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| 1 | Drug resistance mechanisms and novel drug targets for tuberculosis therapy显示文摘Drug-resistant tuberculosis(TB) poses a significant challenge to the successful treatment and control of TB worldwide.Resistance to anti-TB drugs has existed since the beginning of the chemotherapy era.New insights into the resistant mechanisms of anti-TB drugs have been provided.Better understanding of drug resistance mechanisms helps in the development of new tools for the rapid diagnosis of drugresistant TB.There is also a pressing need in the development of new drugs with novel targets to improve the current treatment of TB and to prevent the emergence of drug resistance in Mycobacterium tuberculosis.This review summarizes the anti-TB drug resistance mechanisms,furnishes some possible novel drug targets in the development of new agents for TB therapy and discusses the usefulness using known targets to develop new anti-TB drugs.Whole genome sequencing is currently an advanced technology to uncover drug resistance mechanisms in M.tuberculosis.However,further research is required to unravel the significance of some newly discovered gene mutations in their contribution to drug resistance. | Md Mahmudul Islam H.M. Adnan Hameed Julius Mugweru Chiranjibi Chhotaray Changwei Wang Yaoju Tan Jianxiong Liu Xinjie Li Shouyong Tan Iwao Ojima Wing Wai Yew Eric Nuermberger Gyanu Lamichhane Tianyu Zhang | 2017 | Journal of Genetics and Genomics2017，44，1： | 15 |
| 2 | 质子交换膜燃料电池建模及其PID控制显示文摘针对目前质子交换膜燃料电池(PEMFC)模型难以适用于控制系统的设计,提出利用Matlab-Simulink仿真工具对PEMFC进行系统动态模型建立,并在此基础上采用比例积分微分(PID)算法控制其输出电压。仿真结果表明该模型较好地反映出PEMFC系统的动态特性,有助于改善PEMFC的设计,提高其性能,而且PID算法能够较好地实现对PEMFC系统的控制,可适用于控制系统的设计。 | 李奇 陈维荣 贾俊波 CHAM Yew Thean 韩明 | 2008 | 电源技术2008，32，9： | 14 |
| 3 | Ursolic acid: An overview on its cytotoxic activities against breast and colorectal cancer cells显示文摘Ursolic acid(UA) is a pentacyclic triterpene of the ursane type. As a common chemical constituent among species of the family Lamiaceae, UA possesses a broad spectrum of pharmacological properties. This overview focuses on the anticancer properties of UA against breast cancer(BC) and colorectal cancer(CRC)that are most common among women and men, respectively. In vitro studies have shown that UA inhibited the growth of BC and CRC cell lines through various molecular targets and signaling pathways.There are several in vivo studies on the cytotoxic activity of UA against BC and CRC. UA also inhibits the growth of other types of cancer. Studies on structural modifications of UA have shown that the –OH groups at C3 and at C28 are critical factors influencing the cytotoxic activity of UA and its derivatives.Some needs for future research are suggested. Sources of information were from ScienceDirect, Google Scholar and PubMed. | Eric Wei Chiang Chan Chu Yong Soon Joash Ban Lee Tan Siu Kuin Wong Yew Woh Hui | 2019 | Journal of Integrative Medicine2019，17，3： | 11 |
| 4 | N-Methyl-D-Aspartate Receptor and Apoptosis in Alzheimer's Disease and Multiinfarct Dementia显示文摘 | Marong Fang Jicheng Li S.C. Tiu Lihong Zhang Mingwei Wang David T. Yew | 2005 | 中国生物学文摘2005，19，11： | 6 |
