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| 1 | Cross-sectional rainfall observation on the central-western Tibetan Plateau in the warm season:System design and preliminary results显示文摘The central and western Tibetan Plateau(CWTP)is characterized by harsh environment and strong interactions among the spheres of earth as well as significant changes in climate and water cycles over the past four decades.The lack of precipitation observations is a bottleneck for the study of land surface processes in this region.Over the past six years,we have designed and established two observation transects across the south-north and the west-east in this region to obtain hourly rainfall data during the warm season(May-September).The south-north transect extends from Yadong Valley on the southern slope of the Himalayas to Shuanghu County in the hinterland of the plateau,with a total of 31stations;the west-east transect extends from Shiquanhe in the west to Naqu in the central TP,with a total of 22 stations.The observation dataset has been applied to clarify the spatiotemporal characteristics of precipitation in the CWTP,to evaluate the quality of typical gridded precipitation products,to support the development of regional climate models,and to reveal the processes of summertime lake-air interactions.The observation dataset has been released in the National Tibetan Plateau Data Center. | Kun YANG Yingying CHEN Lazhu Changhui ZHAN Xiaoyan LING Xu ZHOU Yaozhi JIANG Xiangnan YAO Hui LU Xiaogang MA Lin OUYANG Weihao PAN Yanghang REN Changkun SHAO Jiaxin TIAN Yan WANG Hua YANG Siyu YUE Ke ZHANG Dingchi ZHAO Long ZHAO Jianhong ZHOU Mijun ZOU | 2023 | Science China Earth Sciences2023，66，5： | 0 |
| 2 | SHANGHAI WARD FOR WEIGHT LOSS USES TRADITIONAL CHINESE MEDICINE显示文摘A weight-loss clinic which uses traditional Chinese medicine was set up at the Xiangshan Hospital of Traditional Chinese Medicine in Shanghai. In addition to doing exercises, patients receive a treatment of rhubarb that is applied externally or taken orally to lose weight. | ZHANG YAOZHI | 1994 | Women of China1994，，4： | 0 |
| 3 | China's Young Journalists Make Headlines显示文摘A few years ago, the 'Guinness Book of World Records' reported that 'Little Masters' in Shanghai had the largest circulation of any children’s newspaper in the world. At the time of the announcement, the newspaper’s circulation was 500,000.Today, its circulation is over one million. | ZHANG YAOZHI | 1994 | Women of China1994，，6： | 0 |
| 4 | White-collar Ladies in Beijing and Shanghai显示文摘Wang Huan, assistant to the general manager, describes Beijing’s tourist attractions to foreign friends at the International Tourism Business Fair in Germany. | ZHANG YAOZHI ZHANG PING ZHOU HONGMING | 1995 | Women of China1995，，12： | 0 |
| 5 | Society Hugs Them显示文摘Han Zhen, Han Xing, Han Ning and Han Xia were born on April 20, 1994, in Lingwu, Ningxia Hui Autonomous Region. (The combination of their names means 'rejuvenating Ningxia. ') | ZHANG YAOZHI | 1997 | Women of China1997，，11： | 0 |
| 6 | Mettl13 protects against cardiac contractile dysfunction by negatively regulating C-Cbl-mediated ubiquitination of SERCA2a in ischemic heart failure显示文摘Ischemic heart failure(HF)remains a leading cause of morbidity and mortality.Maintaining homeostasis of cardiac function and preventing cardiac remodeling deterioration are critical to halting HF progression.Methyltransferase-like protein 13(Mettl13)has been shown to regulate protein translation efficiency by acting as a protein lysine methyltransferase,but its role in cardiac pathology remains unexplored.This study aims to characterize the roles and mechanisms of Mettl13 in cardiac contractile function and HF.We found that Mettl13 was downregulated in the failing hearts of mice post-myocardial infarction(MI)and in a cellular model of oxidative stress.Cardiomyocyte-specific overexpression of Mettl13 mediated by AAV9-Mettl13 attenuated cardiac contractile dysfunction and fibrosis in response to MI,while silencing of Mettl13 impaired cardiac function in normal mice.Moreover,Mettl13 overexpression abrogated the reduction in cell shortening,Ca^(2+)transient amplitude and SERCA2a protein levels in the cardiomyocytes of adult mice with MI.Conversely,knockdown of Mettl13 impaired the contractility of cardiomyocytes,and decreased Ca^(2+)transient amplitude and SERCA2a protein expression in vivo and in vitro.Mechanistically,Mettl13 impaired the stability of c-Cbl by inducing lysine methylation of c-Cbl,which in turn inhibited ubiquitination-dependent degradation of SERCA2a.Furthermore,the inhibitory effects of knocking down Mettl13 on SERCA2a protein expression and Ca^(2+)transients were partially rescued by silencing c-Cbl in H_(2)O_(2)-treated cardiomyocytes.In conclusion,our study uncovers a novel mechanism that involves the Mettl13/c-Cbl/SERCA2a axis in regulating cardiac contractile function and remodeling,and identifies Mettl13 as a novel therapeutic target for ischemic HF. | Shuting Yu ZhiYong Sun Xiuzhu Wang Tiantian Ju Changhao Wang Yingqi Liu Zhezhe Qu KuiWu Liu Zhongting Mei Na Li Meixi Lu Fan Wu Min Huang Xiaochen Pang Yingqiong Jia Ying Li Yaozhi Zhang Shunkang Dou Jianhao Jiang Xin Li Baofeng Yang Weijie Du | 2023 | Science China(Life Sciences)2023，66，12： | 0 |
| 7 | Investigation and analysis of psychological stress among non-severe COVID-19 patients显示文摘The coronavirus disease 2019(COVID-19)outbreak continues to spread rapidly around the world.By the end of 2020,there have been nearly 80 million confirmed cases and over 1.7 million deaths associated with COVID-19 globally(http://gffzz36b398b81f8a4a4cs0knffo5cvvbw655p.ffgz.tsg.suse.edu.cn/emergencies/diseases/novel-coronavirus-2019),with an estimated mortality rate of 0.03%–40%(Wiersinga et al.,2020).Noticeably,the COVID-19 is predicted to threaten millions of people throughout the world in the coming months and years. | Xiangmin Liu Feng Wang Huanhuan Li Yaozhi Zhang Lan Luo Jiajia Dong Xi Xiang Jinqiu Cao Ting Wu Miao Xue Jiqiang Zhang | 2021 | Journal of Molecular Cell Biology2021，13，3： | 0 |
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