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| 1 | Programmable time-domain digital-coding metasurface for non-linear harmonic manipulation and new wireless communication systems显示文摘Optical non-linear phenomena are typically observed in natural materials interacting with light at high intensities, and they benefit a diverse range of applications from communication to sensing. However,controlling harmonic conversion with high efficiency and flexibility remains a major issue in modern optical and radio-frequency systems. Here, we introduce a dynamic time-domain digital-coding metasurface that enables efficient manipulation of spectral harmonic distribution. By dynamically modulating the local phase of the surface reflectivity, we achieve accurate control of different harmonics in a highly programmable and dynamic fashion, enabling unusual responses, such as velocity illusion. As a relevant application, we propose and realize a novel architecture for wireless communication systems based on the time-domain digital-coding metasurface, which largely simplifies the architecture of modern communication systems, at the same time yielding excellent performance for real-time signal transmission. The presented work, from new concept to new system, opens new pathways in the application of metamaterials to practical technology. | Jie Zhao Xi Yang Jun Yan Dai Qiang Cheng Xiang Li Ning Hua Qi Jun Chen Ke Guo Dong Bai Shuo Liu Shi Jin Andrea Alù Tie Jun Cui | 2019 | National Science Review2019，6，2： | 46 |
| 2 | Brain-derived neurotrophic factor and its related enzymes and receptors play important roles after hypoxic-ischemic brain damage显示文摘Brain-derived neurotrophic factor(BDNF) regulates many neurological functions and plays a vital role during the recovery from central nervous system injuries. However, the changes in BDNF expression and associated factors following hypoxia-ischemia induced neonatal brain damage, and the significance of these changes are not fully understood. In the present study, a rat model of hypoxic-ischemic brain damage was established through the occlusion of the right common carotid artery, followed by 2 hours in a hypoxic-ischemic environment. Rats with hypoxic-ischemic brain damage presented deficits in both sensory and motor functions, and obvious pathological changes could be detected in brain tissues. The m RNA expression levels of BDNF and its processing enzymes and receptors(Furin, matrix metallopeptidase 9, tissuetype plasminogen activator, tyrosine Kinase receptor B, plasminogen activator inhibitor-1, and Sortilin) were upregulated in the ipsilateral hippocampus and cerebral cortex 6 hours after injury;however, the expression levels of these m RNAs were found to be downregulated in the contralateral hippocampus and cerebral cortex. These findings suggest that BDNF and its processing enzymes and receptors may play important roles in the pathogenesis and recovery from neonatal hypoxic-ischemic brain damage. This study was approved by the Animal Ethics Committee of the University of South Australia(approval No. U12-18) on July 30, 2018. | Liu-Lin Xiong Jie Chen Ruo-Lan Du Jia Liu Yan-Jun Chen Mohammed Al Hawwas Xin-Fu Zhou Ting-Hua Wang Si-Jin Yang Xue Bai | 2021 | Neural Regeneration Research2021，16，8： | 12 |
| 3 | Urbanization reduces resource use efficiency of phytoplankton community by altering the environment and decreasing biodiversity显示文摘Urbanization often exerts multiple effects on aquatic and terrestrial organisms,including changes in biodiversity,species composition and ecosystem functions.However,the impacts of urbanization on river phytoplankton in subtropical urbanizing watersheds remain largely unknown.Here,we explored the effects of urbanization on phytoplankton community structure(i.e.,biomass,community composition and diversity)and function(i.e.,resource use efficiency)in a subtropical river at watershed scale in southeast China over 6 years.A total of 318 phytoplankton species belonging into 120 genera and 7 phyla were identified from 108 samples.Bacillariophyta biomass showed an increasing trend with increasing urbanization level.The phytoplankton community shifted from Chlorophyta dominance in rural upstream waters to Bacillariophyta dominance in urbanized downstream waters.Furthermore,phytoplankton