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| 1 | Characteristics of non-erosive gastroesophageal reflux disease refractory to proton pump inhibitor therapy显示文摘AIM:To investigate whether potent acid inhibition is effective in non-erosive reflux disease (NERD) refractory to standard rabeprazole (RPZ) treatment. METHODS:We treated 10 Japanese patients with NERD resistant to standard dosages of RPZ:10 mg or 20 mg od,20 mg bid,or 10 mg qid for 14 d. All patients completed a frequency scale for symptoms of gastroesophageal reflux disease questionnaire frequency scale for the symptoms of GERD (FSSG); and underwent 24 h pH monitoring on day 14. RESULTS:With increased dosages and frequency of administration of RPZ,median intragastric pH significantly increased,and FSSG scores significantly decreased. With RPZ 10 mg qid,potent acid inhibition was attained throughout 24 h. However,five subjects were refractory to RPZ 10 mg qid,although the median intragastric pH in these subjects (6.6,range:6.2-7.1) was similar to that in the remaining five responsive subjects (6.5,range:5.3-7.3). With baseline RPZ 10 mg od,FSSG scores in responsive patients improved by > 30%,whereas there was no significant decrease in the resistant group. CONCLUSION:NERD patients whose FSSG score fails to decrease by > 30% after treatment with RPZ 10 mg od for 14 d are refractory to higher dosage. | Mitsushige Sugimoto Masafumi Nishino Chise Kodaira Mihoko Yamade Takahiro Uotani Mutsuhiro Ikuma Kazuo Umemura Takahisa Furuta | 2011 | World Journal of Gastroenterology2011，17，14： | 10 |
| 2 | Efficacy of Tailored Helicobacter pylori Eradication Treatment Based on Clarithromycin Susceptibility and Maintenance of Acid Secretion显示文摘 | Mitsushige Sugimoto Takahiro Uotani Shu Sahara Hitomi Ichikawa Mihoko Yamade Ken Sugimoto Takahisa Furuta | 2014 | Helicobacter2014，，4： | 3 |
| 3 | Rabeprazole 10?mg q.d.s. decreases 24‐h intragastric acidity significantly more than rabeprazole 20 mg b.d. or 40?mg o.m., overcoming CYP 2 C 19 genotype显示文摘 | M. Sugimoto N. Shirai M. Nishino C. Kodaira T. Uotani M. Yamade S. Sahara H. Ichikawa K. Sugimoto H. Miyajima T. Furuta | 2012 | Aliment Pharmacol Ther2012，，7： | 3 |
| 4 | Ability of Rabeprazole to Prevent Gastric Mucosal Damage From Clopidogrel and Low Doses of Aspirin Depends on CYP2C19 Genotype显示文摘 | Takahiro Uotani Mitsushige Sugimoto Masafumi Nishino Chise Kodaira Mihoko Yamade Shu Sahara Takanori Yamada Satoshi Osawa Ken Sugimoto Tatsuo Tanaka Kazuo Umemura Hiroshi Watanabe Hiroaki Miyajima Takahisa Furuta | 2012 | Clinical Gastroenterology and Hepatology2012，，8： | 2 |
| 5 | Tuberous sclerosis patient with neuroendocrine carcinoma of the esophagogastric junction:A case report显示文摘BACKGROUND Tuberous sclerosis complex(TSC)is a rare inherited disease with non-cancerous tumor growths in the skin,brain,kidneys,heart,and lungs.The co-occurrence of neuroendocrine neoplasm(NEN)with TSC is even rarer.There have been few reports on the relationship between TSC and neuroendocrine tumors(NETs),and fewer on the relationship between TSC and neuroendocrine carcinoma(NEC),a subtype of NEN.This is the first reported case of NEC occurring at the esophagogastric junction in a patient with TSC.CASE SUMMARY A 46-year-old woman visiting our hospital for the treatment of TSC was admitted to the emergency department with tarry stools and dizziness.Computed tomography scans revealed thickness of the gastric cardia,multiple metastatic lesions of the liver,and enlarged lymph nodes near the lesser curvature of the stomach.Esophagogastroduodenoscopy revealed a type 3 tumor located