| 5 | 珍稀食药用真菌虎乳灵芝的研究概况显示文摘综述虎乳灵芝的分类地位、生物学性质、生物化学、营养价值及药理活性等方面的研究进展,并对其发展前景进行展望。 | 吴吉安 曾念开 CHOONG Yew keong 陈向东 | 2013 | 浙江农业科学2013，54，6： | 6 |
| 6 | Capecitabine with radiation is an effective adjuvant therapy in gastric cancers显示文摘AIM:To analyze the outcome of patients who received concurrent capecitabine(Xeloda) and radiation(XRT) compared to the established concurrent 5-fluorouracil(5-FU) with radiation(5FU-RT) and fluoropyrimidine-based chemotherapy alone as adjuvant treatment in gastric cancers.METHODS:All patients with gastric cancers who received adjuvant treatment at the National Cancer Centre Singapore between 1996 and 2006 were reviewed.Treatment outcomes of patients who received XRT were compared with those who had 5FU-RT or chemotherapy alone as adjuvant therapy for gastric cancers.RESULTS:A total of 108 patients were reviewed.Median age at diagnosis was 60.The majority of the patients(64.8%) had advanced stage Ⅲ and Ⅳ disease(with no distant metastasis).All except 4 patients had D2 gastrectomy.Twenty one patients(19.4%) had positive surgical resection margins.Thirty three patients received XRT compared with 52 who had 5FU-RT and 23 who received chemotherapy alone.For the patients in the chemotherapy-only group,all had fluoropyrimidine-based therapy,with added cisplatin in 7 patients and epirubicin in 2 patients.Median recurrence-free survival was longer for the XRT group(52 mo) compared to the 5FU-RT(35 mo) and chemotherapy-only groups(25 mo)(P=0.48).The patients in the XRT group achieved similar median overall survival(53 mo) as the 5FU-RT(54 mo) and the chemotherapy-only groups(44 mo)(P=0.5).CONCLUSION:Capecitabine with concurrent radiation was as effective as concurrent 5FU with radiation or fluoropyrimidine-based chemotherapy alone when used as adjuvant treatment in patients with gastric cancers. | Chee Kian Tham Su Pin Choo Donald Yew Hee Poon Han Chong Toh Simon Yew Kuang Ong Sze Huey Tan Michael Lian Chek Wang Kian Fong Foo | 2010 | World Journal of Gastroenterology2010，16，29： | 6 |
| 7 | 结核分枝杆菌耐药机制显示文摘耐多药结核病和广泛耐药结核病在人类免疫缺陷病毒感染时代的不断增长是有效结核病控制的主要威胁。来自染色体自发突变的结核分枝杆菌耐药概率很低。疾病治疗过程中由于不稳定的药品供应、不合理的治疗方案以及差的患者依从性等人为选择因素导致临床耐药结核病大量发生。已经阐明主要的一线和二线药物包括利福平、异烟肼、吡嗪酰胺、乙胺丁醇、氨基糖甙类和氟喹诺酮类的耐药分子机制。结核分枝杆菌菌株耐药性与毒性/传染性之间的关系需要进一步研究。理解结核分枝杆菌耐药机制将有助于快速分子诊断工具的发展并且可能进一步指导结核病治疗的新药的研制。 | Y.Zhang W. W. Yew 徐彩红(译) 何广学(审校) | 2009 | 国际结核病与肺部疾病杂志2009，4，4： | 5 |
| 8 | Design and implementation of a leader-follower cooperative control system for unmanned helicopters显示文摘In this paper,we present a full scheme for the cooperative control of multiple unmanned aerial vehicle(UAV)helicopters.We adopt the leader-follower pattern to maintain a fixed geometrical formation while navigating the UAVs following certain trajectories.More specifically,the leader is commanded to fly on some predefined trajectories,and each follower is controlled to maintain its position in formation using the measurement of its inertial position and the information of the leader position and velocity,obtained through a wireless modem.More specifications are made for multiple UAV formation flight.In order to avoid possible collisions of UAV helicopters in the actual formation flight test,a collision avoidance scheme based on some predefined alert zones and protected zones is employed.Simulations and experimental results are presented to verify our design. | Ben YUN Ben M. CHEN Kai Yew LUM Tong H. LEE | 2010 | 控制理论与应用(英文版)2010，8，1： | 5 |
