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| 1 | Neuroprotective effects of bovine colostrum on intracerebral hemorrhage-induced apoptotic neuronal cell death in rats显示文摘Brain cell death after intracerebral hemorrhage may be mediated in part by an apoptotic mechanism. Colostrum is the first milk produced by mammals for their young. It plays an important role in protection and development by providing various antibodies, growth factors and nutrients, and has been used for various diseases in many countries. In the present study, we investigated the anti-apoptotic effects of bovine colostrum using organotypic hippocampal slice cultures and an intracerebral hemorrhage animal model. We performed densitometric measurements of propidium iodide uptake, a step-down avoidance task, Nissl staining, and caspase-3 immunohistochemistry. The present results revealed that colostrum treatment significantly suppressed N-methyl-D-aspartic acid-induced neuronal cell death in the rat hippocampus. Moreover, colostrum treatment improved short-term memory by suppressing hemorrhage-induced apoptotic neuronal cell death and decreasing the volume of the lesion induced by intracerebral hemorrhage in the rat hippocampus. These results suggest that colostrum may have a beneficial role in recovering brain function following hemorrhagic stroke by suppressing apoptotic cell death. | Sung Eun Kim ll Gyu Ko Mal Soon Shin Chang Ju Kim Young Gwan Ko Hanjin Cho | 2012 | Neural Regeneration Research2012，7，22： | 2 |
| 2 | Pharmacology ofexenatide (synthetic exendin 4):apotential therapeut icfor improved glycemic cont rol of type 2 diabetes显示文摘 | Nielsen LL Young AA Parkes DG | 2004 | Regul Pept2004，117，2： | 1 |
| 3 | Pharmacology ofexenatide (synthetic exendin-4): a potential therapeutic for improved glycemic control of type 2 diabetes 显示文摘 | Nielsen LL Young AA Parkes DG | 2004 | Regul Pept2004，117，2： | 1 |
| 4 | The effect of lower limb ischaemia-reperfusion on intestinal permeability and the systemic inflammatory response显示文摘 | Edrees WK Lau LL Young IS | 2003 | Eur J Vase Endovasc Surg2003，25，4： | 1 |
| 5 | Pharmacology of exenatide (synthetic exendin -4) : a potential therapeutic for improved glycemic control of type 2 diabetes 显示文摘 | Nielsen LL Young AA Parkes DG | 2004 | Regul Pept2004，117，2： | 1 |
| 6 | Brain activation of monocyte-lineage cells:involvemen of interleukins-6 显示文摘 | Shafer LL McNuty JA Young MR | 2003 | Neuroimmunomodulation2003，10，5： | 1 |
| 7 | Pharmacology of exenatide (synthetic exendin-4):a potential therapeutic for improved glycemic control of type 2 diabetes显示文摘 | Nielsen LL Young AA Parkes DG | | 0，，： | 1 |
| 8 | Pharmacology of exenatide ( synthetic exendin-4) : a potential therapeutic for improved glycemic control of type 2 diabetes显示文摘 | Nielsen LL Young AA Parkes DG | 2004 | Regul Pept2004，117，： | 1 |
| 9 | Heritability and the comorbidity of attention deficit hyperactivity disorder with behavioral disorders and executive function deficits:a preliminary investigation显示文摘 | Coolidge FL Thede LL Young SE | 2000 | Dev Neuropsychol2000，17，： | 1 |
| 10 | Notch Ligation by Deltal inhibits peripheral immune Responses to trar~splantation antigens by a CDs ~ cell-dependent mechanism 显示文摘 | Wong KK Carpenter M J Young LL | 2003 | Clin Invest2003，112，11： | 1 |
| 11 | Ran- domized controlled trial on the safety of intracameral ceph- alosporins in cataract surgery显示文摘 | LAM PT YOUNG AL CHENG LL TAM PM LEE VY | 2010 | Clin Ophthalmol2010，4，： | 1 |
| 12 | Brain activation of monocyte line- age cells:brain-derived soluble factors differentially regulate BV2 mi- croglia and peripheral macrophage immune functions 显示文摘 | Sharer LL McNuhy JA Young MR | 2002 | Neuroim- munomodulation2002，10，5： | 1 |
| 13 | Notch ligation by Delta1 inhibits peripheral immune responses to transplantation antigens by a CD8^+ cell-dependent mechanism显示文摘 | Wong KK Carpenter MJ Young LL | 2003 | J Clin Invest2003，112，： | 1 |
| 14 | A recovery method using recently updated record information in shared-nothing spatial database cluster显示文摘A shared nothing spatial database cluster is system that provides continuous service even if some system failure happens in any node. So, an efficient recovery of system failure is very important. Generally, the existing method recovers the failed node by using both cluster log and local log. This method, however, cause several problems that increase communication cost and size of cluster log. This paper proposes novel recovery method using recently updated record information in shared nothing spatial database cluster. The proposed technique utilizes update information of records and pointers of actual data. This makes a reduction of log size and communication cost. Consequently, this reduces recovery time of failed node due to less processing of update operations. | JEONG Myeong ho JANG Yong ll PARK Soon young BAE Hae young | 2004 | 重庆邮电学院学报(自然科学版)2004，16，5： | 1 |
| 15 | Pharmacology of exenatide (synthetic exendin-4):a potential therapeutic for improved glycemic control of type 2 diabetes显示文摘 | Nielsen LL Young AA Parkes DG | 2004 | Regul Pept2004，117，2： | 1 |
| 16 | Placental expression of vascular endothelial growth factor in placentae from pregnanciescomplicated by pre-eclampsia and intrauterine growth restriction does not support placental hypoxia at delivery显示文摘 | Lay LL F Young A Boswell F | 1997 | Placenta1997，18，： | 1 |
| 17 | Pharmacology of exenatide (synthetic exendin-4) : a potential therapeutic for improved glycemic control of type 2 diabetes 显示文摘 | Nielsen LL Young AA Parkes DG | 2004 | Regul Pept2004，117，2： | 1 |
| 18 | Pharmacology of exenatide (synthetic exendin-4):a potential therapeutic for improved glycemic control of type 2 diabetes显示文摘 | Nielsen LL Young AA Parkes DG | | 0，，： | 1 |
| 19 | The effect of lower limb ischemia-reperfusion on intestinal permeability and the systemic infammatory response显示文摘 | Edrees WK Lau LL Young IS | 2003 | Eur J Vasc Endovasc Sury2003，25，4： | 1 |
| 20 | Notch signalling in the regulation of peripheral T-cell function显示文摘 | Mckenzie GJ Young LL Briend E | 2003 | Cell Dev Biol2003，14，2： | 1 |
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