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| 1 | Alkaline Intrusives at the East Foot of the Taihang-Da Hinggan Mountains:Chronology,Sr,Nd and Pb Isotopic Characteristics and Their Implications显示文摘Based on the Rb-Sr isochron dating results, this paper suggests that the alkaline intrusive belt at the east foot of the Taihang-Da Hinggan Mountains were formed between 135 and 122 Ma. And the alkaline intrusives in the north and south sections of this belt have entirely different Sr, Nd and Pb isotopic characteristics, i.e., all the rocks in the south section have positive εSr(t) and negative εNd(t) values and all those in the north have the opposite values. On the εSr(t) versus εNd(t) correlation diagram, the samples from the south are concentrated along the enriched mantle evolution trend lines and nearby, while those from the north fall along the depleted mantle trend lines and nearby. On the Pb isotope composition diagram, most of the samples from the south section fall on the mantle Pb evolution line and nearby, while those from the north lie between the Pb evolution lines of the mantle and the erogenic belt. The above-stated isotopic characteristics not only indicate that the source rocks | YAN Guohan XU Baoliang MU Baolei WANG Guanyu CHANG Zhaoshan CHEN Tingli ZHAO Yongchao WANG Xiaofang ZHANG Renhu QIAO Guangsheng CHU Zhuyin | 2000 | Acta Geologica Sinica(English Edition)2000，74，4： | 18 |
| 2 | Geological Features of Triassic Alkaline and Subalkaline Igneous Complexes in the Yan-Liao Area显示文摘A number of Triassic (245-195 Ma) alkaline or subalkaline igneous complexes were discovered in theYan-liao area in the northern part of the North China platform. These complexes are all poor in SiO2; most ofthem are rich in Fe, Mg, K and P and such incompatible elements as Rb, Ba, U and Sr and REE; theinitial 87Sr / 86Sr ratios range from 0.7055 to 0.7057. They might have originated in the altered upper mantle.On that basis coupled with the distribution of the Triassic System and the tectonic deformation, it is suggestedthat there should have existed a tectono-magmatic belt in the area in Triassic time, which is an important mani-festation of the Indosinian movement in the area. | Mou Baolei Yan Guohan Department of Geology, Peking University, Beijing Fei Zhenbi | 1992 | Acta Geologica Sinica(English Edition)1992，66，4： | 5 |
| 3 | MEK2 is a prognostic marker and potential chemo-sensitizing target for glioma patients undergoing temozolomide treatment显示文摘尽管 temozolomide (TMZ ) 是为 glioblastoma 的首要的化学疗法的代理人,它经常由于药抵抗是非药品。克服 glioblastoma 房间的抵抗到 TMZ,为结果预言识别预示的标记并且开发敏化 chemo 代理人是必要的。这里, TMZ 抵抗、 TMZ 敏感的样品的基因表示侧面被 microarray 分析,和激活 mitogen 的蛋白质 kinase kinase 比较(MEK2 ) 2 在抵抗 glioma 房间然而并非在敏感肿瘤房间或非肿瘤纸巾明确地是 upregulated。而且,耐心的数据的全面分析表明 MEK2 表示的增加的水平响应 TMZ 治疗与 glioma 等级和更坏的预后的前进相关很好。而且,在 U251 glioma 房间线或 xenografted glioma 减少 MEK2 的水平通过调停 shRNA 的基因为击倒的禁止的房间增长建模并且向 TMZ 治疗提高了房间的敏感。从由即时 PCR 的 glioma 病人的肿瘤样品的进一步的分析显示增加的 MEK2 表示水平仔细与许多药抵抗基因的激活被联系。最后,在 MEK2 是在 vitro 的 silenced 以后,这些抵抗基因是 downregulated,建议导致 MEK2 的 chemo 抵抗的机制能被这些抵抗基因的 transcriptional 激活调停。一起,我们的数据显示 MEK2 的表示水平能为 glioma 化疗用作一个预示的标记并且 MEK2 对手能被用作 chemo-sensitizers 提高 TMZ 的治疗功效。 | Hua He Maojin Yao Wenhao Zhang Bangbao Tao Feili Liu Shu Li Yan Dong Chenran Zhang Yicheng Meng Yuxin Li Guohan Hu Chun Luo Hui Zong Yicheng Lu | 2016 | Cellular & Molecular Immunology2016，13，5： | 1 |
| 4 | A skarn-type lead-zinc deposit related to low ^(18)O magma显示文摘THE Baiyinnuo skarn-type lead-zinc deposit occurs within the Da Hinggan Mountains, in theBalinzuo County 360 km north of the Chifeng City, the Inner Mongolia Autonomous Region.Skarns minerals and relevant igneous rocks in the deposits are extremely depleted in 18O. Thephenomena are also found in other skarn-type lead-zinc deposits in the Baiyinnuo region andshould be further studied. | MU Baolei, SHAO Jian, WANG Guanyu, YAN Guohan and Al YongfuDepartment of Geology , Peking University, Beijing 100871, China | 1997 | Chinese Science Bulletin1997，42，19： | 1 |
| 5 | Triassic alkaline intrusives in the YanLiao-Yanshan area:their chronoogy,Sr,Nd and Pb isotopic characteristics and their implication显示文摘 | Yan Guohan Mu Baolei Xu Baoliang | 1999 | Science in China(Series D)1999，42，6： | 1 |
| 6 | Lentiviral-mediated siRNA against osteopotin in U251 glioma cell line显示文摘Background:It has been reported that the expression of SPP1, the mRNA for osteopontin (OPN), is increased in a number of transformed cell lines and some tumors. Increased serum and plasma OPN levels were associated with advanced-stage carcinomas of the lung, breast, colon and prostate. The extent of OPN expression may be correlated with the malignancy degree of gliomas, but the specific role of OPN in the malignancy of gliomas remains to be clarified. Methods:In this study, we used a lentiviral system, which could induce a long-lasting down-regulation of gene expression, to knock down the OPN gene in human glioma cell line U251. And then we observed the proliferation and apoptosis of glioma cells. Results:OPN mRNA and protein were successfully knocked down in U251 cells, and the expression of caspase-3 and caspase-9 were increased about by 2 folds in OPN down-regulated U251 cells. 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium (MTT) assay showed that OPN down-regulation did not affect the proliferation of U251 cells. Conclusion:Our findings indicate that OPN might play a role in apoptosis, but not in cell proliferation in U251 glioma cells. | Xu Tao Chen Juxiang Lu Yicheng Zhou Jinxu Yan Yong Hu Guohan Luo Chun Huang Yan | 2010 | Journal of Medical Colleges of PLA(China)2010，25，1： | 0 |
| 7 | The Rb-Sr age and geological implication of alkaline syenitic complex from Liangtun-Kuangdonggou at Gaixian,eastern Liaoning Province显示文摘Liangtun-Kuangdonggou complex, 30 km southeast of Gaixian Town, Liaoning Province, is composed of aegirine-augite hornblende syenite, aegirine-augite syenite, hornblende syenite, pyroxene syenite and syeno-aegirinolite. Rb-Sr isotopic data to the complex are reported and used for discussion of chronology and geological implication. They show that the complex occurred in early Proterozoic and is a tectonic sign of extension setting. Moreover, the date indicates that the Liaohe Group, which is metamorphic wall rock of the complex, formed over 1 900 Ma ago. | Baoliang Xu Guohan Yan Baolei Mu Linkun Tan Zhongfu He Guangsheng Qiao Renhu Zhang | 1999 | Chinese Science Bulletin1999，44，8： | 0 |
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