| 9 | 菜蓟提取复合物对罗非鱼生长性能和肝脏保护效果的评价显示文摘菜蓟为双子叶植物药菊科菜蓟的叶,有利胆和保肝作用,并有抗脂肪肝功效。试验采用的菜蓟提取复合物,其有效成分主要包括菜蓟提取物和氯化胆碱等,试验验证菜蓟提取复合物对尼罗罗非鱼生长性能、肝脏抗氧化机能、血浆生化指标和肝细胞的影响等。试验分为3组:空白对照组、黄曲霉毒素B(1AFB,100 mg/kg)攻毒阳性组和菜蓟提取复合物添加组(300 mg/kg菜蓟提取复合物+AFB 100 mg/kg)。8周的养殖试验结果表明:饲料中含AFB后,罗非鱼的增重率、特定生长率、成活率比对照组显著降低(P<0.05),成活率显著降低至50%,而饵料系数则显著提高1倍多(P<0.05);但在含AFB的饲料中补充了菜蓟提取复合物后,其增重率、特定生长率、成活率和饵料系数得到明显改善,与对照组相比没有显著差异(P>0.05);AFB的添加导致罗非鱼肌肉水分和肝脏粗脂肪含量显著增加和肌肉粗蛋白含量的显著下降(P<0.05),而在含AFB的饲料中补充了菜蓟提取复合物后,其肌肉水分、粗蛋白和肝脏粗脂肪含量与对照组相比无显著差异(P>0.05);AFB的添加使罗非鱼的SOD和CAT活性及MDA生成量较对照组显著提高(P<0.05);补充菜蓟提取复合物后,MDA生成量较AFB组又显著降低(P<0.05);罗非鱼的Hct因AFB的添加而显著降低(P<0.05),而ALT、AST和AGP则显著提高(P<0.05);菜蓟提取复合物补充后,上述指标又恢复至与对照组相比无显著差异;饲喂含AFB日粮的罗非鱼细胞质空泡化,出现明显的核偏位和严重的脂肪浸润,在含AFB的日粮中补充菜蓟提取复合物后,罗非鱼肝脏组织中形成大量的嗜碱性细胞包围着坏死的细胞,但并未形成明显结节。结果表明,含一定剂量的黄曲霉毒素B(1AFB)的日粮对罗非鱼的生长会造成显著的负面影响,同时导致明显的肝损伤,而菜蓟提取复合物的补充能够减少罗非鱼的死亡,有效地保护其肝脏,并促进罗非鱼的生长。 | 饶瑞 桂庆平 郑宗林 Claire Yew Yoke Ching 刘鸿艳 | 2013 | 饲料工业2013，34，14： | 4 |
| 10 | Characterization and thrust measurements from electrolytic decomposition of ammonium dinitramide(ADN)based liquid monopropellant FLP-103 in MEMS thrusters显示文摘Although ammonium dinitramide(ADN)has been targeted as a potential green monopropellant in future space vehicles,its application potential in Micro-electrical–Mechanical System(MEMS)thrusters or microthrusters has been seldom reported in open literature.In this paper,electrolytic decomposition of Ammonium Dinitramide(ADN)-based liquid monopropellant FLP-103 was carried out in an open chamber and MEMS thrusters were fabricated from poly-dimethylsiloxane(PDMS)to characterize the power consumption.Two thrust measurement methods were employed to investigate the electrolytic decomposition of FLP-103 in MEMS microthrusters.The results show that the monopropellant can be successfully ignited at room temperature through 80 V,0.1 A(8 W)using copper wire as electrodes.In the current thruster design,low thrust was obtained at FLP-103 flowrate of 40μl·min^(-1)but it generated the highest specific impulse,Isp,among all the flowrates tested.The experiments successfully demonstrated the potential application of electrolytic decomposition of FLP-103 in MEMS thrusters. | Asad Rahman Jitkai Chin Feroz Kabir Yew Mun Hung | 2018 | Chinese Journal of Chemical Engineering2018，26，9： | 4 |
| 11 | Functional magnetic resonance imaging and the brain: A brief review显示文摘Functional magnetic resonance imaging(fMRI) is em-ployed in many behavior analysis studies, with blood oxygen level dependent-(BOLD-) contrast imaging being the main method used to generate images. The use of BOLD-contrast imaging in f MRI has been refined over the years, for example, the inclusion of a spin echo pulse and increased magnetic strength were shown to produce better recorded images. Taking careful precautions to control variables during measurement, comparisons between different specimen groups can be illustrated by f MRI imaging using both quantitative