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| 1 | Nuclear heat shock protein 110 expression is associated with poor prognosis and hyperthermo-chemotherapy resistance in gastric cancer patients with peritoneal metastasis显示文摘AIM To investigate the significance of heat shock protein 110(HSP110) in gastric cancer(GC) patients with peritoneal metastasis undergoing hyperthermochemotherapy.METHODS Primary GC patients(n = 14) with peritoneal metastasis or positive peritoneal lavage cytology who underwent distal or total gastrectomy between April 2000 and December 2011 were enrolled in this study. The patients underwent postoperative intraperitoneal hyperthermo-chemotherapy using a Thermotron RF-8 heating device two weeks after surgery. We analyzed nuclear HSP110 expression in surgically resected tumors using immunohistochemistry. Additionally, the effect of HSP110 suppression on hyptherthermochemosensitivity was assessed in vitro in the MKN45 GC cell line using the HSP inhibitor KNK437. RESULTS HSP110 immnohistochemical staining in 14 GC patients showed that five(35.7%) samples belonged to the low expression group, and nine(64.3%) samples belonged to the high expression group. Progression-free survival was significantly shorter in the HSP110 high-expression group than in the low-expression group(P = 0.0313). However, no significant relationships were identified between HSP110 expression and the clinicopathological characteristics of patients. Furthermore, high HSP110 expression was not an independent prognostic factor in GC patients with peritoneal metastasis(P = 0.0625). HSP110 expression in MKN45 cells was suppressed by KNK437 at the hyperthermic temperature of 43 ℃ in vitro. Comparison of MKN45 cell proliferation in the presence and absence of KNK437 at 43 ℃, revealed that proliferation was significantly decreased when HSP110 was inhibited by KNK437. Additionally, HSP110 suppression via HSP inhibitor treatment increased cellular sensitivity to hyperthermo-chemotherapy in vitro.CONCLUSION The expression of nuclear HSP110 in GC patients might be a new marker of chemosensitivity and a therapeutic target for patients who are tolerant to existing hyperthermo-chemotherapies. | Akiharu Kimura Kyoichi Ogata Bolag Altan Takehiko Yokobori Erito Mochiki Mitsuhiro Yanai Norimichi Kogure Toru Yanoma Masaki Suzuki Tuya Bai Hiroyuki Kuwano | 2017 | World Journal of Gastroenterology2017，23，42： | 5 |
| 2 | Evaluation of soluble adhesion molecules CD44 (CD44st,CD44v5,CD44v6),ICAM-1,and VCAM-1 as tumor markers in head and neck cancer Am显示文摘 | KAWANO T YANOMA S NAKAMURA Y | 2005 | Otolaryngol2005，26，5： | 1 |
| 3 | Expression of MMP-7 andMT1-MMP in peritoneal dissemination of gastric cancer显示文摘 | Yoshikawa T Yanoma S Tsuburaya A | 2006 | Hepatogas-troenterology2006，53，72： | 1 |
| 4 | Therapeeutic efficiency of IL-2 gene transduced tumor vaccine for head and neck carcinoma显示文摘 | Nizuno H Yanoma S NishimuraG | 2000 | Cancer Lett2000，152，2： | 1 |
| 5 | Expression of MMP-7 and MT1-MMP in peritoneal dissemination of gas- tric cancer 显示文摘 | Yoshikawa T Yanoma S Tsuburaya A | 2006 | Hepatogastroenterology2006，53，72： | 1 |
| 6 | Expression of MMP-7 and MT1-MMP in peritoneal dissemination of gastric cancer显示文摘 | Yoshikawa T Yanoma S Tsuburaya A | 2006 | Hepatogastroenterology2006，53，72： | 1 |
| 7 | Expression of Ecadherin and CD44S and CD44V6 and its association with prognosis in head and neck cancer显示文摘 | Kawano T Nakamura Y Yanoma S | 2004 | Auris Nasus Larynx2004，31，1： | 1 |
| 8 | An experimental model of tumor dormancy therapy for advanced head and neck carcinoma显示文摘 | MISHIMURA G YANOMA S SATAKE K | 2000 | Jpn J Cancer Res2000，91，11： | 1 |
| 9 | A selective cyclooxygenase-2 inhibitor suppresses tumor growth in nude mouse xenografted with human head and neck squamous carcinoma cells显示文摘 | NISHIMURA G YANOMA S MIZUNO H | 1999 | Jpn J Cancer Res1999，90，： | 1 |
| 10 | Evaluation of soluble ad- hesion molecules CD44 ( CD44st, CD44v5, CD44v6 ) , ICAM-1, and VCAM-1 as tumor markers in head and neck cancer 显示文摘 | Kawano T Yanoma S Nakamura Y | 2005 | Am J Otolaryngo12005，26，5： | 1 |
| 11 | Reovirus oncolysis in human head and neck squamous carcinoma cells 显示文摘 | Ikeda Y Nishimura G Yanoma S | 2004 | Auris Nasus Larynx2004，31，4： | 1 |
| 12 | Evaluation of soluble adhesion molecules CD44 (CD44 st,CD44 v5,CD44 v6),ICAM21,and VCAM21 as tumor markers in head and neck cancer显示文摘 | Kawano T Yanoma S Nakamura Y | | 0，，5： | 1 |
| 13 | Expres- sion of MMP-7 and MT1-MMP in peritoneal dissemination of gastric cancer显示文摘 | YOSHIKAWA T YANOMA S TSUBURAYA A | 2006 | Hepatogastroenterology2006，53，72： | 1 |
| 14 | The inhibitory effects of TNP470 on tumour growth of head and neck carcinoma cell producing interleukin-8 显示文摘 | Kawano T Yanoma S Nishimura G | 2001 | J Laryngol Otol2001，115，10： | 1 |
| 15 | Evaluation of soluble adhesion molecules CD44 (CD44st, CD44v5, CD44v6), ICAM-1, and VCAM- 1 as tumor markers in head and neck cancer显示文摘 | KAWANO T YANOMA S NAKAMURA Y | 2005 | Am J Otolaryngol2005，26，： | 1 |
| 16 | Antitumor activity of a combination of trastuzumab (Herceptin) and oral fluoropyrimidine S-1 on human epidermal growth factor receptor 2-overexpressing pancreatic cancer 显示文摘 | Saeki H Yanoma S Takemiya S | 2007 | Oncol Rep2007，18，2： | 1 |
| 17 | Soluble CD44 standard, CD44 variant 5 and CD44 variant 6 and their relation to staging in head and neck cancer显示文摘 | Kawano T Yanoma S Nakamura Y | 2005 | Aeta Otolaryngol2005，125，4： | 1 |
| 18 | Water-generated negative air ions activate NK cell and inhibit carcinogenesis in mice 显示文摘 | R Yamada S Yanoma M Akaike | 2006 | Cancer Letters2006，236，： | 1 |
| 19 | Antiogenesis inhibitor, TNP-470, suppresses growth of peritoneal disseminating foci显示文摘 | Yanoma S Tsuburaya A | 2000 | Hepatogastroenterology2000，47，： | 1 |
| 20 | Expression of MMP-7 and MT1-MMP in peritoneal dissemination of gastric cancer显示文摘 | Yoshikawa T Yanoma S Tsuburaya A | 2006 | Hepatogastroenterolog2006，53，72： | 1 |
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