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| 1 | 烟酰胺磷酸核糖基转移酶促进肺血管重塑,是肺动脉高压的治疗靶点显示文摘肺动脉高压(pulmonary arterial hypertension,PAH)是一种严重的进行性疾病,其标志之一是肺血管重塑。烟酰胺磷酸核糖基转移酶(nicotinamide phosphoribosyl transferase,NAMPT)是调节细胞内烟酰胺腺嘌呤二核苷酸水平、细胞氧化还原状态,调节组蛋白脱乙酰酶,促进细胞增殖和抑制凋亡的一种细胞酶。研究人员假设NAMPT可促进肺血管重塑, | Chen J Sysol JR Singla S Zhao S Yamamura A Valdez-Jasso D Abbasi T Shioura KM Sahni S Reddy V Sridhar A Gao H Torres J Camp SM Tang H Ye SQ Comhair S Dweik R Hassoun P Yuan JX Garcia JG Machado RF 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，2： | 10 |
| 2 | Def defines a conserved nucleolar pathway that leads p53 to proteasome-independent degradation显示文摘通过 ubiquitination 小径的 p53 蛋白质周转是在它的 transcriptional 活动的规定的重要机制;然而,很少通过 proteasome 独立的小径对 p53 周转被知道。消化机关扩大因素(Def ) 蛋白质为消化机关的发展是必要的。在 zebrafish, def 的功能的损失有选择地 upregulates p53 反应基因的表示,它提出至于是在 Def 和 p53 之间的关系的一个问题。我们这里报导 Def 是核仁的蛋白质并且 def 的功能的损失导致 p53 蛋白质的 upregulation,它令人惊讶地在 nucleoli 积累。我们的广泛的研究证明了 Def 能调停这个过程是的 p53 蛋白质和那的降级在 Calpain3 的活动独立于 proteasome 小径,却依赖,半胱氨酸朊酶。我们的调查结果定义调整 p53 的周转功能的一条新奇核仁的小径,它将在 organogenesis 和 tumorigenesis 推进我们 p53 的角色的理解。 | Ting Tao Hui Shi Yihong Guan Delai Huang Ye Chen David P Lane Jun Chen Jinrong Peng | 2013 | Cell Research2013，23，5： | 8 |
| 3 | p53 isoform △113p53/△133p53 promotes DNA double-strand break repair to protect cell from death and senescence in response to DNA damage显示文摘在 DNA 双海滨的 p53 的禁止的角色裂缝(DSB ) 修理对它的压制肿瘤的性质似乎矛盾。p53 isoform Δ 113p53/Δ 133p53 是反对 p53 apoptotic 的 p53 目标基因活动。然而,它在 DNA 损坏修理的功能的信息正在缺乏。这里,我们报导那 Δ 113p53 表示被 γ 强烈导致; -irradiation, 然而并非由紫外照耀或热电震疗法。惊人地, Δ 113p53 支持 DNA DSB 修理小径包括相应再结合,非相应的结束加入并且单个海滨的退火。学习 Δ 的生物意义;在支持 DNA DSB 修理的 113p53,我们产生了 zebrafish Δ 113p53 经由抄写的 M/M 异种像使活跃之物的受动器核酸酶技术并且发现异种对 γ 更敏感;照耀。人的 ortholog, Δ 133p53,被 γ 仅仅也导致;照耀和功能修理支持 DNA DSB。Δ 133p53-knockdown 房间响应 γ 在以后的阶段在 G2 阶段被逮捕;照耀由于 unrepaired DNA DSB 的高水平,它最后导致了房间老朽。而且, Δ 113p53/Δ 133p53 经由 upregulating 支持 DNA DSB 修理由到在他们的倡导者的 p53 应答的元素的一种新奇类型的绑定的修理基因 rad51, lig4 和 rad52 的抄写。我们的结果表明那 Δ 113p53/Δ 133p53 是为由阻止 apoptosis 并且支持 DNA DSB 修理禁止房间老朽的 DNA 损坏应力的一个进化地保存的支持幸存的因素。我们的数据也建议 Δ 的正式就职;在正常房间或纸巾的 133p53 表示为癌症病人提供一个重要忍耐标记给放射疗法。 | Lu Gong Hongjian Gong Xiao Pan Changqing Chang Zhao Ou Shengfan Ye Le Yin Lina Yang Ting Tao Zhenhai Zhang Cong Liu David P Lane Jinrong Peng Jun Chen | 2015 | Cell Research2015，25，3： | 4 |
| 4 | Waste biomass from production process co-firing with coal in a steam boiler to reduce fossil fuel consumption:A case study显示文摘Waste biomass is always generated during the production process in industries.The ordinary way to get rid of the waste biomass is to send them to landfill or burn it in the open field.The waste may potentially be used for co-firing with coal to save fossil fuel consumption and also reduce net carbon emissions.In this case study,the bio-waste from a Nicotiana Tabacum(NT) pre-treatment plant is used as the biomass to co-fire with coal.The samples of NT wastes were analysed.It was found that the wastes were of the relatively high energy content which were suitable for co-firing with coal.To investigate the potential and benefits for adding NT wastes to a Fluidised Bed Combustion(FBC) boiler in the plant,detailed modelling and simulation are carried out using the European Coal Liquefaction Process Simulation and Evaluation (ECLIPSE) process simulation package.The feedstock blending ratios of NT waste to coal studied in this work are varied from 0%to 30%. The results show that the addition of NT wastes may decrease the emissions of CO2 and SOx without reducing the boiler performance. | Hongyan Gu Kai Zhang Yaodong Wang Ye Huang Neil Hewitt Anthony P Roskilly | 2013 | Journal of Energy Chemistry2013，22，3： | 3 |
| 5 | Electrical and thermal conductivity of polymer filled with metal powder 显示文摘 | Ye P Mamunya | 2002 | Eur Polym J2002，38，： | 2 |
| 6 | Predictive modelling of ferroelectric tunnel junctions显示文摘Ferroelectric tunnel junctions combine the phenomena of quantum-mechanical tunnelling and switchable spontaneous polarisation of a nanometre-thick ferroelectric film into novel device functionality.Switching the ferroelectric barrier polarisation direction produces a sizable change in resistance of the junction—a phenomenon known as the tunnelling electroresistance effect.From a fundamental perspective,ferroelectric tunnel junctions and their version with ferromagnetic electrodes,i.e.,multiferroic tunnel junctions,are testbeds for studying the underlying mechanisms of tunnelling electroresistance as well as the interplay between electric and magnetic degrees of freedom and their effect on transport.From a practical