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| 1 | Increased virulence of the oral microbiome in oral squamous cell carcinoma revealed by metatranscriptome analyses显示文摘Oral squamous cell carcinoma(OSCC) is the most prevalent and most commonly studied oral cancer. However, there is a void regarding the role that the oral microbiome may play in OSCC. Although the relationship between microbial community composition and OSCC has been thoroughly investigated, microbial profiles of the human microbiome in cancer are understudied. Here we performed a small pilot study of community-wide metatranscriptome analysis to profile mRNA expression in the entire oral microbiome in OSCC to reveal molecular functions associated with this disease. Fusobacteria showed a statistically significantly higher number of transcripts at tumour sites and tumour-adjacent sites of cancer patients compared to the healthy controls analysed. Regardless of the community composition, specific metabolic signatures were consistently found in disease. Activities such as iron ion transport, tryptophanase activity, peptidase activities and superoxide dismutase were over-represented in tumour and tumour-adjacent samples when compared to the healthy controls. The expression of putative virulence factors in the oral communities associated with OSCC showed that activities related to capsule biosynthesis, flagellum synthesis and assembly, chemotaxis, iron transport, haemolysins and adhesins were upregulated at tumour sites. Moreover, activities associated with protection against reactive nitrogen intermediates, chemotaxis, flagellar and capsule biosynthesis were also upregulated in non-tumour sites of cancer patients. Although they are preliminary, our results further suggest that Fusobacteria may be the leading phylogenetic group responsible for the increase in expression of virulence factors in the oral microbiome of OSCC patients. | Susan Yost Philip Stashenko Yoonhee Choi Maria Kukuruzinska Caroline A.Genco Andrew Salama Ellen O.Weinberg Carolyn D.Kramer Jorge Frias-Lopez | 2018 | International Journal of Oral Science2018，10，4： | 9 |
| 2 | Assessment of several typical physical properties of reclaimed farmland filled with Yellow River sediment in Jining, China显示文摘 | Zhenqi Hu Peijun Wang Russell S. Yost Fang Shao Linghua Duo | 2018 | International Journal of Coal Science & Technology2018，5，1： | 4 |
| 3 | Can shortened midtrimester cervical length predict very early spontaneous preterm birth 显示文摘 | Owen J Yost N Berghella V | 2004 | Am J Obstet Gynecol2004，191，： | 1 |
| 4 | A Note on the Gelatinization of Starch 显示文摘 | Hoseney R C Zeleznak K J and Yost D A | 1994 | Starch/Starke1994，38，12： | 1 |
| 5 | Pitch strength of iterated ripple noise显示文摘 | W A Yost | 1996 | J Acotst Soc Am1996，100，： | 1 |
| 6 | Crown ether-doped sol-gel materiaIs for strontium( 1I ) separation显示文摘 | YOST T L Jr FAGAN B C ALLAIN L R | 2000 | Analytical Chemis- try2000，72，21： | 1 |
| 7 | Ovalbumin Sensifization Changes the Inflammatory Response to Subsequent Parainfluenza Infection: Eosinophils Mediate Airway Hyperresponsiveness, M2 Muscarinic Receptor Dysfunction, and Antiviral Effects显示文摘 | Adamko D J Yost B L Gleich G J | 1999 | J Exp Med1999，190，10： | 1 |
| 8 | Effect of ammonium sulfate fertilization on bahiagrass quality and copper me- tabolism in grazing beef cattle显示文摘 | Arthington J D Rechcigl J E Yost G P | 2002 | Journal of Animal Science2002，80，： | 1 |
| 9 | Oleamide potentiates benzodiazepine-sensitive gamma-aminobutyric acid receptor activity but does not alter minimum alveolar anesthetic concentration 显示文摘 | Yost GS Hampson AJ Leonnudakis D | 1998 | Anesth Analg1998，86，： | 1 |
| 10 | Determination of Precipitate Nucleation and Growth Rates from Ultrasonic Harmonic Generation显示文摘 | CANTRELL J H YOST W T | 2000 | Applied Physics Letters2000，77，13： | 1 |
| 11 | The crystal structure of synthetic boeh- mite 显示文摘 | Reichertzes P P Yost W J | 1946 | Joumal Chemistry Physics1946，14，： | 1 |
| 12 | Application of geostatisticsto spatialstudies of soil properties显示文摘 | Trangmar B B Yost R S Uehara G | 1985 | Advancesin Agronomy1985，38，： | 1 |
| 13 | Application of geostatistical tospatial studies of soil properties显示文摘 | Trangmar B B Yost R S Uehara G | 1985 | Advanced Agronomy1985，38，： | 1 |
| 14 | Changes in phosphorus fractions in soils under intensive plant growth 显示文摘 | Guo F Yost R S Hue N V | 2000 | Soil Sci Soc Am J2000，64，： | 1 |
| 15 | Application of geostatistics to spatial studies of soil properties 显示文摘 | Trangmar B B Yost R S Uehara G | 1985 | Ad- vances in Agronomy1985，38，3： | 1 |
| 16 | Stover and potassium management in an upland rice-soybean rotation on an Indonesian Ultisol显示文摘 | Dierolf T S Yost R S | 2000 | Agron J2000，92，： | 1 |
| 17 | GBP, an inhibitor of GSK-3, is implicated in Xenopus development and oncogenesis显示文摘 | Yost C Farr GH Pierce SB | 1998 | Ce111998，93，： | 1 |
| 18 | Chemical properties of atoll soils in the Marshall Islands and constraints to crop roduction显示文摘 | Dcenik JL Yost RS | 2006 | Geoderma2006，136，34： | 1 |
| 19 | Early versus delayed selective surfactant treatment for neonatal respiratory distress syndrome显示文摘 | Yost C C Soll R F | | 0，，02： | 1 |
| 20 | Ureteroscopic laser endopyelotomy:a single-center experience显示文摘 | Matin SF Yost A Streem SB | 2003 | J Endourol2003，17，6： | 1 |
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