from the esophagogastric junction to the fundus,and the pathological diagnosis by biopsy was NEC.The patient was treated with seven courses of cisplatin+irinotecan,followed by eight courses of ramucirumab+nab-paclitaxel,one course of nivolumab,and two courses of S-1+oxaliplatin.Twenty-three months after the first treatment,the patient died because of disease progression and deterioration of the general condition.CONCLUSION This case of NEC occurring in a patient with TSC indicates a difference in the occurrence of NETs and NECs. | Natsuki Ishida Takahiro Miyazu Satoshi Tamura Satoshi Suzuki Shinya Tani Mihoko Yamade Moriya Iwaizumi Satoshi Osawa Yasushi Hamaya Kazuya Shinmura Haruhiko Sugimura Katsutoshi Miura Takahisa Furuta Ken Sugimoto | 2020 | World Journal of Gastroenterology2020，26，45： | 2 |
| 6 | Value of diffusion- weighted imaging and apparent diffusion coefficient in recent cerebral infractions: a correlative study with contrast- enhanced T1- weighted imaging显示文摘 | Yamade N Imakita S Sakuma T | 1999 | AJNR Am J Neuroradid1999，20，2： | 1 |
| 7 | Plasma TNf-a levels in multiple trauma patients 显示文摘 | Endo S lnada K Yamads Y | 1993 | Bums Incl Therm Inj1993，20，2： | 1 |
| 8 | Nu- cleotides enhance the secretion of interleukin 7 from primary- cultured murine intestinal epithelial cells显示文摘 | Ryuji Murakami Kiyoshi Yamadal Shinya Nagafuchi | 2002 | Cytntechnology2002，40，： | 1 |
| 9 | Red-enhanced white-light-emitting diode using a new red phosphor显示文摘 | YAMAD A M NAIYOU T IZUNO K | 2003 | Jpn J Appl Phys2003，42，： | 1 |
| 10 | Cathepsin L inhi-bition prevents murine autoimmune diabetes via suppres- sion of CD8(+) T cell activity显示文摘 | Yamade A Ishimaru N Arakaki R | 2011 | PLoS One2011，5，12： | 1 |
| 11 | Increased expression of ADAM9 and ADAM15 Mrna in pancreatic caneer显示文摘 | Yamad D Ohuchida K Mizumoto K | 2007 | Anti-canc- er Res2007，27，2： | 1 |
| 12 | Frequent association of p53 gene mutation in invasive bladder cancer显示文摘 | Fujimatot K Yamad Y Okajima E | 1994 | Cancer1994，54，： | 1 |
| 13 | Anti-cyanobacterial fatty acids released from Myriophyllum spicatum显示文摘 | Nakai S Yamad S Hosomi M | 2005 | Hydrobiologia2005，，1： | 1 |
| 14 | Postopera tive cerebra hyperperfusion associated with impaired cognitive function in patient undergoing carotid endarterectomy显示文摘 | Ogasawara N Yamadate N Nobayashi M | 2005 | J Neurosurg2005，102，： | 1 |
| 15 | Sitafloxacin‐based third‐line rescue regimens for H elicobacter pylori infection in J apan显示文摘 | Takahisa Furuta Mitsushige Sugimoto Chise Kodaira Masafumi Nishino Mihoko Yamade Takahiro Uotani Shu Sahara Hitomi Ichikawa Takanori Yamada Satoshi Osawa Ken Sugimoto Hiroshi Watanabe Kazuo Umemura | 2014 | J Gastroenterol Hepatol2014，，3： | 1 |
| 16 | Robust reduced-rank adaptive algorithm based on parallel subgradient projection and krylov subspace显示文摘 | M Yukawa R C De Lamare I Yamad | 2009 | IEEE Transactions on Signal Processing2009，57，12： | 1 |
| 17 | Angiotensin Ⅱ receptor blockers decreased blood glucose levels: a longitudinal survey using data from electronic medical records显示文摘 | Kitamura N Takahashi Y Yamadate S | 2007 | Cardiovasc Diabetol2007，6，： | 1 |
| 18 | The prognostic significance of amplification and overexpression of c-met and cerbt2 in human gastric cancinoma显示文摘 | Nakajima M Sawada H Yamads Y | 1999 | Cancer1999，85，9： | 1 |
| 19 | Developmental process of chronic subdural collections of fluid based on CT scan findings 显示文摘 | Yamad H Watanabe T Mutata S | 1990 | Surg neurol1990，13，： | 1 |
| 20 | 显示文摘 | Ossuk E | 1997 | Appl phys1997，81，： | 1 |
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