| 1 | Multi-centric clinical study of the effect of intervention time on efficacy of gastroparesis external application prescription treatment of gastrointestinal tumor postsurgical gastroparesis显示文摘Objective:This intervention has been shown to be clinically efficacious and safe.The aim of this study was to determine the effect of different intervention times on the efficacy of gastroparesis external application prescription versus placebo for the treatment of gastrointestinal tumor postoperative,postsurgical gastroparesis.Methods:A multicenter,randomized,double-blind,placebo controlled phaseⅢclinical trial was designed to demonstrate superiority and conducted at four grade 3A hospitals in Beijing.Patients diagnosed with gastrointestinal tumor postsurgical gastroparesis and local cold syndrome in the abdomen were enrolled and received conventional treatment(nutritional support,gastrointestinal decompression,and prokinetic medication).Treatment and control groups respectively received gastroparesis external application prescription or placebo acupoint application over a treatment course of 14 days or until the primary efficacy endpoint(clinical efficiency)was achieved.Results:A total of 120 patients were enrolled in the treatment and control groups(n Z 60 per group),and 15 patients dropped out of the study because of skin allergies(n Z 7)or poor efficacy(nZ8).The efficacy among patients in Class B of Group A(treatment group)was marginally better than that of Group B(control group)(64.28%vs.55.56%)although the difference between the two groups was not significant.However,the efficacy among patients in Class C of Group A was significantly better than that of Group B(79.49%vs.43.33%).For Group A,the time for patients in the three classes to achieve the efficacy endpoint increased significantly with disease progression(3.00,6.78,and 8.29 days for Class A,B,and C,respectively).Conclusions:Gastroparesis external application prescription can effectively treat gastrointestinal tumor postsurgical gastroparesis and may be more efficacious in progressive disease compared placebo.Patients with gastrointestinal tumor postsurgical gastroparesis should therefore undergo intervention at an earlier stage. | Qin Zhou Minghuan Zuo Yantao Tian Yanbin Wang Yingjiang Ye Chao An Tian Zhou Chuanbo Liu Kaiwen Hu Quanwang Li | 2016 | Journal of Traditional Chinese Medical Sciences2016，3，4： | 2 |
| 2 | Hydrothermal growth of KTiOPO_(4) crystal for electro-optical application显示文摘'New'electro-optical(EO)crystals are hard to find,'old'EO crystals are scarce and each has its own problems,and the demand for high-performance EO crystals by higher power,higher repetition rate,and narrower pulse width laser is realistic and urgent.The EO performance of KTP was recognized as soon as it was discovered,but after more than 40 years of development,the reports,and products of EO devices based on KTP are less than those of other EO crystals,even though KTP is now almost the cheapest nonlinear optical crystal material.In this paper,based on our understanding of the crystal structure of predecessors and ourselves,especially the understanding and practice of quasi-one-dimensional ionic conduction mechanism,we think that crystal growth is the most important reason that affects the controllability of crystal performance.Through a series of science and technology,we realize the growth of large-size crystals with high-optical uniformity,then reduce the absorption of KTP to a very low level,and grow crystals with resistance to electric damage and laser damage.On this basis,reducing the conductivity and improving the uniformity of optical,electrical,piezoelectric,and ferroelectric properties are emphasized.The extinction ratio,piezoelectric ringing effect,and thermal influence of the EO switch based on KTP crystal are tested,and some publicly available progress of using KTP EO devices in high-repetition rate laser is listed.Finally,we are looking forward to the development of KTP EO crystal for the laser system to EO generator for integrated optics. | Haitao Zhou Xiaoling He Wenyuan Wu Jingfang Tong Jinliang Wang Yanbin Zuo Yicheng Wu Changlong Zhang Zhanggui Hu | 2023 | Light(Science & Applications)2023，12，1： | 1 |
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