diversity and resource use efficiency(RUE=phytoplankton biomass/total phosphorus)were significantly decreased with increasing urbanization level from upstream to downstream.Phytoplankton RUE exhibited a significant positive correlation with species richness,but a negative correlation with phytoplankton evenness.The variation in environmental factors(turbidity,total nitrogen,NH_(4)^(+)-N,total phosphorus,PO_(4)^(3-)-P and percentage urbanized area)was significantly correlated with phytoplankton diversity and RUE.Overall,our results revealed the influence of urbanization on phytoplankton community structure and ecosystem function was due to its altering the environmental conditions.Therefore,human-driven urbanization may play crucial roles in shaping the structure and function of phytoplankton communities in subtropical rivers,and the mechanism of this process can provide important information for freshwater sustainable uses,watershed management and conservation. | Yigang Yang Huihuang Chen Mamun Abdullah Al Jean Claude Ndayishimiye Jun R Yang Alain Isabwe Anqi Luo Jun Yang | 2022 | Journal of Environmental Sciences2022，34，2： | 4 |
| 4 | Efficacy of Yangyin Yiqi Huoxue Granule (养阴益气活血颗粒) in Treatment of Ischemic Stroke Patients with Qi-Yin Deficiency and Blood Stasis Syndrome: A Randomized, Double-Blind, Multicenter, Phase-2 Clinical Trial显示文摘Objective To evaluate the efficacy and safety of Yangyin Yiqi Huoxue Granule(养阴益气活血颗粒,YYHG)in the treatment of ischemic stroke(IS)patients with qi-yin deficiency and blood stasis syndrome(QYDBSS),and to explore its effective dosage.Methods The total of 288 patients were randomly assigned to the YYHG high-dose,YYHG low-dose,positive control(administered Xiaoshuantong Granule,XSTG,消栓通颗粒),or placebo control(administered inert granule)groups(72 cases per group)by software-drived competitive block randomization.The trial was conducted for a 28-day period,with a 180-day follow-up period.The primary outcome was the comprehensive curative evaluation,and secondary outcomes were the National Institute of Health Stroke Scale(NIHSS)score,Barthel activities of daily living(ADL)index score,the quality of life index(QLI)score,and the Chinese medicine syndrome(CMS)score.All analyses were done on an intention-to-treat basis.The clinical safety was also assessed.Results The total of 288 participants were recruited between June 1,2008 and September 30,2009,and 287 patients received intervention;the treatment groups were well balanced at baseline.The comprehensive cure rates of YYHG high-dose,low-dose,positive and placebo control groups were 63.38%,31.94%,36.11%and 6.14%,respectively;there was a statistical difference between the two groups(P<0.01),while the high-dose YYHG treatment group was significantly higher than the other 3 groups(P<0.01).The improvement of NIHSS,ADL,QLI and CMS scores of the YYHG high-dose and low-dose groups was significantly better than that of the positive control group and the placebo control group(P<0.05).In terms of improving the classification of the NIHSS scale and the assessment of the ADL scale,the YYHG high-dose group was significantly better than the other three groups(P<0.05),and the YYHG low-dose group was better than the placebo control group(P<0.01).At the same time,except for the QLI score,the high-dose group was better than the low-dose group(P<0.05).In terms of safety,adverse reactions after YYHG treatment were generally mild(3.78%),and no serious adverse reactions have been reported.Conclusion YYHG is safe and effective in the treatment of IS patients with QYDBSS. | WANG Yu YANG Jie-hong WAN Hai-tong HE Yu XU Bin Al Chang-shan ZHOU Hui-fen YU Li WAN Hao-fang BIE Xiao-dong | 2021 | Chinese Journal of Integrative Medicine2021，27，11： | 4 |
| 5 | Cardiac differentiation and electrophysiology characteristics of bone marrow mesenchymal stem cells显示文摘 | LIU Bo-wu LU An-lin HOU Jing HUANG Wei LI Yao HOU Zhao-lei HOU Hong DA Jing YANG Na Al Shi-yi | 2012 | Chinese Medical Journal2012，，18： | 3 |
| 6 | Interleukin-1 in cerebral ischemia显示文摘 | Betz AL Schielke GP Yang GY | 1996 | Keio J Med1996，45，： | 2 |