perspective,ferroelectric tunnel junctions hold promise for disruptive device applications.In a very short time,they have traversed the path from basic model predictions to prototypes for novel non-volatile ferroelectric random access memories with non-destructive readout.This remarkable progress is to a large extent driven by a productive cycle of predictive modelling and innovative experimental effort.In this review article,we outline the development of the ferroelectric tunnel junction concept and the role of theoretical modelling in guiding experimental work.We discuss a wide range of physical phenomena that control the functional properties of ferroelectric tunnel junctions and summarise the state-of-the-art achievements in the field. | Julian P Velev John D Burton Mikhail Ye Zhuravlev Evgeny Y Tsymbal | 2016 | npj Computational Materials2016，，1： | 2 |
| 7 | Transportation Characteristics Change under Rapid Urban Expansion:A Case Study of Shanghai显示文摘This paper focuses on the economic development and urban morphology as well as its impact on the transportation system during the urban expansion of Shanghai in the last more than 20 years(1986-2008).Based on data from 3 comprehensive transport surveys of Shanghai since 1986,the changes in residential trip demand,vehicle use,and the spatial distribution of trips were studied to understand the demands on the transportation system.The factors contributing to those changes in transportation demand were discussed,by which the conclusions were arrived:1) economic development promotes population growth and stimulates residential trip demand greatly;2) unsynchronized migration of population and job from central district to periphery district of Shanghai make trips and congestion diffuse in the same way;and 3) urban sprawl from a city center encourages the single-occupant vehicle mode,which imposes greater pressure on the roadway system.It is concluded that urban development should coordinate with the transportation system planning and expansion. | LI Ye YE Jianhong CHEN Xiaohong Mohamed A ABDEL-ATY P E CEN Min | 2010 | Chinese Geographical Science2010，20，6： | 2 |
| 8 | Effet of Maotai liguor in inducing metallothioneins and on hepatic stellate cells显示文摘 | Cheng ML Wu J Wang HQ Xue LM Tan YZ Liu P Li CX Huang NH Yao YM Ren LZ Ye L Li L Jia ML | 2001 | Shijie Huaren Xiaohua Zazhi2001，9，12： | 2 |
| 9 | Association between high-sensitivity cardiac troponin T and N-terminal pro-brain natriuretic peptide in a community based population显示文摘 | Xu RY Ye P Luo LM Sheng L Wu HM Xiao WK Zheng J Wang F Xiao TH | 2014 | Chinese Medical Journal2014，，4： | 2 |
| 10 | Application studies of superconducting fault current limitcrs in electric power systems 显示文摘 | YE Lin LIN Liangzhen JUENGST K P | 2002 | IEEE Trans on Applied Superconductivity2002，12，1： | 1 |
| 11 | Fibrin gel as a three dimensional matrix in cardiovascular tissue engineering显示文摘 | Ye Q Benedikt P | 2000 | Eur J Cardiothorac Surg2000，17，3： | 1 |
| 12 | A new model for relationship between light intensity and the rate of photosynthesis in Oryza sativa 显示文摘 | Ye Z P | 2007 | Photosynthetica2007，45，4： | 1 |
| 13 | Metallothioneins are required for formation of cross-adaptation response to neurobehavioral toxicity from lead and mereury exposure in nematodes 显示文摘 | Ye B P Rui Q Wu Q | 2010 | PLoS One2010，5，14： | 1 |
| 14 | Improved efficiency and pace of generating induced pluripotent stem cells from human adult and fetal fibroblasts显示文摘 | Mali P Ye Z Hommond HH | 2008 | Stem Cells2008，26，8： | 1 |
| 15 | Mutant mouse models of insulin-like growth factor actions in the central nervous system显示文摘 | D'Ercole A J Ye P O'Kusky JR | 2002 | Neuropeptides2002，36，： | 1 |
| 16 | Transforming growth factor-beta down-regulates apolipoprotein M in HepG2 cells显示文摘 | Xu N Hurtig M Zhang XY Ye Q Nilsson-Ehle P | 2004 | Biochim Biophys Acta2004，1683，13： | 1 |
| 17 | A simplified homogeneous self-dual linear programming algorithm and its implementation显示文摘 | XU X HUNG P G YE Y | 1996 | Annals of Operations Research1996，62，： | 1 |
| 18 | Organic radionuclide compounds in soils surrounding the Chemobyl Nuclear Power Plant显示文摘 | Yirchenko Ye P Agapkina G I | 1993 | Eurasian Soil Science1993，25，： | 1 |
| 19 | Numerical and Experimental Investigation of Two Phase Flow during Boiling in a Coiled Tube 显示文摘 | Yang Z Peng X F Ye P | 2008 | Int J of Heat & Mass Trans2008，51，： | 1 |
| 20 | Maximum seismic energy in stru- tures 显示文摘 | Ye L P Otani S | 1999 | Earthquake Engineering and Structural Dy- namics1999，28，： | 1 |
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