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| 1 | Scaffolds based therapy for osteochondral lesions of the talus:A systematic review显示文摘AIM To clarify the effectiveness of scaffold-based therapy for osteochondral lesions of the talus(OLT). METHODS A systematic search of MEDLINE and EMBASE databases was performed during August 2016 and updated in January 2017. Included studies were evaluated with regard to the level of evidence(LOE) and quality of evidence(QOE) using the Modified Coleman Methodology Score. Variable reporting outcome data, clinical outcomes, and the percentage of patients who returned to sport at previous level were also evaluated. RESULTS Twenty-eight studies for a total of 897 ankles were included; 96% were either LOE Ⅲ or Ⅳ. Studies were designated as either of poor or fair quality. There were 30 treatment groups reporting six different scaffold repair techniques: 13 matrix-induced autologous chondrocyte transplantation(MACT), nine bone marrow derived cell transplantation(BMDCT), four autologous matrixinduced chondrogeneis(AMIC), and four studies of other techniques. The categories of general demographics(93%) and patient-reported outcome data(85%) were well reported. Study design(73%), imaging data(73%), clinical variables(49%), and patient history(30%) were also included. The weighted mean American Orthopaedic Foot and Ankle Society(AOFAS) score at final follow-up was: 86.7 in MACT, 88.2 in BMDCT, and 82.3 in AMIC. Eight studies reported that a weighted mean of 68.3% ofpatients returned to a previous level of sport activity. CONCLUSION Scaffold-based therapy for OLT may produce favorable clinical outcomes, but low LOE, poor QOE, and variability of the data have confounded the effectiveness of this treatment. | Yoshiharu Shimozono Youichi Yasui Andrew W Ross Wataru Miyamoto John G Kennedy | 2017 | World Journal of Orthopedics2017，8，10： | 4 |
| 2 | Expression of vascular endothelial growth factor in human gastric carcinomas显示文摘 | Yasui W Kitadai Y | 1998 | Pathol Int1998，48，7： | 1 |
| 3 | Reduced expression of cyclin-dependent kinase inhibitor p27 (Kip1) in oral malignant tumors显示文摘 | Ito R Yasui W Ogawa Y | 1999 | Pathobiol1999，67，4： | 1 |
| 4 | Molecular diagnosis of gastric cancer:present and future显示文摘 | Yasui W Oue N Kuniyasu H | 2001 | Gastric Cancer2001，4，： | 1 |
| 5 | Molecular - pathological prognostic factors of gastric cancer : a review 显示文摘 | Yasui W Oue N Aung PP | 2005 | Gastric Cancer2005，8，： | 1 |
| 6 | Expression of podoplanin/D2 -40 in pericryptal stromal cells in superficial colorectal epithelial neoplasia显示文摘 | Nakayama H Enzan H Yasui W | 2013 | Med Mol Morphol2013，46，1： | 1 |
| 7 | Molecular-pathological prognostic factors of gastric cancer: a review 显示文摘 | Yasui W Oue N Aung PP | 2005 | Gastric Cancer2005，8，2： | 1 |
| 8 | Molecular diagnosis of gastrointestinal cancer显示文摘 | Yasui W | 1998 | Gan To Kagaku Ryoho1998，25，2： | 1 |
| 9 | Genetic and epigenetic changes in stomach cancer显示文摘 | Yokozaki H Yasui W Tahara E | 2001 | Int Rev Cytol2001，204，： | 1 |
| 10 | Genetic and epige-netic alterations in multistep carcinogenesis of the stomach 显示文摘 | Yasui W Yokozaki H Fujimoto J | 2000 | J Gastroenterol*2000，35，： | 1 |
| 11 | Ir current and spontaneous activity in mouse embryonic ventrlcular myocytes 显示文摘 | Yasui K Liu W Opthof T ct al | 2001 | Circ Res2001，88，5： | 1 |
| 12 | Reduced expression of cyclin dependent kinase inhibitor p27 KIP1 is associated with advanced stage and invasiness of gastric carcinomas 显示文摘 | Yasui W Kudo Y Semba S | 1997 | Jpn J Cancer Res1997，88，7： | 1 |
| 13 | Distinct pattern of E2F1 expression in human lung tumors: E2F1 is up- regulated in small cell lung caicinoma 显示文摘 | Suzuki T Yasui W Yokozaki H | 2001 | Oncogene2001，20，14： | 1 |
| 14 | Expression of the E2F family in human gastrointestinal carcinomas显示文摘 | SUZUKI T YASUI W YOKOZAKI H | 2011 | Int J Cancer2011，81，1： | 1 |
| 15 | Expression of cyclin E in colorectal adenomas and adenocarcinomas:correlation with expression of Ki-67 antigen and p53 protein显示文摘 | Yasui W Kuniyasu H Yokozaki H | | 0，，01： | 1 |
| 16 | Expression of cyclinE in human gastric adenomas and adenocarcinomas: Correlation with proliferative activity and p53 status显示文摘 | Akama Y kuniyasu H | 1996 | J Exp Ther Oncol1996，1，： | 1 |
| 17 | Reduce expression of nm23 is Associated with metastasis显示文摘 | Nakayama H Yasui W Yokozaki H | 1993 | Jpn J Cancer Res1993，84，： | 1 |
| 18 | Overexpression of cyclin-depen-dent kinase-activating CDC25B phosphatase in human gastric carcinomas显示文摘 | Kudo Y Yasui W Ue T | 1997 | Jpn J Cancer Res1997，88，10： | 1 |
| 19 | Expression of P21WAF1/CIP1 in colorectal adenomas and adenocarvinomas and its correlation with P53 protein expression显示文摘 | Yasui W Akama Y Yokozaki H | 1997 | Pathol Int1997，47，7： | 1 |
| 20 | Expression of P27, cyclinE and E2f-1 in primary and metastatic tumors of gastric carcinoma 显示文摘 | Yasui W Naka K Suzuki T | 1999 | Oncol Rep1999，6，5： | 1 |
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