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| 1 | QT prolongation is associated with increased mortality in end stage liver disease显示文摘AIM To determine the prevalence of QT prolongation in a large series of end stage liver disease(ESLD) patients and its association to clinical variables and mortality.METHODS The QT interval was measured and corrected for heart rate for each patient,with a prolonged QT cutoff defined as QT > 450 ms for males and QT > 470 ms for females.Multiple clinical variables were evaluated including sex,age,serum sodium,international normalized ratio,creatinine,total bilirubin,beta-blocker use,Model for EndStage Liver Disease(MELD),MELD-Na,and etiology of liver disease. RESULTS Among 406 ESLD patients analyzed,207(51.0%) had QT prolongation. The only clinical variable associated with QT prolongation was male gender(OR = 3.04,95%CI:2.01-4.60,P < 0.001). During the study period,187patients(46.1%) died. QT prolongation was a significant independent predictor of mortality(OR = 1.69,95%CI:1.03-2.77,P = 0.039). In addition,mortality was also associated with viral etiology of ESLD,elevated MELD score and its components(P < 0.05 for all). No significant reversibility in the QT interval was seen after liver transplantation. CONCLUSION QT prolongation was commonly encountered in an ESLD population,especially in males,and served as a strong independent marker for increased mortality in ESLD patients. | Sun Moon Kim Bennet George Diego Alcivar-Franco Charles L Campbell Richard Charnigo Brian Delisle Jonathan Hundley Yousef Darrat Gustavo Morales Samy-Claude Elayi Alison L Bailey | 2017 | World Journal of Cardiology2017，9，4： | 3 |
| 2 | The new human kallikrein gene family : implications in carcinogenesis 显示文摘 | Diamandis E P Yousef G M Luo L Y | 2000 | Trends Endocrinol Metab2000，11，2： | 1 |
| 3 | Influence of Al2O3 nano-dispersionson microstructure features and mechanical properties of cast and T6 heat-treated Al-Si hypoeutectic Alloys显示文摘 | I El-Mahallawi H Abdelkader L Yousef A Amer J Mayer A Schwedt | 2012 | Materials Science&Engineering A2012，556，： | 1 |
| 4 | The human kallikrein gene family-implication in carcinogenesis显示文摘 | Diamandis E P Yousef G M Luo L Y | 2000 | Trends Endocrinol Metab2000，11，1： | 1 |
| 5 | A lack of association between elevated serum levels of S100B protein and autoimmunity in autistic children显示文摘 | Yousef L Al-Ayadhi LY Mostafa GA | 2012 | J Neuroinflammation2012，9，： | 1 |
| 6 | One-class SVMs for document classification 显示文摘 | Manevitz L M Yousef M | 2001 | Journal of Machine Learning Research2001，2，1： | 1 |
| 7 | Molecular cloning, physical mapping, and expression analysis of a novel gene, BCL2L12, encoding a proline - rich protein with a highly conserved BH2 domain of the Bcl - 2 family 显示文摘 | Scorilas A Kyriakopoulou L Yousef GM | 2001 | Genomics2001，72，2： | 1 |
| 8 | Protective effect of grape seed proanthocyanidin extract against oxidativestress induced by cisplatin in rats显示文摘 | Yousef M I Saad A A EI-Shnawy L K | 2009 | Food and Chemical Toxicology2009，47，6： | 1 |
| 9 | One-class SVMs for document classification显示文摘 | Manevitz L M Yousef M | 2002 | The Journal of Machine Learning Research2002，2，： | 1 |
| 10 | Quantitative Expression of the human kallikrein gene(KLK9) in Ovarian Cancer, A new independent and favorable prognostic marker显示文摘 | Yousef G M Kyriakopoalou L G Scorilas A | 2001 | Cancer Res2001，61，： | 1 |
| 11 | One-class SVMs for document classification 显示文摘 | Manevitz L M Yousef M Cristianini N | 2001 | Journal of Machine Learning Research2001，2，： | 1 |
| 12 | Finite analytic method and its applications: a review 显示文摘 | LIN W L YOUSEF H RICHARD B | 1997 | Dynamics of Atmospheres and Oceans1997，27，： | 1 |
| 13 | Integrated interpretation of interwell connectivity using injection and production fluctuations 显示文摘 | Yousef A A Jensen J L Lake L W | 2009 | Mathematical Geosciences2009，41，1： | 1 |
| 14 | Stigmasterol and cholesterol regulate the expression of elicitin genes in Phytophthora sojae 显示文摘 | Yousef L F Yousef A F Mymryk J S | 2009 | J Chem Ecol2009，35，： | 1 |
| 15 | Protective effect of grape seed proanthocyanidin extract against oxidative stress induced by cisplatin in rats显示文摘 | YOUSEF M I SAAD A A EL-SHENNAWY L K | 2009 | Food and Chemical Toxicology2009，47，6： | 1 |
| 16 | One-Class SVMs For Document Classifica- tion显示文摘 | Maneivitz L M Yousef M | 2002 | ]qurnal of Machine Leaning Research2002，，2： | 1 |
| 17 | Ginsenosides stimu-late the growth of soil-brone pathogens of American ginseng显示文摘 | NICOL R W YOUSEF L TRAQUAIR J A | 2003 | Phy-tochemistry2003，64，： | 1 |
| 18 | One class SVMs for documentclassification 显示文摘 | Manevitz L Yousef M | 2002 | Journal of Machine Learning Re-search2002，，2： | 1 |
| 19 | One-class SVMs for document classification显示文摘 | Yousef M | 2001 | Journal of Machine Learning Research2001，，2： | 1 |
| 20 | Quantitative expression of the human kallikrein gene 9 (KLK9) in ovarian cancer: a new independent and favorable prognostic marker显示文摘 | Yousef G M Kyriakopoulou L G Scorilas A | 2001 | Cancer Res2001，61，21： | 1 |
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