and qualitative methods. Differences have been observed in comparisons of active and resting, developing and aging, and defective and damaged brains in various studies. However, cognitive studies using f MRI still face a number of challenges in interpretation that can only be overcome by imaging large numbers of samples. Furthermore, f MRI studies of brain cancer, lesions and other brain pathologies of both humans and animals are still to be explored. | Maggie SM Chow Sharon L Wu Sarah E Webb Katie Gluskin DT Yew | 2017 | World Journal of Radiology2017，9，1： | 4 |
| 12 | The four-and-a-half-LIM protein 2 (FHL2) is overexpressed in gliomas and associated with oncogenic activities显示文摘Glia. 2008 Jul 9.Four-and-a-half-LIM protein 2 (FHL2) is a member of FHL protein family, which plays a crucial role in regulating geneexpression, cell survival, and migration.Although its function in oncogenesis appears to be tumor type-specific, its roles | Ng SS Yew DT Wong BC Kung HF | 2008 | 中国神经肿瘤杂志2008，6，2： | 3 |
| 13 | 去卵巢老年大鼠软骨退变与E_2、MMP-13、TNF-α的相关性显示文摘目的探讨去卵巢老年大鼠雌激素下降与软骨退变的相关性。方法 24只6月龄雌性SD大鼠按数字表法随机分为对照组、去卵巢组和去卵巢+跑步组各8只。对照组常规饲养,去卵巢组行双侧卵巢切除术,去卵巢+跑步组行双侧卵巢切除术合并疲劳训练。5周后处死,取左侧膝关节石蜡包埋,行HE染色、免疫组化分析、膝关节软骨Mankin评分,右侧膝关节抽取关节液检测TNF-α含量,取血清检测E_2含量。结果 (1)膝关节切片HE染色显示:与对照组比较,去卵巢组与去卵巢+跑步组膝关节软骨均出现缺损,其中去卵巢+跑步组缺损最重;(2)与对照组比较,去卵巢组和去卵巢+跑步组mankin评分、膝关节MMP-13表达、关节液TNF-α浓度均明显提高(P<0.01),血清E_2浓度明显降低(P<0.01),且以去卵巢+跑步组变化最为显著。结论老年大鼠雌激素的下降与软骨退变具有一定的相关性。 | KHOO YEW LEE 周逸 张俐 | 2018 | 福建中医药2018，49，2： | 3 |
| 14 | Haptic and visual augmented reality interface for programming welding robots显示文摘 | D. Ni A. W. W. Yew S. K. Ong A. Y. C. Nee | 2017 | Advances in Manufacturing2017，5，3： | 3 |
| 15 | 绿茶提取物EGCG治疗卵巢癌分子机制的生物信息学分析显示文摘目的:通过生物信息学方法分析绿茶提取物茶多酚—表没食子儿茶素没食子酸酯(EGCG)治疗卵巢癌的分子机制。方法:在PubChem数据库中查找EGCG活性靶蛋白,在Gene数据库中查找卵巢癌相关基因,运用Ingenuity Pathway Analysis(IPA)软件,构建二者的信号通路和分子网络并进行分析。结果:二者共同作用的通路有232条,排在前面的主要是癌症分子机制通路、炎症反应通路、细胞因子信号通路;共同的分子网络有6个,也主要体现在'细胞死亡与生存,细胞生长、增殖,细胞发育,DNA的复制、重组、修复,转录后修饰与调控,蛋白质合成'等生物学功能上。预测EGCG作用于卵巢癌的靶点主要为Jun、FADD、NF-κB、BCL2、HIF1α和MMP。结论:EGCG可通过干预卵巢癌相关癌症分子信号通路上多个靶点发挥治疗卵巢癌的作用。 | 张牧 宋新强 张雅芳 陈磊 Lee Yew Mun | 2018 | 现代肿瘤医学2018，26，10： | 3 |
| 16 | Ophthalmology simulation for undergraduate and postgraduate clinical education显示文摘This is a review education paper on the current ophthalmology simulators utilized worldwide for undergraduate and postgraduate training. At present,various simulators such as the EYE Exam Simulator(Kyoto Kagaku Co. Ltd., Kyoto, Japan), Eyesi direct ophthalmoscope simulator(VRmagic, Gmb H, Mannheim,Germany), Eyesi indirect ophthalmoscope simulator(VRmagic, Gmb H, Mannheim, Germany) and Eyesi cataract simulators(VRmagic, Gmb H, Mannheim,Germany). These simulators are thought to be able to reduce the initial learning curve for the ophthalmology training but further research will need to be conducted to assess the effectiveness of the simulation-assisted ophthalmology training. Future research will be of great value to assess the medical students and residents' responses and performance regarding the usefulness of the individual eye simulator. | Daniel Shu Wei Ting Shaun Sebastian Khung Peng Sim Christine Wen Leng Yau Mohamad Rosman Ai Tee Aw Ian Yew San Yeo | 2016 | International Journal of Ophthalmology(English edition)2016，9，6： | 3 |