| 7 | Immunogenicity and safety of NVSI-06-07 as a heterologous booster after priming with BBIBP-CorV:a phase 2 trial显示文摘The increased coronavirus disease 2019(COVID-19)breakthrough cases pose the need of booster vaccination.We conducted a randomised,double-blinded,controlled,phase 2 trial to assess the immunogenicity and safety of the heterologous prime-boost vaccination with an inactivated COVID-19 vaccine(BBIBP-CorV)followed by a recombinant protein-based vaccine(NVSI-06-07),using homologous boost with BBIBP-CorV as control.Three groups of healthy adults(600 individuals per group)who had completed two-dose BBIBP-CorV vaccinations 1–3 months,4–6 months and≥6 months earlier,respectively,were randomly assigned in a 1:1 ratio to receive either NVSI-06-07 or BBIBP-CorV boost.Immunogenicity assays showed that in NVSI-06-07 groups,neutralizing antibody geometric mean titers(GMTs)against the prototype SARS-CoV-2 increased by 21.01–63.85 folds on day 28 after vaccination,whereas only 4.20–16.78 folds of increases were observed in control groups.For Omicron variant,the neutralizing antibody GMT elicited by homologous boost was 37.91 on day 14,however,a significantly higher neutralizing GMT of 292.53 was induced by heterologous booster.Similar results were obtained for other SARS-CoV-2 variants of concerns(VOCs),including Alpha,Beta and Delta.Both heterologous and homologous boosters have a good safety profile.Local and systemic adverse reactions were absent,mild or moderate in most participants,and the overall safety was quite similar between two booster schemes.Our findings indicated that NVSI-06-07 is safe and immunogenic as a heterologous booster in BBIBP-CorV recipients and was immunogenically superior to the homologous booster against not only SARS-CoV-2 prototype strain but also VOCs,including Omicron. | Nawal Al Kaabi Yun Kai Yang Jing Zhang Ke Xu Yu Liang Yun Kang Ji Guo Su Tian Yang Salah Hussein Mohamed Saif ElDein Shuai Shao Sen Sen Yang Wenwen Lei Xue Jun Gao Zhiwei Jiang Hui Wang Meng Li Hanadi Mekki Mekki Walid Zaher Sally Mahmoud Xue Zhang Chang Qu Dan Ying Liu Jing Zhang Mengjie Yang Islam Eltantawy Peng Xiao Zhao Nian Wang Jin Liang Yin Xiao Yan Mao Jin Zhang Ning Liu Fu Jie Shen Liang Qu Yun Tao Zhang Xiao Ming Yang Guizhen Wu Qi Ming Li | 2022 | Signal Transduction and Targeted Therapy2022，7，7： | 2 |
| 8 | Experimental intracerebral hemorrhage relationship between brain edema, blood flow, and blood-brain barrier permeability in rat显示文摘 | YANG GY BETZ AL CHENERERT TL | 1994 | J Neurosurg1994，81，1： | 1 |
| 9 | Degradation of dye pollutants by immobilized polyoxometalate with H2O2 under visible-light irradiation显示文摘 | Lei P X Chen C C Yang J el al | 2005 | Environmental Science and Technology2005，39，21： | 1 |
| 10 | The MYB transcription factor super-family of Arabidopsis:expression analysis and phylogenetic comparisonwith the rice MYB family显示文摘 | CHEN Y H YANG X Y HE Ke t al | 2006 | Plant Molecular Biology2006，60，： | 1 |
| 11 | Adenovirus E1B 55-kilodalton oncoprotein inhibits p53 acetylation by PCAF显示文摘 | Liu Y Colosimo AL Yang XJ | 2000 | Mol Cell Biol2000，20，15： | 1 |
| 12 | Reperfusion-induced injury to the blood-brain barrier after middle artery occlusion in rats显示文摘 | Yang GY Betz AL | 1994 | Stroke1994，25，8： | 1 |
| 13 | Experimental intracerebral hemorrhage:relationship between brain edema,blood flow,and blood -brain barrier permeability in rat显示文摘 | Yang GY Betz AL Chenerert TL | 1994 | J Neurosurg1994，81，： | 1 |
| 14 | Phenylbutyric acid protects against spatial memory deficits in a model of repeated electroconvulsive therapy显示文摘 | Yao ZH Kang X Yang L ct al | 2014 | Curr Neurovasc Res2014，11，2： | 1 |
| 15 | Ethyl Pyruvate Ameliorates Liver Injury Secondary to Severe Acute Pancreatitis显示文摘 | Yang R Shaufl AL Killeen ME | | 0，，： | 1 |
| 16 | Journal of Physics D: Applied Physics显示文摘 | Fan X A Yang J Y Chen R G e? al | 2006 | 39(4): 7402006，39，4： | 1 |
| 17 | prevalence of diabetes among men and women in china显示文摘 | Yang W Luj el al | 2010 | N Engl j med2010，362，12： | 1 |
| 18 | Halide salts acceleratedegradation of high explosives by zerovalent iron 显示文摘 | Kim J S Shea P J Yang J E ef al | 2007 | Environmental Pollution2007，147，3： | 1 |
| 19 | Authorized public auditing of dy-namic big data storage on cloud with efficient verifiable fine-grained updates显示文摘 | LIU C CHEN J YANG L T et al | 2014 | IEEE Transactions on Parallel & Distributed Systems2014，25，9： | 1 |
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