10^(-7)level;401 at the suggestive 1×10^(-5)level).Five of the six genomewide significant adaptation SNPs were successfully replicated in an independent Chinese population(N=1395).The corresponding 316 CAT adaptation genes were mostly involved in development and immunity.In addition,265(84%)genes were related to at least one genome-wide association study(GWAS)-mapped human trait,being significantly enriched in anthropometric loci such as those associated with body mass index(χ^(2);P<0.005),immunity,metabolic syndrome,and cancer(χ^(2);P<0.05).For these adaptive SNPs,balancing selection was evident in Euro-Asians,whereas obvious positive and/or purifying selection was observed in Africans.Taken together,our study indicates that CAT is the most important attribute of solar energy that has driven genetic adaptation in development and immunity among global human populations.It also supports the non-neutral hypothesis for the origin of disease-predisposition alleles in common diseases. | Lindan Ji Dongdong Wu Haibing Xie Binbin Yao Yanming Chen David M.Irwin Dan Huang Jin Xu Nelson L.S.Tang Yaping Zhang | 2020 | Genomics, Proteomics & Bioinformatics2020，18，5： | 0 |
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