| 17 | 推拿配合整脊治疗椎动脉型颈椎病的研究概况显示文摘颈椎是人体脊柱活动量最大的关节,纤维环的松弛与颈椎间盘的退变失稳造成颈椎在特定空间及时间范围内发生异常。颈部的肌肉拉伸或收缩持续时间过久容易导致损伤,损伤的软组织使椎体的整体生理曲度改变或小错位而导致颈椎病。其中,椎动脉型颈椎病是颈椎退行性改变后,椎骨内外平衡失稳并压迫. | KHOO YEW LEE 周逸敏 张俐 | 2019 | 福建中医药2019，50，1： | 3 |
| 18 | 中药治疗湿热蕴结型痛风性关节炎研究现状显示文摘痛风是人体嘌呤代谢紊乱、超负荷而导致尿酸盐结晶形成并沉积于皮下、关节、骨骼等而引发局部急、慢性炎症和组织损伤的一种常见病变,其与高尿酸血症直接相关[1]。中医认为该病是因为湿热蕴结于关节处导致其无法排出而发病[2]。饮食过度、肥甘厚腻的生活方式,导致痛风发病率逐渐递增,痛风病患者的生活质量下降[3]。《中医病证诊断疗效标准》中将痛风分为湿热蕴结型、肝肾阴虚型、痰浊阻滞型、瘀热阻滞型4型[4], | KHOO YEW LEE 周逸敏 张俐 | 2018 | 福建中医药2018，49，1： | 3 |
| 19 | Results of intravitreal dexamethasone implant 0.7 mg (Ozurdex^(█)) in non-infectious posterior uveitis显示文摘· AIM: To evaluate the safety and efficacy of dexamethasone implant in patients with non-infectious posterior uveitis with cystoid macular edema(CME).·METHODS: Retrospective analysis of patients reports with CME secondary to non-infectious uveitis treated with dexamethasone implant. Data included type of posterior uveitis, any systemic immunosuppressive therapy, Early Treatment Diabetic Retinopathy Study(ETDRS) best-corrected visual acuity(BCVA), central macular thickness(CMT) on optical coherence tomography(OCT) and signs of intraocular inflammation at baseline and then at 2wk postoperatively and monthly thereafter. Follow-up is up to 10 mo. Any per-operative and post-operative complications were recorded.·RESULTS: Six eyes of 4 patients with CME due to non-infectious posterior uveitis treated with dexamethasone implant. Diagnosis included idiopathic panuveitis, birdshot chorioretinopathy and idiopathic intermediate uveitis. At baseline mean ETDRS BCVA was63 letters and mean CMT 556 μm at 2wk postoperatively mean ETDRS BCVA improved to 70 letters and mean CMT decreased to 329 μm. All eyes showed clinical evidence of decreased inflammation. The duration of effect of the implant was 5 to 6mo and retreatment was required in 2 eyes. Two patients required antiglaucoma therapy for increased intraocular pressures.·CONCLUSION: In patients with non-infectious posterior uveitis dexamethasone implant can be a short-term effective treatment option for controlling intraocular inflammation. | Yew Chong Yap Thomas Papathomas Ahmed Kamal | 2015 | International Journal of Ophthalmology(English edition)2015，8，4： | 2 |
| 20 | A gain-varying UIO approach with adaptive threshold for FDI of nonlinear F16 systems显示文摘A discrete gain-varying unknown input observer (UIO) method is presented for actuator fault detection and isolation (FDI) problems in this paper.A novel residual scheme together with a moving horizon threshold is proposed.This design methodology is applied to a nonlinear F16 system with polynomial aerodynamics coefficient expressions,where the coefficient expressions for the F16 system and UIOs may be slightly different.The simulation results illustrate that a satisfactory FDI performance can be achieved even when the F16 system is under the environment of model uncertainties,exogenous noise and measurement errors. | Jun XU Kai Yew LUM Ai Poh LOH | 2010 | 控制理论与应用(英文版)2010，8，3： | 2 |
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