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| 1 | Is tenecteplase ready to replace alteplase to treat acute ischaemic stroke? The knowns and unknowns显示文摘Tenecteplase(TNKase,TNK-tPA or TNK)is a thrombolytic agent derived from the tissue plasminogen activator(tPA).It is a 527-amino acid glycoprotein developed by replacing three amino acids at the T,N and K positions of the glycoprotein structure of tPA under genetic recombinant technology.After replacing threonine 103 with asparagine,asparagine 117 with glutamine and a tetra-alanine at amino acids 296–299,TNK is about eightfold more potent in dissolving clot,80-fold higher resistance to plasminogen activator inhibitor-1 and 14-fold enhanced relative fibrin specificity,and with a longer half-life(20 min).1 Hence,TNK is administered as a single intravenous bolus. | Yi Dong Yi Sui Xin Cheng David Z Wang | 2022 | Stroke & Vascular Neurology2022，7，1： | 3 |
| 2 | EYA4、GRHL2和DFNA5基因多态性与中国人群噪声性听力损失的关联-一项病例对照研究显示文摘噪声性听力损失(NIHL)是由环境因素和遗传因素共同作用导致的疾病。动物实验已经证实,遗传因素会导致NIHL的发生,人群研究中也已经发现相关的易感基因。考虑到EYA4、GRHL2和DFNA5基因在人耳听觉系统中发挥重要的作用,研究者假设这些基因的多态性可能与NIHL的发生有关。 | Zhang X Yi L Lei Z 徐相蓉 | 2017 | 中华预防医学杂志2017，51，2： | 2 |
| 3 | Improved efficacy of DNA vaccination against breast cancer by boosting with the repeat beta-hcgc-terminal peptide carried by mycobacterial heat-shock protein Hsp65 显示文摘 | Yi H Rong Y Yankai Z | 2006 | Vaccine2006，24，14： | 1 |
| 4 | In situ drift study of low-temperature methanol synthesis mechanism on Cu/ZnO catalysts from CO2-containing syngas using ethanol promoter 显示文摘 | Ruiqin Y Yilu F Yi Z | 2004 | J Catal2004，228，1： | 1 |
| 5 | Influence of environmental factors on reductive bioprecipitation of uranium by sulfate reducing bacteria 显示文摘 | Yi Z J Tan K X Tan A L | 2007 | International Biodeterioration and Biodegradation2007，60，4： | 1 |
| 6 | A fundamental understanding to the failure of cement concrete pavement based on the concept of fracture mechanics显示文摘 | YI Z J YANG Q G TANG B M | 2002 | International Journal of Road Material and Pavement Design2002，3，3： | 1 |
| 7 | Proteome analysis of human liver carcinoma Huh7 cells harboring hepatitis C virus subgenomic replicon显示文摘 | Fang C Yi Z Liu F Lan S Wang J Lu H Yang P Yuan Z | 2006 | Proteomics2006，6，2： | 1 |
| 8 | Numerical modeling of arc root transfer during contact opening in a low voltage air circuit breaker 显示文摘 | YI W RONG M Z YANG F | 2008 | IEEE Transactions2008，，： | 1 |
| 9 | Gambogic acid inhibits angiogenesis and prostate tumor growth by suppressing vascular endothelial growth factor receptor 2 signaling显示文摘 | Yi T Yi Z Cho SG | 2008 | Cancer Res2008，68，6： | 1 |
| 10 | Synthesis and Characterization of Novel Fluorescent BOPIM Dyes with Large Stokes Shift 显示文摘 | MAO M F XIAO S Z YI T | 2011 | J Fluorine Chem2011，132，9： | 1 |
| 11 | Chromosome Variation in the Genus Pinellia(Araceae) in China and Japan 显示文摘 | YI T S LI H LI D Z | 2005 | Bot J Linn Soc2005，147，4： | 1 |
| 12 | Z-Source inverter for residential photovoltaic systems显示文摘 | Huang Yi Shen Miaosen Peng F Z | 2006 | IEEE Transactions on Power Electronics2006，21，6： | 1 |
| 13 | Insight into the electrode mechanism in lithium-sulfur batteries with ordered microporous carbon confined sulfur as the cathode显示文摘 | LI Z YUAN L X YI Z Q | 2014 | Advanced Energy Materials2014，4，13： | 1 |
| 14 | Crosstalk between 5-HT2cR and PTEN signaling pathway in atypical antipsychotic-induced meta- bolic syndrome and cognitive dysfunction 显示文摘 | CAI J YI Z LU W | 2013 | Med Hypotheses2013，80，4： | 1 |
| 15 | Seismie response predictions of multi-span steel bridges through pushover analysis 显示文摘 | Yi Z Tsutomu U Hanhin G | 2003 | Earthquake Engineering & Structural Dynamics2003，32，： | 1 |
| 16 | Emergency surveil-lance of influenza during 2009 in a Chinese city of Qingdao显示文摘 | WANG Z G YI Y YANG T T | 2010 | Influenza and Other Respiratory Viruses2010，5，1： | 1 |
| 17 | Ecological risk assessment of heavy metals in sediment and human health risk assessment of heavy metals in fishes in the middle and lower reaches of the Yangtze River basin 显示文摘 | Yi Y Yang Z Zhang S | 2011 | Environmental Pollution2011，159，10： | 1 |
| 18 | Mutli-period portfolio selection for asset-liability horizon显示文摘 | Yi L Li Z F Li D | 2008 | Journal of Industrial and Management Optimization2008，，： | 1 |
| 19 | High-efficiency dye-sensitized solar cells:the influence of lithium ions on exciton dissociation,charge recombination,and surface states显示文摘 | Yu Q J Wang Y H Yi Z H | 2010 | ACS Nano2010，4，10： | 1 |
| 20 | Functional and evolutionary insights into human brain development through global tnmscriptome analysis显示文摘 | Johnson MB Kawasawa YI Mason CE Krsnik Z Coppola G Bogdanovié D | | 0，，04： | 1 |
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